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Volumn 10, Issue 3, 2014, Pages 263-271

Optimization of anti-EGFR treatment of advanced colorectal cancer

Author keywords

Amphiregulin; Anti EGFR moAbs; Anti EGFR resistance; Anti EGFR sensitivity; Anti EGFR treatments; BRAF; Cetuximab; Circulating tumor DNA; Colorectal cancer subgroups; EGFR dependency; Epiregulin; Gene expression profile; Gene module; HER2 amplification; KRAS; Liquid biopsy; MET amplification; Metastatic colorectal cancer; Molecular subgroups; NRAS; On treatment markers; Panitumumab; Personalized cancer medicine; PI3KCA; PTEN

Indexed keywords

BIOLOGICAL MARKER; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY;

EID: 84902917816     PISSN: 15563790     EISSN: 15563804     Source Type: Journal    
DOI: 10.1007/s11888-014-0232-7     Document Type: Review
Times cited : (1)

References (73)
  • 3
    • 78651241644 scopus 로고    scopus 로고
    • Colorectal cancer molecular biology moves into clinical practice
    • cited 2014 Jun 1; Available from
    • Pritchard CC, Grady WM. Colorectal cancer molecular biology moves into clinical practice. Gut [Internet]. 2011 [cited 2014 Jun 1];60:116-29. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid= 3006043&tool=pmcentrez&rendertype=abstract.
    • (2011) Gut [Internet] , vol.60 , pp. 116-129
    • Pritchard, C.C.1    Grady, W.M.2
  • 4
    • 0034773992 scopus 로고    scopus 로고
    • The EGFR family and its ligands in human cancer. Signalling mechanisms and therapeutic opportunities
    • cited 2014 Jun 1; Available from
    • Yarden Y. The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. Eur. J. Cancer [Internet]. 2001 [cited 2014 Jun 1];37 Suppl 4:S3-8. Available from: http://www.ncbi.nlm.nih.gov/ pubmed/11597398.
    • (2001) Eur. J. Cancer [Internet] , vol.37 , Issue.SUPPL. 4
    • Yarden, Y.1
  • 5
    • 0035256698 scopus 로고    scopus 로고
    • Untangling the ErbB signalling network
    • cited 2014 May 28; Available from
    • Yarden Y, Sliwkowski MX. Untangling the ErbB signalling network. Nat. Rev. Mol. Cell Biol. [Internet]. 2001 [cited 2014 May 28];2:127-37. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11252954.
    • (2001) Nat. Rev. Mol. Cell Biol. [Internet] , vol.2 , pp. 127-137
    • Yarden, Y.1    Sliwkowski, M.X.2
  • 6
    • 40849147041 scopus 로고    scopus 로고
    • EGFR antagonists in cancer treatment
    • Ciardiello F, Tortora G. EGFR antagonists in cancer treatment. N Engl J Med. 2008;358:1160-74.
    • (2008) N Engl J Med , vol.358 , pp. 1160-1174
    • Ciardiello, F.1    Tortora, G.2
  • 7
    • 62649146531 scopus 로고    scopus 로고
    • ERBBs in the gastrointestinal tract: Recent progress and new perspectives
    • cited 2014 Jun 1; Available from
    • Fiske WH, Threadgill D, Coffey RJ. ERBBs in the gastrointestinal tract: recent progress and new perspectives. Exp. Cell Res. [Internet]. 2009 [cited 2014 Jun 1];315:583-601. Available from: http://www.pubmedcentral.nih.gov/ articlerender.fcgi?artid=2941795&tool=pmcentrez&rendertype=abstract.
    • (2009) Exp. Cell Res. [Internet] , vol.315 , pp. 583-601
    • Fiske, W.H.1    Threadgill, D.2    Coffey, R.J.3
  • 8
    • 0037667420 scopus 로고    scopus 로고
    • Targeting HER1/EGFR: A molecular approach to cancer therapy
    • cited 2014 Jun 1; Available from
    • Arteaga C. Targeting HER1/EGFR: a molecular approach to cancer therapy. Semin. Oncol. [Internet]. 2003 [cited 2014 Jun 1];30:3-14. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12840796.
    • (2003) Semin. Oncol. [Internet] , vol.30 , pp. 3-14
    • Arteaga, C.1
  • 9
    • 76949087071 scopus 로고    scopus 로고
    • Colorectal cancer in review: The role of the EGFR pathway
    • cited 2014 Jun 1; Available from
    • Saif MW. Colorectal cancer in review: the role of the EGFR pathway. Expert Opin. Investig. Drugs [Internet]. 2010 [cited 2014 Jun 1];19:357-69. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20095919.
    • (2010) Expert Opin. Investig. Drugs [Internet] , vol.19 , pp. 357-369
    • Saif, M.W.1
  • 10
    • 32044464123 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) signaling in cancer
    • cited 2014 Jun 1; Available from
    • Normanno N, De Luca A, Bianco C, Strizzi L, Mancino M, Maiello MR, et al. Epidermal growth factor receptor (EGFR) signaling in cancer. Gene [Internet]. 2006 [cited 2014 Jun 1];366:2-16. Available from: http://www.ncbi.nlm.nih.gov/ pubmed/16377102.
    • (2006) Gene [Internet] , vol.366 , pp. 2-16
    • Normanno, N.1    De Luca, A.2    Bianco, C.3    Strizzi, L.4    Mancino, M.5    Maiello, M.R.6
  • 11
    • 33746485766 scopus 로고    scopus 로고
    • Epidermal growth factor receptor targeting in cancer
    • cited 2014 Jun 1; Available from
    • Mendelsohn J, Baselga J. Epidermal growth factor receptor targeting in cancer. Semin. Oncol. [Internet]. 2006 [cited 2014 Jun 1];33:369-85. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16890793.
