Wnt/β-catenin pathway deregulation in childhood adrenocortical tumors

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 10, 2011, Pages 3106-3114

  Leal, Letícia F ^a   Mermejo, Lívia M ^a   Ramalho, Leandra Z ^a   Martinelli Jr , Carlos E ^a   Yunes, José A ^b   Seidinger, Ana Luiza ^b   Mastellaro, Maria José ^b   Cardinalli, Izilda A ^b   Brandalise, Silvia R ^b   Moreira, Ayrton C ^a   Tone, Luiz G ^a   Scrideli, Carlos A ^a   Castro, Margaret ^a   Antonini, Sonir Rauber ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Boldrini's Children Center   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; WNT PROTEIN;

ADOLESCENT; ADRENAL CORTEX TUMOR; ARTICLE; AXIN1 GENE; BIOACCUMULATION; CHILD; CHILD DEATH; CHILDHOOD ADRENOCORTICAL TUMOR; CHILDHOOD CANCER; COHORT ANALYSIS; CONTROLLED STUDY; CTNNB1 GENE; DKK3 GENE; FEMALE; GENE; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN TISSUE; INFANT; MAJOR CLINICAL STUDY; MALE; ONCOGENE MYC; OVERALL SURVIVAL; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SFRP1 GENE; TCF7 GENE; TP53 GENE; WISP2 GENE; WNT4 GENE;

ADOLESCENT; ADRENAL CORTEX NEOPLASMS; AXIN PROTEIN; BETA CATENIN; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DNA; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MUTATION; PROTO-ONCOGENE PROTEINS C-MYC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS; T CELL TRANSCRIPTION FACTOR 1; TRANSCRIPTION FACTORS; TREATMENT OUTCOME; TUMOR SUPPRESSOR PROTEIN P53; WNT PROTEINS; WNT4 PROTEIN;

EID: 80053472775     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-0363     Document Type: Article

References (39)

