Differential chemosensitivity to antifolate drugs between RAS and BRAF melanoma cells

Molecular Cancer

Volumn 13, Issue 1, 2014, Pages

  Arozarena, Imanol ^a   Goicoechea, Ibai ^b   Erice, Oihane ^b   Ferguson, Jennnifer ^a   Margison, Geoffrey P ^a   Wellbrock, Claudia ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b BIODONOSTIA HEALTH RESEARCH INSTITUTE   (Spain)

Author keywords

Alkylating agents; BRAF; DNA synthesis; Melanoma; RAS; Salvage

Indexed keywords

B RAF KINASE; DACARBAZINE; FOLIC ACID ANTAGONIST; HYPOXANTHINE; RAS PROTEIN; TEMOZOLOMIDE; ANTINEOPLASTIC AGENT; BRAF PROTEIN, HUMAN; DNA; ENZYME INHIBITOR; GUANOSINE TRIPHOSPHATASE; MEMBRANE PROTEIN; NRAS PROTEIN, HUMAN;

ARTICLE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CELL MUTANT; CELL PROLIFERATION ASSAY; CHEMOSENSITIVITY; DNA ALKYLATION; DNA METHYLATION ASSAY; DNA SYNTHESIS INHIBITION; FLUORESCENCE ACTIVATED CELL SORTING; G1 PHASE CELL CYCLE CHECKPOINT; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MELANOMA CELL; NUCLEOTIDE METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT RESPONSE; ANALOGS AND DERIVATIVES; BIOSYNTHESIS; CELL PROLIFERATION; DNA METHYLATION; DRUG EFFECTS; GENETICS; MELANOMA; MUTATION; PATHOLOGY; SKIN NEOPLASMS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DACARBAZINE; DNA; DNA METHYLATION; ENZYME INHIBITORS; GTP PHOSPHOHYDROLASES; HUMANS; MELANOMA; MEMBRANE PROTEINS; MUTATION; PROTO-ONCOGENE PROTEINS B-RAF; SKIN NEOPLASMS;

EID: 84902742119     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-13-154     Document Type: Article

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