Frizzled 7 expression is positively regulated by SIRT1 and β-catenin in breast cancer cells

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Simmons Jr , Glenn E ^a   Pandey, Somnath ^a   Nedeljkovic Kurepa, Ana ^a   Saxena, Madhurima ^a   Wang, Allison ^a   Pruitt, Kevin ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; FRIZZLED 7 PROTEIN; FRIZZLED PROTEIN; MESSENGER RNA; PROTEIN C JUN; SIRTUIN 1; SIRTUIN 2; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CAMBINOL; FZD7 PROTEIN, HUMAN; NAPHTHALENE DERIVATIVE; PROTEIN BINDING; PYRIMIDINONE DERIVATIVE;

ARTICLE; BREAST CANCER; CANCER CELL LINE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; FZD7 GENE; GENE; GENE EXPRESSION REGULATION; IN VITRO STUDY; INHIBITION KINETICS; PROMOTER REGION; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION SITE; WNT SIGNALING PATHWAY; ANTAGONISTS AND INHIBITORS; BREAST TUMOR; CELL MOTION; FEMALE; GENE SILENCING; GENETICS; HUMAN; METABOLISM; TUMOR CELL LINE;

BETA CATENIN; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; FEMALE; FRIZZLED RECEPTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; NAPHTHALENES; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PYRIMIDINONES; RNA, MESSENGER; SIRTUIN 1; SIRTUIN 2;

EID: 84902525741     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0098861     Document Type: Article

References (38)

