메뉴 건너뛰기




Volumn 8, Issue , 2014, Pages 789-798

New oral anticoagulants in patients with nonvalvular atrial fibrillation: A review of pharmacokinetics, safety, efficacy, quality of life, and cost effectiveness

Author keywords

Apixaban; Dabigatran; Edoxaban; Oral anticoagulation; Rivaroxaban

Indexed keywords

ACETYLSALICYLIC ACID; APIXABAN; DABIGATRAN; DABIGATRAN ETEXILATE; EDOXABAN; LIXIANA; RIVAROXABAN; UNCLASSIFIED DRUG; WARFARIN; ANTICOAGULANT AGENT;

EID: 84902583130     PISSN: 11778881     EISSN: None     Source Type: Journal    
DOI: 10.2147/DDDT.S45644     Document Type: Article
Times cited : (100)

References (66)
  • 1
    • 84902577241 scopus 로고    scopus 로고
    • Klassiker der Medizin Edited by Karl Sudhoff Von Johann Ambrosius Barth V. 1910, Leipzig (Matzdorff AC, Bell WR transl). Canton, Science History Publications
    • Virchow, RLK. Thrombosis und Emboli (1846-1856) In: Klassiker der Medizin Edited by Karl Sudhoff Von Johann Ambrosius Barth V. 1910, Leipzig (Matzdorff AC, Bell WR transl). Canton, Science History Publications, 1998] pp 32, 49, 50, 53, 56, 62, 110, 169.
    • (1998) Thrombosis Und Emboli (1846-1856)
    • Virchow, R.L.K.1
  • 3
    • 0035832261 scopus 로고    scopus 로고
    • Prevalence of diagnosed atrial fibrillation in adults: National implications for rhythm management and stroke prevention: The AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study
    • Go AS, Hylek EM, Phillips KA, et al. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study. JAMA. 2001;285:2370-2375.
    • (2001) JAMA , vol.285 , pp. 2370-2375
    • Go, A.S.1    Hylek, E.M.2    Phillips, K.A.3
  • 4
    • 84860470563 scopus 로고    scopus 로고
    • CHADS2 and CHA2DS2-VASc risk factors to predict first cardiovascular hospitalization among atrial fibrillation/atrial flutter patients
    • Naccarelli GV, Panaccio MP, Cummins G, Tu N. CHADS2 and CHA2DS2-VASc risk factors to predict first cardiovascular hospitalization among atrial fibrillation/atrial flutter patients. Am J Cardiol. 2012;109(10):1526-1533.
    • (2012) Am J Cardiol , vol.109 , Issue.10 , pp. 1526-1533
    • Naccarelli, G.V.1    Panaccio, M.P.2    Cummins, G.3    Tu, N.4
  • 5
    • 84861725443 scopus 로고    scopus 로고
    • Evaluation of risk stratification schemes for ischaemic stroke and bleeding in 182 678 patients with atrial fibrillation: The Swedish Atrial Fibrillation cohort study
    • Friberg L, Rosenqvist M, Lip GY. Evaluation of risk stratification schemes for ischaemic stroke and bleeding in 182 678 patients with atrial fibrillation: the Swedish Atrial Fibrillation cohort study. Eur Heart J. 2012;33(12):1500-1510.
    • (2012) Eur Heart J , vol.33 , Issue.12 , pp. 1500-1510
    • Friberg, L.1    Rosenqvist, M.2    Lip, G.Y.3
  • 6
    • 77957699729 scopus 로고    scopus 로고
    • Guidelines for the management of atrial fibrillation: The Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC)
    • European Heart Rhythm Association; European Association for Cardio-Thoracic Surgery
    • European Heart Rhythm Association; European Association for Cardio-Thoracic Surgery, Camm AJ, et al. Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Eur Heart J. 2010;31:2369-2429.
    • (2010) Eur Heart J , vol.31 , pp. 2369-2429
    • Camm, A.J.1
  • 7
    • 4644230820 scopus 로고    scopus 로고
    • The pharmacology and management of the vitamin K antagonists: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy
    • Ansell J, Hirsh J, Poller L, Bussey H, Jacobson A, Hylek E. The pharmacology and management of the vitamin K antagonists: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004;126(Suppl 3):204S-233S.
    • (2004) Chest , vol.126 , Issue.SUPPL. 3
    • Ansell, J.1    Hirsh, J.2    Poller, L.3    Bussey, H.4    Jacobson, A.5    Hylek, E.6
  • 8
    • 84856745317 scopus 로고    scopus 로고
    • Antithrombotic therapy for atrial fibrillation: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    • You JJ, Singer DE, Howard PA, et al. Antithrombotic therapy for atrial fibrillation: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(Suppl 2):e531S-e575S.
