Good riddance to dopamine: Roles for the dopamine transporter in synaptic function and dopamine-associated brain disorders

Neurochemistry International

Volumn 73, Issue 1, 2014, Pages 42-48

  Gowrishankar, Raajaram ^a   Hahn, Maureen K ^a   Blakely, Randy D ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ADHD; Amphetamine; Dopamine; Genetics; Transporter

Indexed keywords

DOPAMINE; DOPAMINE TRANSPORTER; FLOTILLIN 1;

ARTICLE; ATTENTION DEFICIT DISORDER; AUTISM; BRAIN DISEASE; DOPAMINE RELEASE; DOPAMINERGIC NERVE CELL; HUMAN; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYNAPSE; SYNAPTIC TRANSMISSION; ANIMAL; GENETICS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BRAIN DISEASES; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINERGIC NEURONS; HUMANS; SYNAPSES;

EID: 84902484122     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2013.10.016     Document Type: Review

References (105)

1. A.R. Adamantidis, H.C. Tsai, B. Boutrel, F. Zhang, G.D. Stuber, E.A. Budygin, C. Tourino, A. Bonci, K. Deisseroth, and L. de Lecea Optogenetic interrogation of dopaminergic modulation of the multiple phases of reward-seeking behavior J. Neurosci. 31 2011 10829 10835
2. E.M. Adkins, D.J. Samuvel, J.U. Fog, J. Eriksen, L.D. Jayanthi, C.B. Vaegter, S. Ramamoorthy, and U. Gether Membrane mobility and microdomain association of the dopamine transporter studied with fluorescence correlation spectroscopy and fluorescence recovery after photobleaching Biochemistry 46 2007 10484 10497
3. S.G. Amara, and M.J. Kuhar Neurotransmitter transporters: recent progress Annu. Rev. Neurosci. 16 1993 73 93
4. A.J. Avelar, S.A. Juliano, and P.A. Garris Amphetamine augments vesicular dopamine release in the dorsal and ventral striatum through different mechanisms J. Neurochem. 125 2013 373 385
5. M.J. Beckstead, D.K. Grandy, K. Wickman, and J.T. Williams Vesicular dopamine release elicits an inhibitory postsynaptic current in midbrain dopamine neurons Neuron 42 2004 939 946
6. J.A. Beeler, N. Daw, C.R. Frazier, and X. Zhuang Tonic dopamine modulates exploitation of reward learning Front Behav. Neurosci. 4 2010 170
7. M. Benoit-Marand, B. Ballion, E. Borrelli, T. Boraud, and F. Gonon Inhibition of dopamine uptake by D2 antagonists: an in vivo study J. Neurochem. 116 2011 449 458
8. M. Benoit-Marand, E. Borrelli, and F. Gonon Inhibition of dopamine release via presynaptic D2 receptors: time course and functional characteristics in vivo J. Neurosci. 21 2001 9134 9141
9. K.C. Berridge, and T.E. Robinson What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res. Brain Res. Rev. 28 1998 309 369
10. E.A. Bolan, B. Kivell, V. Jaligam, M. Oz, L.D. Jayanthi, Y. Han, N. Sen, E. Urizar, I. Gomes, L.A. Devi, S. Ramamoorthy, J.A. Javitch, A. Zapata, and T.S. Shippenberg D2 receptors regulate dopamine transporter function via an extracellular signal-regulated kinases 1 and 2-dependent and phosphoinositide 3 kinase-independent mechanism Mol. Pharmacol. 71 2007 1222 1232
11. E. Bowton, C. Saunders, K. Erreger, D. Sakrikar, H.J. Matthies, N. Sen, T. Jessen, R.J. Colbran, M.G. Caron, J.A. Javitch, R.D. Blakely, and A. Galli Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder J. Neurosci. 30 2010 6048 6057
