메뉴 건너뛰기




Volumn 8, Issue 3, 2013, Pages

Met Is the Most Frequently Amplified Gene in Endometriosis-Associated Ovarian Clear Cell Adenocarcinoma and Correlates with Worsened Prognosis

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B BETA; SCATTER FACTOR RECEPTOR; SHORT HAIRPIN RNA;

EID: 84874599497     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057724     Document Type: Article
Times cited : (69)

References (43)
  • 1
    • 70350501512 scopus 로고    scopus 로고
    • Ovarian cancer in endometriosis: molecular biology, pathology, and clinical management
    • Mandai M, Yamaguchi K, Matsumura N, Baba T, Konishi I, (2009) Ovarian cancer in endometriosis: molecular biology, pathology, and clinical management. Int J Clin Oncol 14: 383-391.
    • (2009) Int J Clin Oncol , vol.14 , pp. 383-391
    • Mandai, M.1    Yamaguchi, K.2    Matsumura, N.3    Baba, T.4    Konishi, I.5
  • 2
    • 40749162395 scopus 로고    scopus 로고
    • Contents of endometriotic cysts, especially the high concentration of free iron, are a possible cause of carcinogenesis in the cysts through the iron-induced persistent oxidative stress
    • Yamaguchi K, Mandai M, Toyokuni S, Hamanishi J, Higuchi T, et al. (2008) Contents of endometriotic cysts, especially the high concentration of free iron, are a possible cause of carcinogenesis in the cysts through the iron-induced persistent oxidative stress. Clin Cancer Res 14: 32-40.
    • (2008) Clin Cancer Res , vol.14 , pp. 32-40
    • Yamaguchi, K.1    Mandai, M.2    Toyokuni, S.3    Hamanishi, J.4    Higuchi, T.5
  • 3
    • 38349041715 scopus 로고    scopus 로고
    • Chronic oxidative stress causes amplification and overexpression of ptprz1 protein tyrosine phosphatase to activate beta-catenin pathway
    • Liu YT, Shang D, Akatsuka S, Ohara H, Dutta KK, et al. (2007) Chronic oxidative stress causes amplification and overexpression of ptprz1 protein tyrosine phosphatase to activate beta-catenin pathway. American J Pathol 171: 1978-1988.
    • (2007) American J Pathol , vol.171 , pp. 1978-1988
    • Liu, Y.T.1    Shang, D.2    Akatsuka, S.3    Ohara, H.4    Dutta, K.K.5
  • 4
    • 84865603277 scopus 로고    scopus 로고
    • Fenton Reaction Induced Cancer in Wild Type Rats Recapitulates Genomic Alterations Observed in Human Cancer
    • e43403
    • Akatsuka S, Yamashita Y, Ohara H, Liu YT, Izumiya M, et al. (2012) Fenton Reaction Induced Cancer in Wild Type Rats Recapitulates Genomic Alterations Observed in Human Cancer. PLoS One 7 e43403.
    • (2012) PLoS One , vol.7
    • Akatsuka, S.1    Yamashita, Y.2    Ohara, H.3    Liu, Y.T.4    Izumiya, M.5
  • 5
    • 41349083323 scopus 로고    scopus 로고
    • Mechanisms of chemoresistance and poor prognosis in ovarian clear cell carcinoma
    • Itamochi H, Kigawa J, Terakawa N, (2008) Mechanisms of chemoresistance and poor prognosis in ovarian clear cell carcinoma. Cancer Sci 99: 653-658.
    • (2008) Cancer Sci , vol.99 , pp. 653-658
    • Itamochi, H.1    Kigawa, J.2    Terakawa, N.3
  • 6
    • 65649128979 scopus 로고    scopus 로고
    • Frequent Activating Mutations of PIK3CA in Ovarian Clear Cell Carcinoma
    • Kuo KT, Mao TL, Jones S, Veras E, Ayhan A, et al. (2009) Frequent Activating Mutations of PIK3CA in Ovarian Clear Cell Carcinoma. Am J Pathol174: 1597-1601.
