Acute sterol O-acyltransferase 2 (SOAT2) knockdown rapidly mobilizes hepatic cholesterol for fecal excretion

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Marshall, Stephanie M ^a   Gromovsky, Anthony D ^c   Kelley, Kathryn L ^a   Davis, Matthew A ^a   Wilson, Martha D ^a   Lee, Richard G ^b   Crooke, Rosanne M ^b   Graham, Mark J ^b   Rudel, Lawrence L ^a   Brown, J Mark ^a,c   Temel, Ryan E ^a,d  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b ISIS PHARMACEUTICALS   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B100; APOLIPOPROTEIN B48; BILE ACID; CHOLESTEROL ACYLTRANSFERASE; HIGH DENSITY LIPOPROTEIN; LIVER X RECEPTOR; LOW DENSITY LIPOPROTEIN; STEROL O ACYLTRANSFERASE 2; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRIACYLGLYCEROL LIPASE; TRIACYLGLYCEROL LIPASE 1; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN; ANTISENSE OLIGONUCLEOTIDE; APOLIPOPROTEIN B; APOLIPOPROTEIN E; CHOLESTEROL; CHOLESTEROL ESTER; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; STEROL O-ACYLTRANSFERASE 2;

ABCG8 GENE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CHOLESTEROL LIVER LEVEL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; FECES; FEMALE; GENE; GENE EXPRESSION; GENE SILENCING; LIPID BILE LEVEL; LIPID HOMEOSTASIS; LIPID STORAGE; MOUSE; NONHUMAN; SOAT2 GENE; TRIGLYCERIDE HYDROLASE 1 GENE; ANIMAL; ANTAGONISTS AND INHIBITORS; BILE; BLOOD; C57BL MOUSE; CHEMISTRY; DRUG EFFECTS; GALLBLADDER; GENETICS; LIPID DIET; LIVER; METABOLISM; SMALL INTESTINE;

ANIMALS; APOLIPOPROTEINS B; APOLIPOPROTEINS E; BILE; CHOLESTEROL; CHOLESTEROL ESTERS; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DIET, HIGH-FAT; FECES; FEMALE; GALLBLADDER; INTESTINE, SMALL; LIPOPROTEINS; LIVER; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDES, ANTISENSE; RNA, MESSENGER; STEROL O-ACYLTRANSFERASE;

EID: 84902477272     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0098953     Document Type: Article

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