Circulating autoantibodies and autoimmune comorbidities in vitiligo patients: A multicenter Italian study

Dermatology

Volumn 228, Issue 3, 2014, Pages 240-249

  Ingordo, Vito ^a,l   Cazzaniga, Simone ^c   Raone, Beatrice ^d   Digiuseppe, Maria Donata ^b,l   Musumeci, Maria Letizia ^e,l   Fai, Dario ^f,l   Pellegrino, Michele ^g,l   Pezzarossa, Enrico ^h,l   Di Lernia, Vito ^i,l   Battarra, Vincenzo Claudio ^j,l   Sirna, Riccardo ^k,l   Patrizi, Annalisa ^d,l   Naldi, Luigi ^c,l  

^a Taranto Local Health Unit   (Italy)

^b SS Annunziata Hospital   (Italy)

^c FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^d UNIVERSITY OF BOLOGNA   (Italy)

^e UNIVERSITY OF CATANIA   (Italy)

^f Outpatient Department of Dermatology Romasi Hospital   (Italy)

^g UNIVERSITY OF SIENA   (Italy)

^h Department of Dermatology Istituti Ospitalieri di Cremona ^*  (Italy)

ⁱ S MARIA NUOVA HOSPITAL   (Italy)

^j S ANNA HOSPITAL   (Italy)

^k Local Health Unit   (Italy)

^l Dermatoepidemiology and Evidence Based Dermatology Study Group of ADOI   (Italy)

more..

Author keywords

Autoimmune comorbidities; Circulating autoantibodies; Multicenter Italian study; Vitiligo

Indexed keywords

PARIETAL CELL ANTIBODY; THYROID ANTIBODY; THYROID PEROXIDASE; AUTOANTIBODY; ANTINUCLEAR ANTIBODY; CALCINEURIN; CORTICOSTEROID; THYROGLOBULIN;

ADULT; ANTIBODY DETECTION; ARTICLE; ASTHMA; AUTOIMMUNE THYROIDITIS; CAUCASIAN; COMORBIDITY; DISEASE COURSE; DISEASE DURATION; DYSGAMMAGLOBULINEMIA; FAMILY HISTORY; FEMALE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; OUTPATIENT CARE; PHYSICAL EXAMINATION; PREVALENCE; PRIORITY JOURNAL; SUBCLINICAL HYPERTHYROIDISM; SUBCLINICAL HYPOTHYROIDISM; THYROID FUNCTION; VITILIGO; ADOLESCENT; AGE DISTRIBUTION; AGED; ANALYSIS OF VARIANCE; AUTOIMMUNE DISEASES; BLOOD; CHILD; CLINICAL TRIAL; COHORT ANALYSIS; CONFIDENCE INTERVAL; IMMUNOLOGY; ITALY; MIDDLE AGED; MULTICENTER STUDY; MULTIVARIATE ANALYSIS; PATHOPHYSIOLOGY; PRESCHOOL CHILD; PROGNOSIS; RETROSPECTIVE STUDY; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; SEX RATIO; STATISTICAL MODEL; VERY ELDERLY; YOUNG ADULT; AUTOIMMUNE DISEASE; AUTOIMMUNITY; BODY SURFACE; CONTROLLED STUDY; ECHOGRAPHY; HYPERTHYROIDISM; HYPOTHYROIDISM; OBSERVATIONAL STUDY; ONSET AGE; PHOTOTHERAPY; THYROID FUNCTION TEST;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; AUTOANTIBODIES; AUTOIMMUNE DISEASES; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; COMORBIDITY; CONFIDENCE INTERVALS; FEMALE; HUMANS; ITALY; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PREVALENCE; PROGNOSIS; RETROSPECTIVE STUDIES; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; SEX DISTRIBUTION; VITILIGO; YOUNG ADULT;

EID: 84902532788     PISSN: 10188665     EISSN: 14219832     Source Type: Journal    
DOI: 10.1159/000357807     Document Type: Article

References (58)