    • (2012) Chest , vol.141 , Issue.SUPPL. 2
    • You, J.J.1    Singer, D.E.2    Howard, P.A.3
  • 9
    • 0035128503 scopus 로고    scopus 로고
    • Oral anticoagulants: Mechanism of action, clinical effectiveness, and optimal therapeutic range
    • Hirsh J, Dalen J, Anderson DR, et al. Oral anticoagulants: mechanism of action, clinical effectiveness, and optimal therapeutic range. Chest. 2001;119(Suppl 1):8S-21S.
    • (2001) Chest , vol.119 , Issue.SUPPL. 1
    • Hirsh, J.1    Dalen, J.2    Anderson, D.R.3
  • 10
    • 80052485992 scopus 로고    scopus 로고
    • Rivaroxaban: Population pharmacokinetic analyses in patients treated for acute deep-vein thrombosis and exposure simulations in patients with atrial fibrillation treated for stroke prevention
    • Mueck W, Lensing AW, Agnelli G, Decousus H, Prandoni P, Misselwitz F. Rivaroxaban: population pharmacokinetic analyses in patients treated for acute deep-vein thrombosis and exposure simulations in patients with atrial fibrillation treated for stroke prevention. Clin Pharmacokinet. 2011;50(10):675-686.
    • (2011) Clin Pharmacokinet , vol.50 , Issue.10 , pp. 675-686
    • Mueck, W.1    Lensing, A.W.2    Agnelli, G.3    Decousus, H.4    Prandoni, P.5    Misselwitz, F.6
  • 12
    • 84879433290 scopus 로고    scopus 로고
    • Rivaroxaban and other novel oral anticoagulants: Pharmacokinetics in healthy subjects, specific patient populations and relevance of coagulation monitoring
    • Mueck W, Schwers S, Stampfuss J. Rivaroxaban and other novel oral anticoagulants: pharmacokinetics in healthy subjects, specific patient populations and relevance of coagulation monitoring. Thromb J. 2013;11(1):10.
    • (2013) Thromb J , vol.11 , Issue.1 , pp. 10
    • Mueck, W.1    Schwers, S.2    Stampfuss, J.3
  • 13
    • 77953787643 scopus 로고    scopus 로고
    • Clinical safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel factor Xa inhibitor edoxaban in healthy volunteers
    • Ogata K, Mendell-Harary J, Tachibana M, et al. Clinical safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel factor Xa inhibitor edoxaban in healthy volunteers. J Clin Pharmacol. 2010;50(7):743-753.
    • (2010) J Clin Pharmacol , vol.50 , Issue.7 , pp. 743-753
    • Ogata, K.1    Mendell-Harary, J.2    Tachibana, M.3
  • 14
    • 77952167209 scopus 로고    scopus 로고
    • Pharmacology, pharmacokinetics, and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor
    • Stangier J, Clemens A. Pharmacology, pharmacokinetics, and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor. Clin Appl Thromb Hemost. 2009;15 Suppl 1:9S-16S.
    • (2009) Clin Appl Thromb Hemost , vol.15 , Issue.SUPPL. 1
    • Stangier, J.1    Clemens, A.2
  • 15
    • 84856435683 scopus 로고    scopus 로고
    • Twice daily dosing of dabigatran for stroke prevention in atrial fibrillation: A pharmacokinetic justification
    • Clemens A, Haertter S, Friedman J, et al. Twice daily dosing of dabigatran for stroke prevention in atrial fibrillation: a pharmacokinetic justification. Curr Med Res Opin. 2012;28(2):195-201.
    • (2012) Curr Med Res Opin , vol.28 , Issue.2 , pp. 195-201
    • Clemens, A.1    Haertter, S.2    Friedman, J.3
  • 16
    • 84863989146 scopus 로고    scopus 로고
    • Periprocedural bleeding and thromboembolic events with dabigatran compared with warfarin: Results from the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) randomized trial
    • Healey JS, Eikelboom J, Douketis J, et al. Periprocedural bleeding and thromboembolic events with dabigatran compared with warfarin: results from the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) randomized trial. Circulation. 2012;126(3):343-348.
    • (2012) Circulation , vol.126 , Issue.3 , pp. 343-348
    • Healey, J.S.1    Eikelboom, J.2    Douketis, J.3
  • 17
    • 80052592404 scopus 로고    scopus 로고
    • Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
    • Patel MR, Mahaffey KW, Garg J, et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med. 2011;365(10):883-891.
