TMEPAI inhibits TGF-β signaling by promoting lysosome degradation of TGF-β receptor and contributes to lung cancer development

Cellular Signalling

Volumn 26, Issue 9, 2014, Pages 2030-2039

  Bai, Xilong ^a   Jing, Lei ^a   Li, Yinchuan ^a   Li, Yuyin ^a   Luo, Shenheng ^a   Wang, Shasha ^a   Zhou, Jie ^a   Liu, Zhe ^b   Diao, Aipo ^a  

^a TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Lung cancer; Lysosome; TGF receptor; TGF signaling; TMEPAI

Indexed keywords

PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSMEMBRANE PROSTATE ANDROGEN INDUCED PROTEIN; UBIQUITIN PROTEIN LIGASE NEDD4; UNCLASSIFIED DRUG; ESCRT PROTEIN; MEMBRANE PROTEIN; NEDD4 UBIQUITIN PROTEIN LIGASES; PMEPA1 PROTEIN, HUMAN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UBIQUITIN PROTEIN LIGASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; ENDOSOME; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; LUNG CANCER; LUNG CARCINOGENESIS; LYSOSOME; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL MOTION; DISEASE COURSE; GENETICS; HEK293 CELL LINE; LUNG TUMOR; METABOLISM; PATHOLOGY; RNA INTERFERENCE; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DISEASE PROGRESSION; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; ENDOSOMES; HEK293 CELLS; HUMANS; LUNG NEOPLASMS; LYSOSOMES; MEMBRANE PROTEINS; MICE; MICE, NUDE; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; TRANSPLANTATION, HETEROLOGOUS; UBIQUITIN-PROTEIN LIGASES;

EID: 84902995724     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2014.06.001     Document Type: Article

References (30)

1. Liu R., Zhou Z., Huang J., Chen C. J. Pathol. 2011, 223:683-694.
2. Hirokawa Y.S., Takagi A., Uchida K., Kozuka Y., Yoneda M., Watanabe M., Shiraishi T. Cell. Mol. Biol. Lett. 2007, 12:370-377.
3. Singha P.K., Yeh I.T., Venkatachalam M.A., Saikumar P. Cancer Res. 2010, 70:6377-6383.
4. Giannini G., Ambrosini M.I., Di Marcotullio L., Cerignoli F., Zani M., MacKay A.R., Screpanti I., Frati L., Gulino A. Mol. Carcinog. 2003, 38:188-200.
5. Brunschwig E.B., Wilson K., Mack D., Dawson D., Lawrence E., Willson J.K., Lu S., Nosrati A., Rerko R.M., Swinler S., Beard L., Lutterbaugh J.D., Willis J., Platzer P., Markowitz S. Cancer Res. 2003, 63:1568-1575.
6. Hu Y., He K., Wang D., Yuan X., Liu Y., Ji H., Song J. Carcinogenesis 2013, 34:1764-1772.
7. Vo Nguyen T.T., Watanabe Y., Shiba A., Noguchi M., Itoh S., Kato M. Cancer Sci. 2014, 105:334-341.
8. Rae F.K., Hooper J.D., Nicol D.L., Clements J.A. Mol. Carcinog. 2001, 32:44-53.
9. Rajkumar T., Vijayalakshmi N., Gopal G., Sabitha K., Shirley S., Raja U.M., Ramakrishnan S.A. Cancer Cell Int. 2010, 10:45.
10. Saadi A., Shannon N.B., Lao-Sirieix P., O'Donovan M., Walker E., Clemons N.J., Hardwick J.S., Zhang C., Das M., Save V., Novelli M., Balkwill F., Fitzgerald R.C. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:2177-2182.
11. Xu L.L., Shi Y., Petrovics G., Sun C., Makarem M., Zhang W., Sesterhenn I.A., McLeod D.G., Sun L., Moul J.W., Srivastava S. Cancer Res. 2003, 63:4299-4304.
12. Chen C., Matesic L.E. Cancer Metastasis Rev. 2007, 26:587-604.
13. Eide P.W., Cekaite L., Danielsen S.A., Eilertsen I.A., Kjenseth A., Fykerud T.A., Agesen T.H., Bruun J., Rivedal E., Lothe R.A., Leithe E. Cell. Signal. 2013, 25:12-18.
14. Hicke L. Mol. Cell Biol. 2001, 2:195-201.
15. Hicke L., Dunn R. Annu. Rev. Cell Dev. Biol. 2003, 19:141-172.
16. Shi Y., Massague J. Cell 2003, 113:685-700.
17. Wrighton K.H., Feng X.H. Cell. Signal. 2008, 20:1579-1591.
18. Kuratomi G., Komuro A., Goto K., Shinozaki M., Miyazawa K., Miyazono K., Imamura T. Biochem. J. 2005, 386:461-470.
19. Komuro A., Imamura T., Saitoh M., Yoshida Y., Yamori T., Miyazono K., Miyazawa K. Oncogene 2004, 23:6914-6923.
20. Ebisawa T., Fukuchi M., Murakami G., Chiba T., Tanaka K., Imamura T., Miyazono K. J. Biol. Chem. 2001, 276:12477-12480.
21. Kavsak P., Rasmussen R.K., Causing C.G., Bonni S., Zhu H., Thomsen G.H., Wrana J.L. Mol. Cell 2000, 6:1365-1375.
22. Watanabe Y., Itoh S., Goto T., Ohnishi E., Inamitsu M., Itoh F., Satoh K., Wiercinska E., Yang W., Shi L., Tanaka A., Nakano N., Mommaas A.M., Shibuya H., Ten Dijke P., Kato M. Mol. Cell 2010, 37:123-134.
23. Nakano N., Itoh S., Watanabe Y., Maeyama K., Itoh F., Kato M. J. Biol. Chem. 2010, 285:38023-38033.
24. Xu L.H., Luo S.H., Wang S.S., Hou G.L., Diao A.P. Expression and purification of PMEPA1 protein and its antibody preparation, Shandong University (Natural, Science Edition) 2013, 47:10-13.
25. Chen Y.G. Cell Res. 2009, 19:58-70.
26. Belgareh-Touze N., Leon S., Erpapazoglou Z., Stawiecka-Mirota M., Urban-Grimal D., Haguenauer-Tsapis R. Biochem. Soc. Trans. 2008, 36:791-796.
27. Pak Y., Glowacka W.K., Bruce M.C., Pham N., Rotin D. J. Cell Biol. 2006, 175:631-645.
28. Xu L.L., Shanmugam N., Segawa T., Sesterhenn I.A., McLeod D.G., Moul J.W., Srivastava S. Genomics 2000, 66:257-263.
29. Li H., Xu L.L., Masuda K., Raymundo E., McLeod D.G., Dobi A., Srivastava S. J. Biol. Chem. 2008, 283:28988-28995.
30. Zuo W., Huang F., Chiang Y.J., Li M., Du J., Ding Y., Zhang T., Lee H.W., Jeong L.S., Chen Y., Deng H., Feng X.H., Luo S., Gao C., Chen Y.G. Mol. Cell 2013, 49:499-510.