The effects of fluoxetine treatment in a chronic mild stress rat model on depression-related behavior, brain neurotrophins and ERK expression

Journal of Molecular Neuroscience

Volumn 45, Issue 2, 2011, Pages 246-255

  First, Maya ^a   Gil Ad, Irit ^a   Taler, Michal ^a   Tarasenko, Igor ^a   Novak, Nurit ^a   Weizman, Abraham ^a,b  

^a TEL AVIV UNIVERSITY   (Israel)

^b GEHA MENTAL HEALTH CENTER   (Israel)

Author keywords

Chronic mild stress (CMS); Extracellular signal regulated kinase (ERK); Frontal cortex; Hippocampus; Insulin like growth factor 1 receptor (IGF 1R)

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; FLUOXETINE; MITOGEN ACTIVATED PROTEIN KINASE; SOMATOMEDIN C RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC MILD STRESS; CHRONIC STRESS; COGNITION; CONTROLLED STUDY; DEPRESSION; DRUG EFFECT; DRUG MECHANISM; ENZYME PHOSPHORYLATION; EXPLORATORY BEHAVIOR; FRONTAL CORTEX; HIPPOCAMPUS; MALE; MAZE TEST; MENTAL STRESS; MORRIS WATER MAZE; NONHUMAN; PROTEIN EXPRESSION; RAT; SPATIAL MEMORY; TISSUE LEVEL;

ANIMALS; BEHAVIOR, ANIMAL; BODY WEIGHT; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; DEPRESSION; DISEASE MODELS, ANIMAL; EATING; EXPLORATORY BEHAVIOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLUOXETINE; LEARNING; MALE; NERVE GROWTH FACTORS; RATS; RATS, WISTAR; SEROTONIN UPTAKE INHIBITORS; STRESS, PSYCHOLOGICAL;

ANIMALIA; RATTUS;

EID: 80054927982     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-011-9515-5     Document Type: Article

References (59)

