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Volumn 10, Issue 3, 2014, Pages 436-451

Effectiveness of milk whey protein-based ready-to-use therapeutic food in treatment of severe acute malnutrition in Malawian under-5 children: A randomised, double-blind, controlled non-inferiority clinical trial

Author keywords

Community based; Malnutrition; Randomised controlled trial; Therapeutic feeding; Undernutrition; Whey protein

Indexed keywords

MILK PROTEIN; WHEY PROTEIN;

EID: 84902549695     PISSN: 17408695     EISSN: 17408709     Source Type: Journal    
DOI: 10.1111/mcn.12112     Document Type: Article
Times cited : (36)

References (58)
  • 2
    • 33751432455 scopus 로고    scopus 로고
    • Efficacy and effectiveness of community-based treatment of severe malnutrition
    • Ashworth A. (2006) Efficacy and effectiveness of community-based treatment of severe malnutrition. Food and Nutrition Bulletin 27 (Suppl. 3), S24-S48.
    • (2006) Food and Nutrition Bulletin , vol.27 , Issue.SUPPL. 3
    • Ashworth, A.1
  • 4
    • 52449129918 scopus 로고    scopus 로고
    • Uptake of HIV testing and outcomes within a Community-based Therapeutic Care (CTC) programme to treat severe acute malnutrition in Malawi: a descriptive study
    • Bahwere P., Piwoz E., Joshua M.C., Sadler K., Grobler-Tanner C.H., Guerrero S. & Collins S. (2008) Uptake of HIV testing and outcomes within a Community-based Therapeutic Care (CTC) programme to treat severe acute malnutrition in Malawi: a descriptive study. BMC Infectious Diseases 8, 106.
    • (2008) BMC Infectious Diseases , vol.8 , pp. 106
    • Bahwere, P.1    Piwoz, E.2    Joshua, M.C.3    Sadler, K.4    Grobler-Tanner, C.H.5    Guerrero, S.6    Collins, S.7
  • 5
    • 1542527021 scopus 로고    scopus 로고
    • Nutritional physiology of whey and whey components
    • Barth C.A. & Behnke U. (1997) Nutritional physiology of whey and whey components. Die Nahrung 41, 2-12.
    • (1997) Die Nahrung , vol.41 , pp. 2-12
    • Barth, C.A.1    Behnke, U.2
  • 8
    • 0020308864 scopus 로고
    • 'Proving the null hypothesis' in clinical trials
    • Blackwelder W.C. (1982) 'Proving the null hypothesis' in clinical trials. Controlled Clinical Trials 3, 345-353.
    • (1982) Controlled Clinical Trials , vol.3 , pp. 345-353
    • Blackwelder, W.C.1
  • 11
    • 33745671270 scopus 로고    scopus 로고
    • The promise of a community-based approach to managing severe malnutrition: a case study from Ethiopia 15
    • Chaiken M.S., Deconinck H. & Degefie T. (2006) The promise of a community-based approach to managing severe malnutrition: a case study from Ethiopia 15. Food and Nutrition Bulletin 27, 95-104.
    • (2006) Food and Nutrition Bulletin , vol.27 , pp. 95-104
    • Chaiken, M.S.1    Deconinck, H.2    Degefie, T.3
  • 12
    • 33746848050 scopus 로고    scopus 로고
    • Home-based therapy for oedematous malnutrition with ready-to-use therapeutic food
    • Ciliberto M.A., Manary M.J., Ndekha M.J., Briend A. & Ashorn P. (2006) Home-based therapy for oedematous malnutrition with ready-to-use therapeutic food. Acta Paediatrica 95, 1012-1015.
    • (2006) Acta Paediatrica , vol.95 , pp. 1012-1015
    • Ciliberto, M.A.1    Manary, M.J.2    Ndekha, M.J.3    Briend, A.4    Ashorn, P.5
  • 13
    • 17844388592 scopus 로고    scopus 로고
    • Comparison of home-based therapy with ready-to-use therapeutic food with standard therapy in the treatment of malnourished Malawian children: a controlled, clinical effectiveness trial
    • Ciliberto M.A., Sandige H., Ndekha M.J., Ashorn P., Briend A., Ciliberto H.M. & Manary M.J. (2005) Comparison of home-based therapy with ready-to-use therapeutic food with standard therapy in the treatment of malnourished Malawian children: a controlled, clinical effectiveness trial. American Journal of Clinical Nutrition 81, 864-870.
