메뉴 건너뛰기




Volumn 271, Issue , 2014, Pages 116-121

Effects of curcumin on learning and memory deficits, BDNF, and ERK protein expression in rats exposed to chronic unpredictable stress

Author keywords

Brain derived neurotrophic factor (BDNF); Chronic unpredictable stress; Cucurmin; Depression; Extracellular signal regulated kinase (ERK); Learning and memory

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CURCUMIN; MITOGEN ACTIVATED PROTEIN KINASE; ANTIDEPRESSANT AGENT;

EID: 84902652917     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2014.05.068     Document Type: Article
Times cited : (138)

References (46)
  • 1
    • 25844512651 scopus 로고    scopus 로고
    • Innovative approaches for the development of antidepressant drugs: current and future strategies
    • Schechter L.E., Ring R.H., Beyer C.E., Hughes Z.A., Khawaja X., Malberg J.E., et al. Innovative approaches for the development of antidepressant drugs: current and future strategies. NeuroRx 2005, 2:590-611.
    • (2005) NeuroRx , vol.2 , pp. 590-611
    • Schechter, L.E.1    Ring, R.H.2    Beyer, C.E.3    Hughes, Z.A.4    Khawaja, X.5    Malberg, J.E.6
  • 2
    • 0942298912 scopus 로고    scopus 로고
    • Cognitive functions in depressive disorders: evidence from a population-based study
    • Airaksinen E., Larsson M., Lundberg I., Forsell Y. Cognitive functions in depressive disorders: evidence from a population-based study. Psychol Med 2004, 34:83-91.
    • (2004) Psychol Med , vol.34 , pp. 83-91
    • Airaksinen, E.1    Larsson, M.2    Lundberg, I.3    Forsell, Y.4
  • 3
    • 0035103864 scopus 로고    scopus 로고
    • Stress and hippocampal plasticity: implications for the pathophysiology of affective disorders
    • McEwen B.S., Magarinos A.M. Stress and hippocampal plasticity: implications for the pathophysiology of affective disorders. Hum Psychopharmacol 2001, 16:S7-S19.
    • (2001) Hum Psychopharmacol , vol.16
    • McEwen, B.S.1    Magarinos, A.M.2
  • 4
    • 0032539809 scopus 로고    scopus 로고
    • Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress
    • Gould E., Tanapat P., McEwen B.S., Flugge G., Fuchs E. Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proc Natl Acad Sci USA 1998, 95:3168-3171.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 3168-3171
    • Gould, E.1    Tanapat, P.2    McEwen, B.S.3    Flugge, G.4    Fuchs, E.5
  • 5
    • 80555140031 scopus 로고    scopus 로고
    • The hippocampus, neurotrophic factors and depression: possible implications for the pharmacotherapy of depression
    • Masi G., Brovedani P. The hippocampus, neurotrophic factors and depression: possible implications for the pharmacotherapy of depression. CNS Drugs 2011, 25:913-931.
    • (2011) CNS Drugs , vol.25 , pp. 913-931
    • Masi, G.1    Brovedani, P.2
  • 6
    • 34548395111 scopus 로고    scopus 로고
    • The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior
    • Schmidt H.D., Duman R.S. The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior. Behav Pharmacol 2007, 18:391-418.
    • (2007) Behav Pharmacol , vol.18 , pp. 391-418
    • Schmidt, H.D.1    Duman, R.S.2
  • 7
    • 84876112550 scopus 로고    scopus 로고
    • The effects of reboxetine treatment on depression-like behavior, brain neurotrophins, and ERK expression in rats exposed to chronic mild stress
    • First M., Gil-Ad I., Taler M., Tarasenko I., Novak N., Weizman A. The effects of reboxetine treatment on depression-like behavior, brain neurotrophins, and ERK expression in rats exposed to chronic mild stress. J Mol Neurosci 2013, 50:88-97.
    • (2013) J Mol Neurosci , vol.50 , pp. 88-97
    • First, M.1    Gil-Ad, I.2    Taler, M.3    Tarasenko, I.4    Novak, N.5    Weizman, A.6
  • 8
    • 80051484401 scopus 로고    scopus 로고
    • Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway
    • Buhrmann C., Mobasheri A., Busch F., Aldinger C., Stahlmann R., Montaseri A., et al. Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem 2011, 286:28556-28566.
