메뉴 건너뛰기




Volumn 34, Issue 5, 2014, Pages 2069-2078

Advanced epithelial ovarian cancer: From standard chemotherapy to promising molecular pathway targets - Where are we now?

Author keywords

Conventional chemotherapy; Epithelial ovarian cancer; Histological subtypes; Molecular pathway targets; PARP inhibitors; Review; Tumour angiogenesis; Tyrosine kinase inhibitors

Indexed keywords

ANGIOPOIETIN; BEVACIZUMAB; FOLATE RECEPTOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PACLITAXEL; PROTEIN TYROSINE KINASE INHIBITOR; SOMATOMEDIN; ANTINEOPLASTIC AGENT;

EID: 84903146674     PISSN: 02507005     EISSN: 17917530     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (32)

References (77)
  • 2
    • 0041329867 scopus 로고    scopus 로고
    • A randomized clinical trial of cisplatin/paclitaxel versus carboplatin/paclitaxel as first-line treatment of ovarian cancer
    • Du Bois A, Luck HJ, Meier W et al: A randomized clinical trial of cisplatin/paclitaxel versus carboplatin/paclitaxel as first-line treatment of ovarian cancer. J Natl Cancer Inst 95: 1320-1330, 2003.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 1320-1330
    • Du Bois, A.1    Luck, H.J.2    Meier, W.3
  • 4
    • 70349878651 scopus 로고    scopus 로고
    • Dose-dense paclitaxel once a week in combination with carboplatin every three weeks for advanced ovarian cancer: A phase III, open-label, randomised controlled trial
    • Katsumata N, Yasuda M, Takahashi F et al: Dose-dense paclitaxel once a week in combination with carboplatin every three weeks for advanced ovarian cancer: a phase III, open-label, randomised controlled trial. Lancet 374(9698): 1331-1338, 2009.
    • (2009) Lancet , vol.374 , Issue.9698 , pp. 1331-1338
    • Katsumata, N.1    Yasuda, M.2    Takahashi, F.3
  • 5
    • 84882998935 scopus 로고    scopus 로고
    • Long-term results of dose-dense paclitaxel and carboplatin versus conventional paclitaxel and carboplatin for treatment of advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer (JGOG 3016): A randomised, controlled, open-label trial
    • Katsumata N, Yasuda M, Isonishi S et al: Long-term results of dose-dense paclitaxel and carboplatin versus conventional paclitaxel and carboplatin for treatment of advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer (JGOG 3016): a randomised, controlled, open-label trial. Lancet Oncol 14(10): 1020-1026, 2013.
    • (2013) Lancet Oncol , vol.14 , Issue.10 , pp. 1020-1026
    • Katsumata, N.1    Yasuda, M.2    Isonishi, S.3
  • 6
    • 84855466019 scopus 로고    scopus 로고
    • A phase III trial of bevacizumab in ovarian cancer
    • Perren TJ, Swart AM, Pfisterer J et al: A phase III trial of bevacizumab in ovarian cancer. N Engl J Med 365(26): 2484-2496, 2011.
    • (2011) N Engl J Med , vol.365 , Issue.26 , pp. 2484-2496
    • Perren, T.J.1    Swart, A.M.2    Pfisterer, J.3
  • 7
    • 84917712209 scopus 로고    scopus 로고
    • ICON7 final overall survival results in the GCIG phase III randomized trial of bevacizumab in women with newly diagnosed ovarian cancer
    • September 27-October 1, 2013; Amsterdam, The Netherlands. Abstract LBA6
    • Oza A, Perren T, Swart AM et al: ICON7 final overall survival results in the GCIG phase III randomized trial of bevacizumab in women with newly diagnosed ovarian cancer. Program and abstracts of the European Cancer Congress, 2013; September 27-October 1, 2013; Amsterdam, The Netherlands. Abstract LBA6.
    • Program and Abstracts of the European Cancer Congress, 2013
    • Oza, A.1    Perren, T.2    Swart, A.M.3
  • 8
    • 84855425106 scopus 로고    scopus 로고
    • Incorporation of bevacizumab in the primary treatment of ovarian cancer
    • Burger RA, Brady MD, Bookman MA et al: Incorporation of bevacizumab in the primary treatment of ovarian cancer. N Engl J Med 365(26): 2473-2483, 2011.
    • (2011) N Engl J Med , vol.365 , Issue.26 , pp. 2473-2483
    • Burger, R.A.1    Brady, M.D.2    Bookman, M.A.3
  • 9
    • 84917712208 scopus 로고    scopus 로고
    • Outcome differences in patients with advanced epithelial ovarian, primary peritoneal, and fallopian tube cancers treated with and without Bevacizumab
    • March 9-12, 2013, Los Angeles, CA, USA
    • Randall L, Burger R, Nguyen H et al: Outcome differences in patients with advanced epithelial ovarian, primary peritoneal, and fallopian tube cancers treated with and without Bevacizumab. Presented at the Society for Gynecologic Oncology Annual Meeting on Women's Cancer; March 9-12, 2013, Los Angeles, CA, USA.