    • (2006) Semin. Oncol. [Internet] , vol.33 , pp. 369-385
    • Mendelsohn, J.1    Baselga, J.2
  • 12
    • 79959732370 scopus 로고    scopus 로고
    • The role of the epidermal growth factor receptor in the mechanism and treatment of colorectal cancer
    • cited 2014 Jun 1; Available from
    • Yarom N, Jonker DJ. The role of the epidermal growth factor receptor in the mechanism and treatment of colorectal cancer. Discov. Med. [Internet]. 2011 [cited 2014 Jun 1];11:95-105. Available from: http://www.ncbi.nlm.nih.gov/ pubmed/21356164.
    • (2011) Discov. Med. [Internet] , vol.11 , pp. 95-105
    • Yarom, N.1    Jonker, D.J.2
  • 13
    • 78650597089 scopus 로고    scopus 로고
    • IgG isotype, glycosylation, and EGFR expression determine the induction of antibody-dependent cellular cytotoxicity in vitro by cetuximab
    • cited 2014 Jun 1; Available from
    • Patel D, Guo X, Ng S, Melchior M, Balderes P, Burtrum D, et al. IgG isotype, glycosylation, and EGFR expression determine the induction of antibody-dependent cellular cytotoxicity in vitro by cetuximab. Hum. Antibodies [Internet]. 2010 [cited 2014 Jun 1];19:89-99. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21178280.
    • (2010) Hum. Antibodies [Internet] , vol.19 , pp. 89-99
    • Patel, D.1    Guo, X.2    Ng, S.3    Melchior, M.4    Balderes, P.5    Burtrum, D.6
  • 14
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • cited 2014 May 31; Available from
    • Cunningham D, Humblet Y, Siena S, Khayat D, Bleiberg H, Santoro A, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N. Engl. J. Med. [Internet]. 2004 [cited 2014 May 31];351:337-45. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15269313.
    • (2004) N. Engl. J. Med. [Internet] , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3    Khayat, D.4    Bleiberg, H.5    Santoro, A.6
  • 15
    • 2142641698 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    • cited 2014 Jun 1; Available from
    • Saltz LB, Meropol NJ, Loehrer PJ, Needle MN, Kopit J, Mayer RJ. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J. Clin. Oncol. [Internet]. 2004 [cited 2014 Jun 1];22:1201-8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/ 14993230.
    • (2004) J. Clin. Oncol. [Internet] , vol.22 , pp. 1201-1208
    • Saltz, L.B.1    Meropol, N.J.2    Loehrer, P.J.3    Needle, M.N.4    Kopit, J.5    Mayer, R.J.6
  • 16
    • 20144381957 scopus 로고    scopus 로고
    • Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry
    • cited 2014 Jun 1; Available from
    • Chung KY, Shia J, Kemeny NE, Shah M, Schwartz GK, Tse A, et al. Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J. Clin. Oncol. [Internet]. 2005 [cited 2014 Jun 1];23:1803-10. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15677699.
    • (2005) J. Clin. Oncol. [Internet] , vol.23 , pp. 1803-1810
    • Chung, K.Y.1    Shia, J.2    Kemeny, N.E.3    Shah, M.4    Schwartz, G.K.5    Tse, A.6
  • 17
    • 85039745533 scopus 로고    scopus 로고
    • Internet. Available from
    • EMA [Internet]. Available from: http://www.ema.europa.eu/.
  • 18
    • 85039709879 scopus 로고    scopus 로고
    • No Title [Internet]. Available from
    • No Title [Internet]. Available from: http://www.fda.gov/.
  • 19
    • 33646228635 scopus 로고    scopus 로고
    • KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
    • cited 2014 Jun 1; Available from
    • Lièvre A, Bachet J-B, Le Corre D, Boige V, Landi B, Emile J-F, et al. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res. [Internet]. 2006 [cited 2014 Jun 1];66:3992-5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16618717.
    • (2006) Cancer Res. [Internet] , vol.66 , pp. 3992-3995
    • Lièvre, A.1    Bachet, J.-B.2    Le Corre, D.3    Boige, V.4    Landi, B.5    Emile, J.-F.6
  • 20
    • 34247278727 scopus 로고    scopus 로고
    • Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy
    • cited 2014 Jun 1; Available from
    • Di Fiore F, Blanchard F, Charbonnier F, Le Pessot F, Lamy A, Galais MP, et al. Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy. Br. J. Cancer [Internet]. 2007 [cited 2014 Jun 1];96:1166-9. Available from: http://www.pubmedcentral.nih.gov/ articlerender.fcgi?artid=2360149&tool=pmcentrez&rendertype=abstract.
    • (2007) Br. J. Cancer [Internet] , vol.96 , pp. 1166-1169
    • Di Fiore, F.1    Blanchard, F.2    Charbonnier, F.3    Le Pessot, F.4    Lamy, A.5    Galais, M.P.6
  • 21
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • cited 2014 Jun 1; Available from
    • Amado RG, Wolf M, Peeters M, Van Cutsem E, Siena S, Freeman DJ, et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J. Clin. Oncol. [Internet]. 2008 [cited 2014 Jun 1];26:1626-34. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18316791.
    • (2008) J. Clin. Oncol. [Internet] , vol.26 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3    Van Cutsem, E.4    Siena, S.5    Freeman, D.J.6
  • 22
    • 77955277111 scopus 로고    scopus 로고
    • Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis
    • cited 2014 Jun 1; Available from
    • De Roock W, Claes B, Bernasconi D, De Schutter J, Biesmans B, Fountzilas G, et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis. Lancet Oncol. [Internet]. 2010 [cited 2014 Jun 1];11:753-62. Available from: http://www.ncbi.nlm.nih.gov/ pubmed/20619739.
    • (2010) Lancet Oncol. [Internet] , vol.11 , pp. 753-762
    • De Roock, W.1    Claes, B.2    Bernasconi, D.3    De Schutter, J.4    Biesmans, B.5    Fountzilas, G.6
  • 23
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and benefit from cetuximab in advanced colorectal cancer
    • cited 2014 Jun 1; Available from
    • Karapetis CS, Khambata-Ford S, Jonker DJ, O'Callaghan CJ, Tu D, Tebbutt NC, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N. Engl. J. Med. [Internet]. 2008 [cited 2014 Jun 1];359:1757-65. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18946061.