    • (2011) N Engl J Med , vol.365 , Issue.10 , pp. 883-891
    • Patel, M.R.1    Mahaffey, K.W.2    Garg, J.3
  • 18
    • 84870950721 scopus 로고    scopus 로고
    • Bleeding during treatment with aspirin versus apixaban in patients with atrial fibrillation unsuitable for warfarin: The apixaban versus acetylsalicylic acid to prevent stroke in atrial fibrillation patients who have failed or are unsuitable for vitamin K antagonist treatment (AVERROES) trial
    • Flaker GC, Eikelboom JW, Shestakovska O, et al. Bleeding during treatment with aspirin versus apixaban in patients with atrial fibrillation unsuitable for warfarin: the apixaban versus acetylsalicylic acid to prevent stroke in atrial fibrillation patients who have failed or are unsuitable for vitamin K antagonist treatment (AVERROES) trial. Stroke. 2012;43(12):3291-3297.
    • (2012) Stroke , vol.43 , Issue.12 , pp. 3291-3297
    • Flaker, G.C.1    Eikelboom, J.W.2    Shestakovska, O.3
  • 19
    • 84878535107 scopus 로고    scopus 로고
    • Efficacy and safety of apixaban compared with warfarin at different levels of predicted international normalized ratio control for stroke prevention in atrial fibrillation
    • Wallentin L, Lopes RD, Hanna M, et al. Efficacy and safety of apixaban compared with warfarin at different levels of predicted international normalized ratio control for stroke prevention in atrial fibrillation. Circulation. 2013;127(22):2166-2176.
    • (2013) Circulation , vol.127 , Issue.22 , pp. 2166-2176
    • Wallentin, L.1    Lopes, R.D.2    Hanna, M.3
  • 20
    • 84888362796 scopus 로고    scopus 로고
    • Edoxaban versus warfarin in patients with atrial fibrillation
    • Giugliano RP, Ruff CT, Braunwald E, et al. Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2013;369(22): 2093-2104.
    • (2013) N Engl J Med , vol.369 , Issue.22 , pp. 2093-2104
    • Giugliano, R.P.1    Ruff, C.T.2    Braunwald, E.3
  • 21
    • 84876360360 scopus 로고    scopus 로고
    • Antithrombotic alternatives for stroke prevention in atrial fibrillation: Critical differences and remaining questions
    • 2013
    • Kalus JS. Antithrombotic alternatives for stroke prevention in atrial fibrillation: critical differences and remaining questions. Drugs Context. 2013;2013:212251.
    • (2013) Drugs Context , pp. 212251
    • Kalus, J.S.1
  • 23
    • 0034107497 scopus 로고    scopus 로고
    • Relationship between test frequency and outcomes of anticoagulation: A literature review and commentary with implications for the design of randomized trials of patient self-management
    • Samsa GP, Matchar DB. Relationship between test frequency and outcomes of anticoagulation: a literature review and commentary with implications for the design of randomized trials of patient self-management. J Thromb Thrombolysis. 2000;9:283-292.
    • (2000) J Thromb Thrombolysis , vol.9 , pp. 283-292
    • Samsa, G.P.1    Matchar, D.B.2
  • 24
    • 84864299272 scopus 로고    scopus 로고
    • Does treatment guided by vitamin K in the diet alter the quality of life of anticoagulated patients?
    • Silva de Assis MC, Nascimento Cruz L, Zuchinali P, Rohde LE, Rejane Rabelo E. Does treatment guided by vitamin K in the diet alter the quality of life of anticoagulated patients? Nutr Hosp. 2012;27(4):1328-1333.
    • (2012) Nutr Hosp , vol.27 , Issue.4 , pp. 1328-1333
    • Silva de Assis, M.C.1    Nascimento Cruz, L.2    Zuchinali, P.3    Rohde, L.E.4    Rejane Rabelo, E.5
  • 25
    • 0036066718 scopus 로고    scopus 로고
    • Improving the quality of anticoagulation of patients with atrial fibrillation in managed care organizations: Results of the managing anticoagulation services trial
    • Matchar DB, Samsa GP, Cohen SJ, Oddone EZ, Jurgelski AE. Improving the quality of anticoagulation of patients with atrial fibrillation in managed care organizations: results of the managing anticoagulation services trial. Am J Med. 2002;113(1):42-51.
    • (2002) Am J Med , vol.113 , Issue.1 , pp. 42-51
    • Matchar, D.B.1    Samsa, G.P.2    Cohen, S.J.3    Oddone, E.Z.4    Jurgelski, A.E.5
  • 26
    • 0034622382 scopus 로고    scopus 로고
    • Oral anticoagulation self-management and management by a specialist anticoagulation clinic: A randomized cross-over comparison
    • Cromheecke ME, Levi M, Colly LP, et al. Oral anticoagulation self-management and management by a specialist anticoagulation clinic: a randomized cross-over comparison. Lancet. 2000;356(8):97-102.