1. ND Aberg KG Brywe J Isgaard 2006 Aspects of growth hormone and insulin-like growth factor-I related to neuroprotection, regeneration, and functional plasticity in the adult brain Sci World J 6 53 80
2. M Adachi M Barrot AE Autry D Theobald LM Monteggia 2008 Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy Biol Psychiatry 63 642 649 17981266 10.1016/j.biopsych. 2007.09.019 1:CAS:528:DC%2BD1cXjtVWnu7k%3D (Pubitemid 351329281)
3. I Banegas I Prieto F Alba F Vives A Araque AB Segarra R Durán M de Gasparo M Ramírez 2005 Angiotensinase activity is asymmetrically distributed in the amygdala, HC and prefrontal cortex of the rat Behav Brain Res 156 2 321 326 15582118 10.1016/j.bbr.2004.06.002 1:CAS:528:DC%2BD2cXhtVCktb7N (Pubitemid 39576072)
4. JD Bremner M Narayan ER Anderson LH Staib HL Miller DS Charney 2000 Hippocampal volume reduction in major depression Am J Psychiatry 157 115 118 10618023 10.1176/appi.ajp.157.7.1120 1:STN:280:DC%2BD3c%2FosVyhtQ%3D%3D (Pubitemid 30432494)
5. L Cai XB Yan XN Chen QY Meng JN Zhou 2010 Chronic all-trans retinoic acid administration induced hyperactivity of HPA axis and behavioral changes in young rats Eur Neuropsychopharmacol 20 12 839 847 20659790 10.1016/j.euroneuro. 2010.06.019 1:CAS:528:DC%2BC3cXhtlentrfI
6. S Campbell G McQueen 2004 The role of the hippocampus in the pathophysiology of major depression J Psychiatry Neurosci 29 417 426 15644983 (Pubitemid 40075713)
7. E Castren 2004 Neurotrophic effects of antidepressant drugs Curr Opin Pharmacol 4 58 64 15018840 10.1016/j.coph.2003.10.004 1:CAS:528: DC%2BD2cXpsVGjtQ%3D%3D (Pubitemid 38145839)
8. KH Choy Y de Visser NR Nichols M van den Buuse 2008 Combined neonatal stress and young-adult glucocorticoid stimulation in rats reduce BDNF expression in hippocampus: effects on learning and memory Hippocampus 18 655 667 18398848 10.1002/hipo.20425 1:CAS:528:DC%2BD1cXpslKgu7c%3D (Pubitemid 352032391)
9. G De Foubert SL Carney CS Robinson EJ Destexhe R Tomlinson CA Hicks TK Murray JP Gaillard C Deville V Xhenseval CE Thomas MJ O'Neill TS Zetterström 2004 Fluoxetine-induced change in rat brain expression of brain-derived neurotrophic factor varies depending on length of treatment Neurosci 128 597 604 10.1016/j.neuroscience.2004.06.054 (Pubitemid 39277429)
10. P De Saint Blanquat V Hok A Alvernhe E Save B Poucet 2010 Tagging items in spatial working memory: a unit-recording study in the rat medial prefrontal cortex Behav Brain Res 209 2 267 273 20144660 10.1016/j.bbr.2010.02.004
11. BC Detanico ÂL Piato JJ Freitas FL Lhullier MP Hidalgo W Caumo E Elisabetsky 2009 Antidepressant-like effects of melatonin in the mouse chronic mild stress model Eur J Pharmacol 607 1-3 121 125 19249298 10.1016/j.ejphar. 2009.02.037 1:CAS:528:DC%2BD1MXjsFWls7Y%3D
12. RS Duman LM Monteggia 2006 A neurotrophic model for stress-related mood disorders Biol Psychiatry 59 1116 1127 16631126 10.1016/j.biopsych.2006.02.013 1:CAS:528:DC%2BD28XmtVOisbc%3D
13. GD Gamaro ME Prediger J Lopes MG Bassani C Dalmaz 2008 FLX alters feeding behavior and leptin levels in chronically-stressed rats Pharmacol Biochem Behav 90 312 317 18423829 10.1016/j.pbb.2008.03.005 1:CAS:528:DC%2BD1cXmvV2lurY%3D
14. J Glowinski LL Iversen 1966 Regional studies of catecholamines in the rat brain I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain J Neurochem 13 655 669 5950056 10.1111/j.1471-4159. 1966.tb09873.x 1:CAS:528:DyaF28Xks1Kqtrw%3D
15. AM Gouirand L Matuszewich 2005 The effects of chronic unpredictable stress on male rats in the water maze Physiol Behav 86 21 31 16099481 10.1016/j.physbeh.2005.06.027 1:CAS:528:DC%2BD2MXhtVWnsbvO (Pubitemid 41316605)
