-
2
-
-
79551587725
-
PARP inhibitor treatment in ovarian and breast cancer
-
PARP inhibitor treatment in ovarian and breast cancer. Curr Probl Cancer 2011; 35: 7-50.
-
(2011)
Curr Probl Cancer
, vol.35
, pp. 7-50
-
-
-
4
-
-
49249119415
-
A synthetic lethal therapeutic approach: poly (ADP ribose) polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair
-
Ashworth A. A synthetic lethal therapeutic approach: poly (ADP ribose) polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair. J Clin Oncol 2008; 26: 3785-3790.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3785-3790
-
-
Ashworth, A.1
-
5
-
-
77149157867
-
Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors
-
Mendes-Pereira AM, Martin SA, Brough R et al. Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors. EMBO Mol Med 2009; 1: 315-322.
-
(2009)
EMBO Mol Med
, vol.1
, pp. 315-322
-
-
Mendes-Pereira, A.M.1
Martin, S.A.2
Brough, R.3
-
7
-
-
67650471685
-
Inhibition of poly (ADP-ribose) polymerase in tumors from BRCA mutation carriers
-
Fong PC, Boss DS, Yap TA et al. Inhibition of poly (ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009; 361: 1-12.
-
(2009)
N Engl J Med
, vol.361
, pp. 1-12
-
-
Fong, P.C.1
Boss, D.S.2
Yap, T.A.3
-
8
-
-
77954032829
-
Poly (ADP ribose) polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum free interval
-
Fong PC, Yap TA, Boss DS et al. Poly (ADP ribose) polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum free interval. J Clin Oncol 2010; 28: 2512-2519.
-
(2010)
J Clin Oncol
, vol.28
, pp. 2512-2519
-
-
Fong, P.C.1
Yap, T.A.2
Boss, D.S.3
-
9
-
-
77955039099
-
Oral poly (ADP ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof of concept trial
-
Audeh MW, Carmichael J, Penson RT et al. Oral poly (ADP ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof of concept trial. N Engl J Med 2010; 376: 245-251.
-
(2010)
N Engl J Med
, vol.376
, pp. 245-251
-
-
Audeh, M.W.1
Carmichael, J.2
Penson, R.T.3
-
10
-
-
79551577398
-
Phase II study of the oral PARP inhibitor olaparib (AZD2281) versus liposomal doxorubicin in ovarian cancer patients with BRCA1 and/or BRCA2 mutations
-
Abstr 3725
-
Kaye S, Kaufmann B, Lubinsky J et al. Phase II study of the oral PARP inhibitor olaparib (AZD2281) versus liposomal doxorubicin in ovarian cancer patients with BRCA1 and/or BRCA2 mutations. Ann Oncol 2010; 21 (Suppl 8): vii304 (Abstr 3725).
-
(2010)
Ann Oncol
, vol.21
, Issue.SUPPL. 8
, pp. 304
-
-
Kaye, S.1
Kaufmann, B.2
Lubinsky, J.3
-
11
-
-
77955019962
-
Can we define tumors that will respond to PARP inhibitors? A phase II correlative study of olaparib in advanced serous cancer and triple negative breast cancer
-
233s, Abstr 3002
-
Gelmon KA, Hirte HW, Robidoux A et al. Can we define tumors that will respond to PARP inhibitors? A phase II correlative study of olaparib in advanced serous cancer and triple negative breast cancer. J Clin Oncol 2010; 28: 18s (Suppl) 233s, (Abstr 3002).
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL.
-
-
Gelmon, K.A.1
Hirte, H.W.2
Robidoux, A.3
-
12
-
-
59449085305
-
Phase I study of the poly (ADP-ribose) polymerase inhibitor AGO14699 in combination with temozolamide in patients with advanced solid tumors
-
Plummer R, Jones C, Middleton M et al. Phase I study of the poly (ADP-ribose) polymerase inhibitor AGO14699 in combination with temozolamide in patients with advanced solid tumors. Clin Cancer Res 2008; 14: 7917-7923.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7917-7923
-
-
Plummer, R.1
Jones, C.2
Middleton, M.3
-
13
-
-
78751610848
-
Iniparib plus chemotherapy in metastatic triple negative breast cancer
-
O'Shaughnessy J, Osborne C, Pippen JE et al. Iniparib plus chemotherapy in metastatic triple negative breast cancer. N Engl J Med 2011; 364: 205-214.
-
(2011)
N Engl J Med
, vol.364
, pp. 205-214
-
-
O'Shaughnessy, J.1
Osborne, C.2
Pippen, J.E.3
-
14
-
-
80053578082
-
A phase II trial of iniparib (BSI201) in combination with gemcitabine/carboplatin (GC) in patients with platinum sensitive recurrent ovarian cancer
-
Abstr 5004
-
Penson RT. A phase II trial of iniparib (BSI201) in combination with gemcitabine/carboplatin (GC) in patients with platinum sensitive recurrent ovarian cancer. J Clin Oncol 2011; 29 (Suppl): 333s (Abstr 5004).
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Penson, R.T.1
-
15
-
-
80053600436
-
A phase II trial of iniparib (BSI201) in combination with gemcitabine/carboplatin (GC) in patients with platinum resistant recurrent ovarian cancer
-
Abstr 5005
-
Birrer MJ. A phase II trial of iniparib (BSI201) in combination with gemcitabine/carboplatin (GC) in patients with platinum resistant recurrent ovarian cancer. J Clin Oncol 2011; (Suppl): (Abstr 5005).
-
(2011)
J Clin Oncol
, Issue.SUPPL.
-
-
Birrer, M.J.1
-
16
-
-
84869218836
-
A pharmacokinetics/pharmacodynamics study of sequence specificity of the PARP inhibitor olaparib with carboplatin in refractory/recurrent women's cancer: NCT 01237067
-
Abstr TPS158
-
J Lee. A pharmacokinetics/pharmacodynamics study of sequence specificity of the PARP inhibitor olaparib with carboplatin in refractory/recurrent women's cancer: NCT 01237067. J Clin Oncol 2011; (Suppl): 21s (Abstr TPS158).
-
(2011)
J Clin Oncol
, Issue.SUPPL.
-
-
J, Lee.1
-
17
-
-
80053135643
-
Phase II randomized placebo controlled study of olaparib (AZD2281) in patients with platinum sensitive relapsed serous ovarian cancer (PSRSOC)
-
Abstr 5003
-
Ledermann JA. Phase II randomized placebo controlled study of olaparib (AZD2281) in patients with platinum sensitive relapsed serous ovarian cancer (PSRSOC). J Clin Oncol 2011; (Suppl): 332s (Abstr 5003).
-
(2011)
J Clin Oncol
, Issue.SUPPL.
-
-
Ledermann, J.A.1
-
18
-
-
77955894453
-
Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelial ovarian cancer
-
Konstantinopoulos PA, Spentzos D, Karlan BY et al. Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelial ovarian cancer. J Clin Oncol 2010; 28: 3555-3561.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3555-3561
-
-
Konstantinopoulos, P.A.1
Spentzos, D.2
Karlan, B.Y.3
-
19
-
-
77950974130
-
Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly (ADP-ribose) polymerase inhibitors
-
Mukhopadhyay A, Elattar A, Cerbinskaite A et al. Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly (ADP-ribose) polymerase inhibitors. Clin Cancer Res 2010; 16: 2344-2351.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 2344-2351
-
-
Mukhopadhyay, A.1
Elattar, A.2
Cerbinskaite, A.3
|