Astragaloside IV prevents damage to human mesangial cells through the inhibition of the NADPH oxidase/ROS/Akt/NF-κB pathway under high glucose conditions

International Journal of Molecular Medicine

Volumn 34, Issue 1, 2014, Pages 167-176

  Sun, L I ^a   Li, Weiping ^a   Li, Weizu ^a   Xiong, L I ^a   Li, Guiping ^a   Ma, Rong ^b  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

Astragaloside IV; Diabetic nephropathy; Human mesangial cells; Nicotinamide adenine dinucleotide phosphate oxidase; Reactive oxygen species

Indexed keywords

ASTRAGALOSIDE IV; CALCIUM ION; GLUCOSE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; ANTIOXIDANT; ASTRAGALOSIDE A; CALCIUM; NOX4 PROTEIN, HUMAN; SAPONIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRITERPENE; TRPC6 PROTEIN, HUMAN;

ANTIOXIDANT ACTIVITY; ARTICLE; CALCIUM TRANSPORT; CELL DAMAGE; CELL PROLIFERATION; CELL PROTECTION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYPERGLYCEMIA; HYPERTROPHY; MESANGIUM CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; CELL LINE; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; OXIDATIVE STRESS;

ANTIOXIDANTS; CALCIUM; CELL LINE; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GLUCOSE; HUMANS; MESANGIAL CELLS; NADPH OXIDASE; NF-KAPPA B; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SAPONINS; SIGNAL TRANSDUCTION; TRITERPENES; TRPC CATION CHANNELS;

EID: 84902653456     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2014.1741     Document Type: Article

References (51)