    • Presented at the Society for Gynecologic Oncology Annual Meeting on Women's Cancer
    • Randall, L.1    Burger, R.2    Nguyen, H.3
  • 10
    • 34447322566 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity
    • Kumar R, Knick VB, Rudolph SK et al: Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity. Mol Cancer Ther 6(7): 2012-2021, 2007.
    • (2007) Mol Cancer Ther , vol.6 , Issue.7 , pp. 2012-2021
    • Kumar, R.1    Knick, V.B.2    Rudolph, S.K.3
  • 11
    • 84885594084 scopus 로고    scopus 로고
    • Randomized, double-blind, phase III trial of pazopanib versus placebo in women who have not progressed after first-line chemotherapy for advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer (AEOC): Results of an international Intergroup trial (AGO-OVAR16)
    • Du Bois A, Floquet A, Kim JW et al: Randomized, double-blind, phase III trial of pazopanib versus placebo in women who have not progressed after first-line chemotherapy for advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer (AEOC): Results of an international Intergroup trial (AGO-OVAR16). J Clin Oncol 31(suppl; LBA 5503), 2013.
    • (2013) J Clin Oncol , vol.31 , pp. 5503
    • Du Bois, A.1    Floquet, A.2    Kim, J.W.3
  • 12
    • 84894046261 scopus 로고    scopus 로고
    • AGO-OVAR 12: A randomized placebo-controlled GCIG/ENGOT-Intergroup phase III trial of standard frontline chemotherapy +/-nintedanib for advanced ovarian cancer
    • Du Bois A, Kristensen G, Ray-Coquard I et al: AGO-OVAR 12: A randomized placebo-controlled GCIG/ENGOT-Intergroup phase III trial of standard frontline chemotherapy +/-nintedanib for advanced ovarian cancer. Int J Gynecol Cancer Vol. 23, Issue 8, Supplement 1, 2013.
    • (2013) Int J Gynecol Cancer , vol.23 , Issue.8
    • Du Bois, A.1    Kristensen, G.2    Ray-Coquard, I.3
  • 13
    • 84861736119 scopus 로고    scopus 로고
    • OCEANS: A randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or withoutbevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer
    • Aghajanian C, Blank SV, Goff BA et al: OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or withoutbevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer. J Clin Oncol 30(17): 2039-2045, 2012.
    • (2012) J Clin Oncol , vol.30 , Issue.17 , pp. 2039-2045
    • Aghajanian, C.1    Blank, S.V.2    Goff, B.A.3
  • 14
    • 84866493383 scopus 로고    scopus 로고
    • (2012) AURELIA: A randomized phase III trial evaluating bevacizumab (BEV) plus chemotherapy (CT) for platinum (PT)-resistant recurrent ovarian cancer (OC) (LBA5002)
    • Pujade-Lauraine E, Hilpert F, Weber B et al: (2012) AURELIA: A randomized phase III trial evaluating bevacizumab (BEV) plus chemotherapy (CT) for platinum (PT)-resistant recurrent ovarian cancer (OC) (LBA5002). J Clin Oncol 30(Suppl. Abstracts): LBA5002, 2012.
    • (2012) J Clin Oncol , vol.30 , pp. LBA5002
    • Pujade-Lauraine, E.1    Hilpert, F.2    Weber, B.3
  • 15
    • 84917712207 scopus 로고    scopus 로고
    • Final overall survival (OS) results from AURELIA, an open-label randomised phase III trial of chemotherapy (CT) with or without bevacizumab (BEV) for platinum-resistant recurrent ovarian cancer (OC)
    • September 27-October 1, 2013; Amsterdam, The Netherlands. Abstract LBA 5
    • Witteveen P, Lortholary A, Fehm T et al: Final overall survival (OS) results from AURELIA, an open-label randomised phase III trial of chemotherapy (CT) with or without bevacizumab (BEV) for platinum-resistant recurrent ovarian cancer (OC). Program and abstracts of the European Cancer Congress, September 27-October 1, 2013; Amsterdam, The Netherlands. Abstract LBA 5, 2013.
    • (2013) Program and Abstracts of the European Cancer Congress
    • Witteveen, P.1    Lortholary, A.2    Fehm, T.3
  • 16
    • 84894050019 scopus 로고    scopus 로고
    • Randomised double-blind phase III trial of cediranib (AZD 2171) in relapsed platinum sensitive ovarian cancer: Results of the ICON6 trial
    • September 27-October 1, 2013; Amsterdam, The Netherlands. Abstract LBA 10
    • Ledermann JA, Perren T, Raja FA et al: Randomised double-blind phase III trial of cediranib (AZD 2171) in relapsed platinum sensitive ovarian cancer: Results of the ICON6 trial. Program and abstracts of the European Cancer Congress, September 27-October 1, 2013; Amsterdam, The Netherlands. Abstract LBA 10, 2013.
