Protective effect of periconceptional folic acid supplements on the risk of congenital heart defects: A registry-based case-control study in the northern Netherlands

European Heart Journal

Volumn 31, Issue 4, 2010, Pages 464-471

  Van Beynum, Ingrid M ^a   Kapusta, Livia ^a   Bakker, Marian K ^b   Den Heijer, Martin ^a   Blom, Henk J ^a,c   De Walle, Hermien E K ^b  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Congenital heart defects; Epidemiology; Periconceptional folic acid use; Prevention; Registries

Indexed keywords

FOLIC ACID;

ADOLESCENT; ADULT; ALCOHOL CONSUMPTION; ARTICLE; BODY MASS; CHROMOSOME DISORDER; CONGENITAL HEART MALFORMATION; DATA BASE; DELIVERY; EDUCATIONAL STATUS; FEMALE; GENETIC DISORDER; HEART SEPTUM DEFECT; HUMAN; INFANT; MAJOR CLINICAL STUDY; MATERNAL AGE; NETHERLANDS; PRIORITY JOURNAL; SMOKING; VITAMIN SUPPLEMENTATION;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; DIETARY SUPPLEMENTS; FEMALE; FOLIC ACID; HEART DEFECTS, CONGENITAL; HUMANS; MIDDLE AGED; NETHERLANDS; PRECONCEPTION CARE; PREGNANCY; REGISTRIES; RISK FACTORS; VITAMIN B COMPLEX; YOUNG ADULT;

EID: 77249110308     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehp479     Document Type: Article

References (35)