    • (2005) American Journal of Clinical Nutrition , vol.81 , pp. 864-870
    • Ciliberto, M.A.1    Sandige, H.2    Ndekha, M.J.3    Ashorn, P.4    Briend, A.5    Ciliberto, H.M.6    Manary, M.J.7
  • 14
    • 34247877476 scopus 로고    scopus 로고
    • Treating severe acute malnutrition seriously
    • Collins S. (2007) Treating severe acute malnutrition seriously. Archives of Disease in Childhood 92, 453-461.
    • (2007) Archives of Disease in Childhood , vol.92 , pp. 453-461
    • Collins, S.1
  • 16
    • 84902541628 scopus 로고    scopus 로고
    • Alternative RUTF formulations. Emergency Nutrition Network special supplement[2], 35-37. Ref Type: Serial (Book, Monograph).
    • Collins S. & Henry C.J.K. Alternative RUTF formulations. Emergency Nutrition Network special supplement[2], 35-37. 2004. Ref Type: Serial (Book, Monograph).
    • (2004)
    • Collins, S.1    Henry, C.J.K.2
  • 18
    • 68949121935 scopus 로고    scopus 로고
    • Current and potential role of specially formulated foods and food supplements for preventing malnutrition among 6- to 23-month-old children and for treating moderate malnutrition among 6- to 59-month-old children
    • de Pee S. & Bloem M.W. (2009) Current and potential role of specially formulated foods and food supplements for preventing malnutrition among 6- to 23-month-old children and for treating moderate malnutrition among 6- to 59-month-old children. Food and Nutrition Bulletin 30 (Suppl. 3), S434-S463.
    • (2009) Food and Nutrition Bulletin , vol.30 , Issue.SUPPL. 3
    • de Pee, S.1    Bloem, M.W.2
  • 19
    • 84862082180 scopus 로고    scopus 로고
    • Low-cost, ready-to-use therapeutic foods can be designed using locally available commodities with the aid of linear programming
    • Dibari F., Diop El H.I., Collins S. & Seal A. (2012) Low-cost, ready-to-use therapeutic foods can be designed using locally available commodities with the aid of linear programming. The Journal of Nutrition 142, 955-961.
    • (2012) The Journal of Nutrition , vol.142 , pp. 955-961
    • Dibari, F.1    Diop El, H.I.2    Collins, S.3    Seal, A.4
  • 20
    • 0041567051 scopus 로고    scopus 로고
    • Comparison of the efficacy of a solid ready to use food and a liquid milk-based diet for the rehabilitation of severely malnourished children: a randomized trial
    • Diop E.H.I., Dossou N.I., Ndour M.M., Briend A. & Wade S. (2003) Comparison of the efficacy of a solid ready to use food and a liquid milk-based diet for the rehabilitation of severely malnourished children: a randomized trial. American Journal of Clinical Nutrition 78, 302-307.
    • (2003) American Journal of Clinical Nutrition , vol.78 , pp. 302-307
    • Diop, E.H.I.1    Dossou, N.I.2    Ndour, M.M.3    Briend, A.4    Wade, S.5
  • 21
    • 84902541623 scopus 로고    scopus 로고
    • Fellows, P. Local Production of RUTF. Emergency Nutrition Network Special supplement[2], 33-35. Ref Type: Generic.
    • Fellows, P. Local Production of RUTF. Emergency Nutrition Network Special supplement[2], 33-35. 2004. Ref Type: Generic.
    • (2004)
  • 22
    • 84902541624 scopus 로고    scopus 로고
    • Government of Malawi & Ministry of Health. Interim guidelines for the management of acute malnutrition through community-based therapeutic care. Ref Type: Generic.
    • Government of Malawi & Ministry of Health. Interim guidelines for the management of acute malnutrition through community-based therapeutic care. 2007. Ref Type: Generic.
    • (2007)
  • 23
    • 0038045562 scopus 로고    scopus 로고
    • Functional properties of whey, whey components, and essential amino acids: mechanisms underlying health benefits for active people (review)
    • Ha E. & Zemel M.B. (2003) Functional properties of whey, whey components, and essential amino acids: mechanisms underlying health benefits for active people (review). The Journal of Nutritional Biochemistry 14, 251-258.
    • (2003) The Journal of Nutritional Biochemistry , vol.14 , pp. 251-258
    • Ha, E.1    Zemel, M.B.2
  • 24
    • 79955504880 scopus 로고    scopus 로고
    • Transforming growth factor-beta, a whey protein component, strengthens the intestinal barrier by upregulating claudin-4 in HT-29/B6 cells
    • Hering N.A., Andres S., Fromm A., van Tol E.A., Amasheh M., Mankertz J., Fromm M. & Schulzke J.D. (2011) Transforming growth factor-beta, a whey protein component, strengthens the intestinal barrier by upregulating claudin-4 in HT-29/B6 cells. The Journal of Nutrition 141, 783-789.
