Regulatory variant of the TPH2 gene and early life stress are associated with heightened attention to social signals of fear in infants

Journal of Child Psychology and Psychiatry and Allied Disciplines

Volumn 55, Issue 7, 2014, Pages 793-801

  Forssman, Linda ^a   Peltola, Mikko J ^a,b   Yrttiaho, Santeri ^a   Puura, Kaija ^c   Mononen, Nina ^a   Lehtimäki, Terho ^a   Leppänen, Jukka M ^a  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b LEIDEN UNIVERSITY   (Netherlands)

^c TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

Attention; facial expression; fear; infancy; maternal stress; tryptophan hydroxylase 2 gene

Indexed keywords

TPH2 PROTEIN, HUMAN; TRYPTOPHAN HYDROXYLASE;

ATTENTION; DEPRESSION; FACIAL EXPRESSION; FEAR; FEMALE; GENETICS; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; INFANT; MALE; MENTAL STRESS; MOTHER; PHYSIOLOGY; PSYCHOLOGY;

ATTENTION; DEPRESSION; FACIAL EXPRESSION; FEAR; FEMALE; GENE-ENVIRONMENT INTERACTION; GENOTYPE; HUMANS; INFANT; MALE; MOTHERS; STRESS, PSYCHOLOGICAL; TRYPTOPHAN HYDROXYLASE;

EID: 84903175144     PISSN: 00219630     EISSN: 14697610     Source Type: Journal    
DOI: 10.1111/jcpp.12181     Document Type: Article

References (33)