    • (2008) N. Engl. J. Med. [Internet] , vol.359 , pp. 1757-1765
    • Karapetis, C.S.1    Khambata-Ford, S.2    Jonker, D.J.3    O'Callaghan, C.J.4    Tu, D.5    Tebbutt, N.C.6
  • 24
    • 59949091448 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
    • cited 2014 Jun 1; Available from
    • Bokemeyer C, Bondarenko I, Makhson A, Hartmann JT, Aparicio J, de Braud F, et al. Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J. Clin. Oncol. [Internet]. 2009 [cited 2014 Jun 1];27:663-71. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19114683.
    • (2009) J. Clin. Oncol. [Internet] , vol.27 , pp. 663-671
    • Bokemeyer, C.1    Bondarenko, I.2    Makhson, A.3    Hartmann, J.T.4    Aparicio, J.5    De Braud, F.6
  • 25
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • cited 2014 May 25; Available from
    • Van Cutsem E, Köhne C-H, Hitre E, Zaluski J, Chang Chien C-R, Makhson A, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N. Engl. J. Med. [Internet]. 2009 [cited 2014 May 25];360:1408-17. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19339720.
    • (2009) N. Engl. J. Med. [Internet] , vol.360 , pp. 1408-1417
    • Van Cutsem, E.1    Köhne, C.-H.2    Hitre, E.3    Zaluski, J.4    Chang Chien, C.-R.5    Makhson, A.6
  • 26
    • 78149250536 scopus 로고    scopus 로고
    • Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreatedmetastatic colorectal cancer: The PRIME study
    • cited 2014 May 26; Available from
    • Douillard J-Y, Siena S, Cassidy J, Tabernero J, Burkes R, Barugel M, et al. Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreatedmetastatic colorectal cancer: the PRIME study. J. Clin. Oncol. [Internet]. 2010 [cited 2014 May 26];28:4697-705. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20921465.
    • (2010) J. Clin. Oncol. [Internet] , vol.28 , pp. 4697-4705
    • Douillard, J.-Y.1    Siena, S.2    Cassidy, J.3    Tabernero, J.4    Burkes, R.5    Barugel, M.6
  • 27
    • 65349189958 scopus 로고    scopus 로고
    • American Society of Clinical Oncology provisional clinical opinion: Testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy
    • cited 2014 Jun 1; Available from
    • Allegra CJ, Jessup JM, Somerfield MR, Hamilton SR, Hammond EH, Hayes DF, et al. American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy. J. Clin. Oncol. [Internet]. 2009 [cited 2014 Jun 1];27:2091-6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19188670.
    • (2009) J. Clin. Oncol. [Internet] , vol.27 , pp. 2091-2096
    • Allegra, C.J.1    Jessup, J.M.2    Somerfield, M.R.3    Hamilton, S.R.4    Hammond, E.H.5    Hayes, D.F.6
  • 28
    • 0005783808 scopus 로고    scopus 로고
    • Molecular biology of gastrointestinal cancers
    • eds Devita
    • Rosen N. Molecular biology of gastrointestinal cancers. Cancer - Principles Pract. Oncol. 5th edn. eds Devita. 1997. p. 971-9.
    • (1997) Cancer - Principles Pract. Oncol. 5th Edn. , pp. 971-979
    • Rosen, N.1
  • 30
    • 58749102224 scopus 로고    scopus 로고
    • High concordance of KRAS status between primary colorectal tumors and related metastatic sites: Implications for clinical practice
    • cited 2014 Jun 1; Available from
    • Santini D, Loupakis F, Vincenzi B, Floriani I, Stasi I, Canestrari E, et al. High concordance of KRAS status between primary colorectal tumors and related metastatic sites: implications for clinical practice. Oncologist [Internet]. 2008 [cited 2014 Jun 1];13:1270-5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19056857.
    • (2008) Oncologist [Internet] , vol.13 , pp. 1270-1275
    • Santini, D.1    Loupakis, F.2    Vincenzi, B.3    Floriani, I.4    Stasi, I.5    Canestrari, E.6
  • 31
    • 51649084560 scopus 로고    scopus 로고
    • Mutations of KRAS and BRAF in primary and matched metastatic sites of colorectal cancer
    • cited 2014 Jun 1; Available from
    • Artale S, Sartore-Bianchi A, Veronese SM, Gambi V, Sarnataro CS, Gambacorta M, et al. Mutations of KRAS and BRAF in primary and matched metastatic sites of colorectal cancer. J. Clin. Oncol. [Internet]. 2008 [cited 2014 Jun 1];26:4217-9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/ 18757341.
    • (2008) J. Clin. Oncol. [Internet] , vol.26 , pp. 4217-4219
    • Artale, S.1    Sartore-Bianchi, A.2    Veronese, S.M.3    Gambi, V.4    Sarnataro, C.S.5    Gambacorta, M.6
  • 33
    • 68749119351 scopus 로고    scopus 로고
    • KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-typemetastatic colorectal cancer
    • cited 2014 Jun 1; Available from
    • Loupakis F, Ruzzo A, Cremolini C, Vincenzi B, Salvatore L, Santini D, et al. KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-typemetastatic colorectal cancer. Br. J. Cancer [Internet]. 2009 [cited 2014 Jun 1];101:715-21. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2736831&tool= pmcentrez&rendertype=abstract.
    • (2009) Br. J. Cancer [Internet] , vol.101 , pp. 715-721
    • Loupakis, F.1    Ruzzo, A.2    Cremolini, C.3    Vincenzi, B.4    Salvatore, L.5    Santini, D.6
  • 34
    • 78049341541 scopus 로고    scopus 로고
    • Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab
    • cited 2014 Jun 1; Available from
    • De Roock W, Jonker DJ, Di Nicolantonio F, Sartore-Bianchi A, Tu D, Siena S, et al. Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab. JAMA [Internet]. 2010 [cited 2014 Jun 1];304:1812-20. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20978259.