    • (2000) Lancet , vol.356 , Issue.8 , pp. 97-102
    • Cromheecke, M.E.1    Levi, M.2    Colly, L.P.3
  • 27
    • 0344851886 scopus 로고    scopus 로고
    • Comparison of the quality of oral anticoagulant therapy through patient self management and management by specialized anticoagulation clinics in the Netherlands
    • Gadisseur AP, Breukink-Engbers WG, van der Meer FJ, van den Besselaar AM, Sturk A, Rosendaal FR. Comparison of the quality of oral anticoagulant therapy through patient self management and management by specialized anticoagulation clinics in the Netherlands. Arch Intern Med. 2003;163:2639-2646.
    • (2003) Arch Intern Med , vol.163 , pp. 2639-2646
    • Gadisseur, A.P.1    Breukink-Engbers, W.G.2    van der Meer, F.J.3    van den Besselaar, A.M.4    Sturk, A.5    Rosendaal, F.R.6
  • 28
    • 22744453897 scopus 로고    scopus 로고
    • Patients' perceptions regarding oral anticoagulation therapy and its effect on quality of life
    • Casais P, Meschengieser SS, Sanchez-Luceros A, Lazzari MA. Patients' perceptions regarding oral anticoagulation therapy and its effect on quality of life. Curr Med Res Opin. 2005;21(7):1085-1090.
    • (2005) Curr Med Res Opin , vol.21 , Issue.7 , pp. 1085-1090
    • Casais, P.1    Meschengieser, S.S.2    Sanchez-Luceros, A.3    Lazzari, M.A.4
  • 29
    • 5144227220 scopus 로고    scopus 로고
    • Patient self-management of oral anticoagulant care vs management by specialized anticoagulation clinics: Positive effects on quality of life
    • Gadisseur AP, Kaptein AA, Breukink-Engbers WG, van der Meer FJ, Rosendaal FR. Patient self-management of oral anticoagulant care vs management by specialized anticoagulation clinics: positive effects on quality of life. J Thromb Haemost. 2004;2(4):584-591.
    • (2004) J Thromb Haemost , vol.2 , Issue.4 , pp. 584-591
    • Gadisseur, A.P.1    Kaptein, A.A.2    Breukink-Engbers, W.G.3    van der Meer, F.J.4    Rosendaal, F.R.5
  • 30
    • 15444376404 scopus 로고    scopus 로고
    • Impact of adherence, knowledge, and quality of life on anticoagulation control
    • Davis NJ, Billett HH, Cohen HW, Arnsten JH. Impact of adherence, knowledge, and quality of life on anticoagulation control. Ann Pharmacother. 2005;39(4):632-636.
    • (2005) Ann Pharmacother , vol.39 , Issue.4 , pp. 632-636
    • Davis, N.J.1    Billett, H.H.2    Cohen, H.W.3    Arnsten, J.H.4
  • 31
    • 84881474743 scopus 로고    scopus 로고
    • Measuring the anticoagulant effects of target specific oral anticoagulants-reasons, methods and current limitations
    • Mani H, Kasper A, Lindhoff-Last E. Measuring the anticoagulant effects of target specific oral anticoagulants-reasons, methods and current limitations. J Thromb Thrombolysis. 2013;36(2):187-194.
    • (2013) J Thromb Thrombolysis , vol.36 , Issue.2 , pp. 187-194
    • Mani, H.1    Kasper, A.2    Lindhoff-Last, E.3
  • 32
    • 77952679761 scopus 로고    scopus 로고
    • New oral antithrombotics: A need for laboratory monitoring. For
    • Mismetti P, Laporte S. New oral antithrombotics: a need for laboratory monitoring. For. J Thromb Haemost. 2010;8(4):621-626.
    • (2010) J Thromb Haemost , vol.8 , Issue.4 , pp. 621-626
    • Mismetti, P.1    Laporte, S.2
  • 33
    • 79955432850 scopus 로고    scopus 로고
    • European Medicines Agency, London: European Medicines Agency, Available from, Accessed April 24, 2014
    • European Medicines Agency. Xarelto-Summary of Product Characteristics. London: European Medicines Agency; 2013. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Summary_for_the_public/human/000944/WC500057109.pdf. Accessed April 24, 2014.