12. M.T. Brown, C. Bellone, M. Mameli, G. Labouebe, C. Bocklisch, B. Balland, L. Dahan, R. Lujan, K. Deisseroth, and C. Luscher Drug-driven AMPA receptor redistribution mimicked by selective dopamine neuron stimulation PLoS ONE 5 2010 e15870
13. B. Cagniard, P.D. Balsam, D. Brunner, and X. Zhuang Mice with chronically elevated dopamine exhibit enhanced motivation, but not learning, for a food reward Neuropsychoparmacology 31 2006 1362 1370
14. B. Cagniard, J.A. Beeler, J.P. Britt, D.S. McGehee, M. Marinelli, and X. Zhuang Dopamine scales performance in the absence of new learning Neuron 51 2006 541 547
15. A. Carlsson The occurrence, distribution and physiological role of catecholamines in the nervous system Pharmacol. Rev. 11 1959 490 493
16. A. Carlsson Perspectives on the discovery of central monoaminergic neurotransmission Annu. Rev. Neurosci. 10 1987 19 40
17. A. Carlsson, M. Lindqvist, and T. Magnusson 3,4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists Nature 180 1957 1200
18. A. Carlsson, M. Lindqvist, T. Magnusson, and B. Waldeck On the presence of 3-hydroxytyramine in brain Science 127 1958 471
19. L. Carvelli, R.D. Blakely, and L.J. DeFelice Dopamine transporter/syntaxin 1A interactions regulate transporter channel activity and dopaminergic synaptic transmission Proc. Natl. Acad. Sci. USA 105 2008 14192 14197
20. L. Carvelli, P.W. McDonald, R.D. Blakely, and L.J. Defelice Dopamine transporters depolarize neurons by a channel mechanism Proc. Natl. Acad. Sci. USA 101 2004 16046 16051
21. A. Charara, Y. Smith, and A. Parent Glutamatergic inputs from the pedunculopontine nucleus to midbrain dopaminergic neurons in primates: Phaseolus vulgaris-leucoagglutinin anterograde labeling combined with postembedding glutamate and GABA immunohistochemistry J. Comp. Neurol. 364 1996 254 266
22. D. Chaudhury, J.J. Walsh, A.K. Friedman, B. Juarez, S.M. Ku, J.W. Koo, D. Ferguson, H.C. Tsai, L. Pomeranz, D.J. Christoffel, A.R. Nectow, M. Ekstrand, A. Domingos, M.S. Mazei-Robison, E. Mouzon, M.K. Lobo, R.L. Neve, J.M. Friedman, S.J. Russo, K. Deisseroth, E.J. Nestler, and M.H. Han Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons Nature 493 2013 532 536
23. B.T. Chen, H.J. Yau, C. Hatch, I. Kusumoto-Yoshida, S.L. Cho, F.W. Hopf, and A. Bonci Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking Nature 496 2013 359 362
24. A. Cheramy, V. Leviel, and J. Glowinski Dendritic release of dopamine in the substantia nigra Nature 289 1981 537 542
25. E.H. Cook Jr., M.A. Stein, M.D. Krasowski, N.J. Cox, D.M. Olkon, J.E. Kieffer, and B.L. Leventhal Association of attention-deficit disorder and the dopamine transporter gene Am. J. Hum. Genet. 56 1995 993 998
26. R.M. Costa, R. Gutierrez, I.E. de Araujo, M.R. Coelho, A.D. Kloth, R.R. Gainetdinov, M.G. Caron, M.A. Nicolelis, and S.A. Simon Dopamine levels modulate the updating of tastant values Gene. Brain Behav. 6 2007 314 320
27. D.P. Covey, S.A. Juliano, and P.A. Garris Amphetamine elicits opposing actions on readily releasable and reserve pools for dopamine PLoS ONE 8 2013 e60763
28. J.N. Crawley, J.R. Evers, and S.M. Paul Polyamines inhibit N-methyl-d-aspartate antagonist-induced darting behavior in the rat prefrontal cortex Brain Res. 586 1992 6 11
