메뉴 건너뛰기




Volumn 22, Issue SUPPL.8, 2011, Pages 72-76

Update on PARP1 inhibitors in ovarian cancer

Author keywords

DNA repair; Ovarian cancer; PARP; PARP inhibition

Indexed keywords

CARBOPLATIN; CISPLATIN; DOXORUBICIN; ENZYME INHIBITOR; GEMCITABINE; INIPARIB; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; OLAPARIB; PACLITAXEL; PLACEBO; PLATINUM; POLY(ADENOSINE DIPHOSPHATE RIBOSE)POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PARP1 PROTEIN, HUMAN; PHTHALAZINE DERIVATIVE; PIPERAZINE DERIVATIVE;

EID: 84857383257     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdr528     Document Type: Conference Paper
Times cited : (37)

References (19)
  • 2
    • 79551587725 scopus 로고    scopus 로고
    • PARP inhibitor treatment in ovarian and breast cancer
    • PARP inhibitor treatment in ovarian and breast cancer. Curr Probl Cancer 2011; 35: 7-50.
    • (2011) Curr Probl Cancer , vol.35 , pp. 7-50
  • 4
    • 49249119415 scopus 로고    scopus 로고
    • A synthetic lethal therapeutic approach: poly (ADP ribose) polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair
    • Ashworth A. A synthetic lethal therapeutic approach: poly (ADP ribose) polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair. J Clin Oncol 2008; 26: 3785-3790.
    • (2008) J Clin Oncol , vol.26 , pp. 3785-3790
    • Ashworth, A.1
  • 5
    • 77149157867 scopus 로고    scopus 로고
    • Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors
    • Mendes-Pereira AM, Martin SA, Brough R et al. Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors. EMBO Mol Med 2009; 1: 315-322.
    • (2009) EMBO Mol Med , vol.1 , pp. 315-322
    • Mendes-Pereira, A.M.1    Martin, S.A.2    Brough, R.3
  • 6
    • 4944229642 scopus 로고    scopus 로고
    • Hallmarks of 'BRCAness' in sporadic cancers
    • Turner N, Tutt A, Ashworth A. Hallmarks of 'BRCAness' in sporadic cancers. Nat Rev Cancer 2004; 4: 1-6.
    • (2004) Nat Rev Cancer , vol.4 , pp. 1-6
    • Turner, N.1    Tutt, A.2    Ashworth, A.3
  • 7
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly (ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • Fong PC, Boss DS, Yap TA et al. Inhibition of poly (ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009; 361: 1-12.
    • (2009) N Engl J Med , vol.361 , pp. 1-12
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3
  • 8
    • 77954032829 scopus 로고    scopus 로고
    • Poly (ADP ribose) polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum free interval
    • Fong PC, Yap TA, Boss DS et al. Poly (ADP ribose) polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum free interval. J Clin Oncol 2010; 28: 2512-2519.
    • (2010) J Clin Oncol , vol.28 , pp. 2512-2519
    • Fong, P.C.1    Yap, T.A.2    Boss, D.S.3
  • 9
    • 77955039099 scopus 로고    scopus 로고
    • Oral poly (ADP ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof of concept trial
    • Audeh MW, Carmichael J, Penson RT et al. Oral poly (ADP ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof of concept trial. N Engl J Med 2010; 376: 245-251.
    • (2010) N Engl J Med , vol.376 , pp. 245-251
    • Audeh, M.W.1    Carmichael, J.2    Penson, R.T.3
  • 10
    • 79551577398 scopus 로고    scopus 로고
    • Phase II study of the oral PARP inhibitor olaparib (AZD2281) versus liposomal doxorubicin in ovarian cancer patients with BRCA1 and/or BRCA2 mutations
    • Abstr 3725
    • Kaye S, Kaufmann B, Lubinsky J et al. Phase II study of the oral PARP inhibitor olaparib (AZD2281) versus liposomal doxorubicin in ovarian cancer patients with BRCA1 and/or BRCA2 mutations. Ann Oncol 2010; 21 (Suppl 8): vii304 (Abstr 3725).
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL. 8 , pp. 304
    • Kaye, S.1    Kaufmann, B.2    Lubinsky, J.3
  • 11
    • 77955019962 scopus 로고    scopus 로고
    • Can we define tumors that will respond to PARP inhibitors? A phase II correlative study of olaparib in advanced serous cancer and triple negative breast cancer
    • 233s, Abstr 3002