    • (2009) Am J Pathol , vol.174 , pp. 1597-1601
    • Kuo, K.T.1    Mao, T.L.2    Jones, S.3    Veras, E.4    Ayhan, A.5
  • 7
    • 77957731999 scopus 로고    scopus 로고
    • Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma
    • Jones S, Wang TL, Shih IM, Mao TL, Nakayama K, et al. (2010) Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma. Science 330: 228-231.
    • (2010) Science , vol.330 , pp. 228-231
    • Jones, S.1    Wang, T.L.2    Shih, I.M.3    Mao, T.L.4    Nakayama, K.5
  • 8
    • 77957946398 scopus 로고    scopus 로고
    • ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas
    • Wiegand KC, Shah SP, Al-Agha OM, Zhao YJ, Tse K, et al. (2010) ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas. New Eng J Med363: 1532-1543.
    • (2010) New Eng J Med , vol.363 , pp. 1532-1543
    • Wiegand, K.C.1    Shah, S.P.2    Al-Agha, O.M.3    Zhao, Y.J.4    Tse, K.5
  • 9
    • 77950687396 scopus 로고    scopus 로고
    • DNA Copy Numbers Profiles in Affinity-Purified Ovarian Clear Cell Carcinoma
    • Kuo KT, Mao TL, Chen X, Feng YJ, Nakayama K, et al. (2010) DNA Copy Numbers Profiles in Affinity-Purified Ovarian Clear Cell Carcinoma. Clin Cancer Res 16: 1997-2008.
    • (2010) Clin Cancer Res , vol.16 , pp. 1997-2008
    • Kuo, K.T.1    Mao, T.L.2    Chen, X.3    Feng, Y.J.4    Nakayama, K.5
  • 10
    • 0038115834 scopus 로고    scopus 로고
    • Cytogenetic alterations in ovarian clear cell carcinoma detected by comparative genomic hybridisation
    • Dent J, Hall GD, Wilkinson N, Perren TJ, Richmond I, et al. (2003) Cytogenetic alterations in ovarian clear cell carcinoma detected by comparative genomic hybridisation. Brit J Cancer 88: 1578-1583.
    • (2003) Brit J Cancer , vol.88 , pp. 1578-1583
    • Dent, J.1    Hall, G.D.2    Wilkinson, N.3    Perren, T.J.4    Richmond, I.5
  • 11
    • 0033919389 scopus 로고    scopus 로고
    • Genetic aberrations detected by comparative genomic hybridization in ovarian clear cell adenocarcinomas
    • Suehiro Y, Sakamoto M, Umayahara K, Iwabuchi H, Sakamoto H, et al. (2000) Genetic aberrations detected by comparative genomic hybridization in ovarian clear cell adenocarcinomas. Oncology 59: 50-56.
    • (2000) Oncology , vol.59 , pp. 50-56
    • Suehiro, Y.1    Sakamoto, M.2    Umayahara, K.3    Iwabuchi, H.4    Sakamoto, H.5
  • 12
    • 79952712084 scopus 로고    scopus 로고
    • Genomic Analysis Reveals the Molecular Heterogeneity of Ovarian Clear Cell Carcinomas
    • Tan DSP, Iravani M, McCluggage WG, Lambros MBK, Milanezi F, et al. (2011) Genomic Analysis Reveals the Molecular Heterogeneity of Ovarian Clear Cell Carcinomas. Clin Cancer Res 17: 1521-1534.
    • (2011) Clin Cancer Res , vol.17 , pp. 1521-1534
    • Tan, D.S.P.1    Iravani, M.2    McCluggage, W.G.3    Lambros, M.B.K.4    Milanezi, F.5
  • 13
    • 79961028656 scopus 로고    scopus 로고
    • Gene amplification and protein overexpression of MET are common events in ovarian clear-cell adenocarcinoma: their roles in tumor progression and prognostication of the patient
    • Yamamoto S, Tsuda H, Miyai K, Takano M, Tamai S, et al. (2011) Gene amplification and protein overexpression of MET are common events in ovarian clear-cell adenocarcinoma: their roles in tumor progression and prognostication of the patient. Mod Pathol 24: 1146-1155.