    • (2013) Program and Abstracts of the European Cancer Congress
    • Ledermann, J.A.1    Perren, T.2    Raja, F.A.3
  • 17
    • 84917712205 scopus 로고    scopus 로고
    • ClinicalTrials.gov identifier: NCT01468909
    • ClinicalTrials.gov identifier: NCT01468909.
  • 18
    • 84863012011 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled phase II study of AMG 386 combined with weekly paclitaxel in patients with recurrent ovarian cancer
    • Karlan BY, Oza AM, Richardson GE et al: Randomized, double-blind, placebo-controlled phase II study of AMG 386 combined with weekly paclitaxel in patients with recurrent ovarian cancer. J Clin Oncol 30(4): 362-371, 2012.
    • (2012) J Clin Oncol , vol.30 , Issue.4 , pp. 362-371
    • Karlan, B.Y.1    Oza, A.M.2    Richardson, G.E.3
  • 19
    • 84975065203 scopus 로고    scopus 로고
    • A phase III randomized double-blind trial of weekly paclitaxel plus the angiopoeitin 1 and 2 inhibitor trebananib or placebo in women with recurrent ovarian cancer: TRINOVA-1
    • 1 October during the Gynaecological Cancer Proffered Papers Session (Abstract E17-7107)
    • Monk BJ, Poveda A, Vergote I et al: A phase III, randomized, double-blind trial of weekly paclitaxel plus the angiopoeitin 1 and 2 inhibitor, trebananib, or placebo in women with recurrent ovarian cancer: TRINOVA-1. 17th ECCO-38th ESMO-32nd ESTRO European Cancer Congress. 2013, 1 October during the Gynaecological Cancer Proffered Papers Session (Abstract E17-7107).
    • (2013) 17th ECCO-38th ESMO-32nd ESTRO European Cancer Congress.
    • Monk, B.J.1    Poveda, A.2    Vergote, I.3
  • 20
    • 84917712203 scopus 로고    scopus 로고
    • ClinicalTrials.gov identifier: NCT01281254
    • ClinicalTrials.gov identifier: NCT01281254.
  • 21
    • 84864026311 scopus 로고    scopus 로고
    • BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: A report from the Australian Ovarian Cancer Study Group
    • Alsop K, Fereday S, Meldrum C et al: BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: a report from the Australian Ovarian Cancer Study Group. J Clin Oncol 30(21): 2654-2663, 2012.
    • (2012) J Clin Oncol , vol.30 , Issue.21 , pp. 2654-2663
    • Alsop, K.1    Fereday, S.2    Meldrum, C.3
  • 22
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • Fong PC, Boss DS, Yap TA et al: Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 361(2): 123-134, 2009.
    • (2009) N Engl J Med , vol.361 , Issue.2 , pp. 123-134
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3
  • 23
    • 49249119415 scopus 로고    scopus 로고
    • A synthetic lethal therapeutic approach: Poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair
    • Ashworth A: A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair. J Clin Oncol 26: 3785-3790, 2008.
    • (2008) J Clin Oncol , vol.26 , pp. 3785-3790
    • Ashworth, A.1
  • 24
    • 80052389761 scopus 로고    scopus 로고
    • Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: A phase II, multicentre, open-label, non-randomised study
    • Gelmon KA, Tischkowitz M, Mackay H et al: Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase II, multicentre, open-label, non-randomised study. Lancet Oncol 12(9): 852-861, 2011.
    • (2011) Lancet Oncol , vol.12 , Issue.9 , pp. 852-861
    • Gelmon, K.A.1    Tischkowitz, M.2    Mackay, H.3
  • 25
    • 39549091276 scopus 로고    scopus 로고
    • Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities
    • Press JZ, De Luca A, Boyd N et al: Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities. BMC Cancer 8: 17, 2008.
    • (2008) BMC Cancer , vol.8 , pp. 17
    • Press, J.Z.1    De Luca, A.2    Boyd, N.3
  • 26
    • 84859523588 scopus 로고    scopus 로고
    • Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer
    • Ledermann JA, Harter P, Gourley C et al: Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer. N Engl J Med 366(15): 1382-1392, 2012.
    • (2012) N Engl J Med , vol.366 , Issue.15 , pp. 1382-1392
    • Ledermann, J.A.1    Harter, P.2    Gourley, C.3
  • 27
    • 84885420701 scopus 로고    scopus 로고
    • Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer (SOC) and a BRCA mutation (BRCAm)
    • Ledermann JA, Harter P, Gourley C et al: Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer (SOC) and a BRCA mutation (BRCAm). J Clin Oncol 31, (suppl; abstr 5505), 2013.