    • (2011) The Journal of Nutrition , vol.141 , pp. 783-789
    • Hering, N.A.1    Andres, S.2    Fromm, A.3    van Tol, E.A.4    Amasheh, M.5    Mankertz, J.6    Fromm, M.7    Schulzke, J.D.8
  • 26
    • 84902541625 scopus 로고    scopus 로고
    • Milk-free soy-maize-sorghum based ready-to-use therapeutic food is non-inferior to standard RUTF with 25% milk among severely acutely malnourished Zambian children; cluster randomized trial. Ref Type: Unpublished Work.
    • Irena A., Bahwere P., Owino V.O., Diop E.H.I., Bachmann M.O., Mbwili M., Dibari F. & Collins S. Milk-free soy-maize-sorghum based ready-to-use therapeutic food is non-inferior to standard RUTF with 25% milk among severely acutely malnourished Zambian children; cluster randomized trial. 2012. Ref Type: Unpublished Work.
    • (2012)
    • Irena, A.1    Bahwere, P.2    Owino, V.O.3    Diop, E.H.I.4    Bachmann, M.O.5    Mbwili, M.6    Dibari, F.7    Collins, S.8
  • 27
    • 84953849363 scopus 로고    scopus 로고
    • Comparison of the effectiveness of a milk-free soy-maize-sorghum based ready-to-use therapeutic food to standard ready-to-use therapeutic food with 25% milk in nutrition management of severely acutely malnourished Zambian children: an equivalence non-blinded cluster randomized controlled trial
    • doi: 10.1111/mcn.12054
    • Irena A.H., Bahwere P., Owino V.O., Diop El H.I., Bachmann M.O., Mbwili-Muleya C., Dibari F., Sadler K. & Collins S. (2013) Comparison of the effectiveness of a milk-free soy-maize-sorghum based ready-to-use therapeutic food to standard ready-to-use therapeutic food with 25% milk in nutrition management of severely acutely malnourished Zambian children: an equivalence non-blinded cluster randomized controlled trial. Maternal and Child Nutrition. doi: 10.1111/mcn.12054
    • (2013) Maternal and Child Nutrition
    • Irena, A.H.1    Bahwere, P.2    Owino, V.O.3    Diop El, H.I.4    Bachmann, M.O.5    Mbwili-Muleya, C.6    Dibari, F.7    Sadler, K.8    Collins, S.9
  • 28
    • 0024260904 scopus 로고
    • Effect of isotope infusion and sampling sites on glucose kinetics during a euglycemic clamp
    • Jahoor F., Klein S., Miyoshi H. & Wolfe R.R. (1988) Effect of isotope infusion and sampling sites on glucose kinetics during a euglycemic clamp. The American Journal of Physiology 255 (6 Pt 1), E871-E874.
    • (1988) The American Journal of Physiology , vol.255 , Issue.6 PART 1
    • Jahoor, F.1    Klein, S.2    Miyoshi, H.3    Wolfe, R.R.4
  • 29
    • 4344584922 scopus 로고    scopus 로고
    • Sample sizes for clinical trials with normal data
    • Julious S.A. (2004) Sample sizes for clinical trials with normal data. Statistics in Medicine 23, 1921-1986.
    • (2004) Statistics in Medicine , vol.23 , pp. 1921-1986
    • Julious, S.A.1
  • 30
    • 33745931889 scopus 로고    scopus 로고
    • Good enough: a primer on the analysis and interpretation of noninferiority trials
    • Kaul S. & Diamond G.A. (2006) Good enough: a primer on the analysis and interpretation of noninferiority trials. Annals of Internal Medicine 145, 62-69.
    • (2006) Annals of Internal Medicine , vol.145 , pp. 62-69
    • Kaul, S.1    Diamond, G.A.2
  • 31
    • 67649849676 scopus 로고    scopus 로고
    • Probiotics and prebiotics for severe acute malnutrition (PRONUT study): a double-blind efficacy randomised controlled trial in Malawi
    • Kerac M., Bunn J., Seal A., Thindwa M., Tomkins A., Sadler K., Bahwere P. & Collins S. (2009) Probiotics and prebiotics for severe acute malnutrition (PRONUT study): a double-blind efficacy randomised controlled trial in Malawi. Lancet 374, 136-144.