    • (2011) J Biol Chem , vol.286 , pp. 28556-28566
    • Buhrmann, C.1    Mobasheri, A.2    Busch, F.3    Aldinger, C.4    Stahlmann, R.5    Montaseri, A.6
  • 9
    • 68549083507 scopus 로고    scopus 로고
    • Curcumin inhibits proliferation of colorectal carcinoma by modulating Akt/mTOR signaling
    • Johnson S.M., Gulhati P., Arrieta I., Wang X., Uchida T., Gao T., et al. Curcumin inhibits proliferation of colorectal carcinoma by modulating Akt/mTOR signaling. Anticancer Res 2009, 29:3185-3190.
    • (2009) Anticancer Res , vol.29 , pp. 3185-3190
    • Johnson, S.M.1    Gulhati, P.2    Arrieta, I.3    Wang, X.4    Uchida, T.5    Gao, T.6
  • 10
    • 84934436057 scopus 로고    scopus 로고
    • Antioxidant and anti-inflammatory properties of curcumin
    • Menon V.P., Sudheer A.R. Antioxidant and anti-inflammatory properties of curcumin. Adv Exp Med Biol 2007, 595:105-125.
    • (2007) Adv Exp Med Biol , vol.595 , pp. 105-125
    • Menon, V.P.1    Sudheer, A.R.2
  • 11
    • 73949136192 scopus 로고    scopus 로고
    • Potentials of curcumin as an antidepressant
    • Kulkarni S., Dhir A., Akula K.K. Potentials of curcumin as an antidepressant. Sci World J 2009, 9:1233-1241.
    • (2009) Sci World J , vol.9 , pp. 1233-1241
    • Kulkarni, S.1    Dhir, A.2    Akula, K.K.3
  • 12
    • 56549103334 scopus 로고    scopus 로고
    • Antidepressant activity of curcumin: involvement of serotonin and dopamine system
    • Kulkarni S.K., Bhutani M.K., Bishnoi M. Antidepressant activity of curcumin: involvement of serotonin and dopamine system. Psychopharmacology (Berlin) 2008, 201:435-442.
    • (2008) Psychopharmacology (Berlin) , vol.201 , pp. 435-442
    • Kulkarni, S.K.1    Bhutani, M.K.2    Bishnoi, M.3
  • 13
    • 58549120562 scopus 로고    scopus 로고
    • Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes
    • Bhutani M.K., Bishnoi M., Kulkarni S.K. Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes. Pharmacol Biochem behav 2009, 92:39-43.
    • (2009) Pharmacol Biochem behav , vol.92 , pp. 39-43
    • Bhutani, M.K.1    Bishnoi, M.2    Kulkarni, S.K.3
  • 14
    • 26444486974 scopus 로고    scopus 로고
    • Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats
    • Xu Y., Ku B.S., Yao H.Y., Lin Y.H., Ma X., Zhang Y.H., et al. Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats. Pharmacol Biochem Behav 2005, 82:200-206.
    • (2005) Pharmacol Biochem Behav , vol.82 , pp. 200-206
    • Xu, Y.1    Ku, B.S.2    Yao, H.Y.3    Lin, Y.H.4    Ma, X.5    Zhang, Y.H.6
  • 15
    • 79952899810 scopus 로고    scopus 로고
    • Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats
    • Huang Z., Zhong X.M., Li Z.Y., Feng C.R., Pan A.J., Mao Q.Q. Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats. Neurosci Lett 2011, 493:145-148.
    • (2011) Neurosci Lett , vol.493 , pp. 145-148
    • Huang, Z.1    Zhong, X.M.2    Li, Z.Y.3    Feng, C.R.4    Pan, A.J.5    Mao, Q.Q.6
  • 16
    • 33750718770 scopus 로고    scopus 로고
    • Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB
    • Xu Y., Ku B., Tie L., Yao H., Jiang W., Ma X., et al. Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB. Brain Res 2006, 1122:56-64.
    • (2006) Brain Res , vol.1122 , pp. 56-64
    • Xu, Y.1    Ku, B.2    Tie, L.3    Yao, H.4    Jiang, W.5    Ma, X.6
  • 17
    • 84864761504 scopus 로고    scopus 로고
    • Curcumin produces antidepressant effects via activating MAPK/ERK-dependent brain-derived neurotrophic factor expression in the amygdala of mice
    • Zhang L., Xu T., Wang S., Yu L., Liu D., Zhan R., et al. Curcumin produces antidepressant effects via activating MAPK/ERK-dependent brain-derived neurotrophic factor expression in the amygdala of mice. Behav Brain Res 2012, 235:67-72.
    • (2012) Behav Brain Res , vol.235 , pp. 67-72
    • Zhang, L.1    Xu, T.2    Wang, S.3    Yu, L.4    Liu, D.5    Zhan, R.6
  • 18
    • 34447621228 scopus 로고    scopus 로고
    • Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats
    • Xu Y., Ku B., Cui L., Li X., Barish P.A., Foster T.C., et al. Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats. Brain Res 2007, 1162:9-18.