1. Parving HH: Diabetic nephropathy: prevention and treatment. Kidney Int 60: 2041-2055, 2001.
2. Bank N: Mechanisms of diabetic hyperfiltration. Kidney Int 40: 792-807, 1991.
3. Wei P, Lane PH, Lane JT, Padanilam BJ and Sansom SC: Glomerular structural and functional changes in a high-fat diet mouse model of early-stage Type 2 diabetes. Diabetologia 47: 1541-1549, 2004. (Pubitemid 39371636)
4. Schlöndorff D and Banas B: The mesangial cell revisited: no cell is an island. J Am Soc Nephrol 20: 1179-1187, 2009.
5. 2+ influx in cultured rat mesangial cells by a protein kinase C-dependent mechanism. Diabetologia 40: 521-527, 1997.
6. Nutt LK and O'Neil RG: Effect of elevated glucose on endothelin-induced store-operated and non-store-operated calcium influx in renal mesangial cells. J Am Soc Nephrol 11: 1225-1235, 2000. (Pubitemid 30416218)
7. Whiteside CI, Hurst RD and Stevanovic ZS: Calcium signaling and contractile response of diabetic glomerular mesangial cells. Kidney Int 51 (Suppl): S28-S33, 1995.
8. Wu JP, Zhang W, Wu F, et al: Honokiol: an effective inhibitor of high-glucose-induced upregulation of inflammatory cytokine production in human renal mesangial cells. Inflamm Res 59: 1073-1079, 2010.
9. Hsu YJ, Hoenderop JG and Bindels RJ: TRP channels in kidney disease. Biochim Biophys Acta 1772: 928-936, 2007. (Pubitemid 47189632)
10. Smyth JT, Hwang SY, Tomita T, DeHaven WI, Mercer JC and Putney JW: Activation and regulation of store-operated calcium entry. J Cell Mol Med 14: 2337-2349, 2010.
11. Nilius B and Owsianik G: The transient receptor potential family of ion channels. Genome Biol 12: 218, 2011.
12. Dietrich A and Gudermann T: Trpc6. Handb Exp Pharmacol: 125-141, 2007.
13. 2+ channel in renal microcirculation and glomeruli. Exp Biol Med (Maywood) 231: 145-153, 2006.
14. Möller CC, Wei C, Altintas MM, et al: Induction of TRPC6 channel in acquired forms of proteinuric kidney disease. J Am Soc Nephrol 18: 29-36, 2007. (Pubitemid 46053419)
15. 2+ signaling in glomerular mesangial cells in diabetes. Am J Physiol Renal Physiol 293: F1381-F1390, 2007.
16. Danesh FR, Sadeghi MM, Amro N, et al: 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/p21 signaling pathway: Implications for diabetic nephropathy. Proc Natl Acad Sci USA 99: 8301-8305, 2002. (Pubitemid 34651047)
17. Banday AA, Fazili FR and Lokhandwala MF: Oxidative stress causes renal dopamine D1 receptor dysfunction and hypertension via mechanisms that involve nuclear factor-kappaB and protein kinase C. J Am Soc Nephrol 18: 1446-1457, 2007. (Pubitemid 46717511)
18. Forbes JM, Coughlan MT and Cooper ME: Oxidative stress as a major culprit in kidney disease in diabetes. Diabetes 57: 1446-1454, 2008.
19. Ha H and Lee HB: Reactive oxygen species as glucose signaling molecules in mesangial cells cultured under high glucose. Kidney Int Suppl 77: S19-S25, 2000.
20. Hool LC and Corry B: Redox control of calcium channels: from mechanisms to therapeutic opportunities. Antioxid Redox Signal 9: 409-435, 2007.
21. Gill PS and Wilcox CS: NADPH oxidases in the kidney. Antioxid Redox Signal 8: 1597-1607, 2006. (Pubitemid 44726334)
22. Babior BM, Lambeth JD and Nauseef W: The neutrophil NADPH oxidase. Arch Biochem Biophys 397: 342-344, 2002. (Pubitemid 34852301)
23. Nauseef WM: Biological roles for the NOX family NADPH oxidases. J Biol Chem 283: 16961-16965, 2008.
24. Block K, Eid A, Griendling KK, Lee DY, Wittrant Y and Gorin Y: Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression. J Biol Chem 283: 24061-24076, 2008.
25. Koyasu S: The role of PI3K in immune cells. Nat Immunol 4: 313-319, 2003.
26. Shiojima I and Walsh K: Role of Akt signaling in vascular homeostasis and angiogenesis. Circ Res 90: 1243-1250, 2002. (Pubitemid 34787405)
27. Kim SY, Park KH, Gul R, Jang KY and Kim UH: Role of kidney ADP-ribosyl cyclase in diabetic nephropathy. Am J Physiol Renal Physiol 296: F291-F297, 2009.
28. Kim SY, Gul R, Rah SY, et al: Molecular mechanism of ADP-ribosyl cyclase activation in angiotensin II signaling in murine mesangial cells. Am J Physiol Renal Physiol 294: F982-F989, 2008.
29. Sousa LP, Carmo AF, Rezende BM, et al: Cyclic AMP enhances resolution of allergic pleurisy by promoting inflammatory cell apoptosis via inhibition of PI3K/Akt and NF-kappaB. Biochem Pharmacol 78: 396-405, 2009.