29. M.L. Cremona, H.J. Matthies, K. Pau, E. Bowton, N. Speed, B.J. Lute, M. Anderson, N. Sen, S.D. Robertson, R.A. Vaughan, J.E. Rothman, A. Galli, J.A. Javitch, and A. Yamamoto Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT Nat. Neurosci. 14 2011 469 477
30. D.P. Daberkow, H.D. Brown, K.D. Bunner, S.A. Kraniotis, M.A. Doellman, M.E. Ragozzino, P.A. Garris, and M.F. Roitman Amphetamine paradoxically augments exocytotic dopamine release and phasic dopamine signals J. Neurosci. 33 2013 452 463
31. S.D. Dickinson, J. Sabeti, G.A. Larson, K. Giardina, M. Rubinstein, M.A. Kelly, D.K. Grandy, M.J. Low, G.A. Gerhardt, and N.R. Zahniser Dopamine D2 receptor-deficient mice exhibit decreased dopamine transporter function but no changes in dopamine release in dorsal striatum J. Neurochem. 72 1999 148 156
32. P.A. Dombrowski, T.V. Maia, S.L. Boschen, M. Bortolanza, E. Wendler, R.K. Schwarting, M.L. Brandao, P. Winn, C.D. Blaha, and C. Da Cunha Evidence that conditioned avoidance responses are reinforced by positive prediction errors signaled by tonic striatal dopamine Behav. Brain Res. 241 2013 112 119
33. B.H. Falkenburger, K.L. Barstow, and I.M. Mintz Dendrodendritic inhibition through reversal of dopamine transport Science 293 2001 2465 2470
34. S.B. Floresco, A.R. West, B. Ash, H. Moore, and A.A. Grace Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission Nat. Neurosci. 6 2003 968 973
35. J.U. Fog, H. Khoshbouei, M. Holy, W.A. Owens, C.B. Vaegter, N. Sen, Y. Nikandrova, E. Bowton, D.G. McMahon, R.J. Colbran, L.C. Daws, H.H. Sitte, J.A. Javitch, A. Galli, and U. Gether Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport Neuron 51 2006 417 429
36. J.D. Foster, S.D. Adkins, J.R. Lever, and R.A. Vaughan Phorbol ester induced trafficking-independent regulation and enhanced phosphorylation of the dopamine transporter associated with membrane rafts and cholesterol J. Neurochem. 105 2008 1683 1699
37. R.R. Gainetdinov, S.R. Jones, and M.G. Caron Functional hyperdopaminergia in dopamine transporter knock-out mice Biol. Psychiatry 46 1999 303 311
38. R.R. Gainetdinov, W.C. Wetsel, S.R. Jones, E.D. Levin, M. Jaber, and M.G. Caron Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity Science 283 1999 397 401
39. S.C. Gantz, J.R. Bunzow, and J.T. Williams Spontaneous inhibitory synaptic currents mediated by a G protein-coupled receptor Neuron 78 2013 807 812
40. U. Gether, P.H. Andersen, O.M. Larsson, and A. Schousboe Neurotransmitter transporters: molecular function of important drug targets Trends Pharmacol. Sci. 27 2006 375 383
41. B. Giros, and M.G. Caron Molecular characterization of the dopamine transporter Trends Pharmacol. Sci. 14 1993 43 49
42. B. Giros, M. Jaber, S.R. Jones, R.M. Wightman, and M.G. Caron Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter Nature 379 1996 606 612
43. Y. Goto, and A.A. Grace Dopaminergic modulation of limbic and cortical drive of nucleus accumbens in goal-directed behavior Nat. Neurosci. 8 2005 805 812
44. Y. Goto, S. Otani, and A.A. Grace The Yin and Yang of dopamine release: a new perspective Neuropharmacology 53 2007 583 587
