Down-regulation of liver Galβ1, 4GlcNAc α2, 6-sialyltransferase gene by ethanol significantly correlates with alcoholic steatosis in humans

Metabolism: Clinical and Experimental

Volumn 57, Issue 12, 2008, Pages 1663-1668

  Gong, Maokai ^a   Castillo, Leslie ^a   Redman, Robert S ^b   Garige, Mamatha ^a   Hirsch, Kenneth ^b   Azuine, Magnus ^a   Amdur, Richard L ^b   Seth, Devanshi ^c   Haber, Paul S ^c   Lakshman, M Raj ^a  

^a GEORGE WASHINGTON UNIVERSITY   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CHOLESTEROL; MESSENGER RNA; SIALYLTRANSFERASE; ST6 BETA GALACTOSAMIDE ALPHA 2,6 SIALYLTRANFERASE 1; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADULT; ALCOHOL CONSUMPTION; ALCOHOLIC FATTY LIVER; ALCOHOLISM; ARTICLE; CHOLESTEROL LIVER LEVEL; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LIPID LIVER LEVEL; LIPID TRANSPORT; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; PROTEIN TRANSPORT;

ADULT; AGED; ALCOHOL DRINKING; DOWN-REGULATION; ETHANOL; FATTY LIVER, ALCOHOLIC; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LIPID METABOLISM; LIPOPROTEINS; LIVER; MIDDLE AGED; RNA, MESSENGER; SIALYLTRANSFERASES; YOUNG ADULT;

EID: 55649102288     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2008.07.021     Document Type: Article

References (20)

1. Molina P.E., McClain C., Vall D., Guidot D., Diehl A.M., Lang C.H., et al. Molecular pathology and clinical aspects of alcohol-induced tissue injury. Al Clin Exp Res. 26 (2002) 120-128
2. Stewart S., Jones D., and Day C.P. Alcoholic liver disease: new insights into mechanisms and preventative strategies. Trends Mol Med 7 (2001) 408-413
3. Lakshman M.R. Some novel insights into pathogenesis of alcoholic steatosis. Alcohol 34 (2004) 45-48
4. You M., Fisher M., Deeg M.A., and Crabb D.W. Ethanol induces fatty acid synthesis pathway by activation of sterol regulatory element-binding protein (SREBP). J Biol Chem 277 (2002) 29342-29347
5. Fisher M., You M., Matsumoto M., and Crabb D.W. Peroxisome proliferator-activated receptor alpha (PPAR-alpha) agonist treatment reverses PPAR-alpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice. J Biol Chem 278 (2003) 27997-28004
6. Ghosh P., Liu Q.H., and Lakshman M.R. Long term ethanol exposure impairs glycosylation of both N- and O-glycosylated proteins in rat. Metabolism 44 (1995) 890-898
7. Ghosh P., Hale E.A., and Lakshman M.R. Long-term ethanol exposure alters the sialylation index of plasma apolipoprotein J in rats. Alc Clin Exp Res 23 (1999) 720-725
8. Marmillot P., Rao M.N., and Lakshman M.R. Chronic ethanol exposure in rats affects rabs-dependent hepatic trafficking of apolipoprotein E and transferrin. Alcohol 25 (2001) 195-200
9. Marmillot P., Rao M.N., Liu Q.-H., and Lakshman M.R. Desialylation of human apolipoprotein E decreases its binding to human high-density lipoprotein and its ability to deliver esterified cholesterol to the liver. Metabolism 48 (1999) 1184-1192
10. 1 and E in rats. J Nutr 118 (1988) 1299-1303
11. Marmillot P., Rao M.N., Liu Q.-H., Chirtel S.J., and Lakshman M.R. Effect of dietary omega3-fatty acids and chronic ethanol consumption on reverse cholesterol transport in rats. Metabolism 49 (2000) 508-512
12. Rao M.N., Liu Q.-H., Marmillot P., Seeff L.B., Strader D.B., and Lakshman M.R. High density lipoproteins from human alcoholics exhibit impaired reverse cholesterol transport function. Metabolism 49 (2000) 1406-1410
13. Rao M.N., and Lakshman M.R. Chronic ethanol downregulates 2, 6-sialyltransferase and 2, 3-sialyltransferase mRNAs in rat liver. Alcohol Clin Exp Res 21 (1997) 348-351
14. Rao M.N., and Lakshman M.R. Chronic ethanol consumption leads to destabilization of rat liver 2, 6-sialyltransferase mRNA. Metabolism 48 (1999) 797-803
15. Gong M., Garige M., Hirsch K., and Lakshman M.R. Liver Galβ1, 4GlcNAc α2, 6-sialyltransferase is down-regulated in human alcoholics: possible cause for the appearance of asialoconjugates. Metabolism 56 (2007) 1241-1247
16. Folch J., Lees M., and Stanley G.H.S. A simple method for the isolation and purification of total lipid for animal tissues. J Biol Chem 226 (1957) 497-509
17. In: Luna L.G. (Ed). Manual of histologic staining methods of the Armed Forces Institute of Pathology. 3rd ed. (1968), Mcgraw-Hill, New York (NY) 141-142
18. Petretti T., Kemmner W., Schulze B., and Schlag P.M. Altered mRNA expression of glycosyltransferases in human colorectal carcinomas and liver metastases. Gut 46 (2000) 359-366
19. Wang P.H., Lee W.L., Lee Y.R., Juang C.M., Chen Y.J., Chao H.T., et al. Enhanced expression of alpha 2,6-sialyltransferase ST6Gal I in cervical squamous cell carcinoma. Gynecol Oncol 89 (2003) 395-401
20. Dall'Olio F., Chiricolo M., D'Errico A., Gruppioni E., Altimari A., Fiorentino M., et al. Expression of beta-galactoside alpha2, 6 sialyltransferase and of alpha2, 6-sialylated glycoconjugates in normal human liver, hepatocarcinoma, and cirrhosis. Glycobiology 14 (2004) 39-49