30. Li J and Bertram JF: Review: Endothelial-myofibroblast transition, a new player in diabetic renal fibrosis. Nephrology (Carlton) 15: 507-512, 2010.
31. Yang WS, Seo JW, Han NJ, et al: High glucose-induced NF-kappaB activation occurs via tyrosine phosphorylation of IkappaBalpha in human glomerular endothelial cells: involvement of Syk tyrosine kinase. Am J Physiol Renal Physiol 294: F1065-F1075, 2008.
32. Nitti M, Furfaro AL, Patriarca S, et al: Human mesangial cells resist glycoxidative stress through an antioxidant response. Int J Mol Med 27: 213-219, 2011.
33. Wang XW, Tan BZ, Sun M, Ho B and Ding JL: Thioredoxin-like 6 protects retinal cell line from photooxidative damage by upregulating NF-kappaB activity. Free Radic Biol Med 45: 336-344, 2008.
34. Ren S, Zhang H, Mu Y, Sun M and Liu P: Pharmacological effects of Astragaloside IV: a literature review. J Tradit Chin Med 33: 413-416, 2013.
35. You H, Lu Y, Gui D, Peng A, Chen J and Gu Y: Aqueous extract of Astragali Radix ameliorates proteinuria in adriamycin nephropathy rats through inhibition of oxidative stress and endothelial nitric oxide synthase. J Ethnopharmacol 134: 176-182, 2011.
36. Motomura K, Fujiwara Y, Kiyota N, et al: Astragalosides isolated from the root of astragalus radix inhibit the formation of advanced glycation end products. J Agric Food Chem 57: 7666-7672, 2009.
37. Wang O, Cai K, Pang S, et al: Mechanisms of glucose-induced expression of pancreatic-derived factor in pancreatic beta-cells. Endocrinology 149: 672-680, 2008. (Pubitemid 351159330)
38. Jeong SI, Kim SJ, Kwon TH, Yu KY and Kim SY: Schizandrin prevents damage of murine mesangial cells via blocking NADPH oxidase-induced ROS signaling in high glucose. Food Chem Toxicol 50: 1045-1053, 2012.
39. Wu F and Chen X: A review of pharmacological study on Astragalus membranaceus (Fisch.) Bge. Zhong Yao Cai 27: 232-234, 2004 (In Chinese).
40. Gui D, Guo Y, Wang F, et al: Astragaloside IV, a novel anti-oxidant, prevents glucose-induced podocyte apoptosis in vitro and in vivo. PloS one 7: e39824, 2012.
41. Gui D, Huang J, Liu W, Guo Y, Xiao W and Wang N: Astragaloside IV prevents acute kidney injury in two rodent models by inhibiting oxidative stress and apoptosis pathways. Apoptosis 18: 409-422, 2013.
42. Cao LL, Li WZ, Si XL, Sun L and Li WP: Protective effect and mechanism of astragaloside IV on oxidative stress injury of mesangial cells. Zhongguo Zhong Yao Za Zhi 38: 725-730, 2013 (In Chinese).
43. Ha H, Hwang IA, Park JH and Lee HB: Role of reactive oxygen species in the pathogenesis of diabetic nephropathy. Diabetes Res Clin Pract 82 (Suppl 1): S42-S45, 2008.
44. Hodgkinson AD, Bartlett T, Oates PJ, Millward BA and Demaine AG: The response of antioxidant genes to hyperglycemia is abnormal in patients with type 1 diabetes and diabetic nephropathy. Diabetes 52: 846-851, 2003. (Pubitemid 36323595)
45. Babior BM: NADPH oxidase. Curr Opin Immunol 16: 42-47, 2004.
46. Gorin Y, Ricono JM, Kim NH, Bhandari B, Choudhury GG and Abboud HE: Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells. Am J Physiol Renal Physiol 285: F219-F229, 2003. (Pubitemid 36871194)
47. Devaraj S, Cheung AT, Jialal I, et al: Evidence of increased inflammation and microcirculatory abnormalities in patients with type 1 diabetes and their role in microvascular complications. Diabetes 56: 2790-2796, 2007. (Pubitemid 350044923)
48. Gruden G, Setti G, Hayward A, et al: Mechanical stretch induces monocyte chemoattractant activity via an NF-kappaB-dependent monocyte chemoattractant protein-1-mediated pathway in human mesangial cells: inhibition by rosiglitazone. J Am Soc Nephrol 16: 688-696, 2005. (Pubitemid 41725105)
49. Iwamoto M, Mizuiri S, Arita M and Hemmi H: Nuclear factor-kappaB activation in diabetic rat kidney: evidence for involvement of P-selectin in diabetic nephropathy. Tohoku J Exp Med 206: 163-171, 2005. (Pubitemid 40895046)
50. phox is critical for alpha-platelet-derived growth factor receptor-induced production of reactive oxygen species. J Biol Chem 283: 7864-7876, 2008.
51. Graham S, Gorin Y, Abboud HE, et al: Abundance of TRPC6 protein in glomerular mesangial cells is decreased by ROS and PKC in diabetes. Am J Physiol Cell Physiol 301: C304-C315, 2011.