1. Kovacs SO: Vitiligo. J Am Acad Dermatol 1998; 38: 647-666
2. Alkhateeb A, Fain PR, Thody A, Bennet DC, Spritz RA: Epidemiology of vitiligo and associated autoimmune diseases in Caucasian probands and their relatives. Pigment Cell Res 2003; 16: 208-214. (Pubitemid 36597056
3. Taieb A, Picardo M; VETF Members: The definition and assessment of vitiligo: A consensus report of the Vitiligo European Task Force. Pigment Cell Res 2007; 20: 27-35. (Pubitemid 46090162
4. Gawkrodger DJ, Ormerod AD, Shaw L, Mauri-Sole I, Whitton ME, Watts MJ, Anstey AV, Ingham J, Young K; Therapy Guidelines and Audit Subcommittee, British Association of Dermatologists; Clinical Standards Department, Royal College of Physicians of London; Cochrane Skin Group; Vitiligo Society: Guideline for the diagnosis and management of vitiligo. Br J Dermatol 2008; 159: 1051-1076
5. Le Poole IC, Luiten RM: Autoimmune etiology of generalized vitiligo. Curr Dir Autoimmun 2008; 10: 227-243
6. Mason CP, Gawkrodger DJ: Vitiligo presentation in adults. Clin Exp Dermatol 2005; 30: 344-345. (Pubitemid 40835323
7. Betterle C, Caretto A, De Zio A, Pedini B, Veller-Fornasa C, Cecchetto A, Accordi F, Peserico A: Incidence and significance of organ-specific autoimmune disorders (clinical, latent or only autoantibodies) in patients with vitiligo. Dermatologica 1985; 171: 419-423. (Pubitemid 16127755
8. Barona MI, Arrunategui A, Falabella R, Alzate A: An epidemiologic case-control study in a population with vitiligo. J Am Acad Dermatol 1995; 33: 621-625
9. Zettinig G, Tanew A, Fischer G, Mayr W, Dudzac R, Weissel M: Autoimmune diseases in vitiligo: Do anti-nuclear antibodies decrease thyroid volume?. Clin Exp Immunol 2003; 131: 347-354
10. Mandry RC, Ortiz LJ, Lugo-Somolinos A, Sanchez JL: Organ-specific autoantibodies in vitiligo patients and their relatives. Int J Dermatol 1996; 35: 18-21. (Pubitemid 26034118
11. Zauli D, Tosti A, Biasco G, Miserocchi F, Patrizi A, Azzaroni D, Andriani G, Di Febo G, Callegari C: Prevalence of autoimmune atrophic gastritis in vitiligo. Digestion 1986; 34: 169-172. (Pubitemid 16064242
12. Rodriguez-Martin M, Saez M, Merino de Paz N, Ferrer PC, Eliche MP, Rodriguez-Martin B, Cabrera AN: When are laboratory tests indicated in patients with vitiligo?. Dermatoendocrinol 2012; 4: 53-57
13. Pradhan V, Patwardhan M, Thakkar V, Kharkar V, Khopkar U, Ghosh K, Weetman AP, Gawkrodger DJ, Kemp EH: Vitiligo patients from India (Mumbai) show differences in clinical, demographic and autoantibody profiles compared to patients in western countries. J Eur Acad Dermatol Venereol 2013; 27: 279-286
14. Narita T, Oiso N, Fukai K, Kabashima K, Kawada A, Suzuki T: Generalized vitiligo and associated autoimmune diseases in Japanese patients and their families. Allergol Int 2011; 60: 505-508
15. Poojary SA: Vitiligo and associated autoimmune disorders: A retrospective hospitalbased study in Mumbai, India. Allergol Immunopathol (Madr) 2011; 39: 356-361
16. Akay BN, Bozkir M, Anadolu Y, Gullu S: Epidemiology of vitiligo, associated autoimmune diseases and audiological abnormalities: Ankara study of 80 patients in Turkey. J Eur Acad Dermatol Venereol 2010; 24: 1144-1150
17. Tanioka M, Yamamoto Y, Katoh M, Takahashi K, Miyachi Y: Vitiligo vulgaris and autoimmune diseases in Japan: A report from vitiligo clinic in Kyoto University Hospital. Dermatoendocrinol 2009; 1: 43-45
18. Sheth VM, Guo Y, Qureshi AA: Comorbidities associated with vitiligo: A ten-year retrospective study. Dermatology 2013; 227: 311-315
