Serotonin and early cognitive development: Variation in the tryptophan hydroxylase 2 gene is associated with visual attention in 7-month-old infants

Journal of Child Psychology and Psychiatry and Allied Disciplines

Volumn 52, Issue 11, 2011, Pages 1144-1152

  Leppänen, Jukka M ^a   Peltola, Mikko J ^a   Puura, Kaija ^b   Mäntymaa, Mirjami ^b   Mononen, Nina ^a   Lehtimäki, Terho ^a  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

Attention; cognition; development; emotion; infancy; serotonin

Indexed keywords

SEROTONIN; TPH2 PROTEIN, HUMAN; TRYPTOPHAN HYDROXYLASE;

ARTICLE; ATTENTION; CHILD DEVELOPMENT; COGNITION; EMOTION; EYE FIXATION; GENETICS; HUMAN; INFANT; PHYSIOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

ATTENTION; CHILD DEVELOPMENT; COGNITION; EMOTIONS; FIXATION, OCULAR; HUMANS; INFANT; POLYMORPHISM, SINGLE NUCLEOTIDE; SEROTONIN; TRYPTOPHAN HYDROXYLASE;

EID: 80053918035     PISSN: 00219630     EISSN: 14697610     Source Type: Journal    
DOI: 10.1111/j.1469-7610.2011.02391.x     Document Type: Article

References (44)