    • (2010) JAMA [Internet] , vol.304 , pp. 1812-1820
    • De Roock, W.1    Jonker, D.J.2    Di Nicolantonio, F.3    Sartore-Bianchi, A.4    Tu, D.5    Siena, S.6
  • 35
    • 84867117207 scopus 로고    scopus 로고
    • Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab
    • cited 2014 Jun 1; Available from
    • Tejpar S, Celik I, Schlichting M, Sartorius U, Bokemeyer C, Van Cutsem E. Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab. J. Clin. Oncol. [Internet]. 2012 [cited 2014 Jun 1];30:3570-7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22734028.
    • (2012) J. Clin. Oncol. [Internet] , vol.30 , pp. 3570-3577
    • Tejpar, S.1    Celik, I.2    Schlichting, M.3    Sartorius, U.4    Bokemeyer, C.5    Van Cutsem, E.6
  • 36
    • 84879240684 scopus 로고    scopus 로고
    • KRAS gene amplification in colorectal cancer and impact on response to EGFR-targeted therapy
    • cited 2014 Jun 1; Available from
    • Valtorta E, Misale S, Sartore-Bianchi A, Nagtegaal ID, Paraf F, Lauricella C, et al. KRAS gene amplification in colorectal cancer and impact on response to EGFR-targeted therapy. Int. J. Cancer [Internet]. 2013 [cited 2014 Jun 1];133:1259-65. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23404247.
    • (2013) Int. J. Cancer [Internet] , vol.133 , pp. 1259-1265
    • Valtorta, E.1    Misale, S.2    Sartore-Bianchi, A.3    Nagtegaal, I.D.4    Paraf, F.5    Lauricella, C.6
  • 37
    • 40149088765 scopus 로고    scopus 로고
    • KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab
    • cited 2014 May 23; Available from
    • De Roock W, Piessevaux H, De Schutter J, Janssens M, De Hertogh G, Personeni N, et al. KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab. Ann. Oncol. [Internet]. 2008 [cited 2014 May 23];19:508-15. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17998284.
    • (2008) Ann. Oncol. [Internet] , vol.19 , pp. 508-515
    • De Roock, W.1    Piessevaux, H.2    De Schutter, J.3    Janssens, M.4    De Hertogh, G.5    Personeni, N.6
  • 38
    • 84903694472 scopus 로고    scopus 로고
    • Final results from PRIME: Randomized phase 3 study of panitumumab with FOLFOX4 for first-line treatment of metastatic colorectal cancer
    • cited 2014 Jun 3; Available from
    • Douillard JY, Siena S, Cassidy J, Tabernero J, Burkes R, Barugel M, et al. Final results from PRIME: randomized phase 3 study of panitumumab with FOLFOX4 for first-line treatment of metastatic colorectal cancer. Ann. Oncol. [Internet]. 2014 [cited 2014 Jun 3]; Available from: http://www.ncbi.nlm.nih. gov/pubmed/24718886.
    • (2014) Ann. Oncol. [Internet]
    • Douillard, J.Y.1    Siena, S.2    Cassidy, J.3    Tabernero, J.4    Burkes, R.5    Barugel, M.6
  • 39
    • 84896121177 scopus 로고    scopus 로고
    • Analysis of KRAS/NRAS and BRAF mutations in FIRE-3: A randomized phase III study of FOLFIRI plus cetuximab or bevacizumab as first-line treatment for wild-type (WT) KRAS (exon 2) metastatic colorectal cancer (mCRC) patients
    • Stintzing S, Jung A RL. Analysis of KRAS/NRAS and BRAF mutations in FIRE-3: A randomized phase III study of FOLFIRI plus cetuximab or bevacizumab as first-line treatment for wild-type (WT) KRAS (exon 2) metastatic colorectal cancer (mCRC) patients. European Cancer Congress 2013.
    • (2013) European Cancer Congress
    • Stintzing, S.1    Jung, A.R.L.2
  • 40
    • 84905870196 scopus 로고    scopus 로고
    • PEAK: A Randomized, Multicenter Phase II Study of Panitumumab Plus Modified Fluorouracil, Leucovorin, and Oxaliplatin (mFOLFOX6) or Bevacizumab Plus mFOLFOX6 in Patients With Previously Untreated, Unresectable, Wild-Type KRAS Exon 2 Metastatic Colorectal
    • cited 2014 Jun 3; Available from
    • Schwartzberg LS, Rivera F, Karthaus M, Fasola G, Canon J-L, Hecht JR, et al. PEAK: A Randomized, Multicenter Phase II Study of Panitumumab Plus Modified Fluorouracil, Leucovorin, and Oxaliplatin (mFOLFOX6) or Bevacizumab Plus mFOLFOX6 in Patients With Previously Untreated, Unresectable, Wild-Type KRAS Exon 2 Metastatic Colorectal. J. Clin. Oncol. [Internet]. 2014 [cited 2014 Jun 3]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/24687833.
    • (2014) J. Clin. Oncol. [Internet]
    • Schwartzberg, L.S.1    Rivera, F.2    Karthaus, M.3    Fasola, G.4    Canon, J.-L.5    Hecht, J.R.6
  • 41
    • 84907023716 scopus 로고    scopus 로고
    • Treatment outcome according to tumor RAS mutation status in CRYSTAL study patients with metastatic colorectal cancer (mCRC) randomized to FOLFIRI with/without cetuximab
    • EVC. Available from: 2014 abstr 3506. KRAS exon2 mutation had already been shown to be associated with lack of response to anti-EGFR moAbs, thus leading, in 2008, the competent authorities to restrict the use of anti-EGFR moAbs to KRAS WT mCRC patients only. The studies reported in references 38, 39, 40 and 41 prove that the KRAS mutation alone is not sufficient for selection of patients who will benefit from cetuximab and panitumumab. They clearly demonstrate that other mutations in KRAS, not only exon 2 but also exons 3 and 4, and mutations in NRAS exons 2, 3, and 4 are important for selection of patients to treat with anti-EGFR moAbs. The importance of these studies is that the RAS analysis seems to be required for all RAS genes, and this might change clinical practice
    • Fortunato Ciardiello, Heinz-Josef Lenz, Claus-Henning Kohne, Volker Heinemann, Sabine Tejpar, Ivan Melezinek, Frank Beier, Christopher Stroh EVC. Treatment outcome according to tumor RAS mutation status in CRYSTAL study patients with metastatic colorectal cancer (mCRC) randomized to FOLFIRI with/without cetuximab. 2014. Available from: J Clin Oncol 32:5s, 2014 (suppl; abstr 3506). KRAS exon2 mutation had already been shown to be associated with lack of response to anti-EGFR moAbs, thus leading, in 2008, the competent authorities to restrict the use of anti-EGFR moAbs to KRAS WT mCRC patients only. The studies reported in references 38, 39, 40 and 41 prove that the KRAS mutation alone is not sufficient for selection of patients who will benefit from cetuximab and panitumumab. They clearly demonstrate that other mutations in KRAS, not only exon 2 but also exons 3 and 4, and mutations in NRAS exons 2, 3, and 4 are important for selection of patients to treat with anti-EGFR moAbs. The importance of these studies is that the RAS analysis seems to be required for all RAS genes, and this might change clinical practice.