    • (2013) Xarelto-Summary of Product Characteristics
  • 34
    • 84860512524 scopus 로고    scopus 로고
    • European Medicines Agency, London: European Medicines Agency, Available from, Accessed April 24, 2014
    • European Medicines Agency. Eliquis-Summary of Product Characteristics. London: European Medicines Agency; 2013. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Summary_for_the_public/human/002148/WC500107773.pdf. Accessed April 24, 2014.
    • (2013) Eliquis-Summary of Product Characteristics
  • 35
    • 84878921385 scopus 로고    scopus 로고
    • Effect of extremes of body weight on the pharmacokinetics, pharmacodynamics, safety and tolerability of apixaban in healthy subjects
    • Upreti VV, Wang J, Barrett YC, et al. Effect of extremes of body weight on the pharmacokinetics, pharmacodynamics, safety and tolerability of apixaban in healthy subjects. Br J Clin Pharmacol. 2013;76(6): 908-916.
    • (2013) Br J Clin Pharmacol , vol.76 , Issue.6 , pp. 908-916
    • Upreti, V.V.1    Wang, J.2    Barrett, Y.C.3
  • 36
    • 79955432850 scopus 로고    scopus 로고
    • European Medicines Agency, London: European Medicines Agency, Available from, Accessed April 24, 2014
    • European Medicines Agency. Pradaxa-Summary of Product Characteristics. London: European Medicines Agency; 2013. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Summary_for_the_public/human/000829/WC500041060.pdf. Accessed April 24, 2014.
    • (2013) Pradaxa-Summary of Product Characteristics
  • 37
    • 84893160985 scopus 로고    scopus 로고
    • RE-LY Investigators.The effect of dabigatran plasma concentrations and patient characteristics on the frequency of ischemic stroke and major bleeding in atrial fibrillation patients: The RE-LY Trial (Randomized Evaluation of Long-Term Anticoagulation Therapy)
    • Reilly PA, Lehr T, Haertter S, et al. RE-LY Investigators.The effect of dabigatran plasma concentrations and patient characteristics on the frequency of ischemic stroke and major bleeding in atrial fibrillation patients: the RE-LY Trial (Randomized Evaluation of Long-Term Anticoagulation Therapy). J Am Coll Cardiol. 2014;63(4):321-328.
    • (2014) J Am Coll Cardiol , vol.63 , Issue.4 , pp. 321-328
    • Reilly, P.A.1    Lehr, T.2    Haertter, S.3
  • 38
    • 84857853180 scopus 로고    scopus 로고
    • Bleeding risk with dabigatran in the frail elderly
    • Harper P, Young L, Merriman E. Bleeding risk with dabigatran in the frail elderly. N Engl J Med. 2012;366(9):864-866.
    • (2012) N Engl J Med , vol.366 , Issue.9 , pp. 864-866
    • Harper, P.1    Young, L.2    Merriman, E.3
  • 39
    • 79960955075 scopus 로고    scopus 로고
    • The use of dabigatran in elderly patients
    • Legrand M, Mateo J, Aribaud A, et al. The use of dabigatran in elderly patients. Arch Intern Med. 2011;171(14):1285-1286.
    • (2011) Arch Intern Med , vol.171 , Issue.14 , pp. 1285-1286
    • Legrand, M.1    Mateo, J.2    Aribaud, A.3
  • 40
    • 84862132761 scopus 로고    scopus 로고
    • Reversal of warfarin: Case-based practice recommendations
    • Garcia DA, Crowther MA. Reversal of warfarin: case-based practice recommendations. Circulation. 2012;125(23):2944-2947.
    • (2012) Circulation , vol.125 , Issue.23 , pp. 2944-2947
    • Garcia, D.A.1    Crowther, M.A.2
  • 41
    • 77955094322 scopus 로고    scopus 로고
    • Prothrombin complex concentrates for oral anticoagulant therapy-related intracranial hemorrhage: A review of the literature
    • Bershad EM, Suarez JI. Prothrombin complex concentrates for oral anticoagulant therapy-related intracranial hemorrhage: a review of the literature. Neurocrit Care. 2010;12(3):403-413.
    • (2010) Neurocrit Care , vol.12 , Issue.3 , pp. 403-413
    • Bershad, E.M.1    Suarez, J.I.2
  • 42
    • 42149134772 scopus 로고    scopus 로고
    • Recombinant human factor VIIa and a factor VIIa-analogue reduces heparin and low molecular weight heparin (LMWH)-induced bleeding in rats
    • Lauritzen B, Hedner U, Johansen PB, Tranholm M, Ezban M. Recombinant human factor VIIa and a factor VIIa-analogue reduces heparin and low molecular weight heparin (LMWH)-induced bleeding in rats. J Thromb Haemost. 2008;6(5):804-811.
