Tumour-experienced T cells promote NK cell activity through trogocytosis of NKG2D and NKp46 ligands

EMBO Reports

Volumn 10, Issue 8, 2009, Pages 908-915

  Domaica, Carolina I ^a   Fuertes, Mercedes B ^a,b   Rossi, Lucas E ^a   Girart, María V ^a,b   Ávila, Damián E ^a   Rabinovich, Gabriel A ^a,b   Zwirner, Norberto W ^a,b  

^a Universidad Nacional de Río Cuarto Consejo Nacional de Investigaciones Científicas y Técnicas   (Argentina)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE PROTEIN; GAMMA INTERFERON; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1 CHAIN RELATED PROTEIN A; NATURAL KILLER CELL P46; NATURAL KILLER CELL RECEPTOR; NATURAL KILLER CELL RECEPTOR NKG2D; UNCLASSIFIED DRUG;

ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL FUNCTION; CELL INTERACTION; CELL SURFACE; CELL TRANSFER; COCULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; DEGRANULATION; EFFECTOR CELL; HUMAN; HUMAN CELL; MELANOMA; NATURAL KILLER CELL; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TROGOCYTOSIS; TUMOR CELL;

CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; CELLS, CULTURED; FLOW CYTOMETRY; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-2; KILLER CELLS, NATURAL; MICROSCOPY, CONFOCAL; MITOGENS; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; NEOPLASMS; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY K; PHYTOHEMAGGLUTININS; T-LYMPHOCYTES;

EID: 68249104197     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2009.92     Document Type: Article

References (14)

1. Caumartin J, Favier B, Daouya M, Guillard C, Moreau P, Carosella ED, LeMaoult J (2007) Trogocytosis-based generation of suppressive NK cells. EMBO J 26: 1423-1433
2. Eagle RA, Trowsdale J (2007) Promiscuity and the single receptor: NKG2D. Nat Rev Immunol 7: 737-744
3. Fuertes MB, Girart MV, Molinero LL, Domaica CI, Rossi LE, Barrio MM, Mordoh J, Rabinovich GA, Zwirner NW (2008) Intracellular retention of the NKG2D ligand MHC class I chain-related gene A in human melanomas confers immune privilege and prevents NK cell-mediated cytotoxicity. J Immunol 180: 4606-4614
4. Girart MV, Fuertes MB, Domaica CI, Rossi LE, Zwirner NW (2007) Engagement of TLR3, TLR7, and NKG2D regulate IFN-γ secretion but not NKG2D-mediated cytotoxicity by human NK cells stimulated with suboptimal doses of IL-12. J Immunol 179: 3472-3479
5. Hirst CE, Buzza MS, Bird CH, Warren HS, Cameron PU, Zhang M, Ashton-Rickardt PG, Bird PI (2003) The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency. J Immunol 170: 805-815
6. Hudrisier D, Aucher A, Puaux AL, Bordier C, Joly E (2007) Capture of target cell membrane components via trogocytosis is triggered by a selected set of surface molecules on T or B cells. J Immunol 178: 3637-3647
7. Hudrisier D, Bongrand P (2002) Intercellular transfer of antigen-presenting cell determinants onto T cells: Molecular mechanisms and biological significance. FASEB J 16: 477-486
8. Li Z, Pradera F, Kammertoens T, Li B, Liu S, Qin Z (2007) Cross-talk between T cells and innate immune cells is crucial for IFN-{gamma}-dependent tumor rejection. J Immunol 179: 1568-1576
9. McCann FE, Eissmann P, Onfelt B, Leung R, Davis DM (2007) The activating NKG2D ligand MHC class I-related chain A transfers from target cells to NK cells in a manner that allows functional consequences. J Immunol 178: 3418-3426
10. Moretta L, Bottino C, Pende D, Castriconi R, Mingari MC, Moretta A (2006) Surface NK receptors and their ligands on tumor cells. Semin Immunol 18: 151-158
11. Mumberg D, Monach PA, Wanderling S, Philip M, Toledano AY, Schreiber RD, Schreiber H (1999) CD4+ T cells eliminate MHC class II-negative cancer cells in vivo by indirect effects of IFN-γ. Proc Natl Acad Sci USA 96: 8633-8638
12. Rabinovich GA, Sotomayor E, Gabrilovich D (2007) Immunosuppressive strategies that are mediated by tumor cells. Annu Rev Immunol 25: 267-296
13. Segal BM, Glass DD, Shevach EM (2002) IL-10-producing CD4+ T cells mediate tumor rejection. J Immunol 168: 1-4
14. Shankaran V, Ikeda H, Bruce AT, White JM, Swanson PE, Old LJ, Schreiber RD (2001) IFN[gamma] and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 410: 1107-1111