    • (2013) J Clin Oncol , vol.31 , pp. 5505
    • Ledermann, J.A.1    Harter, P.2    Gourley, C.3
  • 28
    • 84917712202 scopus 로고    scopus 로고
    • ClinicalTrials.gov Identifier: NCT01844986
    • ClinicalTrials.gov Identifier: NCT01844986.
  • 29
    • 84917712201 scopus 로고    scopus 로고
    • ClinicalTrials.gov Identifier: NCT01874353
    • ClinicalTrials.gov Identifier: NCT01874353.
  • 30
    • 84880777712 scopus 로고    scopus 로고
    • The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: A phase i dose-escalation trial
    • Sandhu SK, Schelman WR, Wilding G et al: The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase I dose-escalation trial. Lancet Oncol 14(9): 882-892, 2013.
    • (2013) Lancet Oncol , vol.14 , Issue.9 , pp. 882-892
    • Sandhu, S.K.1    Schelman, W.R.2    Wilding, G.3
  • 31
    • 84917712200 scopus 로고    scopus 로고
    • ClinicalTrials.gov Identifier: NCT01847274
    • ClinicalTrials.gov Identifier: NCT01847274.
  • 32
    • 84917712199 scopus 로고    scopus 로고
    • ClinicalTrials.gov Identifier: NCT01891344
    • ClinicalTrials.gov Identifier: NCT01891344.
  • 33
    • 84917712198 scopus 로고    scopus 로고
    • PARP inhibition with BMN 673 in ovarian and breast cancer patients with deleterious mutations of BRCA1 and BRCA2
    • September 27-October 1, 2013; Amsterdam, The Netherlands. Abstract LBA 29
    • Ramanathan R, Wainberg Z, Mina L et al: PARP inhibition with BMN 673 in ovarian and breast cancer patients with deleterious mutations of BRCA1 and BRCA2. Program and abstracts of the European Cancer Congress, September 27-October 1, 2013; Amsterdam, The Netherlands. Abstract LBA 29, 2013.
    • (2013) Program and Abstracts of the European Cancer Congress
    • Ramanathan, R.1    Wainberg, Z.2    Mina, L.3
  • 34
    • 84917712197 scopus 로고    scopus 로고
    • Olaparib plus chemotherapy, followed by maintenance monotherapy, in women with platinum-sensitive recurrent serous ovarian cancer (PSR SOC):BRCA1/2 mutation (BRCAm) and interim overall survival analyses
    • September 27-October 1, 2013; Amstersdam, The Netherlands. Abstract 3002
    • Oza AM, Cibula D, Benzaquen AO et al: Olaparib plus chemotherapy, followed by maintenance monotherapy, in women with platinum-sensitive recurrent serous ovarian cancer (PSR SOC):BRCA1/2 mutation (BRCAm) and interim overall survival analyses. Program and abstracts of the European Cancer Congress, September 27-October 1, 2013; Amstersdam, The Netherlands. Abstract 3002, 2013.
    • (2013) Program and Abstracts of the European Cancer Congress
    • Oza, A.M.1    Cibula, D.2    Benzaquen, A.O.3
  • 35
    • 84857383257 scopus 로고    scopus 로고
    • Update on PARP1 inhibitors in ovarian cancer
    • Sessa C. Update on PARP1 inhibitors in ovarian cancer. Ann Oncol 22(Suppl 8): viii72-viii76, 2011.
    • (2011) Ann Oncol , vol.22 , pp. viii72-viii76
    • Sessa, C.1
  • 36
    • 84870003033 scopus 로고    scopus 로고
    • The promise of combining inhibition of PI3K and PARP as cancer therapy
    • Rehman FL, Lord CJ, Ashworth A. The promise of combining inhibition of PI3K and PARP as cancer therapy. Cancer Discov 2(11): 982-984, 2012.
    • (2012) Cancer Discov , vol.2 , Issue.11 , pp. 982-984
    • Rehman, F.L.1    Lord, C.J.2    Ashworth, A.3
  • 37
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr CJ. Cancer cell cycles. Science 274(5293): 1672-1677, 1996.
    • (1996) Science , vol.274 , Issue.5293 , pp. 1672-1677
    • Sherr, C.J.1
  • 38
    • 0024387728 scopus 로고
    • Mutations in the p53 gene occur in diverse human tumour types
    • Nigro JM, Baker SJ, Preisinger AC et al: Mutations in the p53 gene occur in diverse human tumour types. Nature 342(6250): 705-708, 1989.
    • (1989) Nature , vol.342 , Issue.6250 , pp. 705-708
    • Nigro, J.M.1    Baker, S.J.2    Preisinger, A.C.3
  • 39
    • 0035890610 scopus 로고    scopus 로고
    • Radiosensitization of p53 Mutant Cells by PD0166285, a Novel G2 Checkpoint Abrogator
    • Wang Y, Li J, Booher RN et al: Radiosensitization of p53 Mutant Cells by PD0166285, a Novel G2 Checkpoint Abrogator. Cancer Res 61(22): 8211-8217, 2001.