    • (2008) J Thromb Haemost , vol.6 , Issue.5 , pp. 804-811
    • Lauritzen, B.1    Hedner, U.2    Johansen, P.B.3    Tranholm, M.4    Ezban, M.5
  • 43
    • 84878460192 scopus 로고    scopus 로고
    • A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa
    • Lu G, DeGuzman FR, Hollenbach SJ, et al. A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa. Nat Med. 2013;19(4):446-451.
    • (2013) Nat Med , vol.19 , Issue.4 , pp. 446-451
    • Lu, G.1    Deguzman, F.R.2    Hollenbach, S.J.3
  • 44
    • 84879548455 scopus 로고    scopus 로고
    • A specific antidote for dabigatran: Functional and structural characterization
    • Schiele F, van Ryn J, Canada K, et al. A specific antidote for dabigatran: functional and structural characterization. Blood. 2013;121(18): 3554-3562.
    • (2013) Blood , vol.121 , Issue.18 , pp. 3554-3562
    • Schiele, F.1    van Ryn, J.2    Canada, K.3
  • 45
    • 84902599560 scopus 로고    scopus 로고
    • Los Angeles: AHA, Available from, Accessed April 24, 2014
    • Laulicht B, Bakhru S, Lee C, et al. Small Molecule Antidote for Anticoagulants. Los Angeles: AHA; 2012. Available from: http://www.perosphere.com/content/presentations/documents/Perosphere_ISTH_Talk.pdf. Accessed April 24, 2014.
    • (2012) Small Molecule Antidote For Anticoagulants
    • Laulicht, B.1    Bakhru, S.2    Lee, C.3
  • 46
    • 77953851760 scopus 로고    scopus 로고
    • Underuse of oral anticoagulants in atrial fibrillation: A systematic review
    • 638-645. e4
    • Ogilvie IM, Newton N, Welner SA, Cowell W, Lip GY. Underuse of oral anticoagulants in atrial fibrillation: a systematic review. Am J Med. 2010;123(7):638-645. e4.
    • (2010) Am J Med , vol.123 , Issue.7
    • Ogilvie, I.M.1    Newton, N.2    Welner, S.A.3    Cowell, W.4    Lip, G.Y.5
  • 47
    • 57149140461 scopus 로고    scopus 로고
    • Benefit of oral anticoagulant over antiplatelet therapy in atrial fibrillation depends on the quality of international normalized ratio control achieved by centers and countries as measured by time in therapeutic range
    • Connolly SJ, Pogue J, Eikelboom J, et al. Benefit of oral anticoagulant over antiplatelet therapy in atrial fibrillation depends on the quality of international normalized ratio control achieved by centers and countries as measured by time in therapeutic range. Circulation. 2008;118(20): 2029-2037.
    • (2008) Circulation , vol.118 , Issue.20 , pp. 2029-2037
    • Connolly, S.J.1    Pogue, J.2    Eikelboom, J.3
  • 48
    • 84856784474 scopus 로고    scopus 로고
    • Oral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    • Ageno W, Gallus AS, Wittkowsky A, et al. Oral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(Suppl 2): e44S-e88S.
    • (2012) Chest , vol.141 , Issue.SUPPL. 2
    • Ageno, W.1    Gallus, A.S.2    Wittkowsky, A.3
  • 49
    • 34447522035 scopus 로고    scopus 로고
    • In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate
    • Wienen W, Stassen JM, Priepke H, Ries UJ, Hauel N. In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate. Thromb Haemost. 2007;98:155-162.
    • (2007) Thromb Haemost , vol.98 , pp. 155-162
    • Wienen, W.1    Stassen, J.M.2    Priepke, H.3    Ries, U.J.4    Hauel, N.5
  • 50
    • 77952044405 scopus 로고    scopus 로고
    • Assessment of laboratory assays to measure rivaroxaban-an oral, direct factor Xa inhibitor
    • Samama MM, Martinoli JL, LeFlem L, et al. Assessment of laboratory assays to measure rivaroxaban-an oral, direct factor Xa inhibitor. Thromb Haemost. 2010;103(4):815-825.
    • (2010) Thromb Haemost , vol.103 , Issue.4 , pp. 815-825
    • Samama, M.M.1    Martinoli, J.L.2    Leflem, L.3
  • 51
    • 77953168824 scopus 로고    scopus 로고
    • Dabigatran etexilate-a novel, reversible, oral direct thrombin inhibitor: Interpretation of coagulation assays and reversal of anticoagulant activity
    • van Ryn J, Stangier J, Haertter S, et al. Dabigatran etexilate-a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity. Thromb Haemost. 2010;103(6):1116-1127.