1. Baehne, C.G., Ehlis, A.C., Plichta, M.M., Conzelmann, A., Pauli, P., Jacob, C., et al., (2008). TPH2 gene variants modulate response control processes in adult ADHD patients and healthy individuals. Molecular Psychiatry, 14, 1032-1039.
2. Bigos, K.L., Pollock, B.G., Aizenstein, H.J., Fisher, P.M., Bies, R.R., &, Hariri, A.R., (2008). Acute 5-HT reuptake blockade potentiates human amygdala reactivity. Neuropsychopharmacology, 33, 3221-3225.
3. Brown, S.M., Peet, E., Manuck, S.B., Williamson, D.E., Dahl, R.E., Ferrell, R.E., et al., (2005). A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity. Molecular Psychiatry, 10, 884-888. (Pubitemid 43080123)
4. Browning, M., Reid, C., Cowen, P.J., Goodwin, G.M., &, Harmer, C.J., (2007). A single dose of citalopram increases fear recognition in healthy subjects. Journal of Psychopharmacology, 21, 684-690. (Pubitemid 47437913)
5. Canli, T., Congdon, E., Constable, R.T., &, Lesch, K.P., (2008). Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on neural correlates of affective processing. Biological Psychology, 79, 118-125.
6. Canli, T., Congdon, E., Gutknecht, L., Constable, R.T., &, Lesch, K.P., (2005). Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation. Journal of Neural Transmission, 112, 1479-1485. (Pubitemid 41504264)
7. Chen, G.-L., Vallender, E., &, Miller, G., (2008). Functional characterization of the human TPH2 5′ regulatory region: Untranslated region and polymorphisms modulate gene expression in vitro. Human Genetics, 122, 645-657.
8. Csibra, G., Tucker, L.A., &, Johnson, M.H., (1998). Neural correlates of saccade planning in infants: A high-density ERP study. International Journal of Psychophysiology, 29, 201-215. (Pubitemid 28306605)
9. Fakra, E., Hyde, L. W., Gorka, A., Fisher, P.M., Munoz, K.E., Kimak, M., et al., (2009). Effects of HTR1A C(-1019)G on amygdala reactivity and trait anxiety. Archives of General Psychiatry, 66, 33-40.
10. Fox, N.A., Henderson, H., Pérez-Edgar, K., &, White, L., (2008). The biology of temperament: An integrative approach. In, C.A. Nelson, &, M. Luciana, (Eds.), Handbook of developmental cognitive neuroscience (2nd edn, pp. 839-853). Cambridge, MA: MIT Press.
11. Fox, S.E., Levitt, P., &, Nelson, C.A., (2009). How the timing and quality of early experiences influence the development of brain architecture. Child Development, 81, 28-40.
12. Frick, J.E., Colombo, J., &, Saxon, T.F., (1999). Individual and developmental differences in disengagement of fixation in early infancy. Child Development, 70, 537-548.
13. Furmark, T., Appel, L., Henningsson, S., Ahs, F., Faria, V., Linnman, C., et al., (2008). A link between serotonin-related gene polymorphisms, amygdala activity, and placebo-induced relief from social anxiety. Journal of Neuroscience, 28, 13066-13074.
14. Gaspar, P., Cases, O., &, Maroteaux, L., (2003). The developmental role of serotonin: News from mouse molecular genetics. Nature Reviews Neuroscience, 4, 1002-1012. (Pubitemid 37486676)
15. Gross, C., Zhuang, X., Stark, K., Ramboz, S., Oosting, R., Kirby, L., et al., (2002). Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature, 416, 396-400. (Pubitemid 34272867)
16. Gutknecht, L., Jacob, C., Strobel, A., Kriegebaum, C., Muller, J., et al., (2007). Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation. International Journal of Neuropsychopharmacology, 10, 309-320. (Pubitemid 46701011)
17. Hariri, A.R., &, Holmes, A., (2006). Genetics of emotional regulation: The role of the serotonin transporter in neural function. Trends in Cognitive Sciences, 10, 182-191.
18. Herrmann, M.J., Huter, T., Muller, F., Muhlberger, A., Pauli, P., Reif, A., et al., (2007). Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on emotional processing. Cerebral Cortex, 17, 1160-1163. (Pubitemid 46598857)
19. Holmboe, K., Fearon, R.M., Csibra, G., Tucker, L.A., &, Johnson, M.H., (2008). Freeze-Frame: A new infant inhibition task and its relation to frontal cortex tasks during infancy and early childhood. Journal of Experimental Child Psychology, 100, 89-114.
20. Holmboe, K., Nemoda, Z., Fearon, R.M.P., Csibra, G., Sasvari-Szekely, M., &, Johnson, M.H., (2010). Polymorphisms in dopamine system genes are associated with individual differences in attention in infancy. Developmental Psychology, 46, 404-416.
21. Hood, B.M., (1995). Shifts of visual attention in the human infant: A neuroscientific approach. In, C. Roveer-Collier, &, L. Lipsett, (Eds.), Advances in infancy research (vol. 9, pp. 163-216). Norwood, NJ: Ablex.