    • (2001) Cancer Res , vol.61 , Issue.22 , pp. 8211-8217
    • Wang, Y.1    Li, J.2    Booher, R.N.3
  • 40
    • 84874777985 scopus 로고    scopus 로고
    • WEE1 inhibition by MK-1775 leads to tumor inhibition and enhances efficacy of gemcitabine in human sarcomas
    • Kreahling JM, Foroutan P, Reed D et al: WEE1 inhibition by MK-1775 leads to tumor inhibition and enhances efficacy of gemcitabine in human sarcomas. PLoS One 8(3): e57523, 2013.
    • (2013) PLoS One , vol.8 , Issue.3 , pp. e57523
    • Kreahling, J.M.1    Foroutan, P.2    Reed, D.3
  • 41
    • 84879311843 scopus 로고    scopus 로고
    • Inhibition of WEE1, AKT, and CDK4 underlies the efficacy of the HSP90 inhibitor XL888 in an in vivo model of NRAS-mutant melanoma
    • Haarberg HE, Paraiso KH, Wood E et al: Inhibition of WEE1, AKT, and CDK4 underlies the efficacy of the HSP90 inhibitor XL888 in an in vivo model of NRAS-mutant melanoma. Mol Cancer Ther 12(6): 901-912, 2013.
    • (2013) Mol Cancer Ther , vol.12 , Issue.6 , pp. 901-912
    • Haarberg, H.E.1    Paraiso, K.H.2    Wood, E.3
  • 42
    • 84872533885 scopus 로고    scopus 로고
    • Combination therapy targeting the Chk1 and Wee1 kinases shows therapeutic efficacy in neuroblastoma
    • Russell MR, Levin K, Rader J et al: Combination therapy targeting the Chk1 and Wee1 kinases shows therapeutic efficacy in neuroblastoma. Cancer Res 73(2): 776-784, 2013.
    • (2013) Cancer Res , vol.73 , Issue.2 , pp. 776-784
    • Russell, M.R.1    Levin, K.2    Rader, J.3
  • 43
    • 83355174034 scopus 로고    scopus 로고
    • Targeting radiation-induced G(2) checkpoint activation with the WEE-1 inhibitor MK-1775 in glioblastoma cell lines
    • Sarcar B, Kahali S, Prabhu AH et al: Targeting radiation-induced G(2) checkpoint activation with the WEE-1 inhibitor MK-1775 in glioblastoma cell lines. Mol Cancer Ther 10(12): 2405-2414, 2011.
    • (2011) Mol Cancer Ther , vol.10 , Issue.12 , pp. 2405-2414
    • Sarcar, B.1    Kahali, S.2    Prabhu, A.H.3
  • 44
    • 79955492036 scopus 로고    scopus 로고
    • MK-1775, a potent WEE1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts
    • Rajeshkumar N V, De Oliveira E, Ottenhof N et al: MK-1775, a potent WEE1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts. Clin Cancer Res 17(9): 2799-2806, 2011.
    • (2011) Clin Cancer Res , vol.17 , Issue.9 , pp. 2799-2806
    • Rajeshkumar, N.V.1    De Oliveira, E.2    Ottenhof, N.3
  • 45
    • 84917712196 scopus 로고    scopus 로고
    • ClinicalTrials.gov Identifier: NCT01357161
    • ClinicalTrials.gov Identifier: NCT01357161.
  • 46
    • 39249085399 scopus 로고    scopus 로고
    • Folate receptor alpha as a tumor target in epithelial ovarian cancer
    • Kalli KR, Oberg AL, Keeney GL et al: Folate receptor alpha as a tumor target in epithelial ovarian cancer. Gynecol Oncol 108: 619-626, 2008.
    • (2008) Gynecol Oncol , vol.108 , pp. 619-626
    • Kalli, K.R.1    Oberg, A.L.2    Keeney, G.L.3
  • 47
    • 84891854386 scopus 로고    scopus 로고
    • PRECEDENT: A randomized phase II trial comparing vintafolide (EC145) and Pegylated Liposomal Doxorubicin (PLD) in combination versus PLD alone in patients with platinum-resistant ovarian cancer
    • Naumann RW, Coleman RL, Burger RA et al: PRECEDENT: A randomized phase II trial comparing vintafolide (EC145) and Pegylated Liposomal Doxorubicin (PLD) in combination versus PLD alone in patients with platinum-resistant ovarian cancer. J Clin Oncol 31(35): 4400-4406, 2013.
    • (2013) J Clin Oncol , vol.31 , Issue.35 , pp. 4400-4406
    • Naumann, R.W.1    Coleman, R.L.2    Burger, R.A.3
  • 48
    • 84917712195 scopus 로고    scopus 로고
    • ClinicalTrials.gov Identifier: NCT01170650
    • ClinicalTrials.gov Identifier: NCT01170650.