    • (2011) Mod Pathol , vol.24 , pp. 1146-1155
    • Yamamoto, S.1    Tsuda, H.2    Miyai, K.3    Takano, M.4    Tamai, S.5
  • 14
    • 84861333600 scopus 로고    scopus 로고
    • Prognostic and therapeutic impact of the chromosome 20q13.2 ZNF217 locus amplification in ovarian clear cell carcinoma
    • Rahman MT, Nakayama K, Rahman M, Nakayama N, Ishikawa M, et al. (2012) Prognostic and therapeutic impact of the chromosome 20q13.2 ZNF217 locus amplification in ovarian clear cell carcinoma. Cancer 118: 2846-2857.
    • (2012) Cancer , vol.118 , pp. 2846-2857
    • Rahman, M.T.1    Nakayama, K.2    Rahman, M.3    Nakayama, N.4    Ishikawa, M.5
  • 15
    • 33750033153 scopus 로고    scopus 로고
    • Immortalization of Epstein-Barr virus-negative human B lymphocytes with minimal chromosomal instability
    • Yamashita Y, Tsurumi T, Mori N, Kiyono T, (2006) Immortalization of Epstein-Barr virus-negative human B lymphocytes with minimal chromosomal instability. Pathol Int 56: 659-667.
    • (2006) Pathol Int , vol.56 , pp. 659-667
    • Yamashita, Y.1    Tsurumi, T.2    Mori, N.3    Kiyono, T.4
  • 16
    • 77649104601 scopus 로고    scopus 로고
    • Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma
    • Hu Q, Akatsuka S, Yamashita Y, Ohara H, Nagai H, et al. (2010) Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma. Lab Invest 90: 360-373.
    • (2010) Lab Invest , vol.90 , pp. 360-373
    • Hu, Q.1    Akatsuka, S.2    Yamashita, Y.3    Ohara, H.4    Nagai, H.5
  • 17
    • 79954602254 scopus 로고    scopus 로고
    • XCR1 Expression and Biased V-H Gene Usage Are Distinct Feautres of Diffuse Large B-Cell Lymphoma Initially Manifesting in the Bone Marrow
    • Yamashita Y, Kajiura D, Tang L, Hasegawa Y, Kinoshita T, et al. (2011) XCR1 Expression and Biased V-H Gene Usage Are Distinct Feautres of Diffuse Large B-Cell Lymphoma Initially Manifesting in the Bone Marrow. Am J Clin Pathol 135: 556-564.
    • (2011) Am J Clin Pathol , vol.135 , pp. 556-564
    • Yamashita, Y.1    Kajiura, D.2    Tang, L.3    Hasegawa, Y.4    Kinoshita, T.5
  • 18
    • 84863398440 scopus 로고    scopus 로고
    • ACTN4 gene amplification and actinin-4 protein overexpression drive tumour development and histological progression in a high-grade subset of ovarian clear-cell adenocarcinomas
    • Yamamoto S, Tsuda H, Honda K, Takano M, Tamai S, et al. (2011) ACTN4 gene amplification and actinin-4 protein overexpression drive tumour development and histological progression in a high-grade subset of ovarian clear-cell adenocarcinomas. Histopathology 60: 1073-1083.
    • (2011) Histopathology , vol.60 , pp. 1073-1083
    • Yamamoto, S.1    Tsuda, H.2    Honda, K.3    Takano, M.4    Tamai, S.5
  • 19
    • 0034027258 scopus 로고    scopus 로고
    • Ovarian endometriosis associated with ovarian carcinoma: A clinicopathological and immunohistochemical study
    • Ogawa S, Kaku T, Amada S, Kobayashi H, Hirakawa T, et al. (2000) Ovarian endometriosis associated with ovarian carcinoma: A clinicopathological and immunohistochemical study. Gynecol Oncol 77: 298-304.
