Risk of congenital malformations among offspring of mothers and fathers with celiac disease: A nationwide cohort study

Clinical Gastroenterology and Hepatology

Volumn 12, Issue 7, 2014, Pages

  Zugna, Daniela ^a,b   Richiardi, Lorenzo ^a   Stephansson, Olof ^b   Pasternak, Björn ^c   Ekbom, Anders ^b   Cnattingius, Sven ^b   Ludvigsson, Jonas F ^b,d  

^a UNIVERSITY OF TURIN   (Italy)

^b KAROLINSKA INSTITUTE   (Sweden)

^c STATENS SERUM INSTITUT   (Denmark)

^d ÖREBRO UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Autoimmunity; Celiac; Child; Congenital malformation; Gluten intolerance

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CELIAC DISEASE; COHORT ANALYSIS; CONFIDENCE INTERVAL; CONGENITAL MALFORMATION; FATHER; FEMALE; HISTOPATHOLOGY; HUMAN; INTESTINE VILLUS ATROPHY; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MOTHER; PREVALENCE; PROGENY; REGISTER; SWEDEN;

EID: 84902544553     PISSN: 15423565     EISSN: 15427714     Source Type: Journal    
DOI: 10.1016/j.cgh.2013.10.012     Document Type: Article

References (52)

1. Ludvigsson J.F., Green P.H. Clinical management of coeliac disease. JIntern Med 2011, 269:560-571.
2. Sollid L.M., Markussen G., Ek J., et al. Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer. JExp Med 1989, 169:345-350.
3. Martinelli P., Troncone R., Paparo F., et al. Coeliac disease and unfavourable outcome of pregnancy. Gut 2000, 46:332-335.
4. Tata L.J., Card T.R., Logan R.F., et al. Fertility and pregnancy-related events in women with celiac disease: a population-based cohort study. Gastroenterology 2005, 128:849-855.
5. Ludvigsson J.F., Montgomery S.M., Ekbom A. Celiac disease and risk of adverse fetal outcome: a population-based cohort study. Gastroenterology 2005, 129:454-463.
6. Folic acid and statistics 2013, Volume 2013. Centers for Disease Control and Prevention, CDC, Center for Disease Control and Prevention, Available at: http://www.cdc.gov/ncbddd/folicacid/data.html. Accessed May 28, 2013.
7. Bode S., Gudmand-Hoyer E. Symptoms and haematologic features in consecutive adult coeliac patients. Scand J Gastroenterol 1996, 31:54-60.
8. Saibeni S., Lecchi A., Meucci G., et al. Prevalence of hyperhomocysteinemia in adult gluten-sensitive enteropathy at diagnosis: role of B12, folate, and genetics. Clin Gastroenterol Hepatol 2005, 3:574-580.
9. Hallert C., Grant C., Grehn S., et al. Evidence of poor vitamin status in coeliac patients on a gluten-free diet for 10 years. Aliment Pharmacol Ther 2002, 16:1333-1339.
10. Yazynina E., Johansson M., Jägerstad M., et al. Low folate content in gluten-free cereal products and their main ingredients. Food Chemistry 2008, 111:236-242.
11. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group. Lancet 1991, 338:131-137.
12. Berry R.J., Li Z., Erickson J.D., et al. Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention corrected. NEngl J Med 1999, 341:1485-1490.
13. Blencowe H., Cousens S., Modell B., et al. Folic acid to reduce neonatal mortality from neural tube disorders. Int J Epidemiol 2010, 39(Suppl 1):i110-i121.
14. Carmichael S.L., Shaw G.M., Schaffer D.M., et al. Dieting behaviors and risk of neural tube defects. Am J Epidemiol 2003, 158:1127-1131.
15. Badovinac R.L., Werler M.M., Williams P.L., et al. Folic acid-containing supplement consumption during pregnancy and risk for oral clefts: a meta-analysis. Birth Defects Res A Clin Mol Teratol 2007, 79:8-15.
16. Bille C., Murray J.C., Olsen S.F. Folic acid and birth malformations. BMJ 2007, 334:433-434.
17. Bailey L.B., Berry R.J. Folic acid supplementation and the occurrence of congenital heart defects, orofacial clefts, multiple births, and miscarriage. Am J Clin Nutr 2005, 81:1213S-1217S.
18. Wilcox A.J., Lie R.T., Solvoll K., et al. Folic acid supplements and risk of facial clefts: national population based case-control study. BMJ 2007, 334:464.
19. Shaw G.M., O'Malley C.D., Wasserman C.R., et al. Maternal periconceptional use of multivitamins and reduced risk for conotruncal heart defects and limb deficiencies among offspring. Am J Med Genet 1995, 59:536-545.
20. Robitaille J., Carmichael S.L., Shaw G.M., et al. Maternal nutrient intake and risks for transverse and longitudinal limb deficiencies: data from the National Birth Defects Prevention Study, 1997-2003. Birth Defects Res A Clin Mol Teratol 2009, 85:773-779.
21. de Almeida R.C., Lima B.O., Castro L.C., et al. Maternal celiac disease: improbable risk factor for neural tube defect. Eur J Gastroenterol Hepatol 2009, 21:805-808.