  • 49
    • 2642704208 scopus 로고    scopus 로고
    • Antisense phosphorothioate oligodeoxynucleotide down-regulation of the insulin-like growth factor 1 receptor in ovarian cancer Cells
    • Muller M, Dietel M, Turzynski A and Wiechen K: Antisense phosphorothioate oligodeoxynucleotide down-regulation of the insulin-like growth factor 1 receptor in ovarian cancer Cells. Int J Cancer 77(4): 567-571, 1998.
    • (1998) Int J Cancer , vol.77 , Issue.4 , pp. 567-571
    • Muller, M.1    Dietel, M.2    Turzynski, A.3    Wiechen, K.4
  • 50
    • 33746840153 scopus 로고    scopus 로고
    • IGF-I mediated survival pathways in normal and malignant cells
    • Kurmasheva RT and Houghton PJ: IGF-I mediated survival pathways in normal and malignant cells. Biochim Biophys Acta 1766(1): 1-22, 2006.
    • (2006) Biochim Biophys Acta , vol.1766 , Issue.1 , pp. 1-22
    • Kurmasheva, R.T.1    Houghton, P.J.2
  • 51
    • 56749184290 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor signaling in neoplasia
    • Pollak M. Insulin and insulin-like growth factor signaling in neoplasia. Nature Rev Cancer 8: 915-928, 2008.
    • (2008) Nature Rev Cancer , vol.8 , pp. 915-928
    • Pollak, M.1
  • 52
    • 33644779775 scopus 로고    scopus 로고
    • The relationship of insulin like growth factor-II, insulin-like growth factor binding protein-3, and estrogen receptor-Alpha expression to disease progression in epithelial ovarian cancer
    • Lu L, Katsaros D, Wiley A et al: The relationship of insulin like growth factor-II, insulin-like growth factor binding protein-3, and estrogen receptor-Alpha expression to disease progression in epithelial ovarian cancer. Clin Cancer Res 12(4): 1208-1214, 2006.
    • (2006) Clin Cancer Res , vol.12 , Issue.4 , pp. 1208-1214
    • Lu, L.1    Katsaros, D.2    Wiley, A.3
  • 53
    • 12344328267 scopus 로고    scopus 로고
    • High insulin-like growth factor-2 (IGF-2) gene expression is an independent predictor of poor survival for patients with advanced-stage serous epithelial ovarian cancer
    • Sayer R, Lancaster JM, Pittman J et al: High insulin-like growth factor-2 (IGF-2) gene expression is an independent predictor of poor survival for patients with advanced-stage serous epithelial ovarian cancer. Gynecol Oncol 96(2): 355-361, 2005.
    • (2005) Gynecol Oncol , vol.96 , Issue.2 , pp. 355-361
    • Sayer, R.1    Lancaster, J.M.2    Pittman, J.3
  • 54
    • 84874630622 scopus 로고    scopus 로고
    • A phase i study evaluating the combination of OSI-906, a dual inhibitor of insulin growth factor-1 receptor (IGF-1R) and insulin receptor (IR) with weekly paclitaxel (PAC) in patients with advanced solid tumors
    • Harb WA, Sessa C, Hirte HW et al: A phase I study evaluating the combination of OSI-906, a dual inhibitor of insulin growth factor-1 receptor (IGF-1R) and insulin receptor (IR) with weekly paclitaxel (PAC) in patients with advanced solid tumors. J Clin Oncol (Meeting Abstracts) 29(Suppl No15): 3099, 2011.
    • (2011) J Clin Oncol (Meeting Abstracts) , vol.29 , pp. 3099
    • Harb, W.A.1    Sessa, C.2    Hirte, H.W.3
  • 55
    • 84917712194 scopus 로고    scopus 로고
    • ClinicalTrials.gov Identifier: NCT00889382
    • ClinicalTrials.gov Identifier: NCT00889382.
  • 56
    • 16444378374 scopus 로고    scopus 로고
    • Inactivation of the mitogen-Activated protein kinase pathway as a potential target-based therapy in ovarian serous tumors with KRAS or BRAF mutations
    • Pohl G, Ho CL, Kurman RJ et al: Inactivation of the mitogen-Activated protein kinase pathway as a potential target-based therapy in ovarian serous tumors with KRAS or BRAF mutations. Cancer Res 65: 1994-2000, 2005.
    • (2005) Cancer Res , vol.65 , pp. 1994-2000
    • Pohl, G.1    Ho, C.L.2    Kurman, R.J.3
  • 57
    • 0037454224 scopus 로고    scopus 로고
    • Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma
    • Singer G, Oldt R 3rd, Cohen Y et al: Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma. J Natl Cancer Inst 95: 484-486, 2003.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 484-486
    • Singer, G.1    Oldt Iii., R.2    Cohen, Y.3
  • 58
    • 57549098807 scopus 로고    scopus 로고
    • The Catalogue of Somatic Mutations in Cancer (COSMIC)
    • Chapter 10: Unit 10 1
    • Forbes SA, Bhamra G, Bamford S et al: The Catalogue of Somatic Mutations in Cancer (COSMIC). Curr Protoc Hum Genet Chapter 10: Unit 10 1, 2008.