    • (2000) Gynecol Oncol , vol.77 , pp. 298-304
    • Ogawa, S.1    Kaku, T.2    Amada, S.3    Kobayashi, H.4    Hirakawa, T.5
  • 20
    • 58149305448 scopus 로고    scopus 로고
    • Role of iron in carcinogenesis: Cancer as a ferrotoxic disease
    • Toyokuni S, (2009) Role of iron in carcinogenesis: Cancer as a ferrotoxic disease. Cancer Sci 100: 9-16.
    • (2009) Cancer Sci , vol.100 , pp. 9-16
    • Toyokuni, S.1
  • 21
    • 69249208791 scopus 로고    scopus 로고
    • The Akt kinases Isoform specificity in metabolism and cancer
    • Gonzalez E, McGraw TE, (2009) The Akt kinases Isoform specificity in metabolism and cancer. Cell Cycle 8: 2502-2508.
    • (2009) Cell Cycle , vol.8 , pp. 2502-2508
    • Gonzalez, E.1    McGraw, T.E.2
  • 22
    • 33751190974 scopus 로고    scopus 로고
    • Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms
    • Nakayama K, Nakayama N, Kurman RL, Cope L, Pohl G, et al. (2006) Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms. Cancer Biol Ther 5: 779-785.
    • (2006) Cancer Biol Ther , vol.5 , pp. 779-785
    • Nakayama, K.1    Nakayama, N.2    Kurman, R.L.3    Cope, L.4    Pohl, G.5
  • 23
    • 0035793091 scopus 로고    scopus 로고
    • Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways
    • Xiao GH, Jeffers M, Bellacosa A, Mitsuuchi Y, Vande Woude GF, et al. (2001) Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways. Proc Nat Acad Sci U.S.A. 98: 247-252.
    • (2001) Proc Nat Acad Sci U.S.A , vol.98 , pp. 247-252
    • Xiao, G.H.1    Jeffers, M.2    Bellacosa, A.3    Mitsuuchi, Y.4    Vande Woude, G.F.5
  • 24
    • 34248151416 scopus 로고    scopus 로고
    • Met acts on Mdm2 via mTOR to signal cell survival during development
    • Moumen A, Patane S, Porras A, Dono R, Maina F, (2007) Met acts on Mdm2 via mTOR to signal cell survival during development. Development 134: 1443-1451.
    • (2007) Development , vol.134 , pp. 1443-1451
    • Moumen, A.1    Patane, S.2    Porras, A.3    Dono, R.4    Maina, F.5
  • 25
    • 68849093989 scopus 로고    scopus 로고
    • Tumour suppression by p53: the importance of apoptosis and cellular senescence
    • Zuckerman V, Wolyniec K, Sionov RV, Haupt S, Haupt Y, (2009) Tumour suppression by p53: the importance of apoptosis and cellular senescence. J Pathol 219: 3-15.
    • (2009) J Pathol , vol.219 , pp. 3-15
    • Zuckerman, V.1    Wolyniec, K.2    Sionov, R.V.3    Haupt, S.4    Haupt, Y.5
  • 28
  • 29
    • 30944452172 scopus 로고    scopus 로고
    • Genomic amplification of MET with boundaries within fragile site FRA7G and upregulation of MET pathways in esophageal adenocarcinoma
    • Miller CT, Lin L, Casper AM, Lim J, Thomas DG, et al. (2006) Genomic amplification of MET with boundaries within fragile site FRA7G and upregulation of MET pathways in esophageal adenocarcinoma. Oncogene 25: 409-418.
    • (2006) Oncogene , vol.25 , pp. 409-418
    • Miller, C.T.1    Lin, L.2    Casper, A.M.3    Lim, J.4    Thomas, D.G.5
  • 30
    • 63849163410 scopus 로고    scopus 로고
    • Increased MET Gene Copy Number Negatively Affects Survival of Surgically Resected Non-Small-Cell Lung Cancer Patients
    • Cappuzzo F, Marchetti A, Skokan M, Rossi E, Gajapathy S, et al. (2009) Increased MET Gene Copy Number Negatively Affects Survival of Surgically Resected Non-Small-Cell Lung Cancer Patients. J Clin Oncol 27: 1667-1674.
