Mining of the pyrrolamide antibiotics analogs in Streptomyces netropsis reveals the amidohydrolase-dependent "iterative strategy" underlying the pyrrole polymerization

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Hao, Chunlin ^a   Huang, Sheng ^a   Deng, Zixin ^a,c   Zhao, Changming ^a   Yu, Yi ^a,b  

^a WUHAN UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^c Centre for Biomedicine Research   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDASE; ANTIBIOTIC AGENT; CONGOCIDINE; DISTAMYCIN A; MICROBIAL PRODUCTS NOT CLASSIFIED ELSEWHERE; PYRROLAMIDE DERIVATIVE; PYRROLE; UNCLASSIFIED DRUG; AMIDE; ANTIINFECTIVE AGENT; BIOLOGICAL PRODUCT; POLYMER; POLYPYRROLE; PYRROLE DERIVATIVE;

ACTINOBACTERIA; ARTICLE; BACTERIAL GENE; DEACETYLATION; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; GENE CLUSTER; GENE SEQUENCE; MASS SPECTROMETRY; NONHUMAN; OPEN READING FRAME; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; STREPTOMYCES NETROPSIS; BIOCATALYSIS; BIOSYNTHESIS; CHEMISTRY; GENETICS; METABOLISM; MULTIGENE FAMILY; STREPTOMYCES; TANDEM MASS SPECTROMETRY;

AMIDES; AMIDOHYDROLASES; ANTI-BACTERIAL AGENTS; BIOCATALYSIS; BIOLOGICAL PRODUCTS; DISTAMYCINS; MULTIGENE FAMILY; NETROPSIN; POLYMERS; PYRROLES; STREPTOMYCES; TANDEM MASS SPECTROMETRY;

EID: 84902531849     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0099077     Document Type: Article

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