45. A.A. Grace Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia Neuroscience 41 1991 1 24
46. A.A. Grace, and B.S. Bunney Intracellular and extracellular electrophysiology of nigral dopaminergic neurons-1. Identification and characterization Neuroscience 10 1983 301 315
47. A.A. Grace, and B.S. Bunney The control of firing pattern in nigral dopamine neurons: single spike firing J. Neurosci. 4 1984 2866 2876
48. A.A. Grace, and B.S. Bunney Opposing effects of striatonigral feedback pathways on midbrain dopamine cell activity Brain Res. 333 1985 271 284
49. A.A. Grace, S.B. Floresco, Y. Goto, and D.J. Lodge Regulation of firing of dopaminergic neurons and control of goal-directed behaviors Trends Neurosci. 30 2007 220 227
50. H. Gu, S.C. Wall, and G. Rudnick Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence J. Biol. Chem. 269 1994 7124 7130
51. J. Guiramand, J.P. Montmayeur, J. Ceraline, M. Bhatia, and E. Borrelli Alternative splicing of the dopamine D2 receptor directs specificity of coupling to G-proteins J. Biol. Chem. 270 1995 7354 7358
52. P.J. Hamilton, N.G. Campbell, S. Sharma, K. Erreger, F. Herborg Hansen, C. Saunders, A.N. Belovich, M.A. Sahai, E.H. Cook, U. Gether, H.S. McHaourab, H.J. Matthies, J.S. Sutcliffe, and A. Galli De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder Mol. Psychiatry 2013
53. N. Hironaka, K. Ikeda, I. Sora, G.R. Uhl, and H. Niki Food-reinforced operant behavior in dopamine transporter knockout mice: enhanced resistance to extinction Ann. NY Acad. Sci. 1025 2004 140 145
54. O. Hornykiewicz Dopamine (3-hydroxytyramine) in the central nervous system and its relation to the Parkinson syndrome in man Dtsch. Med. Wochenschr 87 1962 1807 1810
55. S.L. Ingram, B.M. Prasad, and S.G. Amara Dopamine transporter-mediated conductances increase excitability of midbrain dopamine neurons Nat. Neurosci. 5 2002 971 978
56. S.R. Jones, R.R. Gainetdinov, M. Jaber, B. Giros, R.M. Wightman, and M.G. Caron Profound neuronal plasticity in response to inactivation of the dopamine transporter Proc. Natl. Acad. Sci. USA 95 1998 4029 4034
57. S.R. Jones, R.R. Gainetdinov, R.M. Wightman, and M.G. Caron Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter J. Neurosci. 18 1998 1979 1986
58. K.M. Kahlig, F. Binda, H. Khoshbouei, R.D. Blakely, D.G. McMahon, J.A. Javitch, and A. Galli Amphetamine induces dopamine efflux through a dopamine transporter channel Proc. Natl. Acad. Sci. USA 102 2005 3495 3500
59. H. Khoshbouei, N. Sen, B. Guptaroy, L. Johnson, D. Lund, M.E. Gnegy, A. Galli, and J.A. Javitch N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux PLoS Biol. 2 2004 E78
60. H. Khoshbouei, H. Wang, J.D. Lechleiter, J.A. Javitch, and A. Galli Amphetamine-induced dopamine efflux. A voltage-sensitive and intracellular Na+-dependent mechanism J. Biol. Chem. 278 2003 12070 12077
61. J.E. Kilty, D. Lorang, and S.G. Amara Cloning and expression of a cocaine-sensitive rat dopamine transporter Science 254 1991 578 579