    • (2009) J Clin Oncol , vol.27 , pp. 1667-1674
    • Cappuzzo, F.1    Marchetti, A.2    Skokan, M.3    Rossi, E.4    Gajapathy, S.5
  • 31
    • 73649102105 scopus 로고    scopus 로고
    • Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC
    • Turke AB, Zejnullahu K, Wu YL, Song Y, Dias-Santagata D, et al. (2010) Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC. Cancer Cell 17: 77-88.
    • (2010) Cancer Cell , vol.17 , pp. 77-88
    • Turke, A.B.1    Zejnullahu, K.2    Wu, Y.L.3    Song, Y.4    Dias-Santagata, D.5
  • 32
    • 0028946604 scopus 로고
    • Overexpression and Amplification of the Met/Hgf Receptor Gene During the Progression of Colorectal-Cancer
    • Direnzo MF, Olivero M, Giacomini A, Porte H, Chastre E, et al. (1995) Overexpression and Amplification of the Met/Hgf Receptor Gene During the Progression of Colorectal-Cancer. Clin Cancer Res 1: 147-154.
    • (1995) Clin Cancer Res , vol.1 , pp. 147-154
    • Direnzo, M.F.1    Olivero, M.2    Giacomini, A.3    Porte, H.4    Chastre, E.5
  • 33
    • 66149135285 scopus 로고    scopus 로고
    • The MET Receptor Tyrosine Kinase Is a Potential Novel Therapeutic Target for Head and Neck Squamous Cell Carcinoma
    • Seiwert TY, Jagadeeswaran R, Faoro L, Janamanchi V, Nallasura V, et al. (2009) The MET Receptor Tyrosine Kinase Is a Potential Novel Therapeutic Target for Head and Neck Squamous Cell Carcinoma. Cancer Res 69: 3021-3031.
    • (2009) Cancer Res , vol.69 , pp. 3021-3031
    • Seiwert, T.Y.1    Jagadeeswaran, R.2    Faoro, L.3    Janamanchi, V.4    Nallasura, V.5
  • 34
    • 0033135820 scopus 로고    scopus 로고
    • The prognostic significance of amplification and overexpression of c-met and c-erb B-2 in human gastric carcinomas
    • Nakajima M, Sawada H, Yamada Y, Watanabe A, Tatsumi M, et al. (1999) The prognostic significance of amplification and overexpression of c-met and c-erb B-2 in human gastric carcinomas. Cancer 85: 1894-1902.
    • (1999) Cancer , vol.85 , pp. 1894-1902
    • Nakajima, M.1    Sawada, H.2    Yamada, Y.3    Watanabe, A.4    Tatsumi, M.5
  • 35
    • 21344438897 scopus 로고    scopus 로고
    • Amplification and overexpression of c-erbB-2, epidermal growth factor receptor, and c-met in biliary tract cancers
    • Nakazawa K, Dobashi Y, Suzuki S, Fujii H, Takeda Y, et al. (2005) Amplification and overexpression of c-erbB-2, epidermal growth factor receptor, and c-met in biliary tract cancers. J Pathol 206: 356-365.
    • (2005) J Pathol , vol.206 , pp. 356-365
    • Nakazawa, K.1    Dobashi, Y.2    Suzuki, S.3    Fujii, H.4    Takeda, Y.5
  • 36
    • 33847746580 scopus 로고    scopus 로고
    • c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion
    • Sawada K, Radjabi AR, Shinomiya N, Kistner E, Kenny H, et al. (2007) c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion. Cancer Res 67: 1670-1679.
