High prevalence of autoimmune thyroiditis in children and adolescents with vitiligo

Hormone Research in Paediatrics

Volumn 79, Issue 3, 2013, Pages 137-144

  Kroon, Marije W ^a   Vrijman, Charlotte ^a   Chandeck, Charlotte ^a   Wind, Bas S ^a   Wolkerstorfer, Albert ^a   Luiten, Rosalie M ^a   Bos, Jan D ^a   Geskus, Ronald B ^b   Van Trotsenburg, Paul ^b   Van Der Veen, J P Wietze ^a,c  

^a Netherlands Institute for Pigment Disorders   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

Author keywords

Adolescents; Autoimmune thyroid disease; Screening; Vitiligo

Indexed keywords

THYROID PEROXIDASE ANTIBODY; THYROTROPIN; THYROXINE; THYROID PEROXIDASE;

ADOLESCENT; ADULT; ARTICLE; AUTOIMMUNE THYROIDITIS; AUTOIMMUNITY; CHILD; CONCENTRATION (PARAMETERS); FEMALE; FREE THYROXINE INDEX; HUMAN; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; SCHOOL CHILD; SCREENING; THYROID DISEASE; THYROID FUNCTION; VITILIGO; ALOPECIA AREATA; ANTIBODY BLOOD LEVEL; CHILDHOOD DISEASE; COMPARATIVE STUDY; COST EFFECTIVENESS ANALYSIS; DOWN SYNDROME; HYPOTHYROIDISM; INSULIN DEPENDENT DIABETES MELLITUS; MEDICAL HISTORY; ONSET AGE; POPULATION; RHEUMATOID ARTHRITIS; SCREENING TEST; THYROID FUNCTION TEST; THYROTROPIN BLOOD LEVEL;

ADOLESCENT; AUTOIMMUNE DISEASES; CHILD; FEMALE; HUMANS; IODIDE PEROXIDASE; MALE; NETHERLANDS; PREVALENCE; THYROID DISEASES; THYROIDITIS, AUTOIMMUNE; THYROTROPIN; THYROXINE; VITILIGO;

EID: 84876797037     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000348388     Document Type: Article

References (55)