    • (2014) J Clin Oncol , vol.32 , Issue.SUPPL.
    • Ciardiello, F.1    Lenz, H.-J.2    Kohne, C.-H.3    Heinemann, V.4    Tejpar, S.5    Melezinek, I.6    Beier, F.7    Stroh, C.8
  • 42
    • 57449095367 scopus 로고    scopus 로고
    • Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
    • cited 2014 Jun 1; Available from
    • Di Nicolantonio F, Martini M, Molinari F, Sartore-Bianchi A, Arena S, Saletti P, et al. Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J. Clin. Oncol. [Internet]. 2008 [cited 2014 Jun 1];26:5705-12. Available from: http://www.ncbi.nlm.nih.gov/ pubmed/19001320.
    • (2008) J. Clin. Oncol. [Internet] , vol.26 , pp. 5705-5712
    • Di Nicolantonio, F.1    Martini, M.2    Molinari, F.3    Sartore-Bianchi, A.4    Arena, S.5    Saletti, P.6
  • 43
    • 68149165771 scopus 로고    scopus 로고
    • Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer
    • cited 2014 Jun 1; Available from
    • Souglakos J, Philips J, Wang R, Marwah S, Silver M, Tzardi M, et al. Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer. Br. J. Cancer [Internet]. 2009 [cited 2014 Jun 1];101:465-72. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2720232&tool= pmcentrez&rendertype=abstract.
    • (2009) Br. J. Cancer [Internet] , vol.101 , pp. 465-472
    • Souglakos, J.1    Philips, J.2    Wang, R.3    Marwah, S.4    Silver, M.5    Tzardi, M.6
  • 44
    • 73349094741 scopus 로고    scopus 로고
    • Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer
    • cited 2014 May 28; Available from
    • Laurent-Puig P, Cayre A, Manceau G, Buc E, Bachet J-B, Lecomte T, et al. Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer. J. Clin. Oncol. [Internet]. 2009 [cited 2014 May 28];27:5924-30. Available from: http://www.ncbi.nlm.nih. gov/pubmed/19884556.
    • (2009) J. Clin. Oncol. [Internet] , vol.27 , pp. 5924-5930
    • Laurent-Puig, P.1    Cayre, A.2    Manceau, G.3    Buc, E.4    Bachet, J.-B.5    Lecomte, T.6
  • 45
    • 84862026304 scopus 로고    scopus 로고
    • Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: Pooled analysis of the CRYSTAL and OPUS randomised clinical trials
    • cited 2014 Jun 1; Available from
    • Bokemeyer C, Van Cutsem E, Rougier P, Ciardiello F, Heeger S, Schlichting M, et al. Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: pooled analysis of the CRYSTAL and OPUS randomised clinical trials. Eur. J. Cancer [Internet]. 2012 [cited 2014 Jun 1];48:1466-75. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22446022.
    • (2012) Eur. J. Cancer [Internet] , vol.48 , pp. 1466-1475
    • Bokemeyer, C.1    Van Cutsem, E.2    Rougier, P.3    Ciardiello, F.4    Heeger, S.5    Schlichting, M.6
  • 46
    • 84862772839 scopus 로고    scopus 로고
    • A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer
    • cited 2014 Jun 1; Available from
    • Bertotti A, Migliardi G, Galimi F, Sassi F, Torti D, Isella C, et al. A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer. Cancer Discov. [Internet]. 2011 [cited 2014 Jun 1];1:508-23. Available from: http://www.ncbi.nlm.nih.gov/pubmed/ 22586653.
    • (2011) Cancer Discov. [Internet] , vol.1 , pp. 508-523
    • Bertotti, A.1    Migliardi, G.2    Galimi, F.3    Sassi, F.4    Torti, D.5    Isella, C.6
  • 47
    • 80052591747 scopus 로고    scopus 로고
    • Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab
    • cited 2014 Jun 1; Available from
    • Yonesaka K, Zejnullahu K, Okamoto I, Satoh T, Cappuzzo F, Souglakos J, et al. Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab. Sci. Transl. Med. [Internet]. 2011 [cited 2014 Jun 1];3:99ra86. Available from: http://www.pubmedcentral.nih.gov/articlerender. fcgi?artid=3268675&tool=pmcentrez&rendertype=abstract.
    • (2011) Sci. Transl. Med. [Internet] , vol.3
    • Yonesaka, K.1    Zejnullahu, K.2    Okamoto, I.3    Satoh, T.4    Cappuzzo, F.5    Souglakos, J.6
  • 48
    • 53249123419 scopus 로고    scopus 로고
    • Clinical usefulness of EGFR gene copy number as a predictive marker in colorectal cancer patients treated with cetuximab: A fluorescent in situ hybridization study
    • cited 2014 Jun 1; Available from
    • Personeni N, Fieuws S, Piessevaux H, De Hertogh G, De Schutter J, Biesmans B, et al. Clinical usefulness of EGFR gene copy number as a predictive marker in colorectal cancer patients treated with cetuximab: a fluorescent in situ hybridization study. Clin. Cancer Res. [Internet]. 2008 [cited 2014 Jun 1];14:5869-76. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18794099.