    • (2007) Cancer Res , vol.67 , pp. 1670-1679
    • Sawada, K.1    Radjabi, A.R.2    Shinomiya, N.3    Kistner, E.4    Kenny, H.5
  • 37
    • 0032523074 scopus 로고    scopus 로고
    • Expression of c-met is a strong independent prognostic factor in breast carcinoma
    • Ghoussoub RAD, Dillon DA, D'Aquila T, Rimm EB, Fearon ER, et al. (1998) Expression of c-met is a strong independent prognostic factor in breast carcinoma. Cancer 82: 1513-1520.
    • (1998) Cancer , vol.82 , pp. 1513-1520
    • Ghoussoub, R.A.D.1    Dillon, D.A.2    D'Aquila, T.3    Rimm, E.B.4    Fearon, E.R.5
  • 38
    • 33745220780 scopus 로고    scopus 로고
    • Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype
    • Kaposi-Novak P, Lee JS, Gomez-Quiroz L, Coulouarn C, Factor VM, et al. (2006) Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype. J Clin Invest116: 1582-1595.
    • (2006) J Clin Invest , vol.116 , pp. 1582-1595
    • Kaposi-Novak, P.1    Lee, J.S.2    Gomez-Quiroz, L.3    Coulouarn, C.4    Factor, V.M.5
  • 39
    • 33646492630 scopus 로고    scopus 로고
    • Effect of c-Met expression on survival in head and neck squamous cell carcinoma
    • Lo Muzio L, Farina A, Rubini C, Coccia E, Capogreco M, et al. (2006) Effect of c-Met expression on survival in head and neck squamous cell carcinoma. Tumor Biol 27: 115-121.
    • (2006) Tumor Biol , vol.27 , pp. 115-121
    • Lo Muzio, L.1    Farina, A.2    Rubini, C.3    Coccia, E.4    Capogreco, M.5
  • 40
    • 33144462553 scopus 로고    scopus 로고
    • Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752
    • Smolen GA, Sordella R, Muir B, Mohapatra G, Barmettler A, et al. (2006) Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752. Proc Nat Acad Sci U.S.A. 103: 2316-2321.
    • (2006) Proc Nat Acad Sci U.S.A , vol.103 , pp. 2316-2321
    • Smolen, G.A.1    Sordella, R.2    Muir, B.3    Mohapatra, G.4    Barmettler, A.5
  • 41
    • 56249137901 scopus 로고    scopus 로고
    • HER kinase activation confers resistance to MET tyrosine kinase inhibition in MET oncogene-addicted gastric cancer cells
    • Bachleitner-Hofmann T, Sun MY, Chen CT, Tang L, Song L, et al. (2008) HER kinase activation confers resistance to MET tyrosine kinase inhibition in MET oncogene-addicted gastric cancer cells. Mol Cancer Ther 7: 3499-3508.
    • (2008) Mol Cancer Ther , vol.7 , pp. 3499-3508
    • Bachleitner-Hofmann, T.1    Sun, M.Y.2    Chen, C.T.3    Tang, L.4    Song, L.5
  • 42
    • 10744228765 scopus 로고    scopus 로고
    • A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo
    • Christensen JG, Schreck R, Burrows J, Kuruganti P, Chan E, et al. (2003) A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo. Cancer Res 63: 7345-7355.
    • (2003) Cancer Res , vol.63 , pp. 7345-7355
    • Christensen, J.G.1    Schreck, R.2    Burrows, J.3    Kuruganti, P.4    Chan, E.5
  • 43
    • 51749095291 scopus 로고    scopus 로고
    • Effect of a c-Met-specific, ATP-competitive small-molecule inhibitor SU11274 on human ovarian carcinoma cell growth, motility, and invasion
    • Koon EC, Ma PC, Salgia R, Welch WR, Christensen JG, et al. (2008) Effect of a c-Met-specific, ATP-competitive small-molecule inhibitor SU11274 on human ovarian carcinoma cell growth, motility, and invasion. Int J Gynecol Cancer 18: 976-984.
    • (2008) Int J Gynecol Cancer , vol.18 , pp. 976-984
    • Koon, E.C.1    Ma, P.C.2    Salgia, R.3    Welch, W.R.4    Christensen, J.G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.