    • (2010) Thromb Haemost , vol.103 , Issue.6 , pp. 1116-1127
    • van Ryn, J.1    Stangier, J.2    Haertter, S.3
  • 52
    • 78650943861 scopus 로고    scopus 로고
    • The International Normalized Ratio calibrated for rivaroxaban has the potential to normalize prothrombin time results for rivaroxaban-treated patients: Results of an in vitro study
    • Tripodi A, Chantarangkul V, Guinet C, Samama MM. The International Normalized Ratio calibrated for rivaroxaban has the potential to normalize prothrombin time results for rivaroxaban-treated patients: results of an in vitro study. J Thromb Haemost. 2011;9(1):226-228.
    • (2011) J Thromb Haemost , vol.9 , Issue.1 , pp. 226-228
    • Tripodi, A.1    Chantarangkul, V.2    Guinet, C.3    Samama, M.M.4
  • 53
    • 79954534386 scopus 로고    scopus 로고
    • Laboratory assessment of new anticoagulants
    • Samama MM, Guinet C. Laboratory assessment of new anticoagulants. Clin Chem Lab Med. 2011;49(5):761-772.
    • (2011) Clin Chem Lab Med , vol.49 , Issue.5 , pp. 761-772
    • Samama, M.M.1    Guinet, C.2
  • 54
    • 79960068693 scopus 로고    scopus 로고
    • Rivaroxaban differentially influences ex vivo global coagulation assays based on the administration time
    • Mani H, Hesse C, Stratmann G, Lindhoff-Last E. Rivaroxaban differentially influences ex vivo global coagulation assays based on the administration time. Thromb Haemost. 106(1):156-164.
    • Thromb Haemost , vol.106 , Issue.1 , pp. 156-164
    • Mani, H.1    Hesse, C.2    Stratmann, G.3    Lindhoff-Last, E.4
  • 55
    • 84856293397 scopus 로고    scopus 로고
    • Evaluation of the prothrombin time for measuring rivaroxaban plasma concentrations using calibrators and controls: Results of a multicenter field trial
    • Samama MM, Contant G, Spiro TE, et al. Evaluation of the prothrombin time for measuring rivaroxaban plasma concentrations using calibrators and controls: results of a multicenter field trial. Clin Appl Thromb Hemost. 2012;18(2):150-158.
    • (2012) Clin Appl Thromb Hemost , vol.18 , Issue.2 , pp. 150-158
    • Samama, M.M.1    Contant, G.2    Spiro, T.E.3
  • 56
    • 84860528205 scopus 로고    scopus 로고
    • Impact of dabigatran on a large panel of routine or specific coagulation assays. Laboratory recommendations for monitoring of dabigatran etexilate
    • Douxfils J, Mullier F, Robert S, Chatelain C, Chatelain B, Dogné JM. Impact of dabigatran on a large panel of routine or specific coagulation assays. Laboratory recommendations for monitoring of dabigatran etexilate. Thromb Haemost. 2012;107(5):985-997.
    • (2012) Thromb Haemost , vol.107 , Issue.5 , pp. 985-997
    • Douxfils, J.1    Mullier, F.2    Robert, S.3    Chatelain, C.4    Chatelain, B.5    Dogné, J.M.6
  • 57
    • 84858332563 scopus 로고    scopus 로고
    • Rivaroxaban: Quantification by anti-FXa assay and influence on coagulation tests: A study in 9 Swiss laboratories
    • Asmis LM, Alberio L, Angelillo-Scherrer A, et al. Rivaroxaban: Quantification by anti-FXa assay and influence on coagulation tests: a study in 9 Swiss laboratories. Thromb Res. 2012;129(4):492-498.
    • (2012) Thromb Res , vol.129 , Issue.4 , pp. 492-498
    • Asmis, L.M.1    Alberio, L.2    Angelillo-Scherrer, A.3
  • 58
    • 84863679656 scopus 로고    scopus 로고
    • Accurate determination of rivaroxaban levels requires different calibrator sets but not addition of antithrombin
    • Mani H, Rohde G, Stratmann G, et al. Accurate determination of rivaroxaban levels requires different calibrator sets but not addition of antithrombin. Thromb Haemost. 2012;108(1):191-198.
    • (2012) Thromb Haemost , vol.108 , Issue.1 , pp. 191-198
    • Mani, H.1    Rohde, G.2    Stratmann, G.3
  • 59
    • 82955195864 scopus 로고    scopus 로고
    • Determination of rivaroxaban by different factor Xa specific chromogenic substrate assays: Reduction of interassay variability
    • Harenberg J, Krämer R, Giese C, Marx S, Weiss C, Wehling M. Determination of rivaroxaban by different factor Xa specific chromogenic substrate assays: reduction of interassay variability. J Thromb Thrombolysis. 2011;32(3):267-271.