    • (2008) Clin. Cancer Res. [Internet] , vol.14 , pp. 5869-5876
    • Personeni, N.1    Fieuws, S.2    Piessevaux, H.3    De Hertogh, G.4    De Schutter, J.5    Biesmans, B.6
  • 49
    • 73349094741 scopus 로고    scopus 로고
    • Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer
    • cited 2014 May 28; Available from
    • Laurent-Puig P, Cayre A, Manceau G, Buc E, Bachet J-B, Lecomte T, et al. Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer. J. Clin. Oncol. [Internet]. 2009 [cited 2014 May 28];27:5924-30. Available from: http://www.ncbi.nlm.nih. gov/pubmed/19884556.
    • (2009) J. Clin. Oncol. [Internet] , vol.27 , pp. 5924-5930
    • Laurent-Puig, P.1    Cayre, A.2    Manceau, G.3    Buc, E.4    Bachet, J.-B.5    Lecomte, T.6
  • 50
    • 79251633445 scopus 로고    scopus 로고
    • Impact of KRAS, BRAF, PIK3CA mutations, PTEN, AREG, EREG expression and skin rash in ≥ 2 line cetuximab-based therapy of colorectal cancer patients
    • cited 2014 Jun 1; Available from
    • Saridaki Z, Tzardi M, Papadaki C, Sfakianaki M, Pega F, Kalikaki A, et al. Impact of KRAS, BRAF, PIK3CA mutations, PTEN, AREG, EREG expression and skin rash in ≥ 2 line cetuximab-based therapy of colorectal cancer patients. PLoS One [Internet]. 2011 [cited 2014 Jun 1];6:e15980. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3024325&tool= pmcentrez&rendertype=abstract.
    • (2011) PLoS One [Internet] , vol.6
    • Saridaki, Z.1    Tzardi, M.2    Papadaki, C.3    Sfakianaki, M.4    Pega, F.5    Kalikaki, A.6
  • 51
    • 65649086786 scopus 로고    scopus 로고
    • PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer
    • cited 2014 Jun 1; Available from
    • Prenen H, De Schutter J, Jacobs B, De Roock W, Biesmans B, Claes B, et al. PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer. Clin. Cancer Res. [Internet]. 2009 [cited 2014 Jun 1];15:3184-8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19366826.
    • (2009) Clin. Cancer Res. [Internet] , vol.15 , pp. 3184-3188
    • Prenen, H.1    De Schutter, J.2    Jacobs, B.3    De Roock, W.4    Biesmans, B.5    Claes, B.6
  • 52
    • 59049089201 scopus 로고    scopus 로고
    • PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients
    • cited 2014 Jun 1; Available from
    • Perrone F, Lampis A, Orsenigo M, Di Bartolomeo M, Gevorgyan A, Losa M, et al. PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients. Ann. Oncol. [Internet]. 2009 [cited 2014 Jun 1];20:84-90. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18669866.
    • (2009) Ann. Oncol. [Internet] , vol.20 , pp. 84-90
    • Perrone, F.1    Lampis, A.2    Orsenigo, M.3    Di Bartolomeo, M.4    Gevorgyan, A.5    Losa, M.6
  • 53
    • 62449302407 scopus 로고    scopus 로고
    • PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies
    • cited 2014 Jun 1; Available from
    • Sartore-Bianchi A, Martini M, Molinari F, Veronese S, Nichelatti M, Artale S, et al. PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies. Cancer Res. [Internet]. 2009 [cited 2014 Jun 1];69:1851-7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19223544.
    • (2009) Cancer Res. [Internet] , vol.69 , pp. 1851-1857
    • Sartore-Bianchi, A.1    Martini, M.2    Molinari, F.3    Veronese, S.4    Nichelatti, M.5    Artale, S.6
  • 54
    • 35348908314 scopus 로고    scopus 로고
    • PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients
    • cited 2014 Jun 1; Available from
    • Frattini M, Saletti P, Romagnani E, Martin V, Molinari F, Ghisletta M, et al. PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients. Br. J. Cancer [Internet]. 2007 [cited 2014 Jun 1];97:1139-45. Available from: http://www.pubmedcentral.nih.gov/articlerender. fcgi?artid=2360431&tool=pmcentrez&rendertype=abstract.
    • (2007) Br. J. Cancer [Internet] , vol.97 , pp. 1139-1145
    • Frattini, M.1    Saletti, P.2    Romagnani, E.3    Martin, V.4    Molinari, F.5    Ghisletta, M.6
  • 55
    • 66849140563 scopus 로고    scopus 로고
    • PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer
    • cited 2014 Jun 1; Available from
    • Loupakis F, Pollina L, Stasi I, Ruzzo A, Scartozzi M, Santini D, et al. PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer. J. Clin. Oncol. [Internet]. 2009 [cited 2014 Jun 1];27:2622-9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19398573.
    • (2009) J. Clin. Oncol. [Internet] , vol.27 , pp. 2622-2629
    • Loupakis, F.1    Pollina, L.2    Stasi, I.3    Ruzzo, A.4    Scartozzi, M.5    Santini, D.6
  • 56
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Tcga. Nature Publishing Group; cited 2014 May 23; Available from
    • Tcga. Comprehensive molecular characterization of human colon and rectal cancer. Nature [Internet]. Nature Publishing Group; 2012 [cited 2014 May 23];487:330-7. Available from: http://www.pubmedcentral.nih.gov/articlerender. fcgi?artid=3401966&tool=pmcentrez&rendertype=abstract.
    • (2012) Nature [Internet] , vol.487 , pp. 330-337
  • 57
    • 34548238762 scopus 로고    scopus 로고
    • Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
    • cited 2014 May 24; Available from
    • Khambata-Ford S, Garrett CR, Meropol NJ, Basik M, Harbison CT, Wu S, et al. Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J. Clin. Oncol. [Internet]. 2007 [cited 2014 May 24];25:3230-7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17664471.