1. Holloway KR, Barbieri A, Malyarchuk S, Saxena M, Nedeljkovic-Kurepa A, et al. (2013) SIRT1 positively regulates breast cancer associated human aromatase (CYP19A1) expression. Mol Endocrinol 27: 480-490.
2. Lee H, Kim KR, Noh SJ, Park HS, Kwon KS, et al. (2011) Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma. Hum Pathol 42: 204-213.
3. Yang L, Wu X, Wang Y, Zhang K, Wu J, et al. (2011) FZD7 has a critical role in cell proliferation in triple negative breast cancer. Oncogene 30: 4437-4446.
4. Jang KY, Hwang SH, Kwon KS, Kim KR, Choi HN, et al. (2008) SIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphoma. Am J Surg Pathol 32: 1523-1531.
5. Cha EJ, Noh SJ, Kwon KS, Kim CY, Park BH, et al. (2009) Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma. Clin Cancer Res 15: 4453-4459.
6. Nosho K, Shima K, Irahara N, Kure S, Firestein R, et al. (2009) SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. Mod Pathol 22: 922-932.
7. Leko V, Park GJ, Lao U, Simon JA, Bedalov A (2013) Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model. PLoS One 8: e66283.
8. Roth M, Chen WY (2013) Sorting out functions of sirtuins in cancer. Oncogene.
9. Pruitt K, Zinn RL, Ohm JE, McGarvey KM, Kang SH, et al. (2006) Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genet 2: e40.
10. Hussain M, Rao M, Humphries AE, Hong JA, Liu F, et al. (2009) Tobacco smoke induces polycomb-mediated repression of Dickkopf-1 in lung cancer cells. Cancer Res 69: 3570-3578.
11. Holloway KR, Calhoun TN, Saxena M, Metoyer CF, Kandler EF, et al. (2010) SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling. Proc Natl Acad Sci U S A 107: 9216-9221.
12. Zhang Y, Zhang M, Dong H, Yong S, Li X, et al. (2009) Deacetylation of cortactin by SIRT1 promotes cell migration. Oncogene 28: 445-460.
13. Saxena M, Dykes SS, Malyarchuk S, Wang AE, Cardelli JA, et al. (2013) The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration. Oncogene.
14. Yao Y, Li H, Gu Y, Davidson NE, Zhou Q (2010) Inhibition of SIRT1 deacetylase suppresses estrogen receptor signaling. Carcinogenesis 31: 382-387.
15. Kojima K, Ohhashi R, Fujita Y, Hamada N, Akao Y, et al. (2008) A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells. Biochem Biophys Res Commun 373: 423-428.
16. Liang XJ, Finkel T, Shen DW, Yin JJ, Aszalos A, et al. (2008) SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism. Mol Cancer Res 6: 1499-1506.
17. Angers S, Moon RT (2009) Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol 10: 468-477.
18. Wharton KA Jr (2003) Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction. Dev Biol 253: 1-17.
19. Hu J, Dong A, Fernandez-Ruiz V, Shan J, Kawa M, et al. (2009) Blockade of Wnt signaling inhibits angiogenesis and tumor growth in hepatocellular carcinoma. Cancer Res 69: 6951-6959.
20. Wei W, Chua MS, Grepper S, So SK (2011) Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin. Mol Cancer 10: 16.
21. Gurney A, Axelrod F, Bond CJ, Cain J, Chartier C, et al. (2012) Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors. Proc Natl Acad Sci U S A 109: 11717-11722.
22. King TD, Suto MJ, Li Y (2012) The Wnt/beta-catenin signaling pathway: a potential therapeutic target in the treatment of triple negative breast cancer. J Cell Biochem 113: 13-18.
23. Heltweg B, Gatbonton T, Schuler AD, Posakony J, Li H, et al. (2006) Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res 66: 4368-4377.
24. Katoh M (2007) Comparative integromics on FZD7 orthologs: conserved binding sites for PU.1, SP1, CCAAT-box and TCF/LEF/SOX transcription factors within 5′-promoter region of mammalian FZD7 orthologs. Int J Mol Med 19: 529-533.
25. Vincan E, Flanagan DJ, Pouliot N, Brabletz T, Spaderna S (2010) Variable FZD7 expression in colorectal cancers indicates regulation by the tumour microenvironment. Dev Dyn 239: 311-317.
26. Gan XQ, Wang JY, Xi Y, Wu ZL, Li YP, et al. (2008) Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction. J Cell Biol 180: 1087-1100. (Pubitemid 351468467)
27. Voloshanenko O, Erdmann G, Dubash TD, Augustin I, Metzig M, et al. (2013) Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells. Nat Commun 4: 2610.
28. Lindvall C, Bu W, Williams BO, Li Y (2007) Wnt signaling, stem cells, and the cellular origin of breast cancer. Stem Cell Rev 3: 157-168. (Pubitemid 350129718)
29. Leal LF, Mermejo LM, Ramalho LZ, Martinelli CE Jr, Yunes JA, et al. (2011) Wnt/beta-catenin pathway deregulation in childhood adrenocortical tumors. J Clin Endocrinol Metab 96: 3106-3114.
30. Kaler P, Augenlicht L, Klampfer L (2012) Activating mutations in beta-catenin in colon cancer cells alter their interaction with macrophages; the role of snail. PLoS One 7: e45462.
31. Mei H, Nakatsu MN, Baclagon ER, Deng SX (2014) Frizzled 7 maintains the undifferentiated state of human limbal stem/progenitor cells. Stem Cells 32: 938-945.
32. Byles V, Zhu L, Lovaas JD, Chmilewski LK, Wang J, et al. (2012) SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis. Oncogene 31: 4619-4629.
33. Chen Z, Ma T, Huang C, Zhang L, Lv X, et al. (2013) MiR-27a modulates the MDR1/P-glycoprotein expression by inhibiting FZD7/beta-catenin pathway in hepatocellular carcinoma cells. Cell Signal 25: 2693-2701.
34. Ueno K, Hiura M, Suehiro Y, Hazama S, Hirata H, et al. (2008) Frizzled-7 as a potential therapeutic target in colorectal cancer. Neoplasia 10: 697-705. (Pubitemid 351883886)
35. Ueno K, Hazama S, Mitomori S, Nishioka M, Suehiro Y, et al. (2009) Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells. Br J Cancer 101: 1374-1381.
36. Kirikoshi H, Sekihara H, Katoh M (2001) Up-regulation of Frizzled-7 (FZD7) in human gastric cancer. Int J Oncol 19: 111-115.
37. King TD, Zhang W, Suto MJ, Li Y (2012) Frizzled7 as an emerging target for cancer therapy. Cell Signal 24: 846-851.
38. Wang Q, Zhou Y, Rychahou P, Liu C, Weiss HL, et al. (2013) NFAT5 represses canonical Wnt signaling via inhibition of beta-catenin acetylation and participates in regulating intestinal cell differentiation. Cell Death Dis 4: e671.