62. M.A. Kurian, Y. Li, J. Zhen, E. Meyer, N. Hai, H.J. Christen, G.F. Hoffmann, P. Jardine, A. von Moers, S.R. Mordekar, F. O'Callaghan, E. Wassmer, E. Wraige, C. Dietrich, T. Lewis, K. Hyland, S. Heales Jr., T. Sanger, P. Gissen, B.E. Assmann, M.E. Reith, and E.R. Maher Clinical and molecular characterisation of hereditary dopamine transporter deficiency syndrome: an observational cohort and experimental study Lancet Neurol. 10 2011 54 62
63. M.A. Kurian, J. Zhen, S.Y. Cheng, Y. Li, S.R. Mordekar, P. Jardine, N.V. Morgan, E. Meyer, L. Tee, S. Pasha, E. Wassmer, S.J. Heales, P. Gissen, M.E. Reith, and E.R. Maher Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia J. Clin. Invest. 119 2009 1595 1603
64. M.G. Lacey, N.B. Mercuri, and R.A. North Dopamine acts on D2 receptors to increase potassium conductance in neurones of the rat substantia nigra zona compacta J. Physiol. 392 1987 397 416
65. F.J. Lee, L. Pei, A. Moszczynska, B. Vukusic, P.J. Fletcher, and F. Liu Dopamine transporter cell surface localization facilitated by a direct interaction with the dopamine D2 receptor Embo J. 26 2007 2127 2136
66. O. Lindvall, and A. Bjorklund Anatomy of the dopaminergic neuron systems in the rat brain Adv. Biochem. Psychopharmacol. 19 1978 1 23
67. J.E. Lisman, and A.A. Grace The hippocampal-VTA loop: controlling the entry of information into long-term memory Neuron 46 2005 703 713
68. D.J. Lodge, and A.A. Grace The hippocampus modulates dopamine neuron responsivity by regulating the intensity of phasic neuron activation Neuropsychoparmacology 31 2006 1356 1361
69. D.J. Lodge, and A.A. Grace The laterodorsal tegmentum is essential for burst firing of ventral tegmental area dopamine neurons Proc. Natl. Acad. Sci. USA 103 2006 5167 5172
70. R.D. Mayfield, and N.R. Zahniser Dopamine D2 receptor regulation of the dopamine transporter expressed in Xenopus laevis oocytes is voltage-independent Mol. Pharmacol. 59 2001 113 121
71. M.S. Mazei-Robison, E. Bowton, M. Holy, M. Schmudermaier, M. Freissmuth, H.H. Sitte, A. Galli, and R.D. Blakely Anomalous dopamine release associated with a human dopamine transporter coding variant J. Neurosci. 28 2008 7040 7046
72. M.A. Mergy, R. Gowrishankar, G.L. Davis, T.L. Jessen, J. Wright, and G.D. Stanwood et al. Genetic targeting of the amphetamine and methylphenidate- sensitive dopamine transporter: On the path to an animal model of Attention-deficit Hyperactivity Disorder Neurochemistry International 73 2013 56 70
73. J. Mill, P. Asherson, I. Craig, and U.M. D'Souza Transient expression analysis of allelic variants of a VNTR in the dopamine transporter gene (DAT1) BMC Genet. 6 2005 3
74. C. Missale, S.R. Nash, S.W. Robinson, M. Jaber, and M.G. Caron Dopamine receptors: from structure to function Physiol. Rev. 78 1998 189 225
75. K.F. Moquin, and A.C. Michael An inverse correlation between the apparent rate of dopamine clearance and tonic autoinhibition in subdomains of the rat striatum: a possible role of transporter-mediated dopamine efflux J. Neurochem. 117 2011 133 142
76. E. Morice, J.M. Billard, C. Denis, F. Mathieu, C. Betancur, J. Epelbaum, B. Giros, and M. Nosten-Bertrand Parallel loss of hippocampal LTD and cognitive flexibility in a genetic model of hyperdopaminergia Neuropsychoparmacology 32 2007 2108 2116