1. Hoffman JI, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol 2002;39:1890-1900.
2. Eurocat Northern Netherlands. Prevalence of congenital malformations in the Northern Netherlands 1981-2005. Available from http://www.rug.nl/umcg/ faculteit/disciplinegroepen/MedischeGenetica/Eurocat/professionals/tabellen (1 August 2007).
3. Bruins CL, Temmermans AM. Kindercardiologie in Nederland in de tachtiger jaren (Pediatric cardiology in the Netherlands). Verslag van NHS project 84-143: Voorkomen en prognose van hart en vaatafwijkingen bij jeugdigen in Nederland. Report 84-143 of the Netherlands Heart Foundation, The Hague, 1990.
4. MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 1991;338:131-137.
5. Czeizel AE, Dudas I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 1992;327:1832-1835.
6. Czeizel AE. Periconceptional folic acid containing multivitamin supplementation. Eur J Obstst Gynecol Reprod Biol 1998;78:151-161.
7. Botto LD, Mulinare J, Erickson JD. Occurrence of congenital heart defects in relation to maternal multivitamin use. Am J Epidemiol 2000;151:878-884.
8. Shaw GM, O?Malley CD, Wasserman CR, Tolarova MM, Lammer EJ. Maternal periconceptional use of multivitamins and reduced risk for conotruncal heart defects and limb deficiencies among offspring. Am J Med Genet 1995;59:536-545.
9. Scanlon KS, Ferencz C, Loffredo CA, Wilson PD, Correa-Villasenor A, Khoury MJ, Willett WC. Periconceptional folate intake and malformations of the cardiac outflow tract. Epidemiology 1998;9:95-98.
10. Werler MM, Hayes C, Louik C, Shapiro S, Mitchell AA. Multivitamin supplementation and risk of birth defects. Am J Epidemiol 1999;150:675-682.
11. Inspectorate of Public Health (The Netherlands). Prevention of neural tube defects. Continued advice concerning folic acid use in relation to neural tube defects. [Vervolgadvies inzake foliumzuurvoorziening in relatie tot neuraalbuisdefecten]. The Hague: Inspectorate of Public Health;1993
12. de Walle HEK, de Jong-van den Berg LTW. Ten years after the Dutch public health campaign on folic acid: the continuing challenge. Eur J Clin Pharmacol 2008;64:539-543.
13. Riehle-Colarusso T, Strickland MJ, Reller MD, Mahle WT, Botto LD, Siffel C, Atkinson M, Correa A. Improving the quality of surveillance data on congenital heart defects in the metropolitan Atlanta congenital defects program. Birth Defects Res (Part A) 2007;79:743-753.
14. Botto LD, Lin AE, Riehle-Colarusso T, Malik S, Correa A National Birth Defects Prevention Study. Seeking causes: classifying and evaluating congenital heart defects in etiologic studies. Birth Defects Res (Part A) 2007;79:714-727.
15. Wilcox AJ, Lie RT, Solvoll K, Taylor J, McConnaughey DR, Abyholm F, Vindenes H, Vollset SE, Drevon CA. Folic supplements and risk of facial clefts: national population based case-control study. Br Med J 2007;334:464.
16. Yang Q, Khoury MJ, Olney RS, Mulinare J. Does periconceptional multivitamin use reduce the risk for limb deficiency in offspring? Epidemiology 1997;8:157-161.
17. de Walle HEK, van der Pal KM, de Jong-van den Berg LTW, Jeeninga W, Schouten JSAG, de Rover CM, Buitendijk SE, Cornel MC. Effect of mass media campaign to reduce socioeconomic differences in women?s awareness and behaviour concerning use of folic acid: cross sectional study. Br Med J 1999; 319:291-292.
18. de Walle HEK, Cornel MC, de Jong-van den Berg LTW. Three years after the Dutch folic acid campaign: growing socioeconomic differences. Prev Med 2002; 35:65-69.
19. de Walle HEK, de Jong-van den Berg LTW. Insufficient folic acid intake in the Netherlands: what about the future? Teratology 66:40-43.
20. de Walle HEK, de Jong-van den Berg LTW. Growing gap in folic acid intake with respect to level of education in the Netherlands. Community Genet 2007;10: 93-96.
21. Larsen WJ. Human Embryology. 3rd ed. New York: Churchill Livingstone; 2001. 157-234.
22. Czeizel AE, Rockenbauer M, Sorensen HT, Olsen J. The teratogenic risk of trimethoprim-sulfonamides: a population based case-control study. Reprod Toxicol 2001;15:637-646.
23. Hernandez-Diaz S, Werler MM, Walker AM, Mitchell AA. Folic acid antagonists during pregnancy and the risk of birth defects. N Engl J Med 2000;343:1608-1614.
24. Aberg A, Westbom L, Källen B. Congenital malformations among infants whose mothers had gestational diabetes or preexisting diabetes. Early Hum Dev 2001; 61:85-95.
25. Nielsen GL, Norgard B, Puho E, Rothman KJ, Sorensen HT, Czeizel AE. Risk of specific congenital abnormalities in offspring of women with diabetes. Diabetes Med 2005;22:693-696. (Pubitemid 40805888)
26. Botto LD, Khoury MJ, Mulinare J, Erickson JD. Periconceptional multivitamin use and the occurrence of conotruncal heart defects: results from a population-based, case-control. Pediatrics 1996;98:911-917.
27. Zhu H, Wlodarczyk BJ, Scott M, Yu W, Merriweather M, Gelineau-van Waes J, Schwartz RJ, Finnell RH. Cardiovascular abnormalities in Folr1 knockout mice and folate rescue. Birth Defects Res (Part A) 2007;79:257-268.
28. Tang LS, Wlodarczyk BJ, Santillano DR, Miranda RC, Finnell RH. Development consequences of abnormal folate transport during murine heart morphogenesis. Birth Defects Res (Part A) 2004;70:449-458.
29. Blom HJ, Shaw GM, den Heijer M, Finnell RH. Neural tube defects and folate: case far from closed. Nat Rev Neurosci 2006;7:724-731.
30. Botto LD, Correa A. Decreasing the burden of congenital heart anomalies: an epi-demiologic evaluation of risk factors and survival. Prog Pediatr Cardiol 2003;18: 111-121.
31. Roguin N, Du ZD, Barak M, Nasser N, Hershkowithz S, Milgram E. High prevalence of muscular ventricular septal defect in neonates. J Am Coll Cardiol 1995; 26:1545-1548.
32. Du ZD, Roguin N, Barak M, Bihari SG, Ben-Elisha M. High prevalence of muscular ventricular septal defect in preterm neonates. Am J Cardiol 1996;78:1183-1185.
33. Hoffman JIE, Kaplan S, Liberthson RR. Prevalence of congenital heart disease. Am Heart J 2004;147:425-439.
34. Ray JG, Wyatt PR, Vermeulen MJ, Meier C, Cole DE. Greater maternal weight and the ongoing risk of neural tube defects after folic acid flour fortification. Obstet Gynecol 2005;105:261-265.
35. Mojtabai R. Body mass index and serum folate in childbearing age women. Eur J Epidemiol 2004;19:1029-1036.