16. SL Gourley FJ Wu DD Kiraly JE Ploski AT Kedves RS Duman JR Taylor 2008 Regionally specific regulation of ERK MAP kinase in a model of antidepressant-sensitive chronic depression Biol Psychiatry 63 353 359 17889834 10.1016/j.biopsych.2007.07.016 1:CAS:528:DC%2BD1cXhsVShs7k%3D
17. J Grønli C Bramham R Murison T Kanhema E Fiske B Bjorvatn R Ursin CM Portas 2006 Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper Pharmacol Biochem Behav 85 842 849 17204313 10.1016/j.pbb.2006.11.021 (Pubitemid 46149013)
18. N Grunbaum-Novak M Taler I Gil-Ad A Weizman H Cohen R Weizman 2008 Relationship between antidepressants and IGF-1 system in the brain: possible role in cognition Eur Neuropsychopharmacol 18 431 438 17961991 10.1016/j.euroneuro.2007.08.004 1:CAS:528:DC%2BD1cXlsFOiu7o%3D (Pubitemid 351608552)
19. CJ Harmer Z Bhagwagar PJ Cowen GM Goodwin 2002 Acute administration of citalopram facilitates memory consolidation in healthy volunteers Sychopharmacology (Berl) 163 106 110 10.1007/s00213-002-1151-x 1:CAS:528:DC%2BD38XosVGrur4%3D (Pubitemid 34985319)
20. RBS Harris J Zhou BD Youngblood GN Smagin DH Ryan 1997 Failure to change exploration or saccharin preference in rats exposed to chronic mild stress Physio Behav 63 1 91 100 10.1016/S0031-9384(97)00425-3 1:STN:280: DyaK1c%2Fms1answ%3D%3D (Pubitemid 27499949)
21. S Hayley MO Poulter Z Merali H Anisman 2005 The pathogenesis of clinical depression: stressor- and cytokine-induced alterations of neuroplasticity Neurosci 135 659 678 10.1016/j.neuroscience.2005.03.051 1:CAS:528: DC%2BD2MXhtVymtrzE Review (Pubitemid 41407732)
22. I Herrera-Guzmán E Gudayol-Ferré D Herrera-Guzmán J Guàrdia-Olmos E Hinojosa-Calvo JE Herrera-Abarca 2009 Effects of selective serotonin reuptake and dual serotonergic-noradrenergic reuptake treatments on memory and mental processing speed in patients with major depressive disorder J Psychiatr Res 43 855 863 19128810 10.1016/j.jpsychires. 2008.10.015
23. BA Hoshaw JE Malberg I Lucki 2005 Central administration of IGF-I and BDNF leads to long-lasting antidepressant-like effects Brain Res 1037 204 208 15777771 10.1016/j.brainres.2005.01.007 1:CAS:528:DC%2BD2MXitleqtrs%3D (Pubitemid 40362398)
24. GJ Huang J Herbert 2006 Stimulation of neurogenesis in the hippocampus of the adult rat by fluoxetine requires rhythmic change in corticosterone Biol Psychiatry 59 619 624 16325782 10.1016/j.biopsych.2005.09.016 1:CAS:528:DC%2BD28Xit1Ojur8%3D (Pubitemid 43357956)
25. BL Jacobs H van Praag FH Gage 2000 Adult brain neurogenesis and psychiatry: a novel theory of depression Mol Psychiatry 5 262 269 10889528 10.1038/sj.mp.4000712 1:CAS:528:DC%2BD3cXlslGisr4%3D (Pubitemid 30438401)
26. NN Johnson-Farley K Patel D Kim DS Cowen 2007 Interaction of FGF-2 with IGF-1 and BDNF in stimulating Akt, ERK, and neuronal survival in hippocampal cultures Brain Res 18 1154 40 49 10.1016/j.brainres.2007.04.026 (Pubitemid 46856346)
27. S Kar JG Chabot R Quirion 1993 Quantitative autoradiographic localization of [125I]insulin-like growth factor I, [125I]insulin-like growth factor II, and [125I]insulin receptor binding sites in developing and adult rat brain J Comp Neurol 333 375 397 8349849 10.1002/cne.903330306 1:CAS:528:DyaK3sXlsFaksrY%3D (Pubitemid 23187534)
28. T Kato 2007 Molecular genetics of bipolar disorder and depression Psychiatry Clin Neurosci 61 3 19 17239033 10.1111/j.1440-1819.2007.01604.x 1:CAS:528:DC%2BD2sXitV2iur4%3D Review (Pubitemid 46089400)
29. D LeRoith M McGuinness J Shemer B Stannard F Lanau TN Faria H Kato H Werner M Adamo CT Roberts Jr 1992 Insulin-like growth factors Biol Signals 1 173 181 1307923 10.1159/000109323 1:CAS:528:DyaK3sXlt1GgtQ%3D%3D
30. IP Levshina NN Shuikin 2002 Peculiarities of exploration behavior of socially deprived rats in stress situation Zh Vyssh Nerv Deiat Im I P Pavlova 52 602 608 12449839 1:STN:280:DC%2BD38nos1OjsA%3D%3D