    • (2007) J. Clin. Oncol. [Internet] , vol.25 , pp. 3230-3237
    • Khambata-Ford, S.1    Garrett, C.R.2    Meropol, N.J.3    Basik, M.4    Harbison, C.T.5    Wu, S.6
  • 58
    • 73349098041 scopus 로고    scopus 로고
    • Amphiregulin and epiregulin mRNA expression in primary tumors predicts outcome in metastatic colorectal cancer treated with cetuximab
    • cited 2014 May 24; Available from
    • Jacobs B, De Roock W, Piessevaux H, Van Oirbeek R, Biesmans B, De Schutter J, et al. Amphiregulin and epiregulin mRNA expression in primary tumors predicts outcome in metastatic colorectal cancer treated with cetuximab. J. Clin. Oncol. [Internet]. 2009 [cited 2014 May 24];27:5068-74. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19738126.
    • (2009) J. Clin. Oncol. [Internet] , vol.27 , pp. 5068-5074
    • Jacobs, B.1    De Roock, W.2    Piessevaux, H.3    Van Oirbeek, R.4    Biesmans, B.5    De Schutter, J.6
  • 59
    • 77949887855 scopus 로고    scopus 로고
    • Pharmacogenomic and pharmacoproteomic studies of cetuximab in metastatic colorectal cancer: Biomarker analysis of a phase I dose-escalation study
    • cited 2014 May 24; Available from
    • Tabernero J, Cervantes A, Rivera F, Martinelli E, Rojo F, von Heydebreck A, et al. Pharmacogenomic and pharmacoproteomic studies of cetuximab in metastatic colorectal cancer: biomarker analysis of a phase I dose-escalation study. J. Clin. Oncol. [Internet]. 2010 [cited 2014 May 24];28:1181-9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20100964.
    • (2010) J. Clin. Oncol. [Internet] , vol.28 , pp. 1181-1189
    • Tabernero, J.1    Cervantes, A.2    Rivera, F.3    Martinelli, E.4    Rojo, F.5    Von Heydebreck, A.6
  • 60
    • 84874645608 scopus 로고    scopus 로고
    • A combined oncogenic pathway signature of BRAF, KRAS and PI3KCA mutation improves colorectal cancer classification and cetuximab treatment prediction
    • cited 2014 May 29; Available from
    • Tian S, Simon I, Moreno V, Roepman P, Tabernero J, Snel M, et al. A combined oncogenic pathway signature of BRAF, KRAS and PI3KCA mutation improves colorectal cancer classification and cetuximab treatment prediction. Gut [Internet]. 2013 [cited 2014 May 29];62:540-9. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3596735&tool= pmcentrez&rendertype=abstract.
    • (2013) Gut [Internet] , vol.62 , pp. 540-549
    • Tian, S.1    Simon, I.2    Moreno, V.3    Roepman, P.4    Tabernero, J.5    Snel, M.6
  • 61
    • 79551580548 scopus 로고    scopus 로고
    • Tumour gene expression predicts response to cetuximab in patients with KRAS wild-type metastatic colorectal cancer
    • cited 2014May 24; Available from
    • Baker JB, Dutta D, Watson D, Maddala T, Munneke BM, Shak S, et al. Tumour gene expression predicts response to cetuximab in patients with KRAS wild-type metastatic colorectal cancer. Br. J. Cancer [Internet]. 2011 [cited 2014May 24];104:488-95. Available from: http://www.pubmedcentral.nih.gov/articlerender. fcgi?artid=3049558&tool=pmcentrez&rendertype=abstract.
    • (2011) Br. J. Cancer [Internet] , vol.104 , pp. 488-495
    • Baker, J.B.1    Dutta, D.2    Watson, D.3    Maddala, T.4    Munneke, B.M.5    Shak, S.6
  • 62
    • 84870793137 scopus 로고    scopus 로고
    • Gene Expression Modules Associated with Cetuximab Response in Metastatic Colorectal Cancer Predict Additional Patient Populations Likely to Respond
    • The authors of both reference 60 and 62 demonstrate that, compared with single gene alterations, use of gene modules can enable better prediction of the response to targeted agents, thus highlighting the concept that we should go beyond the assumption of a binary relationship between one genetic event and response or resistance to anti-EGFR drugs and that several factors can affect the response to these agents
    • Rhodes DR, Lockwood Banka W CA. Gene Expression Modules Associated with Cetuximab Response in Metastatic Colorectal Cancer Predict Additional Patient Populations Likely to Respond. AACR Translation of the Cancer Genome. The authors of both reference 60 and 62 demonstrate that, compared with single gene alterations, use of gene modules can enable better prediction of the response to targeted agents, thus highlighting the concept that we should go beyond the assumption of a binary relationship between one genetic event and response or resistance to anti-EGFR drugs and that several factors can affect the response to these agents.
    • AACR Translation of the Cancer Genome
    • Rhodes, D.R.1    Lockwood Banka, W.C.A.2
  • 63
    • 84865092896 scopus 로고    scopus 로고
    • Intrapatient cetuximab dose escalation in metastatic colorectal cancer according to the grade of early skin reactions: The randomized EVEREST study
    • cited 2014 Jun 1; Available from
    • Van Cutsem E, Tejpar S, Vanbeckevoort D, Peeters M, Humblet Y, Gelderblom H, et al. Intrapatient cetuximab dose escalation in metastatic colorectal cancer according to the grade of early skin reactions: the randomized EVEREST study. J. Clin. Oncol. [Internet]. 2012 [cited 2014 Jun 1];30:2861-8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22753904.
    • (2012) J. Clin. Oncol. [Internet] , vol.30 , pp. 2861-2868
    • Van Cutsem, E.1    Tejpar, S.2    Vanbeckevoort, D.3    Peeters, M.4    Humblet, Y.5    Gelderblom, H.6
  • 64
    • 34147103678 scopus 로고    scopus 로고
    • Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy- refractory metastatic colorectal cancer
    • cited 2014 Jun 1; Available from
    • Van Cutsem E, Peeters M, Siena S, Humblet Y, Hendlisz A, Neyns B, et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J. Clin. Oncol. [Internet]. 2007 [cited 2014 Jun 1];25:1658-64. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17470858.