    • (2009) Lancet , vol.374 , pp. 136-144
    • Kerac, M.1    Bunn, J.2    Seal, A.3    Thindwa, M.4    Tomkins, A.5    Sadler, K.6    Bahwere, P.7    Collins, S.8
  • 32
    • 84455160829 scopus 로고    scopus 로고
    • A novel fortified blended flour, corn-soy blend 'plus-plus', is not inferior to lipid-based ready-to-use supplementary foods for the treatment of moderate acute malnutrition in Malawian children
    • LaGrone L.N., Trehan I., Meuli G.J., Wang R.J., Thakwalakwa C., Maleta K. & Manary M.J. (2012) A novel fortified blended flour, corn-soy blend 'plus-plus', is not inferior to lipid-based ready-to-use supplementary foods for the treatment of moderate acute malnutrition in Malawian children. American Journal of Clinical Nutrition 95, 212-219.
    • (2012) American Journal of Clinical Nutrition , vol.95 , pp. 212-219
    • LaGrone, L.N.1    Trehan, I.2    Meuli, G.J.3    Wang, R.J.4    Thakwalakwa, C.5    Maleta, K.6    Manary, M.J.7
  • 34
    • 84902541626 scopus 로고    scopus 로고
    • Epidata entry version 3.02:A comprehensive tool for validated entry and documentation of data. [3.02]. The Epidata Association. Ref Type: Computer Program.
    • Lauritsen J.M. & Bruus M. Epidata entry version 3.02:A comprehensive tool for validated entry and documentation of data. [3.02]. 2003. The Epidata Association. Ref Type: Computer Program.
    • (2003)
    • Lauritsen, J.M.1    Bruus, M.2
  • 36
    • 34249889931 scopus 로고    scopus 로고
    • A large-scale operational study of home-based therapy with ready-to-use therapeutic food in childhood malnutrition in Malawi
    • Linneman Z., Matilsky D., Ndekha M., Manary M.J., Maleta K. & Manary M.J. (2007) A large-scale operational study of home-based therapy with ready-to-use therapeutic food in childhood malnutrition in Malawi. Maternal and Child Nutrition 3, 206-215.
    • (2007) Maternal and Child Nutrition , vol.3 , pp. 206-215
    • Linneman, Z.1    Matilsky, D.2    Ndekha, M.3    Manary, M.J.4    Maleta, K.5    Manary, M.J.6
  • 38
    • 34249876097 scopus 로고    scopus 로고
    • Local production and provision of ready-to-use therapeutic food (RUTF) spread for the treatment of severe childhood malnutrition
    • Manary M.J. (2006) Local production and provision of ready-to-use therapeutic food (RUTF) spread for the treatment of severe childhood malnutrition. Food and Nutrition Bulletin 27 (Suppl. 3), S83-S89.
    • (2006) Food and Nutrition Bulletin , vol.27 , Issue.SUPPL. 3
    • Manary, M.J.1
  • 39
    • 3042686006 scopus 로고    scopus 로고
    • Therapeutic applications of whey protein
    • Marshall K. (2004) Therapeutic applications of whey protein. Alternative Medicine Review 9, 136-156.
    • (2004) Alternative Medicine Review , vol.9 , pp. 136-156
    • Marshall, K.1
  • 41
    • 0027347215 scopus 로고
    • Whey protein concentrates and isolates: processing and functional properties
    • Morr C.V. & Ha E.Y. (1993) Whey protein concentrates and isolates: processing and functional properties. Critical Reviews in Food Science and Nutrition 33, 431-476.
    • (1993) Critical Reviews in Food Science and Nutrition , vol.33 , pp. 431-476
    • Morr, C.V.1    Ha, E.Y.2
  • 42
    • 0033996318 scopus 로고    scopus 로고
    • Integrated management of childhood illness in resource-poor countries: an initiative from the World Health Organization
    • Nicoll A. (2000) Integrated management of childhood illness in resource-poor countries: an initiative from the World Health Organization. Transactions of the Royal Society of Tropical Medicine and Hygiene 94, 9-11.
    • (2000) Transactions of the Royal Society of Tropical Medicine and Hygiene , vol.94 , pp. 9-11
    • Nicoll, A.1
  • 43
    • 0032105409 scopus 로고    scopus 로고
    • A double-blind placebo-controlled pilot study of glutamine therapy for abnormal intestinal permeability in patients with AIDS
    • Noyer C.M., Simon D., Borczuk A., Brandt L.J., Lee M.J. & Nehra V. (1998) A double-blind placebo-controlled pilot study of glutamine therapy for abnormal intestinal permeability in patients with AIDS. The American Journal of Gastroenterology 93, 972-975.