77. B.M. Neale, Y. Kou, L. Liu, A. Ma'ayan, K.E. Samocha, A. Sabo, C.F. Lin, C. Stevens, L.S. Wang, V. Makarov, P. Polak, S. Yoon, J. Maguire, E.L. Crawford, N.G. Campbell, E.T. Geller, O. Valladares, C. Schafer, H. Liu, T. Zhao, G. Cai, J. Lihm, R. Dannenfelser, O. Jabado, Z. Peralta, U. Nagaswamy, D. Muzny, J.G. Reid, I. Newsham, Y. Wu, L. Lewis, Y. Han, B.F. Voight, E. Lim, E. Rossin, A. Kirby, J. Flannick, M. Fromer, K. Shakir, T. Fennell, K. Garimella, E. Banks, R. Poplin, S. Gabriel, M. DePristo, J.R. Wimbish, B.E. Boone, S.E. Levy, C. Betancur, S. Sunyaev, E. Boerwinkle, J.D. Buxbaum, E.H. Cook Jr., B. Devlin, R.A. Gibbs, K. Roeder, G.D. Schellenberg, J.S. Sutcliffe, and M.J. Daly Patterns and rates of exonic de novo mutations in autism spectrum disorders Nature 485 2012 242 245
78. M.J. Nirenberg, J. Chan, A. Pohorille, R.A. Vaughan, G.R. Uhl, M.J. Kuhar, and V.M. Pickel The dopamine transporter: comparative ultrastructure of dopaminergic axons in limbic and motor compartments of the nucleus accumbens J. Neurosci. 17 1997 6899 6907
79. M.J. Nirenberg, J. Chan, R.A. Vaughan, G.R. Uhl, M.J. Kuhar, and V.M. Pickel Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area J. Neurosci. 17 1997 4037 4044
80. M.J. Nirenberg, R.A. Vaughan, G.R. Uhl, M.J. Kuhar, and V.M. Pickel The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons J. Neurosci. 16 1996 436 447
81. C.M. O'Hara, A. Uhland-Smith, K.L. O'Malley, and R.D. Todd Inhibition of dopamine synthesis by dopamine D2 and D3 but not D4 receptors J. Pharmacol. Exp. Ther. 277 1996 186 192
82. V. Olivier, B. Guibert, and V. Leviel Direct in vivo comparison of two mechanisms releasing dopamine in the rat striatum Brain Res. 695 1995 1 9
83. F. Opazo, J.B. Schulz, and B.H. Falkenburger PKC links Gq-coupled receptors to DAT-mediated dopamine release J. Neurochem. 114 2010 587 596
84. P.G. Overton, and D. Clark Burst firing in midbrain dopaminergic neurons Brain Res. Brain Res. Rev. 25 1997 312 334
85. A.B. Pizzo, C.S. Karam, Y. Zhang, H. Yano, R.J. Freyberg, D.S. Karam, Z. Freyberg, A. Yamamoto, B.D. McCabe, and J.A. Javitch The membrane raft protein Flotillin-1 is essential in dopamine neurons for amphetamine-induced behavior in Drosophila Mol. Psychiatry 18 2013 824 833
86. M.E. Rice, S.J. Cragg, and S.A. Greenfield Characteristics of electrically evoked somatodendritic dopamine release in substantia nigra and ventral tegmental area in vitro J. Neurophysiol. 77 1997 853 862
87. T.W. Robbins Dopamine and cognition Curr. Opin. Neurol. 16 Suppl 2 2003 S1 2
88. D. Sakrikar, M.S. Mazei-Robison, M.A. Mergy, N.W. Richtand, Q. Han, P.J. Hamilton, E. Bowton, A. Galli, J. Veenstra-Vanderweele, M. Gill, and R.D. Blakely Attention deficit/hyperactivity disorder-derived coding variation in the dopamine transporter disrupts microdomain targeting and trafficking regulation J. Neurosci. 32 2012 5385 5397
89. A. Salahpour, I.O. Medvedev, J.M. Beaulieu, R.R. Gainetdinov, and M.G. Caron Local knockdown of genes in the brain using small interfering RNA: a phenotypic comparison with knockout animals Biol. Psychiatry 61 2007 65 69
90. A. Salahpour, A.J. Ramsey, I.O. Medvedev, B. Kile, T.D. Sotnikova, E. Holmstrand, V. Ghisi, P.J. Nicholls, L. Wong, K. Murphy, S.R. Sesack, R.M. Wightman, R.R. Gainetdinov, and M.G. Caron Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter Proc. Natl. Acad. Sci. USA 105 2008 4405 4410