19. Spritz RA: Six decades of vitiligo genetics: Genome-wide studies provide insights into autoimmune pathogenesis. J Invest Dermatol 2012; 132: 268-273
20. Bystryn JC: Serum antibodies in vitiligo patients. Clin Dermatol 1989; 7: 136-145
21. Shankar DS, Shashikala K, Madala R: Clinical patterns of vitiligo and its associated comorbidities: A prospective controlled cross-sectional study in South India. Indian Dermatol Online J 2012; 3: 114-118
22. Laberge G, Mailloux CM, Gowan K, Holland P, Bennett DC, Fain PR, Spritz RA: Early disease onset and increased risk of other autoimmune diseases in familial generalized vitiligo. Pigment Cell Res 2005; 18: 300-305. (Pubitemid 41032889
23. Karelson M, Silm H, Salum T, Koks S, Kingo K: Differences between familial and sporadic cases of vitiligo. J Eur Acad Dermatol Venereol 2012; 26: 915-918
24. Amerio P, Di Rollo D, Carbone A, Auriemma M, Marra ME, De Remigis P, Feliciani C, Tracanna M, Tulli A: Polyglandular autoimmune diseases in a dermatological clinical setting: Vitiligo associated autoimmune diseases. Eur J Dermatol 2010; 20: 354-358
25. Brostoff J: Autoantibodies in patients with vitiligo. Lancet 1969; 2: 177-178
26. Woolfson H, Finn OA, Mackie RM, Mc-Queen A, MacSween RN: Serum anti-Tumour antibodies and autoantibodies in vitiligo. Br J Dermatol 1975; 92: 395-400
27. Grimes PE, Halder RM, Jones C, Chakrabarti SG, Enterline J, Minus HR, Kenney JA Jr: Autoantibodies and their clinical significance in a black vitiligo population. Arch Dermatol 1983; 119: 300-303. (Pubitemid 13160917
28. Ingordo V, Gentile C, Iannazzone SS, Cusano F, Naldi L: Vitiligo and autoimmunity: An epidemiological study in a representative sample of young Italian males. J Eur Acad Dermatol Venereol 2011; 25: 105-109
29. Bor S, Feiwel M, Chanarin I: Vitiligo and its aetiological relationship to organ-specific autoimmune disease. Br J Dermatol 1969; 81: 83-88
30. Howitz J, Schwartz M: Vitiligo, achlorhydria and pernicious anemia. Lancet 1971; 1: 1331-1335
31. Korkij W, Soltani K, Simjee S, Marcinicin PG, Chuang TY: Tissue-specific autoantibodies and autoimmune disorders in vitiligo and alopecia areata: A retrospective study. J Cutan Pathol 1984; 11: 522-530. (Pubitemid 15175263
32. Barsky S, Knapp DP, Levine M, Schuller-Goldman S: Vitiligo in a black population. Arch Dermatol 1979; 115: 225. (Pubitemid 9115736
33. Schallreuter KU, Lemke R, Brandt O, Schwartz R, Westhofen M, Montz R, Berger J: Vitiligo and other diseases: Coexistence or true association?. Hamburg study on 321 patients. Dermatology 1994; 188: 269-275. (Pubitemid 24105481
34. Sawicki J, Siddha S, Rosen C: Vitiligo and associated autoimmune disease: Retrospective review of 300 patients. J Cutan Med Surg 2012; 16: 261-266
35. Shahmoradi Z, Najafian J, Naeini FF, Fahimipour F: Vitiligo and autoantibodies of celiac disease. Int J Prev Med 2013; 4: 200-203
36. Hegedus L, Heidenheim M, Gervil M, Hoier-Madsen M: High frequency of thyroid dysfunction in patients with vitiligo. Acta Derm Venereol 1994; 74: 120-123. (Pubitemid 24102472
37. Frati R, Frati C, Sassano PP, Antonaci A: Vitiligo, autoimmune thyroiditis: A rare thyroid cancer arising with bone metastases on maxillofacial area. J Exp Clin Cancer Res 1999; 18: 85-87. (Pubitemid 29232078
38. Dave S, D'Souza M, Thappa DM, Reddy KS, Bobby Z: High frequency of thyroid dysfunction in Indian patients with vitiligo. Indian J Dermatol 2003; 48: 68-72
39. Daneshpazhooh M, Mostofizadeh GM, Behjati J, Akhyani M, Robati RM: Anti-Thyroid peroxidase antibody and vitiligo: A controlled study. BMC Dermatol 2006; 6: 3