1. Sandrini R, Ribeiro RC, DeLacerda L 1997 Childhood adrenocortical tumors. J Clin Endocrinol Metab 82:2027-2031
2. Almeida MQ, Latronico AC 2007 The molecular pathogenesis of childhood adrenocortical tumors. Horm Metab Res 39:461-466 (Pubitemid 46999855)
3. Ribeiro RC, Michalkiewicz EL, Figueiredo BC, DeLacerda L, Sandrini F, Pianovsky MD, Sampaio G, Sandrini R 2000 Adrenocortical tumors in children. Braz J Med Biol Res 33:1225-1234
4. Latronico AC, Pinto EM, Domenice S, Fragoso MC, Martin RM, Zerbini MC, Lucon AM, Mendonca BB 2001Aninherited mutation outside the highly conserved DNA-binding domain of the p53 tumor suppressor protein in children and adults with sporadic adrenocortical tumors. J Clin Endocrinol Metab 86:4970-4973 (Pubitemid 33020551)
5. Sandrini F, Villani DP, Tucci S, Moreira AC, De Castro M, Elias LL 2005 Inheritance of R337H p53 gene mutation in children with sporadic adrenocortical tumor. Horm Metab Res 37:231-235 (Pubitemid 40756344)
6. Giordano TJ, Kuick R, Else T, Gauger PG, Vinco M, Bauersfeld J, Sanders D, Thomas DG, Doherty G, Hammer G 2009 Molecular classification and prognostication of adrenocortical tumors by transcriptome profiling. Clin Cancer Res 15:668-676
7. De Reyniès A, Assié G, Rickman DS, Tissier F, Groussin L, René- Corail F, Dousset B, Bertagna X, Clauser E, Bertherat J 2009 Gene expression profiling reveals a new classification of adrenocortical tumors and identifies molecular predictors of malignancy and survival. J Clin Oncol 27:1108-1115
8. West AN, Neale GA, Pounds S, Figueredo BC, Rodriguez Galindo C, Pianovski MA, Oliveira Filho AG, Malkin D, Lalli E, Ribeiro R, Zambetti GP 2007 Gene expression profiling of childhood adrenocortical tumors. Cancer Res 67:600-608 (Pubitemid 46192198)
9. Pianovski MA, Cavalli LR, Figueiredo BC, Santos SC, Doghman M, Ribeiro RC, Oliveira AG, Michalkiewicz E, Rodrigues GA, Zambetti G, Haddad BR, Lalli E 2006 SF-1 overexpression in childhood adrenocortical tumours. Eur J Cancer 42:1040-1043
10. Figueiredo BC, Cavalli LR, Pianovski MA, Lalli E, Sandrini R, Ribeiro RC, Zambetti G, DeLacerda L, Rodrigues GA, Haddad BR 2005 Amplification of the steroidogenic factor 1 gene in childhood adrenocortical tumors. J Clin Endocrinol Metab 90:615-619 (Pubitemid 40279170)
11. Almeida MQ, Fragoso MC, Lotfi CF, Santos MG, Nishi MY, Costa MH, Lerario AM, Maciel CC, Mattos GE, Jorge AA, Mendonca BB, Latronico AC 2008 Expression of insulin-like growth factor-II and its receptor in pediatric and adult adrenocortical tumors. J Clin Endocrinol Metab 93:3524-3531
12. Suwa T, Chen M, Hawks CL, Hornsby PJ 2003 Zonal expression of dickkopf-3 and components of the Wnt signalling pathways in the human adrenal cortex. J Endocrinol 178:149-158 (Pubitemid 36927019)
13. Chen X, Yang J, Evans PM, Liu C 2008 Wnt signaling: the good and the bad. Acta Biochim Biophys Sin (Shanghai) 40:577-594 (Pubitemid 352009082)
14. HeikkiläM, Peltoketo H, Leppäluoto J, Ilves M, Vuolteenaho O, Vainio S 2002 Wnt-4 deficiency alters mouse adrenal cortex function, reducing aldosterone production. Endocrinology 143:4358-4365 (Pubitemid 35239569)
15. El Wakil A, Lalli E 2011 The Wnt/β-catenin pathway in adrenocortical development and cancer. Mol Cell Endocrinol 332:32-37
16. Mao B, Niehrs C 2003 Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling. Gene 302:179-183 (Pubitemid 36078410)
17. Lavergne E, Hendaoui I, Coulouarn C, Ribault C, Leseur J, Eliat PA, Mebarki S, Corlu A, Clément B, Musso O 2011 Blocking Wnt signaling by SFRP-like molecules inhibits in vivo cell proliferation and tumor growth in cells carrying active β-catenin. Oncogene 30:423-433
18. Stratakis CA, Boikos SA 2007 Genetics of adrenal tumors associated with Cushing's syndrome: a new classification for bilateral adrenocortical hyperplasias. Nat Clin Pract Endocrinol Metab 3:748-757 (Pubitemid 47622602)
19. Tadjine M, Lampron A, Ouadi L, Bourdeau I 2008 Frequent mutations of β-catenin gene in sporadic secreting adrenocortical adenomas. Clin Endocrinol (Oxf) 68:264-270
20. Tissier F, Cavard C, Groussin L, Perlemoine K, Fumey G, Hagneré AM, René-Corail F, Jullian E, Gicquel C, Bertagna X, Vacher- Lavenu MC, Perret C, Bertherat J 2005 Mutations of β-catenin in adrenocortical tumors: activation of the Wnt signaling pathway is a frequent event in both benign and malignant adrenocortical tumors. Cancer Res 65:7622-7627
21. Gaujoux S, Tissier F, Groussin L, Libé R, Ragazzon B, Launay P, Audebourg A, Dousset B, Bertagna X, Bertherat J 2008 Wnt/β- catenin and 3′,5′-cyclic adenosine 5′-monophosphate/protein kinase A signaling pathways alterations and somatic β-catenin gene mutations in the progression of adrenocortical tumors. J Clin Endocrinol Metab 93:4135-4140