    • (2007) Brain Res , vol.1162 , pp. 9-18
    • Xu, Y.1    Ku, B.2    Cui, L.3    Li, X.4    Barish, P.A.5    Foster, T.C.6
  • 19
    • 0031440325 scopus 로고    scopus 로고
    • Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation
    • Willner P. Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. Psychopharmacology (Berlin) 1997, 134:319-329.
    • (1997) Psychopharmacology (Berlin) , vol.134 , pp. 319-329
    • Willner, P.1
  • 20
    • 0027446261 scopus 로고
    • Subsensitivity to rewarding and locomotor stimulant effects of a dopamine agonist following chronic mild stress
    • Papp M., Muscat R., Willner P. Subsensitivity to rewarding and locomotor stimulant effects of a dopamine agonist following chronic mild stress. Psychopharmacology (Berlin) 1993, 110:152-158.
    • (1993) Psychopharmacology (Berlin) , vol.110 , pp. 152-158
    • Papp, M.1    Muscat, R.2    Willner, P.3
  • 21
    • 0035219611 scopus 로고    scopus 로고
    • Corticotropin-releasing hormone mRNA levels in response to chronic mild stress rise in male but not in female rats while tyrosine hydroxylase mRNA levels decrease in both sexes
    • Duncko R., Kiss A., Skultetyova I., Rusnak M., Jezova D. Corticotropin-releasing hormone mRNA levels in response to chronic mild stress rise in male but not in female rats while tyrosine hydroxylase mRNA levels decrease in both sexes. Psychoneuroendocrinology 2001, 26:77-89.
    • (2001) Psychoneuroendocrinology , vol.26 , pp. 77-89
    • Duncko, R.1    Kiss, A.2    Skultetyova, I.3    Rusnak, M.4    Jezova, D.5
  • 22
    • 16844385775 scopus 로고    scopus 로고
    • Effects of chronic mild stress on sexual behavior, locomotor activity and consumption of sucrose and saccharine solutions
    • Gronli J., Murison R., Fiske E., Bjorvatn B., Sorensen E., Portas C.M., et al. Effects of chronic mild stress on sexual behavior, locomotor activity and consumption of sucrose and saccharine solutions. Physiol Behav 2005, 84:571-577.
    • (2005) Physiol Behav , vol.84 , pp. 571-577
    • Gronli, J.1    Murison, R.2    Fiske, E.3    Bjorvatn, B.4    Sorensen, E.5    Portas, C.M.6
  • 23
    • 24944468220 scopus 로고    scopus 로고
    • The effects of chronic unpredictable stress on male rats in the water maze
    • Gouirand A.M., Matuszewich L. The effects of chronic unpredictable stress on male rats in the water maze. Physiol Behav 2005, 86:21-31.
    • (2005) Physiol Behav , vol.86 , pp. 21-31
    • Gouirand, A.M.1    Matuszewich, L.2
  • 24
    • 80054927982 scopus 로고    scopus 로고
    • The effects of fluoxetine treatment in a chronic mild stress rat model on depression-related behavior, brain neurotrophins and ERK expression
    • First M., Gil-Ad I., Taler M., Tarasenko I., Novak N., Weizman A. The effects of fluoxetine treatment in a chronic mild stress rat model on depression-related behavior, brain neurotrophins and ERK expression. J Mol Neurosci 2011, 45:246-255.
    • (2011) J Mol Neurosci , vol.45 , pp. 246-255
    • First, M.1    Gil-Ad, I.2    Taler, M.3    Tarasenko, I.4    Novak, N.5    Weizman, A.6
  • 25
    • 23844500078 scopus 로고    scopus 로고
    • Chronic mild stress (CUS) revisited: consistency and behavioural-neurobiological concordance in the effects of CUS
    • Willner P. Chronic mild stress (CUS) revisited: consistency and behavioural-neurobiological concordance in the effects of CUS. Neuropsychobiology 2005, 52:90-110.
    • (2005) Neuropsychobiology , vol.52 , pp. 90-110
    • Willner, P.1
  • 26
    • 0038689058 scopus 로고    scopus 로고
    • Effects of the selective nonpeptide corticotropin-releasing factor receptor 1 antagonist antalarmin in the chronic mild stress model of depression in mice
    • Ducottet C., Griebel G., Belzung C. Effects of the selective nonpeptide corticotropin-releasing factor receptor 1 antagonist antalarmin in the chronic mild stress model of depression in mice. Prog Neuropsychopharmacol Biol Psychiatry 2003, 27:625-631.
