Autoantibodies to thyroperoxidase (TPOAb) in a large population of euthyroid subjects: Implications for the definition of TPOAb reference intervals

Clinical Laboratory

Volumn 49, Issue 11-12, 2003, Pages 591-600

  Zöphel, Klaus ^a   Saller, Bernhard ^c   Wunderlich, Gerd ^b   Grüning, Thomas ^d   Koch, Rainer ^b   Wilde, Jürgen ^e   Mann, Klaus ^c   Franke, Wolf Gunter ^b  

^a KLINIKUM CHEMNITZ   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

^d DERRIFORD HOSPITAL   (United Kingdom)

^e Nichols Institute Diagnostika GmbH   (Germany)

Author keywords

Autoimmune thyroid disease; Euthyroid subjets; TgAb: autoantibodies to thyroglobulin; TPOAb reference interval; TPOAb: autoantibodies to thyroperoxidase

Indexed keywords

AUTOANTIBODY; THYROID PEROXIDASE;

ADULT; AGE; ARTICLE; AUTOMATION; CHEMOLUMINESCENCE; CONTROLLED STUDY; DATA ANALYSIS; FEMALE; GERMANY; HASHIMOTO DISEASE; HUMAN; IODINE DEFICIENCY; MAJOR CLINICAL STUDY; MALE; POPULATION RESEARCH; PREVALENCE; PROSPECTIVE STUDY; RECEIVER OPERATING CHARACTERISTIC; REFERENCE VALUE; SENSITIVITY ANALYSIS; SENSITIVITY AND SPECIFICITY; SEX; STATISTICAL SIGNIFICANCE; THYROID DISEASE;

ADULT; AGE FACTORS; AUTOANTIBODIES; EUTHYROID SICK SYNDROMES; FEMALE; HUMANS; IODIDE PEROXIDASE; MALE; REFERENCE STANDARDS; SEX FACTORS; THYROID GLAND;

EID: 17544385142     PISSN: 14336510     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Feldt-Rasmussen U, Hoier-Madsen M, Bech K, et al. Antithyroid peroxidase antibodies in thyroid disorders and nonthyroid autoimmune diseases. Autoimmunity 1991; 9: 245-254.
2. Mariotti S, Caturegli P, Piccolo P, Barbesino G, Pinchera A. Antithyroid peroxidase autoantibodies in thyroid diseases. J Clin Endocrinol Metab 1990; 71: 661-669.
3. Ruf J, Czarnocka B, Ferrand M, Doullais F, Carayon P. Novel routine assay of thyroperoxidase autoantibodies. Clin Chem 1988; 34: 2231-2234.
4. Feldt-Rasmussen U. Analytical and clinical performance goals for testing autoantibodies to thyroperoxidase, thyroglobulin, and thyrotropin receptor. Clin Chem 1996; 42: 160-163.
5. Mouthon L, Haury M, Lacroix-Desmazes S, Barreau C, Coutinho A, Kazatchkine MD. Analysis of the normal human IgG antibody repertoire. Evidence that IgG autoantibodies of healthy adults recognize a limited and conserved set of protein antigens in homologous tissues. J Immunol 1995; 154: 5769-5778.
6. Groves CJ, Howells RD, Williams S, Darke C, Parkes AB. Primary standardization for the ELISA of serum thyroperoxidase and thyroglobulin antibodies and their prevalence in a normal Welsh population. J Clin Lab Immunol 1990; 32: 147-151.
7. Mariotti S, Chiovato L, Franceschi C, Pinchera A. Thyroid autoimmunity and aging. Experimental Gerontol 1998; 33: 535-541.
8. Boehm BO, Kuhnl P, Loliger C, et al. HLA-DR3 and HLA-DR5 confer risk for autoantibody positivity against the thyroperoxidase (mic-TPO) antigen in healthy blood donors. Clin Invest 1993; 71: 221-225.
9. Brunn J, Block U, Ruf G, Bos I, Kunze WP, Scriba PC. Volumetrie der Schilddrüsenlappen mittels Real-time-Sonographie. Dtsch Med Wschr 1981; 106: 1338-1340.
10. Mc Lachlan SM and Rapoport B. The molecular biology of thyroid peroxidase: cloning, expression and role as autoantigen in autoimune thyroid disease. Endocr Rev 1992; 13: 192-206.
11. Lacroix-Desmazes S, Mouthon L, Coutinho A, Kazatchkine MD. Analysis of the natural human IgG antibody repertoire: life-long stability of reactivities towards self antigens contrasts with age-dependent diversification of reactivities against bacterial antigens. Europ J Immunol 1995; 25: 2598-2604.
12. Spalter SH, Kaveri SV, Bonnin E, Mani JC, Cartron JP, Kazatchkine MD. Normal human serum contains natural antibodies reactive with autologous ABO blood group antigens. Blood 1999; 93: 4418-4424.
13. Lutomski D, Caron M, Bourin P, Lefebure C, Bladier D, Joubert-Caron R. Purification and characterization of natural antibodies that recognize a human brain lectin. J Neuroimmunol 1995; 57: 9-15.
14. Rink T, Schroth HJ, Holle LH, Garth H. Effects of Iodine and Thyroid Hormones in Inducing and Treating Hashimoto's Thyroiditis. Nuklearmedizin 1999; 38: 144-149.
15. Reinhardt W, Luster M, Rudorff KH, et al. Effect of small doses of iodine on thyroid function in patients with Hashimoto's thyroiditis residing in an area of mild iodine deficiency [see comments]. Europ J Endocrinol 1998; 139: 23-28.
16. Aitkin M, Wilson GT. Mixture models, outliers and the EM algorithm. Technometrics 1980; 22: 325-331.
17. Fahmeir L, Hamerle A. Multivariate statistische Verfahren. Berlin: Walter de Gruyter 1984.
18. SAS/IML Software. Usage and Reference. Cary, 1990.
19. Zweig MH, Campbell G. Receiver-operating characteristic ROC plots: a fundamental evaluation tool in clinical medicine. Clin Chem 1993; 39: 561-577.