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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 14, 2014, Pages 3092-3095

Preparation and biological evaluation of 1′-cyano-2′-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors

(11) Mish, Michael R a Cho, Aesop a Kirschberg, Thorsten a Xu, Jie a Sebastian Zonte, C a Fenaux, Martijn a Park, Yeojin a Babusis, Darius a Feng, Joy Y a Ray, Adrian S a Kim, Choung U a

a GILEAD SCIENCES (United States)

Author keywords

HCV antivirals; NS5B polymerase inhibitor; Nucleotide phosphoramidate prodrugs; Pyrimidine nucleoside analogs

Indexed keywords

1' CYANO 2' C METHYL PYRIMIDINE NUCLEOSIDE; 1' CYANO 2' C METHYL URIDINE; C NUCLEOSIDE; CYTIDINE DEAMINASE; LEWIS ACID; NONSTRUCTURAL PROTEIN 5B; NUCLEOSIDE ANALOG; NUCLEOSIDE TRIPHOSPHATE; PYRIMIDINE NUCLEOSIDE DERIVATIVE; SOFOSBUVIR; UNCLASSIFIED DRUG; URIDINE DERIVATIVE; VALOPICITABINE; ANTIVIRUS AGENT; ENZYME INHIBITOR; NS-5 PROTEIN, HEPATITIS C VIRUS; NUCLEOSIDE; PYRIMIDINE NUCLEOSIDE; RNA DIRECTED RNA POLYMERASE; VIRUS PROTEIN; 1' CYANO 2' C METHYL CYTIDINE; GS 6620; PRODRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DEAMINATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HEPATITIS C VIRUS; PROTON NUCLEAR MAGNETIC RESONANCE; REPLICON; VIRUS REPLICATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CONFORMATION; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; HEPACIVIRUS; METABOLISM; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS; BIOLOGICAL ACTIVITY; ENZYME INHIBITION; HEPATITIS C; NONHUMAN;

HEPATITIS C VIRUS;

ANTIVIRAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HEPACIVIRUS; MICROBIAL SENSITIVITY TESTS; MOLECULAR CONFORMATION; NUCLEOSIDES; PYRIMIDINE NUCLEOSIDES; RNA REPLICASE; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84902537934 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.05.015 Document Type: Article

Times cited : (14)

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