    • (2003) Prog Neuropsychopharmacol Biol Psychiatry , vol.27 , pp. 625-631
    • Ducottet, C.1    Griebel, G.2    Belzung, C.3
  • 27
    • 0023636527 scopus 로고
    • Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant
    • Willner P., Towell A., Sampson D., Sophokleous S., Muscat R. Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology 1987, 93:358-364.
    • (1987) Psychopharmacology , vol.93 , pp. 358-364
    • Willner, P.1    Towell, A.2    Sampson, D.3    Sophokleous, S.4    Muscat, R.5
  • 28
    • 58549101276 scopus 로고    scopus 로고
    • Effects of neuronal and inducible NOS inhibitor 1-[2-(trifluoromethyl)phenyl]imidazole (TRIM) in unpredictable chronic mild stress procedure in mice
    • Mutlu O., Ulak G., Laugeray A., Belzung C. Effects of neuronal and inducible NOS inhibitor 1-[2-(trifluoromethyl)phenyl]imidazole (TRIM) in unpredictable chronic mild stress procedure in mice. Pharmacol Biochem Behav 2009, 92:82-87.
    • (2009) Pharmacol Biochem Behav , vol.92 , pp. 82-87
    • Mutlu, O.1    Ulak, G.2    Laugeray, A.3    Belzung, C.4
  • 29
    • 56249091722 scopus 로고    scopus 로고
    • Multifaceted strain-specific effects in a mouse model of depression and of antidepressant reversal
    • Ibarguen-Vargas Y., Surget A., Touma C., Palme R., Belzung C. Multifaceted strain-specific effects in a mouse model of depression and of antidepressant reversal. Psychoneuroendocrinology 2008, 33:1357-1368.
    • (2008) Psychoneuroendocrinology , vol.33 , pp. 1357-1368
    • Ibarguen-Vargas, Y.1    Surget, A.2    Touma, C.3    Palme, R.4    Belzung, C.5
  • 30
    • 84883419875 scopus 로고    scopus 로고
    • Antidepressant-like effects of curcumin in chronic mild stress of rats: involvement of its anti-inflammatory action
    • Jiang H., Wang Z., Wang Y., Xie K., Zhang Q., Luan Q., et al. Antidepressant-like effects of curcumin in chronic mild stress of rats: involvement of its anti-inflammatory action. Prog Neuropsychopharmacol Biol Psychiatry 2013, 47:33-39.
    • (2013) Prog Neuropsychopharmacol Biol Psychiatry , vol.47 , pp. 33-39
    • Jiang, H.1    Wang, Z.2    Wang, Y.3    Xie, K.4    Zhang, Q.5    Luan, Q.6
  • 32
    • 0033001347 scopus 로고    scopus 로고
    • Behavioral, neuroendocrine and serotonergic consequences of single social defeat and repeated fluoxetine pretreatment in the Lewis rat strain
    • Berton O., Durand M., Aguerre S., Mormede P., Chaouloff F. Behavioral, neuroendocrine and serotonergic consequences of single social defeat and repeated fluoxetine pretreatment in the Lewis rat strain. Neuroscience 1999, 92:327-341.
    • (1999) Neuroscience , vol.92 , pp. 327-341
    • Berton, O.1    Durand, M.2    Aguerre, S.3    Mormede, P.4    Chaouloff, F.5
  • 33
    • 62849090443 scopus 로고    scopus 로고
    • Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats
    • Li Y.C., Wang F.M., Pan Y., Qiang L.Q., Cheng G., Zhang W.Y., et al. Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats. Prog Neuropsychopharmacol Biol Psychiatry 2009, 33:435-449.
    • (2009) Prog Neuropsychopharmacol Biol Psychiatry , vol.33 , pp. 435-449
    • Li, Y.C.1    Wang, F.M.2    Pan, Y.3    Qiang, L.Q.4    Cheng, G.5    Zhang, W.Y.6
  • 34
    • 0021173996 scopus 로고
    • Developments of a water-maze procedure for studying spatial learning in the rat
    • Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 1984, 11:47-60.
    • (1984) J Neurosci Methods , vol.11 , pp. 47-60
    • Morris, R.1
  • 35
    • 0019957779 scopus 로고
    • Place navigation impaired in rats with hippocampal lesions
    • Morris R.G., Garrud P., Rawlins J.N., O'Keefe J. Place navigation impaired in rats with hippocampal lesions. Nature 1982, 297:681-683.