    • (1998) The American Journal of Gastroenterology , vol.93 , pp. 972-975
    • Noyer, C.M.1    Simon, D.2    Borczuk, A.3    Brandt, L.J.4    Lee, M.J.5    Nehra, V.6
  • 44
    • 78649607113 scopus 로고    scopus 로고
    • A ready-to-use therapeutic food containing 10% milk is less effective than one with 25% milk in the treatment of severely malnourished children
    • Oakley E., Reinking J., Sandige H., Trehan I., Kennedy G., Maleta K. & Manary M. (2010) A ready-to-use therapeutic food containing 10% milk is less effective than one with 25% milk in the treatment of severely malnourished children. Journal of Nutrition 140, 2248-2252.
    • (2010) Journal of Nutrition , vol.140 , pp. 2248-2252
    • Oakley, E.1    Reinking, J.2    Sandige, H.3    Trehan, I.4    Kennedy, G.5    Maleta, K.6    Manary, M.7
  • 45
    • 77951589144 scopus 로고    scopus 로고
    • The rationale for consuming protein blends in sports nutrition
    • Paul G.L. (2009) The rationale for consuming protein blends in sports nutrition. Journal of the American College of Nutrition 28 (Suppl.), 464S-472S.
    • (2009) Journal of the American College of Nutrition , vol.28 , Issue.SUPPL.
    • Paul, G.L.1
  • 49
  • 51
    • 84902551707 scopus 로고    scopus 로고
    • Health benefits of whey protein: a review
    • Available at:(Accessed 26 June 2013)
    • Solak B.B. & Akin N. (2012) Health benefits of whey protein: a review. Journal of Food Science and Engineering 2, 129-137. Available at: http://www.davidpublishing.com/davidpublishing/Upfile/4/24/2012/2012042401763045.pdf (Accessed 26 June 2013)
    • (2012) Journal of Food Science and Engineering , vol.2 , pp. 129-137
    • Solak, B.B.1    Akin, N.2
  • 52
    • 77949558576 scopus 로고    scopus 로고
    • StataCorp StataCorp LP: College Station, TX.
    • StataCorp (2009) Stata Release 11. Statistical Software. StataCorp LP: College Station, TX.
    • (2009) Stata Release 11. Statistical Software
  • 53
    • 44649095701 scopus 로고    scopus 로고
    • HIV prevalence in severely malnourished children admitted to nutrition rehabilitation units in Malawi: geographical & seasonal variations a cross-sectional study
    • Thurstans S., Kerac M., Maleta K., Banda T. & Nesbitt A. (2008) HIV prevalence in severely malnourished children admitted to nutrition rehabilitation units in Malawi: geographical & seasonal variations a cross-sectional study. BMC Pediatrics 8, 22.
    • (2008) BMC Pediatrics , vol.8 , pp. 22
    • Thurstans, S.1    Kerac, M.2    Maleta, K.3    Banda, T.4    Nesbitt, A.5
  • 55
    • 84902541627 scopus 로고    scopus 로고
    • WHO, UNICEF, SCN Joint statement on the community-based management of severe malnutrition in children. Ref Type: Hearing.
    • WHO, UNICEF, & SCN Joint statement on the community-based management of severe malnutrition in children. 2007. Ref Type: Hearing.
    • (2007)
  • 56
    • 33646515568 scopus 로고    scopus 로고
    • Emerging therapeutic potential of whey proteins and peptides
    • Yalcin A.S. (2006) Emerging therapeutic potential of whey proteins and peptides. Current Pharmaceutical Design 12, 1637-1643.
    • (2006) Current Pharmaceutical Design , vol.12 , pp. 1637-1643
    • Yalcin, A.S.1
  • 57
    • 84878811495 scopus 로고    scopus 로고
    • Outpatient therapeutic feeding program outcomes and determinants in treatment of severe acute malnutrition in tigray, northern ethiopia: a retrospective cohort study
    • Yebyo H.G., Kendall C., Nigusse D. & Lemma W. (2013) Outpatient therapeutic feeding program outcomes and determinants in treatment of severe acute malnutrition in tigray, northern ethiopia: a retrospective cohort study. PLoS ONE 8, e65840.
    • (2013) PLoS ONE , vol.8
    • Yebyo, H.G.1    Kendall, C.2    Nigusse, D.3    Lemma, W.4
  • 58
    • 33644834318 scopus 로고    scopus 로고
    • The role of dairy foods in weight management
    • Zemel M.B. (2005) The role of dairy foods in weight management. Journal of the American College of Nutrition 24 (Suppl. 6), 537S-546S.
    • (2005) Journal of the American College of Nutrition , vol.24 , Issue.SUPPL. 6
    • Zemel, M.B.1


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