22. Hunnius, S., (2007). The early development of visual attention and its implications for social and cognitive development. Progress in Brain Research, 164, 187-209. (Pubitemid 47494694)
23. Hunnius, S., Geuze, R.H., &, van Geert, P., (2006). Associations between the developmental trajectories of visual scanning and disengagement of attention in infants. Infant Behavior and Development, 29, 108-125. (Pubitemid 43046041)
24. Johnson, M.H., (2005). Developmental cognitive neuroscience (2nd edn). Oxford: Blackwell.
25. Johnson, M.H., Posner, M.I., &, Rothbart, M.K., (1991). Components of visual orienting in early infancy: Contingency learning, anticipatory looking and disengaging. Journal of Cognitive Neuroscience, 3, 335-344.
26. Lemonde, S., Turecki, G., Bakish, D., Du, L., Hrdina, P.D., Bown, C.D., et al., (2003). Impaired repression at a 5-hydroxytryptamine 1a receptor gene polymorphism associated with major depression and suicide. Journal of Neuroscience, 23, 8788-8799. (Pubitemid 37176660)
27. Leppänen, J.M., &, Nelson, C.A., (2009). Tuning the developing brain to social signals of emotion. Nature Reviews Neuroscience, 10, 37-47.
28. Leppänen, J.M., Peltola, M.J., Mäntymaa, M., Koivuluoma, M., Salminen, M., &, Puura, K., (2010). Cardiac and behavioral evidence for emotional influences on attention in 7-month-old infants. International Journal of Behavioral Development, 34, 547-553.
29. Lin, Y.-M. J., Chao, S.-C., Chen, T.-M., Lai, T.-J., Chen, J.-S., &, Sun, H. S., (2007). Association of functional polymorphisms of the human tryptophan hydroxylase 2 gene with risk for bipolar disorder in Han Chinese. Archives of General Psychiatry, 64, 1015-1024. (Pubitemid 47360846)
30. Lucki, I., (1998). The spectrum of behaviors influenced by serotonin. Biological Psychiatry, 44, 151-162. (Pubitemid 28378297)
31. Peltola, M.J., Leppänen, J.M., Palokangas, T., &, Hietanen, J.K., (2008). Fearful faces modulate looking duration and attention disengagement in 7-month-old infants. Developmental Science, 11, 60-68.
32. Posner, M.I., &, Petersen, S.E., (1990). The attention system of the human brain. Annual Review of Neuroscience, 13, 25-42. (Pubitemid 20100639)
33. Preacher, K.J., &, Hayes, A., (2004). SPSS and SAS procedures for estimating indirect effects in simple mediation models. Behavior Research Methods, Instruments, and Computers, 36, 717-731. (Pubitemid 40251423)
34. Reuter, M., Ott, U., Vaitl, D., &, Hennig, J.R., (2007). Impaired executive control is associated with a variation in the promoter region of the tryptophan hydroxylase 2 gene. Journal of Cognitive Neuroscience, 19, 401-408. (Pubitemid 46393568)
35. Rothbart, M.K., (1981). Measurement of temperament in infancy. Child Development, 52, 569-578.
36. Rothbart, M.K., Ellis, L.K., Rueda, M.R., &, Posner, M.I., (2003). Developing mechanisms of conflict resolution. Journal of Personality, 71, 1113-1143.
37. Rothbart, M.K., Ziaie, H., &, O'Boyle, G., (1992). Self-regulation and emotion in infancy. New Directions for Child Development, 55, 7-23.
38. Scheuch, K., Lautenschlager, M., Grohmann, M., Stahlberg, S., Kirchheiner, J., Zill, P., et al., (2007). Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons. Biological Psychiatry, 62, 1288-1292.
39. Sheese, B.E., Voelker, P., Posner, M.I., &, Rothbart, M.K., (2009). Genetic variation influences on the early development of reactive emotions and their regulation by attention. Cognitive Neuropsychiatry, 14, 332-355.
40. Silber, B.Y., &, Schmitt, J.A.J., (2010). Effects of tryptophan loading on human cognition, mood, and sleep. Neuroscience and Biobehavioral Reviews, 34, 387-407.
41. Strobel, A., Dreisbach, G., Müller, J., Goschke, T., Brocke, B., &, Lesch, K.-P., (2007). Genetic variation of serotonin function and cognitive control. Journal of Cognitive Neuroscience, 19, 1923-1931. (Pubitemid 350220505)
42. Walther, D.J., Peter, J.-U., Bashammakh, S., Hörtnagl, H., Voits, M., Fink, H., et al., (2003). Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science, 299, 76. (Pubitemid 36042402)
43. Voelker, P., Sheese, B.E., Rothbart, M.K., &, Posner, M.I., (2009). Variations in catechol-O-methyltransferase gene interact with parenting to influence attention in early development. Neuroscience, 164, 121-130.
44. Wolff, M., Costet, P., Gross, C., Hen, R., Segu, L., &, Buhot, M.-C., (2004). Age-dependent effects of serotonin-1A receptor gene deletion in spatial learning abilities in mice. Molecular Brain Research, 130, 39-48. (Pubitemid 39440735)