1. Attenburrow, M.J., Williams, C., Odontiadis, J., Reed, A., Powell, J., Cowen, P.J., &, Harmer, C.J., (2003). Acute administration of nutritionally sourced tryptophan increases fear recognition. Psychopharmacology (Berl), 169, 104-107.
2. Bagner, D.M., Pettit, J.W., Lewinsohn, P.M., &, Seeley, J.R., (2010). Effect of maternal depression on child behavior: A sensitive period? Journal of the American Academy of Child and Adolescent Psychiatry, 49, 699-707.
3. Bar-Haim, Y., Morag, I., &, Glickman, S., (2011). Training anxious children to disengage attention from threat: A randomized controlled trial. Journal of Child Psychology and Psychiatry, 52, 861-869.
4. Bornstein, M.H., Arterberry, M.E., Mash, C., &, Manian, N., (2011). Discrimination of facial expression by 5-month-old infants of nondepressed and clinically depressed mothers. Infant Behavior and Development, 34, 100-106.
5. Brown, S.M., Peet, E., Manuck, S.B., Williamson, D.E., Dahl, R.E., Ferrell, R.E., &, Hariri, A.R., (2005). A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity. Molecular Psychiatry, 10, 884-888.
6. Brugha, T., Bebington, P., Tennant, C., &, Hurry, J., (1985). The list of threatening experiences: A subset of 12 life events categories with considerable long-term contextual threat. Psychological Medicine, 15, 189-194.
7. Chen, G., &, Miller, G.M., (2012). Advances in tryptophan hydroxylase-2 gene expression regulation: New insights into serotonin-stress interaction and clinical implications. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 159B, 152-171.
8. Chen, G., Vallender, E., &, Miller, G., (2008). Functional characterization of the human TPH2 5′ regulatory region: Untranslated region and polymorphisms modulate gene expression in vitro. Human Genetics, 122, 645-657.
9. Cox, J.L., Holden, J.M., &, Sagovsky, R., (1987). Detection of postnatal depression. development of the 10-item Edinburgh postnatal depression scale. British Journal of Psychiatry, 150, 782-786.
10. Fakra, E., Hyde, L.W., Gorka, A., Fisher, P.M., Munoz, K.E., Kimak, M.,... &, Hariri, A.R., (2009). Effects of HTR1A C(-1019)G on amygdala reactivity and trait anxiety. Archives of General Psychiatry, 66, 33-40.
11. Feldman, R., Granat, A., Pariente, C., Kanety, H., Kuint, J., &, Gilboa-Schechtman, E., (2009). Maternal depression and anxiety across the postpartum year and infant social engagement, fear regulation, and stress reactivity. Journal of the American Academy of Child and Adolescent Psychiatry, 48, 919-927.
12. Fox, N.A., Hane, A.A., &, Pine, D.S., (2007). Plasticity for affective neurocircuitry: How the environment affects gene expression. Current Directions in Psychological Science, 16, 1-5.
13. Gao, J., Pan, Z., Jiao, Z., Li, F., Zhao, G., Wei, Q., &, Evangelou, E., (2012). TPH2 gene polymorphisms and major depression-a meta-analysis. PLoS ONE, 7, e36721.
14. Gardner, K.L., Hale, M.W., Oldfield, S., Lightman, S.L., Plotsky, P.M., &, Lowry, C.A., (2009). Adverse experience during early life and adulthood interact to elevate tph2 mRNA expression in serotonergic neurons within the dorsal raphe nucleus. Neuroscience, 163, 991-1001.
15. Georgiou, G.A., Bleakley, C., Hayward, J., Russo, R., Dutton, K., Eltiti, S., &, Fox, E., (2005). Focusing on fear: Attentional disengagement from emotional faces. Visual Cognition, 12, 145-158.
16. Hahn-Holbrook, J., Holbrook, C., &, Haselton, M.G., (2011). Parental precaution: Neurobiological means and adaptive ends. Neuroscience and Biobehavioral Reviews, 35, 1052-1066.
17. Herrmann, M.J., Huter, T., Muller, F., Muhlberger, A., Pauli, P., Reif, A., &, Lesch, K., (2007). Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on emotional processing. Cerebral Cortex, 17, 1160-1163.
18. Hertzman, C., &, Boyce, T., (2010). How experience gets under the skin to create gradients in developmental health. Annual Review of Public Health, 31, 329-347.
19. Holmboe, K., Nemoda, Z., Fearon, R.M.P., Csibra, G., Sasvari-Szekely, M., &, Johnson, M.H., (2010). Polymorphisms in dopamine system genes are associated with individual differences in attention in infancy. Developmental Psychology, 46, 404-416.
20. LeDoux, J., (2012). Rethinking the emotional brain. Neuron, 73, 653-676.
21. Leonardo, E.D., &, Hen, R., (2007). Anxiety as a developmental disorder. Neuropsychopharmacology, 33, 134-140.
22. Leppänen, J.M., Peltola, M.J., Puura, K., Mäntymaa, M., Mononen, N., &, Lehtimäki, T., (2011). Serotonin and early cognitive development: Variation in the tryptophan hydroxylase 2 gene is associated with visual attention in 7-month-old infants. Journal of Child Psychology and Psychiatry, 52, 1144-1152.
23. Loman, M.M., &, Gunnar, M.R., (2010). Early experience and the development of stress reactivity and regulation in children. Neuroscience and Biobehavioral Reviews, 34, 867-876.
24. Naicker, K., Wickham, M., &, Colman, I., (2012). Timing of first exposure to maternal depression and adolescent emotional disorder in a national canadian cohort. PLoS ONE, 7, e33422.
25. Olsson, A., &, Phelps, E.A., (2007). Social learning of fear. Nature Neuroscience, 10, 1095-1102.
26. Peltola, M.J., Hietanen, J.K., Forssman, L., &, Leppänen, J.M., (2013). The emergence and stability of the attentional bias to fearful faces in infancy. Infancy, 18, 905-926.
27. Pine, D.S., (2007). Research review: A neuroscience framework for pediatric anxiety disorders. Journal of Child Psychology and Psychiatry, 48, 631-648.
28. Raitakari, O.T., Juonala, M., Rönnemaa, T., Keltikangas- Järvinen, L., Räsänen, L., Pietikäinen, M.,... &, Viikari, J.S., (2008). Cohort profile: The Cardiovascular Risk in Young Finns Study. International Journal of Epidemiology, 37, 1220-1226.
29. Rothbart, M.K., (1981). Measurement of temperament in infancy. Child Development, 52, 569-578.
30. Shackman, J.E., Shackman, A.J., &, Pollak, S.D., (2007). Physical abuse amplifies attention to threat and increases anxiety in children. Emotion, 7, 838-852.
31. Strobel, A., Dreisbach, G., Müller, J., Goschke, T., Brocke, B., &, Lesch, K., (2007). Genetic variation of serotonin function and cognitive control. Journal of Cognitive Neuroscience, 19, 1923-1931.
32. Waider, J., Araragi, N., Gutknecht, L., &, Lesch, K., (2011). Tryptophan hydroxylase-2 (TPH2) in disorders of cognitive control and emotion regulation: A perspective. Psychoneuroendocrinology, 36, 393-405.
33. Wass, S., Porayska-Pomsta, K., &, Johnson, M., (2011). Training attentional control in infancy. Current Biology, 21, 1543-1547.