1. Lerner AB: Vitiligo. J Invest Dermatol 1959; 32:285-310.
2. Majumder PP, Nordlund JJ, Nath SK: Pattern of familial aggregation of vitiligo. Arch Dermatol 1993; 129:994-998. (Pubitemid 23238604)
3. Janniger CK: Childhood vitiligo. Cutis 1993; 51:25-28. (Pubitemid 23019425)
4. Jaisankar TJ: Vitiligo in children. Int J Dermatol 1992; 31:621-623.
5. Hu Z, Liu JB, Ma SS, Yang S, Zhang XJ: Profile of childhood vitiligo in China: an analysis of 541 patients. Pediatr Dermatol 2006; 23:114-116.
6. Linthorst Homan MW, de Korte J, Grootenhuis MA, Bos JD, Sprangers MA, van der Veen JP: Impact of childhood vitiligo on adult life. Br J Dermatol 2008; 159:915-920.
7. Naughton GK, Eisinger M, Bystryn JC: Antibodies to normal human melanocytes in vitiligo. J Exp Med 1983; 158:246-251. (Pubitemid 13073526)
8. Kemp EH, Waterman EA, Gawkrodger DJ, Watson PF, Weetman AP: Identification of epitopes on tyrosinase which are recognized by autoantibodies from patients with vitiligo. J Invest Dermatol 1999; 113:267-271. (Pubitemid 30202534)
9. van den Boorn JG, Konijnenberg D, Dellemijn TA, van der Veen JP, Bos JD, Melief CJ, Vyth-Dreese FA, Luiten RM: Autoimmune destruction of skin melanocytes by perilesional T cells from vitiligo patients. J Invest Dermatol 2009; 129:2220-2232.
10. Hann SK, Lee HJ: Segmental vitiligo: clinical findings. J Am Acad Dermatol 1996; 35;671-674.
11. Betterle C, Caretto A, De Zio A, Pedini B, Veller-Fornasa C, Cecchetto A, Accordi F, Peserico A: Incidence and significance of organspecific autoimmune disorders (clinical, latent or only autoantibodies) in patients with vitiligo. Dermatologica 1985; 171:419-423. (Pubitemid 16127755)
12. Hegedus L, Heidenheim M, Gervil M, Hjalgrim H, Hoier-Madsen M: High frequency of thyroid dysfunction in patients with vitiligo. Acta Derm Venereol 1994; 74:120-123. (Pubitemid 24102472)
13. Daneshpazhooh M, Mostofizadeh GM, Behjati J, Akhyani M, Robati RM: Anti-thyroid peroxidase antibody and vitiligo: a controlled study. BMC Dermatol 2006; 10:3.
14. Boelaert K, Newby PR, Simmonds MJ, Holder RL, Carr-Smith JD, Heward JM, Manji N, Al-lahabadia A, Armitage M, Chatterjee KV, Lazarus JH, Pearce SH, Vaidya B, Gough SC, Franklyn JA: Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. Am J Med 2010; 123:183-189.
15. Prindaville B, Rivkees SA: Incidence of vitiligo in children with Graves' disease and Hashimoto's thyroiditis. Int J Pediatr Endocrinol 2011; 2011:18.
16. Laberge G, Mailloux CM, Gowan K, Holland P, Bennett DC, Fain PR, Spritz RA: Early disease onset and increased risk of other autoimmune diseases in familial generalized vitiligo. Pigment Cell Res 2005; 18:300-305. (Pubitemid 41032889)
17. Alkhateeb A, Fain PR, Thody A, Bennett DC, Spritz RA: Epidemiology of vitiligo and associated autoimmune diseases in Caucasian probands and their relatives. Pigment Cell Res 2003; 16:208-214. (Pubitemid 36597056)
18. Spritz RA: Shared genetic relationships underlying generalized vitiligo and autoimmune thyroid disease. Thyroid 2010; 20:745-754.
19. Santaguida MG, Del Duca SC, Virili C, Gargano L, Centanni M: The presence of non-segmental vitiligo modiefies intracellular cytokine subsets with chronic lymphocytic thyroiditis. Int J Immunopathol Pharmacol. 2010;23: 1203-1209.
20. Santaguida MG, Nardo S, Del Duca SC, Lococo E, Virili C, Gargano L, Lenti L, Centanni M: Increased interleukin-4-positive lymphocytes in patients with Hashimoto's thyroiditis and concurrent non-endocrine autoimmune disorders. Clin Exp Immunol 2011; 165:148-154.
21. Sinclair D: Clincal and laboratory aspects of thyroid autoantibodies. Ann Clin Biochem 2006; 43:173-183. (Pubitemid 43668148)
22. Vanderpump MP, Tunbridge WM, French JM, Appleton D, Bates D, Clark F, Grimley-Evans J, Hasan DM, Rodgers H, Tunbridge F, et al: The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham study. Clin Endocrinol 1995; 43: 55-68.
23. Biondi B, Cooper DS: The clinical significance of subclinical thyroid dysfunction. Endocr Rev 2008; 29:76-131. (Pubitemid 351252748)
24. Villar HC, Saconato H, Valente O, Atallah AN: Thyroid hormone replacement for sub-clinical hypothyroidism. Cochrane Database Syst Rev 2007; 18:CD003419.
25. Hoogendoorn EH, Heijer MD, Dijk AJ, Hermus AR: Subclinical hyperthyroidism: to treat or not to treat? Postgrad Med J 2004; 80:394-398. (Pubitemid 38961860)
26. Gawkrodger DJ, Ormered AD, Shaw L, Mauri-Sole I, Whitton ME, Watts MJ, Anstey AV, Ingham J, Young K: Guideline for the diagnosis and management of vitiligo. Br J Dermatol 2008; 159:1051-1076.
27. Taieb A, Picardo M: Vitiligo. N Engl J Med 2009; 360:160-169.
28. Vrijman C, Kroon MW, Limpens J, Leeflang MMG, Luiten RM, van der Veen JPW, Wolkerstorfer A, Spuls PI: The prevalence of thyroid disease in patients with vitiligo: a systematic review. Br J Dermatol 2012; 167:1224-1235.
29. Fernandes NC, Campos MM: Childhood vitiligo and thyroid disease. An Bras Dermatol 2009; 84:200-202.