91. C. Saunders, J.V. Ferrer, L. Shi, J. Chen, G. Merrill, M.E. Lamb, L.M. Leeb-Lundberg, L. Carvelli, J.A. Javitch, and A. Galli Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism Proc. Natl. Acad. Sci. USA 97 2000 6850 6855
92. W. Schultz Predictive reward signal of dopamine neurons J. Neurophysiol. 80 1998 1 27
93. S.R. Sesack, C. Aoki, and V.M. Pickel Ultrastructural localization of D2 receptor-like immunoreactivity in midbrain dopamine neurons and their striatal targets J. Neurosci. 14 1994 88 106
94. M.S. Sonders, S.J. Zhu, N.R. Zahniser, M.P. Kavanaugh, and S.G. Amara Multiple ionic conductances of the human dopamine transporter: the actions of dopamine and psychostimulants J. Neurosci. 17 1997 960 974
95. T.J. Spencer, J. Biederman, B.K. Madras, D.D. Dougherty, A.A. Bonab, E. Livni, P.C. Meltzer, J. Martin, S. Rauch, and A.J. Fischman Further evidence of dopamine transporter dysregulation in ADHD: a controlled PET imaging study using altropane Biol. Psychiatry 62 2007 1059 1061
96. C. Spielewoy, G. Biala, C. Roubert, M. Hamon, C. Betancur, and B. Giros Hypolocomotor effects of acute and daily d-amphetamine in mice lacking the dopamine transporter Psychopharmacology 159 2001 2 9
97. D. Sulzer, M.S. Sonders, N.W. Poulsen, and A. Galli Mechanisms of neurotransmitter release by amphetamines: a review Prog. Neurobiol. 75 2005 406 433
98. H.C. Tsai, F. Zhang, A. Adamantidis, G.D. Stuber, A. Bonci, L. de Lecea, and K. Deisseroth Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning Science 324 2009 1080 1084
99. K.M. Tye, J.J. Mirzabekov, M.R. Warden, E.A. Ferenczi, H.C. Tsai, J. Finkelstein, S.Y. Kim, A. Adhikari, K.R. Thompson, A.S. Andalman, L.A. Gunaydin, I.B. Witten, and K. Deisseroth Dopamine neurons modulate neural encoding and expression of depression-related behaviour Nature 493 2013 537 541
100. S.J. Tye, A.D. Miller, and C.D. Blaha Ventral tegmental ionotropic glutamate receptor stimulation of nucleus accumbens tonic dopamine efflux blunts hindbrain-evoked phasic neurotransmission: implications for dopamine dysregulation disorders Neuroscience 252C 2013 337 345
101. M.A. Ungless, P.J. Magill, and J.P. Bolam Uniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli Science 303 2004 2040 2042
102. R. van Zessen, J.L. Phillips, E.A. Budygin, and G.D. Stuber Activation of VTA GABA neurons disrupts reward consumption Neuron 73 2012 1184 1194
103. N.D. Volkow, G.J. Wang, J. Newcorn, J.S. Fowler, F. Telang, M.V. Solanto, J. Logan, C. Wong, Y. Ma, J.M. Swanson, K. Schulz, and K. Pradhan Brain dopamine transporter levels in treatment and drug naive adults with ADHD Neuroimage 34 2007 1182 1190
104. B. Yang, R.C. Chan, J. Jing, T. Li, P. Sham, and R.Y. Chen A meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3'-UTR of dopamine transporter gene and attention deficit hyperactivity disorder Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B 2007 541 550
105. X. Zhuang, R.S. Oosting, S.R. Jones, R.R. Gainetdinov, G.W. Miller, M.G. Caron, and R. Hen Hyperactivity and impaired response habituation in hyperdopaminergic mice Proc. Natl. Acad. Sci. USA 98 2001 1982 1987