22. Dickey W., Stewart F., Nelson J., et al. Screening for coeliac disease as a possible maternal risk factor for neural tube defect. Clin Genet 1996, 49:107-108.
23. Hozyasz K.K. Coeliac disease and birth defects in offspring. Gut 2001, 49:738.
24. Congdon P.J., Fiddler G.I., Littlewood J.M., et al. Coeliac disease associated with congenital heart disease. Arch Dis Child 1982, 57:78-79.
25. McNeish A.S., Anderson C.M. Coeliac disease. The disorder in childhood. Clin Gastroenterol 1974, 3:127-144.
26. Haslam N., Lock R.J., Unsworth D.J. Coeliac disease, anaemia and pregnancy. Clin Lab 2001, 47:467-469.
27. Ludvigsson J.F., Brandt L., Montgomery S.M., et al. Validation study of villous atrophy and small intestinal inflammation in Swedish biopsy registers. BMC Gastroenterol 2009, 9:19.
28. Cnattingius S., Ericson A., Gunnarskog J., et al. Aquality study of a medical birth registry. Scand J Soc Med 1990, 18:143-148.
29. Ludvigsson J.F., Andersson E., Ekbom A., et al. External review and validation of the Swedish national inpatient register. BMC Public Health 2011, 11:450.
30. Missbildningsregistrering 2004. Stockholm,2005.
31. Ekbom A. The Swedish Multi-generation Register. Methods Mol Biol 2011, 675:215-220.
32. Ludvigsson J.F., Otterblad-Olausson P., Pettersson B.U., et al. The Swedish personal identity number: possibilities and pitfalls in healthcare and medical research. Eur J Epidemiol 2009, 24:659-667.
33. Marsh M.N. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). Gastroenterology 1992, 102:330-354.
34. Ludvigsson J.F., Montgomery S.M., Ekbom A., et al. Small-intestinal histopathology and mortality risk in celiac disease. JAMA 2009, 302:1171-1178.
35. Vrijheid M., Dolk H., Stone D., et al. Socioeconomic inequalities in risk of congenital anomaly. Arch Dis Child 2000, 82:349-352.
36. SNBHW. The Swedish Medical Birth Register: a summary of content and quality. Stockholm, Sweden: Swedish National Board of Health and Welfare, 2003. Available at: http://www.sos.se/fulltext/112/2003-112-3/2003-112-3.pdf.
37. Johannesson I. The Total Population Register of Statistics Sweden. New possibilities and better quality. Statistics Sweden 2002.
38. Peduzzi P., Concato J., Feinstein A.R., et al. Importance of events per independent variable in proportional hazards regression analysis. II. Accuracy and precision of regression estimates. JClin Epidemiol 1995, 48:1503-1510.
39. Farthing M.J., Edwards C.R., Rees L.H., et al. Male gonadal function in coeliac disease: 1. Sexual dysfunction, infertility, and semen quality. Gut 1982, 23:608-614.
40. Stahl O., Boyd H.A., Giwercman A., et al. Risk of birth abnormalities in the offspring of men with a history of cancer: a cohort study using Danish and Swedish national registries. JNatl Cancer Inst 2011, 103:398-406.
41. Hernandez-Diaz S., Werler M.M., Walker A.M., et al. Folic acid antagonists during pregnancy and the risk of birth defects. NEngl J Med 2000, 343:1608-1614.
42. Gardiner H.M., Fouron J.C. Folic acid fortification and congenital heart disease. BMJ 2009, 338:b1144.
43. van Beynum I.M., Kapusta L., Bakker M.K., et al. Protective effect of periconceptional folic acid supplements on the risk of congenital heart defects: a registry-based case-control study in the northern Netherlands. Eur Heart J 2010, 31:464-471.
44. Goldmuntz E., Woyciechowski S., Renstrom D., et al. Variants of folate metabolism genes and the risk of conotruncal cardiac defects. Circ Cardiovasc Genet 2008, 1:126-132.
45. Smedby K.E., Akerman M., Hildebrand H., et al. Malignant lymphomas in coeliac disease: evidence of increased risks for lymphoma types other than enteropathy-type T cell lymphoma. Gut 2005, 54:54-59.
46. Ludvigsson J.F., Rubio-Tapia A., van Dyke C.T., et al. Increasing incidence of celiac disease in a North American population. Am J Gastroenterol 2013, 108:818-824.
47. Anneren G, Ollars B. Report on periconceptional folic acid supplementation for Sweden: Eurocrat Network EU. 2007.
48. Ericson A., Kallen B., Aberg A. Use of multivitamins and folic acid in early pregnancy and multiple births in Sweden. Twin Res 2001, 4:63-66.
49. De Wals P., Tairou F., Van Allen M.I., et al. Reduction in neural-tube defects after folic acid fortification in Canada. NEngl J Med 2007, 357:135-142.
50. Socialstyrelsen. Birth defects 2009 (Fosterskador och kromosomavvikelser). National Board of Health and Welfare. Stockholm,2009.
51. EUROCAT. EUROCAT prevalence tables (European surveillance of congenital anomalies). Volume2013.
52. Rampertab S.D., Pooran N., Brar P., et al. Trends in the presentation of celiac disease. Am J Med 2006, 119. 355.e9-14.