    • (2008) Curr Protoc Hum Genet
    • Forbes, S.A.1    Bhamra, G.2    Bamford, S.3
  • 59
    • 78651330430 scopus 로고    scopus 로고
    • COSMIC: Mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
    • Forbes SA, Bindal N, Bamford S et al: COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. Nucleic Acids Res 39: 945-950, 2011.
    • (2011) Nucleic Acids Res , vol.39 , pp. 945-950
    • Forbes, S.A.1    Bindal, N.2    Bamford, S.3
  • 60
    • 12144287841 scopus 로고    scopus 로고
    • In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low-grade serous tumours
    • Sieben NL, Macropoulos P, Roemen GM et al: In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low-grade serous tumours. J Pathol 202: 336-340, 2004.
    • (2004) J Pathol , vol.202 , pp. 336-340
    • Sieben, N.L.1    Macropoulos, P.2    Roemen, G.M.3
  • 61
    • 57449092484 scopus 로고    scopus 로고
    • KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer
    • Nakayama N, Nakayama K, Yeasmin S et al: KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer. Br J Cancer 99: 2020-2028, 2008.
    • (2008) Br J Cancer , vol.99 , pp. 2020-2028
    • Nakayama, N.1    Nakayama, K.2    Yeasmin, S.3
  • 62
    • 84873079682 scopus 로고    scopus 로고
    • Selumetinib in women with recurrent low-grade serous carcinoma of the ovary or peritoneum: An open-label, single-Arm, phase II study
    • Farley J, Brady WE, Vathipadiekal V et al: Selumetinib in women with recurrent low-grade serous carcinoma of the ovary or peritoneum: an open-label, single-Arm, phase II study. Lancet Oncol 14: 134-140, 2013.
    • (2013) Lancet Oncol , vol.14 , pp. 134-140
    • Farley, J.1    Brady, W.E.2    Vathipadiekal, V.3
  • 63
    • 84917712193 scopus 로고    scopus 로고
    • ClinicalTrials.gov Identifier: NCT01849874
    • ClinicalTrials.gov Identifier: NCT01849874.
  • 64
    • 84917712192 scopus 로고    scopus 로고
    • ClinicalTrials.gov Identifier: NCT01155453
    • ClinicalTrials.gov Identifier: NCT01155453.
  • 65
    • 84865068182 scopus 로고    scopus 로고
    • Updated overall survival (OS) results for BRIM-3, a phase III randomized, open-label, multicenter trial comparing BRAF inhibitor vemurafenib (vem) with dacarbazine (DTIC) in previously untreated patients with BRAFV600E-mutated melanoma
    • (May 20 Supplement)
    • Chapman PB, Hauschild A, Robert C et al: Updated overall survival (OS) results for BRIM-3, a phase III randomized, open-label, multicenter trial comparing BRAF inhibitor vemurafenib (vem) with dacarbazine (DTIC) in previously untreated patients with BRAFV600E-mutated melanoma. J Clin Oncol 2012; ASCO Annual Meeting Proceedings (Post-Meeting Edition).Vol 30, No 15-suppl (May 20 Supplement) 8502, 2012.
    • (2012) J Clin Oncol 2012; ASCO Annual Meeting Proceedings (Post-Meeting Edition). , vol.30 , Issue.15 , pp. 8502
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3
  • 66
    • 84917712191 scopus 로고    scopus 로고
    • The UK Clinical Research Network Study Portfolio
    • http://public.ukcrn.org.uk/search/StudyDetail.aspx?StudyID= 12071. The UK Clinical Research Network Study Portfolio.
  • 67
    • 44649186229 scopus 로고    scopus 로고
    • Do clear cell ovarian carcinomas have poorer prognosis compared to other epithelial cell types? A study of 1411 clear cell ovarian cancers
    • Chan JK, Teoh D, Hu JM et al: Do clear cell ovarian carcinomas have poorer prognosis compared to other epithelial cell types? A study of 1411 clear cell ovarian cancers. Gynecol Oncol 109(3): 370-376, 2008.
    • (2008) Gynecol Oncol , vol.109 , Issue.3 , pp. 370-376
    • Chan, J.K.1    Teoh, D.2    Hu, J.M.3
  • 68
    • 65649128979 scopus 로고    scopus 로고
    • Frequent activating mutations of PIK3CA in ovarian clear cell carcinoma
    • Kuo KT, Mao TL, Jones S et al: Frequent activating mutations of PIK3CA in ovarian clear cell carcinoma. Am J Pathol 174(5): 1597-1601, 2009.