31. S Li C Wang W Wang H Dong P Hou Y Tang 2008 Chronic mild stress impairs cognition in mice: from brain homeostasis to behavior Life Sci 82 934 942 18402983 10.1016/j.lfs.2008.02.010 1:CAS:528:DC%2BD1cXks12ktrY%3D
32. E Malberg AJ Eisch EJ Nestler RS Duman 2000 Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus J Neurosci 20 9104 9110 11124987 1:CAS:528:DC%2BD3MXis1SqsA%3D%3D (Pubitemid 32042912)
33. S Mato R Vidal E Castro A Díaz A Pazos EM Valdizán 2010 Long-term fluoxetine treatment modulates cannabinoid type 1 receptor-mediated inhibition of adenylyl cyclase in the rat prefrontal cortex through 5-hydroxytryptamine 1A receptor-dependent mechanisms Mol Pharmacol 77 3 424 434 19995940 10.1124/mol.109.060079 1:CAS:528:DC%2BC3cXjt1entL4%3D
34. MP Mattson S Maudsley B Martin 2004 A neural signaling triumvirate that influences ageing and age-related disease: insulin/IGF-1, BDNF and serotonin Ageing Res Rev 3 445 464 15541711 10.1016/j.arr.2004.08.001 1:CAS:528: DC%2BD2MXktlWgsg%3D%3D (Pubitemid 39487900)
35. Y Mebratu Y Tesfaigzi 2009 How ERK1/2 activation controls cell proliferation and cell death: is subcellular localization the answer? Cell Cycle 8 8 1168 1175 19282669 10.4161/cc.8.8.8147 1:CAS:528:DC%2BD1MXlvFWit7w%3D
36. A Meneses 2002 Tianeptine: 5-HT uptake sites and 5-HT(1-7) receptors modulate memory formation in an autoshaping Pavlovian/instrumental task Neurosci Biobehav Rev 26 309 319 12034133 10.1016/S0149-7634(02)00005-2 1:CAS:528:DC%2BD38XktVaku7k%3D (Pubitemid 34553317)
37. R Molteni F Calabrese F Bedogni E Tongiorgi F Fumagalli G Racagni MA Riva 2006 Chronic treatment with fluoxetine up-regulates cellular BDNF mRNA expression in rat dopaminergic regions Int J Neuropsychopharmacol 9 307 317 16035958 10.1017/S1461145705005766 1:CAS:528:DC%2BD28Xks1WqtLo%3D (Pubitemid 43780498)
38. JL Moreau R Scherschlicht F Jenck JR Martin 1995 Chronic mild stress-induced anhedonia model of depression; sleep abnormalities and curative effects of electroshock treatment Behav Pharmacol 6 682 687 11224370 10.1097/00008877-199511000-00003
39. L Musazzi M Milanese P Farisello S Zappettini D Tardito VS Barbiero T Bonifacino A Mallei P Baldelli G Racagni M Raiteri F Benfenati G Bonanno M Popoli 2010 Acute stress increases depolarization-evoked glutamate release in the rat prefrontal/frontal cortex: the dampening action of antidepressants PLoS One 5 1 e8566 20052403 10.1371/journal.pone.0008566
40. T Nagai K Takuma H Kamei Y Ito N Nakamichi D Ibi Y Nakanishi M Murai H Mizoguchi T Nabeshima K Yamada 2007 Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex Learn Mem 14 117 125 17337702 10.1101/lm.461407 1:CAS:528:DC%2BD1cXms1Ortbo%3D (Pubitemid 46495188)
41. L Naudon M Hotte TM Jay 2007 Effects of acute and chronic antidepressant treatments on memory performance: a comparison between paroxetine and imipramine Psychopharmacol (Berl) 191 353 364 10.1007/s00213-006-0660-4 1:CAS:528:DC%2BD2sXitlCksLk%3D (Pubitemid 46354618)
42. TM Pham S Soderstrom BG Henriksson AH Mohammed 1997 Effect of neonatal stimulation on later cognitive function and hippocampal nerve growth factor Behav Brain Res 86 113 120 9105589 10.1016/S0166-4328(96)02252-8 1:CAS:528:DyaK2sXivFGms70%3D (Pubitemid 27132778)
43. SB Pinnock SE Lazic HT Wong IH Wong J Herbert 2009 Synergistic effects of dehydroepiandrosterone and fluoxetine on proliferation of progenitor cells in the dentate gyrus of the adult male rat Neuroscience 158 1644 1651 19068226 10.1016/j.neuroscience.2008.10.035 1:CAS:528:DC%2BD1MXit1Oju7Y%3D