    • (2011) J Thromb Thrombolysis , vol.32 , Issue.3 , pp. 267-271
    • Harenberg, J.1    Krämer, R.2    Giese, C.3    Marx, S.4    Weiss, C.5    Wehling, M.6
  • 60
    • 84856632988 scopus 로고    scopus 로고
    • Evaluation of the anti-factor Xa chromogenic assay for the measurement of rivaroxaban plasma concentrations using calibrators and controls
    • Samama MM, Contant G, Spiro TE, et al. Evaluation of the anti-factor Xa chromogenic assay for the measurement of rivaroxaban plasma concentrations using calibrators and controls. Thromb Haemost. 2012;107(2):379-387.
    • (2012) Thromb Haemost , vol.107 , Issue.2 , pp. 379-387
    • Samama, M.M.1    Contant, G.2    Spiro, T.E.3
  • 61
    • 84856593171 scopus 로고    scopus 로고
    • Using the HEMOCLOT direct thrombin inhibitor assay to determine plasma concentrations of dabigatran
    • Stangier J, Feuring M. Using the HEMOCLOT direct thrombin inhibitor assay to determine plasma concentrations of dabigatran. Blood Coagul Fibrinolysis. 2012;23(2):138-143.
    • (2012) Blood Coagul Fibrinolysis , vol.23 , Issue.2 , pp. 138-143
    • Stangier, J.1    Feuring, M.2
  • 62
    • 84866981958 scopus 로고    scopus 로고
    • Measuring direct thrombin inhibitors with routine and dedicated coagulation assays: Which assay is helpful?
    • Curvers J, van de Kerkhof D, Stroobants AK, van den Dool EJ, Scharnhorst V. Measuring direct thrombin inhibitors with routine and dedicated coagulation assays: which assay is helpful? Am J Clin Pathol. 2012;138(4):551-558.
    • (2012) Am J Clin Pathol , vol.138 , Issue.4 , pp. 551-558
    • Curvers, J.1    van de Kerkhof, D.2    Stroobants, A.K.3    van den Dool, E.J.4    Scharnhorst, V.5
  • 63
    • 84857364836 scopus 로고    scopus 로고
    • Anticoagulation management in clinical practice: Preventing stroke in patients with atrial fibrillation
    • Hickey K. Anticoagulation management in clinical practice: preventing stroke in patients with atrial fibrillation. Heart Lung. 2012;41(2): 146-156.
    • (2012) Heart Lung , vol.41 , Issue.2 , pp. 146-156
    • Hickey, K.1
  • 64
    • 84880141189 scopus 로고    scopus 로고
    • Cost-effectiveness of apixaban, dabigatran, rivaroxaban, and warfarin for stroke prevention in atrial fibrillation
    • Harrington AR, Armstrong EP, Nolan PE, Malone DC. Cost-effectiveness of apixaban, dabigatran, rivaroxaban, and warfarin for stroke prevention in atrial fibrillation. Stroke. 2013;44:1676-1681.
    • (2013) Stroke , vol.44 , pp. 1676-1681
    • Harrington, A.R.1    Armstrong, E.P.2    Nolan, P.E.3    Malone, D.C.4
  • 65
    • 84902599561 scopus 로고    scopus 로고
    • Comparison of cost-effectiveness of anticoagulation with dabigatran, rivaroxaban and apixaban in patients with non-valvular atrial fibrillation across countries
    • Epub September 25
    • Krejczy M, Harenberg J, Marx S, Obermann K, Frölich L, Wehling M. Comparison of cost-effectiveness of anticoagulation with dabigatran, rivaroxaban and apixaban in patients with non-valvular atrial fibrillation across countries. J Thromb Thrombolysis. Epub September 25, 2013.
    • (2013) J Thromb Thrombolysis
    • Krejczy, M.1    Harenberg, J.2    Marx, S.3    Obermann, K.4    Frölich, L.5    Wehling, M.6
  • 66
    • 33745662843 scopus 로고    scopus 로고
    • Cost-effectiveness of self-managed versus physician-managed oral anticoagulation therapy
    • Regier DA, Sunderji R, Lynd LD, Gin K, Marra CA. Cost-effectiveness of self-managed versus physician-managed oral anticoagulation therapy. CMAJ. 2006;174(13):1847-1852.
    • (2006) CMAJ , vol.174 , Issue.13 , pp. 1847-1852
    • Regier, D.A.1    Sunderji, R.2    Lynd, L.D.3    Gin, K.4    Marra, C.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.