    • (2009) Am J Pathol , vol.174 , Issue.5 , pp. 1597-1601
    • Kuo, K.T.1    Mao, T.L.2    Jones, S.3
  • 69
    • 33644540515 scopus 로고    scopus 로고
    • PTEN expression in clear cell adenocarcinoma of the ovary
    • Hashiguchi Y, Tsuda H, Inoue T et al: PTEN expression in clear cell adenocarcinoma of the ovary. Gynecol Oncol 101(1): 71-75, 2006.
    • (2006) Gynecol Oncol , vol.101 , Issue.1 , pp. 71-75
    • Hashiguchi, Y.1    Tsuda, H.2    Inoue, T.3
  • 70
    • 84874599497 scopus 로고    scopus 로고
    • MET is the most frequently amplified gene in endometriosis-Associated ovarian clear cell adenocarcinoma and correlates with worsened prognosis
    • Yamashita Y, Akatsuka S, Shinjo K et al: MET is the most frequently amplified gene in endometriosis-Associated ovarian clear cell adenocarcinoma and correlates with worsened prognosis. PLoS One 8(3): e57724, 2013.
    • (2013) PLoS One , vol.8 , Issue.3 , pp. e57724
    • Yamashita, Y.1    Akatsuka, S.2    Shinjo, K.3
  • 71
    • 84917712190 scopus 로고    scopus 로고
    • ClinicalTrials.gov Identifier: NCT01196429
    • ClinicalTrials.gov Identifier: NCT01196429.
  • 72
    • 79959923767 scopus 로고    scopus 로고
    • Identification of novel therapeutic targets in microdissected clear cell ovarian cancers
    • Stany MP, Vathipadiekal V, Ozbun L et al: Identification of novel therapeutic targets in microdissected clear cell ovarian cancers. PLoS One 6(7): e21121, 2011.
    • (2011) PLoS One , vol.6 , Issue.7 , pp. e21121
    • Stany, M.P.1    Vathipadiekal, V.2    Ozbun, L.3
  • 73
    • 84917712189 scopus 로고    scopus 로고
    • ClinicalTrials.gov Identifier: NCT00979992
    • ClinicalTrials.gov Identifier: NCT00979992.
  • 74
    • 34548491626 scopus 로고    scopus 로고
    • Prognostic factors for stage III epithelial ovarian cancer: A Gynecologic Oncology Group Study
    • Winter WE 3rd, Maxwell GL, Tian C et al: Prognostic factors for stage III epithelial ovarian cancer: a Gynecologic Oncology Group Study. J Clin Oncol 25: 3621-3627, 2007.
    • (2007) J Clin Oncol , vol.25 , pp. 3621-3627
    • Winter Iii., W.E.1    Maxwell, G.L.2    Tian, C.3
  • 75
    • 84872862768 scopus 로고    scopus 로고
    • Molecular characterization of mucinous ovarian tumors supports a stratified treatment approach with HER2 targeting in 19% of carcinomas
    • Anglesio MS, Kommoss S, Tolcher M et al: Molecular characterization of mucinous ovarian tumors supports a stratified treatment approach with HER2 targeting in 19% of carcinomas. J Pathol 229(1): 111-120, 2013.
    • (2013) J Pathol , vol.229 , Issue.1 , pp. 111-120
    • Anglesio, M.S.1    Kommoss, S.2    Tolcher, M.3
  • 76
    • 74049094790 scopus 로고    scopus 로고
    • HER2 overexpression and amplification is present in a subset of ovarian mucinous carcinomas and can be targeted with trastuzumab therapy
    • McAlpine JN, Wiegand KC, Vang R et al: HER2 overexpression and amplification is present in a subset of ovarian mucinous carcinomas and can be targeted with trastuzumab therapy. BMC Cancer 9: 433, 2009.
    • (2009) BMC Cancer , vol.9 , pp. 433
    • McAlpine, J.N.1    Wiegand, K.C.2    Vang, R.3
  • 77
    • 0037440042 scopus 로고    scopus 로고
    • Evaluation of monoclonal humanized anti-HER2 antibody, trastuzumab, in patients with recurrent or refractory ovarian or primary peritoneal carcinoma with overexpression of HER2: A phase II trial of the Gynecologic Oncology Group
    • Bookman MA, Darcy KM, Clarke-Pearson D et al: Evaluation of monoclonal humanized anti-HER2 antibody, trastuzumab, in patients with recurrent or refractory ovarian or primary peritoneal carcinoma with overexpression of HER2: a phase II trial of the Gynecologic Oncology Group. J Clin Oncol 21(2): 283-290, 2003.
    • (2003) J Clin Oncol , vol.21 , Issue.2 , pp. 283-290
    • Bookman, M.A.1    Darcy, K.M.2    Clarke-Pearson, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.