44. X Qi W Lin J Li Y Pan W Wang 2006 The depressive-like behaviors are correlated with decreased phosphorylation of mitogen-activated protein kinases in rat brain following chronic forced swim stress Behav Brain Res 175 233 240 17050000 10.1016/j.bbr.2006.08.035 1:CAS:528:DC%2BD28Xht1ersr7K (Pubitemid 44750226)
45. X Qi W Lin J Li H Li W Wang D Wang M Sun 2008 Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress Neurobiol Dis 31 278 285 18586506 10.1016/j.nbd.2008.05.003 1:CAS:528:DC%2BD1cXoslOht78%3D
46. SM Rodrigues GE Schafe JE LeDoux 2004 Molecular mechanisms underlying emotional learning and memory in the lateral amygdala Neuron 44 75 91 15450161 10.1016/j.neuron.2004.09.014 1:CAS:528:DC%2BD2cXovVOksr0%3D (Pubitemid 39348831)
47. HD Schmidt RS Duman 2007 The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior Behav Pharmacol 18 391 418 17762509 10.1097/FBP.0b013e3282ee2aa8 1:CAS:528:DC%2BD2sXpvVems70%3D Review (Pubitemid 47356367)
48. YI Sheline MH Gado HC Kraemer 2003 Untreated depression and hippocampal volume loss Am J Psychiatry 160 1516 1518 12900317 10.1176/appi.ajp.160.8.1516 (Pubitemid 41070930)
49. P Skolnick 1999 Antidepressants for the new millennium Eur J Pharmacol 375 31 40 10443562 10.1016/S0014-2999(99)00330-1 1:CAS:528:DyaK1MXks1Cku7c%3D (Pubitemid 29317590)
50. L Song W Che W Min-Wei Y Murakami K Matsumoto 2006 Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress Pharmacol Biochem Behav 83 186 193 16519925 10.1016/j.pbb.2006.01.004 1:CAS:528:DC%2BD28Xjs1Gms7w%3D
51. CY Sun SS Qi XF Lou SH Sun X Wang KY Dai SW Hu NB Liu 2006 Changes of learning, memory and levels of CaMKII, CaM mRNA, CREB mRNA in the hippocampus of chronic multiple-stressed rats Chin Med J (Engl) 119 140 147 1:CAS:528:DC%2BD28XitFShsbg%3D (Pubitemid 43796930)
52. U Tacke 1989 Fluoxetine: an alternative to the tricyclics in the treatment of major depression? Am J Med Sci 298 126 129 2669476 10.1097/00000441-198908000-00010 1:STN:280:DyaL1MzkvFWqtQ%3D%3D (Pubitemid 19195576)
53. M Taler M Bar I Korob L Lomnitski E Baharav N Grunbaum-Novak A Weizman I Gil-Ad 2008 Evidence for an inhibitory immunomodulatory effect of selected antidepressants on rat splenocytes: possible relevance to depression and hyperactive-immune disorders Int Immunopharmacol 8 526 533 18328443 10.1016/j.intimp.2007.12.003 1:CAS:528:DC%2BD1cXivFyksLk%3D
54. I Torres-Aleman 1999 Insulin-like growth factors as mediators of functional plasticity in the adult brain Horm Metab Res 31 114 119 10226790 10.1055/s-2007-978707 1:CAS:528:DyaK1MXitlKlurc%3D (Pubitemid 29169484)
55. JL Trejo J Piriz MV Llorens-Martin AM Fernandez M Bolós D LeRoith A Nuñez I Torres-Aleman 2007 Central actions of liver-derived insulin-like growth factor I underlying its pro-cognitive effects Mol Psychiatry 12 1118 1128 17848918 10.1038/sj.mp.4002076 1:CAS:528:DC%2BD2sXhtlKmtLjJ (Pubitemid 350191366)
56. P Willner 1997 Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation Psychopharmacology 134 319 329 9452163 10.1007/s002130050456 1:CAS:528:DyaK2sXotVymtbc%3D (Pubitemid 28023396)
57. P Willner 2005 Chronic mild stress (CMS) revisited: consistency and behavioral- neurobiological concordance in the effects of CMS Neuropsychobiology 52 90 110 16037678 10.1159/000087097 1:CAS:528:DC%2BD2MXnvFyhtrw%3D (Pubitemid 41160326)
58. P Willner A Towell D Sampson S Sophokleus R Muscant 1987 Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant Psychopharmacology (Berl) 93 358 364 10.1007/BF00187257 1:CAS:528:DyaL2sXmt12jtrg%3D (Pubitemid 17160661)
59. JL Yau J Noble C Hibberd WB Rowe MJ Meaney RG Morris JR Seckl 2002 Chronic treatment with the antidepressant amitriptyline prevents impairments in water maze learning in aging rats J Neurosci 22 1436 1442 11850470 1:CAS:528:DC%2BD38XhsFektb4%3D (Pubitemid 34163744)