    • (2007) J. Clin. Oncol. [Internet] , vol.25 , pp. 1658-1664
    • Van Cutsem, E.1    Peeters, M.2    Siena, S.3    Humblet, Y.4    Hendlisz, A.5    Neyns, B.6
  • 65
    • 84898542288 scopus 로고    scopus 로고
    • Liquid biopsies: Genotyping circulating tumor DNA
    • cited 2014 May 30; Available from
    • Diaz LA, Bardelli A. Liquid biopsies: genotyping circulating tumor DNA. J. Clin. Oncol. [Internet]. 2014 [cited 2014 May 30];32:579-86. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24449238.
    • (2014) J. Clin. Oncol. [Internet] , vol.32 , pp. 579-586
    • Diaz, L.A.1    Bardelli, A.2
  • 66
    • 84862999938 scopus 로고    scopus 로고
    • Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer
    • cited 2014 May 28; Available from
    • Misale S, Yaeger R, Hobor S, Scala E, Janakiraman M, Liska D, et al. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer. Nature [Internet]. 2012 [cited 2014 May 28];486:532-6. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid= 3927413&tool=pmcentrez&rendertype=abstract
    • (2012) Nature [Internet] , vol.486 , pp. 532-536
    • Misale, S.1    Yaeger, R.2    Hobor, S.3    Scala, E.4    Janakiraman, M.5    Liska, D.6
  • 67
    • 84878862323 scopus 로고    scopus 로고
    • Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer
    • cited 2014 Jun 1; Available from: The authors of reference 66 and 67 introduce two important concepts: the importance of liquid biopsy as validated technique for early detection of the molecular mechanisms of acquired resistance and the discovery of acquired KRAS mutations and MET amplification as mechanisms of secondary resistance to anti-EGFR treatments
    • Bardelli A, Corso S, Bertotti A, Hobor S, Valtorta E, Siravegna G, et al. Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer. Cancer Discov. [Internet]. 2013 [cited 2014 Jun 1];3:658-73. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23729478. The authors of reference 66 and 67 introduce two important concepts: the importance of liquid biopsy as validated technique for early detection of the molecular mechanisms of acquired resistance and the discovery of acquired KRAS mutations and MET amplification as mechanisms of secondary resistance to anti-EGFR treatments.
    • (2013) Cancer Discov. [Internet] , vol.3 , pp. 658-673
    • Bardelli, A.1    Corso, S.2    Bertotti, A.3    Hobor, S.4    Valtorta, E.5    Siravegna, G.6
  • 68
    • 84896078397 scopus 로고    scopus 로고
    • Blockade of EGFR and MEK intercepts heterogeneous mechanisms of acquired resistance to anti-EGFR therapies in colorectal cancer
    • cited 2014 Jun 1; Available from
    • Misale S, Arena S, Lamba S, Siravegna G, Lallo A, Hobor S, et al. Blockade of EGFR and MEK intercepts heterogeneous mechanisms of acquired resistance to anti-EGFR therapies in colorectal cancer. Sci. Transl. Med. [Internet]. 2014 [cited 2014 Jun 1];6:224ra26. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24553387.
    • (2014) Sci. Transl. Med. [Internet] , vol.6
    • Misale, S.1    Arena, S.2    Lamba, S.3    Siravegna, G.4    Lallo, A.5    Hobor, S.6
  • 69
    • 84871676568 scopus 로고    scopus 로고
    • Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines
    • Available from
    • Schlicker A, Beran G, Chresta CM, McWalter G, Pritchard A, Weston S, et al. Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines. BMC Med. Genomics [Internet]. BMC Medical Genomics; 2012;5:66. Available from: http://www.pubmedcentral.nih.gov/ articlerender.fcgi?artid=3543849&tool=pmcentrez&rendertype=abstract.
    • (2012) BMC Med. Genomics [Internet]. BMC Medical Genomics , vol.5 , pp. 66
    • Schlicker, A.1    Beran, G.2    Chresta, C.M.3    McWalter, G.4    Pritchard, A.5    Weston, S.6
  • 70
    • 84885184379 scopus 로고    scopus 로고
    • Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer
    • cited 2014 May 31; Available from
    • Budinska E, Popovici V, Tejpar S, D'Ario G, Lapique N, Sikora KO, et al. Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer. J. Pathol. [Internet]. 2013 [cited 2014 May 31];231:63-76. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid= 3840702&tool=pmcentrez&rendertype=abstract.
    • (2013) J. Pathol. [Internet] , vol.231 , pp. 63-76
    • Budinska, E.1    Popovici, V.2    Tejpar, S.3    D'Ario, G.4    Lapique, N.5    Sikora, K.O.6
  • 71
    • 84877600884 scopus 로고    scopus 로고
    • Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions
    • Nature Publishing Group; cited 2014 May 26; Available from
    • De Sousa E Melo F, Wang X, Jansen M, Fessler E, Trinh A, de Rooij LPMH, et al. Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions. Nat. Med. [Internet]. Nature Publishing Group; 2013 [cited 2014 May 26];19:614-8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23584090.
    • (2013) Nat. Med. [Internet] , vol.19 , pp. 614-618
    • De Sousa, E.1    Melo, F.2    Wang, X.3    Jansen, M.4    Fessler, E.5    Trinh, A.6    De Lpmh, R.7
  • 72
    • 84877619075 scopus 로고    scopus 로고
    • A colorectal cancer classification system that associates cellular phenotype and responses to therapy
    • Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.; cited 2014 May 26; Available from: doi:10.1038/nm.3175
    • Sadanandam A, Lyssiotis C A, Homicsko K, Collisson E A, Gibb WJ, Wullschleger S, et al. A colorectal cancer classification system that associates cellular phenotype and responses to therapy. Nat. Med. [Internet]. Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.; 2013 [cited 2014 May 26];19:619-25. Available from: doi:10.1038/nm.3175.
    • (2013) Nat. Med. [Internet] , vol.19 , pp. 619-625
    • Sadanandam, A.1    Lyssiotis, C.A.2    Homicsko, K.3    Collisson, E.A.4    Gibb, W.J.5    Wullschleger, S.6


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