    • (1982) Nature , vol.297 , pp. 681-683
    • Morris, R.G.1    Garrud, P.2    Rawlins, J.N.3    O'Keefe, J.4
  • 37
    • 33646048297 scopus 로고    scopus 로고
    • Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress
    • Song L., Che W., Min-Wei W., Murakami Y., Matsumoto K. Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress. Pharmacol Biochem Behav 2006, 83:186-193.
    • (2006) Pharmacol Biochem Behav , vol.83 , pp. 186-193
    • Song, L.1    Che, W.2    Min-Wei, W.3    Murakami, Y.4    Matsumoto, K.5
  • 38
    • 34447550544 scopus 로고    scopus 로고
    • Chronic mild stress during gestation worsens neonatal brain lesions in mice
    • Rangon C.M., Fortes S., Lelievre V., Leroux P., Plaisant F., Joubert C., et al. Chronic mild stress during gestation worsens neonatal brain lesions in mice. J Neurosci 2007, 27:7532-7540.
    • (2007) J Neurosci , vol.27 , pp. 7532-7540
    • Rangon, C.M.1    Fortes, S.2    Lelievre, V.3    Leroux, P.4    Plaisant, F.5    Joubert, C.6
  • 39
    • 4243093999 scopus 로고    scopus 로고
    • Delayed effects of chronic variable stress during peripubertal-juvenile period on hippocampal morphology and on cognitive and stress axis functions in rats
    • Isgor C., Kabbaj M., Akil H., Watson S.J. Delayed effects of chronic variable stress during peripubertal-juvenile period on hippocampal morphology and on cognitive and stress axis functions in rats. Hippocampus 2004, 14:636-648.
    • (2004) Hippocampus , vol.14 , pp. 636-648
    • Isgor, C.1    Kabbaj, M.2    Akil, H.3    Watson, S.J.4
  • 40
    • 5744233877 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor
    • Binder D.K., Scharfman H.E. Brain-derived neurotrophic factor. Growth Factors 2004, 22:123-131.
    • (2004) Growth Factors , vol.22 , pp. 123-131
    • Binder, D.K.1    Scharfman, H.E.2
  • 42
    • 79551648304 scopus 로고    scopus 로고
    • The roles of BDNF in the pathophysiology of major depression and in antidepressant treatment
    • Lee B.H., Kim Y.K. The roles of BDNF in the pathophysiology of major depression and in antidepressant treatment. Psychiatry Invest 2010, 7:231-235.
    • (2010) Psychiatry Invest , vol.7 , pp. 231-235
    • Lee, B.H.1    Kim, Y.K.2
  • 43
    • 0034666119 scopus 로고    scopus 로고
    • Involvement of brain-derived neurotrophic factor in spatial memory formation and maintenance in a radial arm maze test in rats
    • Mizuno M., Yamada K., Olariu A., Nawa H., Nabeshima T. Involvement of brain-derived neurotrophic factor in spatial memory formation and maintenance in a radial arm maze test in rats. J Neurosci 2000, 20:7116-7121.
    • (2000) J Neurosci , vol.20 , pp. 7116-7121
    • Mizuno, M.1    Yamada, K.2    Olariu, A.3    Nawa, H.4    Nabeshima, T.5
  • 44
    • 66549109462 scopus 로고    scopus 로고
    • Adult hippocampal neurogenesis and related neurotrophic factors
    • Lee E., Son H. Adult hippocampal neurogenesis and related neurotrophic factors. BMB Rep 2009, 42:239-244.
    • (2009) BMB Rep , vol.42 , pp. 239-244
    • Lee, E.1    Son, H.2
  • 45
    • 33750344403 scopus 로고    scopus 로고
    • Increased limbic phosphorylated extracellular-regulated kinase 1 and 2 expression after chronic stress is reduced by cyclic 17beta-estradiol administration
    • Gerrits M., Westenbroek C., Koch T., Grootkarzijn A., ter Horst G.J. Increased limbic phosphorylated extracellular-regulated kinase 1 and 2 expression after chronic stress is reduced by cyclic 17beta-estradiol administration. Neuroscience 2006, 142:1293-1302.
    • (2006) Neuroscience , vol.142 , pp. 1293-1302
    • Gerrits, M.1    Westenbroek, C.2    Koch, T.3    Grootkarzijn, A.4    ter Horst, G.J.5
  • 46
    • 24944490193 scopus 로고    scopus 로고
    • The ERK cascade: a prototype of MAPK signaling
    • Rubinfeld H., Seger R. The ERK cascade: a prototype of MAPK signaling. Mol Biotechnol 2005, 31:151-174.
    • (2005) Mol Biotechnol , vol.31 , pp. 151-174
    • Rubinfeld, H.1    Seger, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.