22. Bonnet S, Gaujoux S, Launay P, Baudry C, Chokri I, Ragazzon B, Libé R, René-Corail F, Audebourg A, Vacher-Lavenu MC, Groussin L, Bertagna X, Dousset B, Bertherat J, Tissier F 2011 Wnt/β-catenin pathway activation in adrenocortical adenomas is frequently due to somatic CTNNB1-activating mutations, which are associated with larger and nonsecreting tumors: a study in cortisol-secreting and -nonsecreting tumors. J Clin Endocrinol Metab 96:E419-E426
23. Ragazzon B, Libé R, Gaujoux S, Assié G, Fratticci A, Launay P, Clauser E, Bertagna X, Tissier F, De Reyniès A, Bertherat J 2010 Transcriptome analysis reveals that p53 and β-catenin alterations occur in a group of aggressive adrenocortical cancers. Cancer Res 70:8276-8281
24. Gaujoux S, Grabar S, Fassnacht M, Ragazzon B, Launay P, Libé R, Chokri I, Audebourg A, Royer B, Sbiera S, Vacher-Lavenu MC, Dousset B, Bertagna X, Allolio B, Bertherat J, Tissier F 2011 β-Catenin activation is associated with specific clinical and pathological characteristics and a poor outcome in adrenocortical carcinoma. Clin Cancer Res 17:328-336
25. Pusantisampan T, Sangkhathat S, Kayasut K, Kanngurn S, Jaruratanasirikul S, Chotsampancharoen T, Kritsaneepaiboon S 2010 Cushing's syndrome in an infant secondary to malignant adrenocortical tumors with somatic mutation of β-catenin. Pediatr Dev Pathol 13:238-242
26. Berthon A, Sahut-Barnola I, Lambert-Langlais S, De Joussineau C, Damon-Soubeyrand C, Louiset E, Taketo MM, Tissier F, Bertherat J, Lefrançois-Martinez AM, Martinez A, Val P 2010 Constitutive β-catenin activation induces adrenal hyperplasia and promotes adrenal cancer development. Hum Mol Genet 19:1561-1576
27. Tsuji T, Miyazaki M, Sakaguchi M, Inoue Y, Namba M 2000 A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines. Biochem Biophys Res Commun 268:20-24 (Pubitemid 30116603)
28. You A, Fokas E, Wang LF, He H, Kleb B, Niederacher D, Engenhart- Cabillic R, An HX 2011 Expression of the Wnt antagonist DKK3 is frequently suppressed in sporadic epithelial ovarian cancer. J Cancer Res Clin Oncol 137:621-627
29. Yue W, Sun Q, Dacic S, Landreneau RJ, Siegfried JM, Yu J, Zhang L 2008 Downregulation of Dkk3 activates β-catenin/TCF-4 signaling in lung cancer. Carcinogenesis 29:84-92 (Pubitemid 351201745)
30. Zhang LY, Ye J, Zhang F, Li FF, Li H, Gu Y, Liu F, Chen GS, Li Q 2009 Axin induces cell death and reduces cell proliferation in astrocytoma by activating the p53 pathway. Int J Oncol 35:25-32
31. Yang LH, Xu HT, Han Y, Li QC, Liu Y, Zhao Y, Yang ZQ, Dong QZ, Miao Y, Dai SD, Wang EH 2010 Axin downregulates TCF-4 transcription via β-catenin, but not p53, and inhibits the proliferation and invasion of lung cancer cells. Mol Cancer 9:25
32. Ciznadija D, Tothill R, Waterman ML, Zhao L, Huynh D, Yu RM, Ernst M, Ishii S, Mantamadiotis T, Gonda TJ, Ramsay RG, Malaterre J 2009 Intestinal adenoma formation and MYC activation are regulated by cooperation between MYB and Wnt signaling. Cell Death Differ 16:1530-1538
33. Bourdeau I, Antonini SR, Lacroix A, Kirschner LS, Matyakhina L, Lorang D, Libutti SK, Stratakis CA 2004 Gene array analysis of macronodular adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediators. Oncogene 23:1575-1585 (Pubitemid 38406520)
34. Iliopoulos D, Bimpaki EI, Nesterova M, Stratakis CA 2009 MicroRNA signature of primary pigmented nodular adrenocortical disease: clinical correlations and regulation of Wnt signaling. Cancer Res 69:3278-3282
35. Szabó PM, Tamá si V, Molná r V, Andrá sfalvy M, Tömböl Z, Farkas R, Kövesdi K, Patócs A, Tó th M, Szalai C, Falus A, Rácz K, Igaz P 2010 Meta-analysis of adrenocortical tumour genomics data: novel pathogenic pathways revealed. Oncogene 29:3163-3172
36. Szabó PM, Rácz K, Igaz P 2011 Underexpression of C-myc in adrenocortical cancer: a major pathogenic event? Horm Metab Res 43:297-299
37. Okuyama H, Endo H, Akashika T, Kato K, Inoue M 2010 Downregulation of c-MYC protein levels contributes to cancer cell survival under dual deficiency of oxygen and glucose. Cancer Res 70: 10213-10223
38. Doghman M, El Wakil A, Cardinaud B, Thomas E, Wang J, Zhao W, Peralta-Del Valle MH, Figueiredo BC, Zambetti GP, Lalli E 2010 Regulation of insulin-like growth factor-mammalian target of rapamycin signaling by microRNA in childhood adrenocortical tumors. Cancer Res 70:4666-4675
39. Gehrke I, Gandhirajan RK, Kreuzer KA 2009 Targeting the WNT/ β-catenin/TCF/LEF1 axis in solid and haematological cancers: multiplicity of therapeutic options. Eur J Cancer 45:2759-2767