40. Sedighe M, Gholamhossein G: Thyroid dysfunction and thyroid antibodies in Iranian patients with vitiligo. Indian J Dermatol 2008; 53: 9-11
41. Nunes DH, Esser LM: Vitiligo epidemiological profile and the association with thyroid disease. An Bras Dermatol 2011; 86: 241-248
42. Kasumagic-Halilovic E, Prohic A, Begovic B, Ovcina-Kurtovic N: Association between vitiligo and thyroid autoimmunity. J Thyroid Res 2011; 2011: 938257
43. Kumar KV, Priya S, Sharma R, Kapoor U, Saini M, Bisht YS: Autoimmune thyroid disease in patients with vitiligo: Prevalence study in India. Endocr Pract 2012; 18: 194-199
44. Kroon MW, Joore IC, Wind BS, Leloup MA, Wolkerstorfer A, Luiten RM, Bos JD, Geskus RB, van Der Veen JP: Low yield of routine screening for thyroid dysfunction in asymptomatic patients with vitiligo. Br J Dermatol 2012; 166: 532-538
45. Kroon MW, Vrijman C, Chandeck C, Wind BS, Wolkerstorfer A, Luiten RM, Bos JD, Geskus RB, van Trotsenburg P, van Der Veen JP: High prevalence of autoimmune thyroiditis in children and adolescents with vitiligo. Horm Res Paediatr 2013; 18: 147-154
46. Kurtev A, Dourmishev AL: Thyroid function and autoimmunity in children and adolescents with vitiligo. J Eur Acad Dermatol Venereol 2004; 18: 109-111. (Pubitemid 38159379
47. Iacovelli P, Sinagra JLM, Vidolin AP, Marenda S, Capitanio B, Leone G, Picardo M: Relevance of thyroiditis and of other autoimmune diseases in children with vitiligo. Dermatology 2005; 210: 26-30. (Pubitemid 39656715
48. Kakourou T, Kanaka-Gantenbein C, Papadopoulou A, Kaloumenou E, Chrousos GP: Increased prevalence of chronic autoimmune (Hashimoto's) thyroiditis in children and adolescents with vitiligo. J Am Acad Dermatol 2005; 53: 220-223. (Pubitemid 40979575
49. Pagovich OE, Silverberg JI, Freilich E, Silverberg NB: Thyroid abnormalities in pediatric patients with vitiligo in New York City. Cutis 2008; 81: 463-466
50. Fernandes NC, Campos MM: Childhood vitiligo and thyroid disease. An Bras Dermatol 2009; 84: 200-202
51. Yang Y, Lin X, Fu W, Luo X, Kang K: An approach to the correlation between vitiligo and autoimmune thyroiditis in Chinese children. Clin Exp Dermatol 2010; 35: 706-710
52. Prćić S, Djuran V, Katanić D, Vlaški J, Gajinov Z: Vitiligo and thyroid dysfunction in children and adolescents. Acta Dermatovenereol Croat 2011; 19: 248-254
53. Uncu S, Yayli S, Bahadir S, Okyen A, Alpay K: Relevance of autoimmune thyroiditis in children and adolescents with vitiligo. Int J Dermatol 2011; 50: 175-179
54. Zophel K, Saller B, Wunderlich G, Gruning T, Koch R, Wilde J, Mann K, Franke WG: Autoantibodies to thyroperoxidase (TPOAb) in a large population of euthyroid subjects: Implications for the definition of TPOAb reference intervals. Clin Lab 2003; 49: 591-600. (Pubitemid 37493457
55. Bjoro T, Holmen J, Kruger O, Midthjell K, Hunstad K, Schreiner T, Sandnes L, Brochmann H: Prevalence of thyroid disease, thyroid dysfunction and thyroid peroxidase antibodies in a large, unselected population. The Health Study of Nord-Trondelag (HUNT). Eur J Endocrinol 2000; 143: 639-647
56. Kemp EH: Autoantibodies as diagnostic and predictive markers of vitiligo. Autoimmunity 2004; 37: 287-290
57. Nordyke RA, Gilbert FI Jr, Miyamoto LA, Fleury KA: The superiority of antimicrosomal over antithyroglobulin antibodies for detecting Hashimoto's thyroiditis. Arch Intern Med 1993; 153: 862-865. (Pubitemid 23118026
58. Vrijman C, Kroon MW, Limpens J, Leeflang MM, Luiten RM, van Der Veen JP, Wolkerstorfer A, Spuls PI: The prevalence of thyroid disease in patients with vitiligo: A systematic review. Br J Dermatol 2012; 167: 1224-1235.