30. Kurtev A, Dourmishev AL: Thyroid function and autoimmunity in children and adolescents with vitiligo. J Eur Acad Dermatol Venereol 2004; 18:109-111. (Pubitemid 38159379)
31. Kakourou T, Kanaka-Gantenbein C, Papadopoulou, Kaloumenou E, Chrousos GP: Increased prevalence of chronic autoimmune (Hashimoto's) thyroiditis in children and adolescents with vitiligo. J Am Acad Dermatol 2005; 53:220-223. (Pubitemid 40979575)
32. Cho SB, Kim JH, Cho S, Park JM, Park YK, Oh SH: Vitiligo in children and adolescents: association with thyroid dysfunction. J Eur Acad Dermatol Venereol 2011; 25:64-67.
33. Uncu S, Yayli S, Bahadir S, Okten A, Alpay K: Relevance of autoimmune thyroiditis in children and adolescents with vitiligo. Int J Dermatol 2011; 50:175-179.
34. Pagovich OE, Silverberg JI, Freilich E, Silverberg NB: Thyroid abnormalities in pediatric patients with vitiligo in New York city. Cutis 2008; 81:463-466.
35. Yang Y, Lin X, Fu W, Luo X, Kang K: An approach to the correlation between vitiligo and autoimmune thyroiditis in Chinese children. Clin Exp Dermatol 2010; 35:706-710.
36. Iacovelli P, Sinagra JL, Vidolin AP, Marenda S, Capitanio B, Leone G, Picardo M: Relevance of thyroiditis and of other autoimmune diseases in children with vitiligo. Dermatology 2005; 210:6-30.
37. Rallison ML, Dobyns BM, Meikle AW, Bishop M, Lyon JL, Stevens W: Natural history of thyroid abnormalities: prevalence, incidence, and regression of thyroid diseases in adolescents and young adults. 1991; 91:363-370.
38. Jaksic J, Dumic M, Filipovic B, Ille J, Cvijetic M, Gjuric G: Thyroid disease in a school population with thyromegaly. Arch Dis Child 1994; 70:103-106. (Pubitemid 24088960)
39. 4, and thryroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 2002; 87:489-499. (Pubitemid 34158210)
40. Vanderpump MPJ, Ahlquist JAO, Franklyn JA, Clayton RN: Development of consensus for good practice and audit measures in the management of hypothyroidism and hyperthyroidism. BMJ 1996; 313:539-544. (Pubitemid 26336143)
41. Hefland M, Crapo LM: Screening for thyroid disease. Ann Intern Med 1990; 112:840-849. (Pubitemid 20182785)
42. Garber JR, Cobin RH, Gharib H, Hennessey JV, Klein I, Mechanick JI, Pessah-Pollack R, Singer PA: Woeber KA, American Association of Clinical Endocrinologists and the American Thyroid Association Taskforce on Hypothyroidism in Adults: Clinical practice guidelines for hypothyroidism in adults. Thyroid 2012; 22:1200-1235.
43. Bettendorf M: Thyroid disorders in children from birth to adolescence. Eur J Nucl Med Mol Imaging 2002; 2:439-446.
44. Moore DC: Natural course of subclinical hypothyroidism in children and adolescence. Arch Pediatr Adolesc Med 1996; 150:293-297. (Pubitemid 26086094)
45. Wasniewska M, Salerno M, Cassio A, Corrias A, Aversa T, Zirilli G, Capalbo D, Bal M, Mussa A, De Luca F: Prospective evaluation of the natural course of idiopathic subclinical hypothyroidism in childhood and adolescence. Eur J Endocrinol 2009; 160:417-421.
46. Cerbone M, Bravaccio C, Capalbo D, Polizzi M, Wasniewska M, Cioffi D, Improda N, Valenzise M, Bruzzese D, De Luca F, Salerno M: Linear growth and intellectual outcome in children with long-term idiopathic subclinical hypothyroidism. Eur J Endocrinol 2011; 164:591-597.
47. Wu T, Flowers JW, Tudiver F, Wilson JL, Punyasavatsut N: Subclinical thyroid disorders and cognitive performance among adolescents in the United States. BMC Pediatrics 2006; 6:12.
48. Bona G, Prodam F, Monzani A: Subclinical hypothyroidism in children: natural history and when to treat. J Clin Pediatr Endocrinol 2012, E-pub ahead of print.
49. Padberg S, Heller K, Usadel KH, Schumm-Draeger PM: One-year prophylactic treatment of euthyroid Hashimoto's thyroiditis with levothyroxine: is there a benefit? Thyroid 2001; 3:249-255. (Pubitemid 32298422)
50. Schmidt M, Voell M, Rahlff I, Dietlein M, Kobe C, Faust M, Schicha H: Long-term follow-up of antithyroid peroxidase antibodies in patients with chronic autoimmune thyroiditis (Hashimoto's thyroiditis) treated with levothyroxine. Thyroid 2008; 7:755-760. (Pubitemid 352009934)
51. Prummel MF, Wiersinga WM: Thyroid peroxidase in euthyroid subjects. Best Pract Res Clin Endocrinol Metab 2005; 19:1-15.
52. Hutfless S, Matos P, Talor MV, Caturegli P, Rose NR: Significance of prediagnostic thyroid antibodies in women with autoimmune thyroid disease. J Clin Endocrinol Metab 2011; 96:1466-1471.
53. Rallison ML, Dobyns BM, Keating FR, Rall JE, Tyler FH: Occurrence and natural history of chronic lymphocytic thyroiditis in childhood. J Pediatr 1975; 86:675-682.
54. Kroon MW, Joore IC, Wind BS, Leloup MA, Wolkerstorfer A, Luiten RM, Bos JD, Geskus RB, van der Veen JP: Low yield of routine screening for thyroid dysfunction in asymptomatic vitiligo patients. Br J Dermatol 2012; 166:532-538.
55. Wiersinga WM, Podoba J, Srbecky M, van Vessem M, van Beeren HC, Platvoet-Ter Schiphorst MC: A survey of iodine intake and thyroid volume in Dutch schoolchildren: reference values in an iodinesufficient area and the effect of puberty. Eur J Endocrinol 2001; 144:595-603.