    • Gelmon KA, Hirte HW, Robidoux A et al. Can we define tumors that will respond to PARP inhibitors? A phase II correlative study of olaparib in advanced serous cancer and triple negative breast cancer. J Clin Oncol 2010; 28: 18s (Suppl) 233s, (Abstr 3002).
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Gelmon, K.A.1    Hirte, H.W.2    Robidoux, A.3
  • 12
    • 59449085305 scopus 로고    scopus 로고
    • Phase I study of the poly (ADP-ribose) polymerase inhibitor AGO14699 in combination with temozolamide in patients with advanced solid tumors
    • Plummer R, Jones C, Middleton M et al. Phase I study of the poly (ADP-ribose) polymerase inhibitor AGO14699 in combination with temozolamide in patients with advanced solid tumors. Clin Cancer Res 2008; 14: 7917-7923.
    • (2008) Clin Cancer Res , vol.14 , pp. 7917-7923
    • Plummer, R.1    Jones, C.2    Middleton, M.3
  • 13
    • 78751610848 scopus 로고    scopus 로고
    • Iniparib plus chemotherapy in metastatic triple negative breast cancer
    • O'Shaughnessy J, Osborne C, Pippen JE et al. Iniparib plus chemotherapy in metastatic triple negative breast cancer. N Engl J Med 2011; 364: 205-214.
    • (2011) N Engl J Med , vol.364 , pp. 205-214
    • O'Shaughnessy, J.1    Osborne, C.2    Pippen, J.E.3
  • 14
    • 80053578082 scopus 로고    scopus 로고
    • A phase II trial of iniparib (BSI201) in combination with gemcitabine/carboplatin (GC) in patients with platinum sensitive recurrent ovarian cancer
    • Abstr 5004
    • Penson RT. A phase II trial of iniparib (BSI201) in combination with gemcitabine/carboplatin (GC) in patients with platinum sensitive recurrent ovarian cancer. J Clin Oncol 2011; 29 (Suppl): 333s (Abstr 5004).
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Penson, R.T.1
  • 15
    • 80053600436 scopus 로고    scopus 로고
    • A phase II trial of iniparib (BSI201) in combination with gemcitabine/carboplatin (GC) in patients with platinum resistant recurrent ovarian cancer
    • Abstr 5005
    • Birrer MJ. A phase II trial of iniparib (BSI201) in combination with gemcitabine/carboplatin (GC) in patients with platinum resistant recurrent ovarian cancer. J Clin Oncol 2011; (Suppl): (Abstr 5005).
    • (2011) J Clin Oncol , Issue.SUPPL.
    • Birrer, M.J.1
  • 16
    • 84869218836 scopus 로고    scopus 로고
    • A pharmacokinetics/pharmacodynamics study of sequence specificity of the PARP inhibitor olaparib with carboplatin in refractory/recurrent women's cancer: NCT 01237067
    • Abstr TPS158
    • J Lee. A pharmacokinetics/pharmacodynamics study of sequence specificity of the PARP inhibitor olaparib with carboplatin in refractory/recurrent women's cancer: NCT 01237067. J Clin Oncol 2011; (Suppl): 21s (Abstr TPS158).
    • (2011) J Clin Oncol , Issue.SUPPL.
    • J, Lee.1
  • 17
    • 80053135643 scopus 로고    scopus 로고
    • Phase II randomized placebo controlled study of olaparib (AZD2281) in patients with platinum sensitive relapsed serous ovarian cancer (PSRSOC)
    • Abstr 5003
    • Ledermann JA. Phase II randomized placebo controlled study of olaparib (AZD2281) in patients with platinum sensitive relapsed serous ovarian cancer (PSRSOC). J Clin Oncol 2011; (Suppl): 332s (Abstr 5003).
    • (2011) J Clin Oncol , Issue.SUPPL.
    • Ledermann, J.A.1
  • 18
    • 77955894453 scopus 로고    scopus 로고
    • Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelial ovarian cancer
    • Konstantinopoulos PA, Spentzos D, Karlan BY et al. Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelial ovarian cancer. J Clin Oncol 2010; 28: 3555-3561.
    • (2010) J Clin Oncol , vol.28 , pp. 3555-3561
    • Konstantinopoulos, P.A.1    Spentzos, D.2    Karlan, B.Y.3
  • 19
    • 77950974130 scopus 로고    scopus 로고
    • Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly (ADP-ribose) polymerase inhibitors
    • Mukhopadhyay A, Elattar A, Cerbinskaite A et al. Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly (ADP-ribose) polymerase inhibitors. Clin Cancer Res 2010; 16: 2344-2351.
    • (2010) Clin Cancer Res , vol.16 , pp. 2344-2351
    • Mukhopadhyay, A.1    Elattar, A.2    Cerbinskaite, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.