Spermine attenuates the preconditioning of diazoxide against transient focal cerebral ischemia in rats

Neurological Research

Volumn 36, Issue 7, 2014, Pages 666-672

  Zhang, Lin ^a   Wang, Shilei ^a   Dong, Huanli ^b   Li, Yu ^a   Wang, Peng ^a   Li, Shuhong ^a   Guo, Yunliang ^a   Yao, Ruyong ^a  

^a QINGDAO UNIVERSITY MEDICAL COLLEGE   (China)

^b LIAOCHENG PEOPLE'S HOSPITAL   (China)

Author keywords

Apoptosis; Diazoxide; Mitochondria; Reperfusion; Spermine

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CARRIER PROTEINS AND BINDING PROTEINS; CYTOCHROME C; DIAZOXIDE; MITOCHONDRIAL CALCIUM UNIPORTER; PROTEIN BAX; SPERMINE; UNCLASSIFIED DRUG; BAX PROTEIN, RAT; CALCIUM CHANNEL; MITOCHONDRIAL K(ATP) CHANNEL; NEUROPROTECTIVE AGENT; POTASSIUM CHANNEL;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD FLOW; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL DAMAGE; CONTROLLED STUDY; DNA FRAGMENTATION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; ISCHEMIC PRECONDITIONING; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; RAT; SCORING SYSTEM; TISSUE PREPARATION; ANIMAL; BRAIN; DRUG EFFECTS; INFARCTION, MIDDLE CEREBRAL ARTERY; METABOLISM; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; REPERFUSION INJURY; SEVERITY OF ILLNESS INDEX; WISTAR RAT;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BRAIN; CALCIUM CHANNELS; CYTOCHROMES C; DIAZOXIDE; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NEURONS; NEUROPROTECTIVE AGENTS; POTASSIUM CHANNELS; RANDOM ALLOCATION; RATS, WISTAR; REPERFUSION INJURY; SEVERITY OF ILLNESS INDEX; SPERMINE;

EID: 84902954352     PISSN: 01616412     EISSN: 17431328     Source Type: Journal    
DOI: 10.1179/1743132813Y.0000000299     Document Type: Article

References (23)

1. Halestrap AP. Calcium, mitochondria and reperfusion injury: a pore way to die. Biochem Soc Trans. 2006;34:232-7.
2. Szewczyk A, Kajma A, Malinska D, Wrzosek A, Bednarczyk P, Zabłocka B, et al. Pharmacology of mitochondrial potassium channels: dark side of the field. FEBS Lett. 2010;584(10):2063-9.
3. Dirnagl U, Meisel A. Endogenous neuroprotection: mitochondria as gateways to cerebral preconditioning? Neuropharmacology. 2008;55:334-44.
4. Szewczyk A, Wojtczak L. Mitochondria as a pharmacological target. Pharmacol Rev. 2002;54:101-27.
5. Watanabe M, Katsura K, Ohsawa I, Mizukoshi G, Takahashi K, Asoh S, et al. Involvement of mitoKATP channel in protective mechanisms of cerebral ischemic tolerance. Brain Res. 2008;1238:199-207.
6. Kis B, Rajapakse NC, Snipes JA, Nagy K, Horiguchi T, Busija DW. Diazoxide induces delayed preconditioning in cultured rat cortical neurons. J Neurochem. 2003;87:969-80.
7. Nagy K, Kis B, Rajapakse NC, Bari F, Busija DW. Diazoxide preconditioning protects against neuronal cell death by attenuation of oxidative stress upon glutamate stimulation. J Neurosci Res. 2004;76:697-704.
8. Lenzsér G, Kis B, Bari F, Busija DW. Diazoxide preconditioning attenuates global cerebral ischemia-induced blood-brain barrier permeability. Brain Res. 2005;1051:72-80.
9. Hoppe UC. Mitochondrial calcium channels. FEBS Lett. 2010;584(10):1975-981.
10. Duan B, Wang YZ, Yang T, Chu XP, Yu Y, Huang Y, et al. Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. J Neurosci. 2011;31(6):2101-12.
11. Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989;20:84-91.
12. Garcia JH, Wagner S, Liu KF, Hu XJ. Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation. Stroke. 1995;26(4):627-34.
13. Shimizu S, Ide T, Yanagida T, Tsujimoto Y. Electrophysiological study of a novel large pore formed by Bax and the voltage-dependent anion channel that is permeable to cytochrome c. J Biol Chem. 2000;275:12321-5.
14. Nieber K. Hypoxia and neuronal function under in vitro conditions. Pharmacol Ther. 1999;82:71-86.
15. Pivovarova NB, Andrews SB. Calcium-dependent mitochondrial function and dysfunction in neurons, FEBS J. 2010;277:3622-36.
16. Bernardi P, Krauskopf A, Basso E, Petronilli V, Blachly-Dyson E, Di LF, et al. The mitochondrial permeability transition from in vitro artifact to disease target. FEBS J. 2006;273:2077-99.
17. Galluzzi L, Blomgren K, Kroemer G. Mitochondrial membrane permeabilization in neuronal injury. Nat Rev Neurosci. 2009;10:481-94.
18. Ott M, Robertson JD, Gogvadze V, Zhivotovsky B, Orrenius S. Cytochrome c release from mitochondria proceeds by a twostep process. Proc Natl Acad Sci USA. 2002;99(3):1259-63.
19. Paradies G, Petrosillo G, Paradies V, Ruggiero FM. Role of cardiolipin peroxidation and Ca2z in mitochondrial dysfunction and disease. Cell Calcium. 2009;45(6):643-650.
20. Giacomello M, Drago I, Pizzo P, Pozzan T. Mitochondrial Ca2z as a key regulator of cell life and death. Cell Death Differ. 2007;81:1267-74.
21. Engel T, Plesnila N, Prehn JH, Henshall DC. In vivo contributions of BH3-only proteins to neuronal death following seizures, ischemia, and traumatic brain injury. J Cereb Blood Flow Metab. 2011;31(5):1196-210.
22. Cao G, Minami M, Pei W, Yan C, Chen D, O'Horo C, et al. Intracellular Bax translocation after transient cerebral ischemia: implications for a role of the mitochondrialapoptotic signaling pathway in ischemic neuronal death. J Cereb Blood Flow Metab. 2001;21(4):321-33.
23. Dong H, Wang S, Zhang Z, Yu A, Liu Z. The effect of mitochondrial calcium uniporter opener spermine on diazoxide against focal cerebral ischemia reperfusion injury in rats. J Stroke Cerebrovasc Dis. 2013; March 26 [Epub ahead of print].