The negative immunoregulatory effects of serotonin (5-HT) moduline, an endogenous 5-HT1B receptor antagonist with anti-anxiety properties

Cytokine

Volumn 19, Issue 6, 2002, Pages 308-311

  Maes, Michael ^a,b,c   Kenis, Gunter ^a   Bosmans, Eugene ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VANDERBILT UNIVERSITY   (United States)

^c Clinical Research Center for Mental Health of Antwerp   (Belgium)

Author keywords

cAMP; Cytokine; Interferon; Moduline; Serotonin; Tumor necrosis factor

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; LEUCYLSERYLALANYLLEUCINE; SEROTONIN; SEROTONIN 1B ANTAGONIST; TUMOR NECROSIS FACTOR ALPHA; 5-HT-MODULINE; ANXIOLYTIC AGENT; HTR1B PROTEIN, HUMAN; IMMUNOSUPPRESSIVE AGENT; NEUROPEPTIDE; OLIGOPEPTIDE; SEROTONIN 1B RECEPTOR; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR; SEROTONIN UPTAKE INHIBITOR;

ADULT; ANXIETY; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOREGULATION; INTERFERON PRODUCTION; NORMAL HUMAN; PRIORITY JOURNAL; TRANQUILIZING ACTIVITY; BIOSYNTHESIS; MALE; METABOLISM;

ADULT; ANTI-ANXIETY AGENTS; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERFERON TYPE II; INTERLEUKIN-10; MALE; NEUROPEPTIDES; OLIGOPEPTIDES; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; SEROTONIN UPTAKE INHIBITORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036434412     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.2002.1053     Document Type: Article

References (15)

1. Jensen MM (1968) Transitory impairment of interferon production in serotonin treated mice. Proc Soc Exp Biol Med 128:174-178.
2. Kubera M, Kenis G, Bosmans E, Scharpe S, Maes M (2001) Effects of serotonin and serotonergic agonists and antagonists on the production of interferon-gamma and interleukin-10. Neuropsychopharmacology 23:89-98.
3. Maes M, Song C, Lin AH, Bonaccorso S, Kenis G, De Jongh R, Bosmans E, Scharpé S (1999) Negative immunoregulatory effects of antidepressants: Inhibition of interferon-gamma and stimulation of interleukin-10 secretion. Neuropsychopharmacology 20:370-379.
4. O'Shea JJ, Ma A, Lipsky P (2002) Cytokines and autoimmunity. Nature Rev Immunol 2:37-45.
5. Massot O, Rousselle JC, Grimaldi B, Cloez-Tayarani I, Fillion MP, Plantefol M, Bonnin A, Prudhomme N, Fillion G (1998) Molecular, cellular and physiological characteristics of 5-HT-moduline, a novel endogenous modulator of 5-HT1B receptor subtype. Ann N Y Acad Sci 861:174-182.
6. Fillion G, Rousselle JC, Massot O, Zifa E, Fillion MP, Prudhomme N (1996) A new peptide, 5-HT-moduline, isolated and purified from mammalian brain specifically interacts with 5-HT1B/1D receptors. Behav Brain Res 73:313-317.
7. Grimaldi B, Bonnin A, Fillion MP, Massot O, Rouselle JC, Prudhomme N, Fillion G (1999) Interaction of the serotonergic and the immune systems: 5-HT moduline. In: Muller N (ed.) Psychiatry, Psychoimmunology, and Viruses. Springer, Wien/New York, pp. 45-54.
8. Grimaldi B, Fillion G (2000) 5-HT-moduline controls serotonergic activity: Implication in neuroimmune reciprocal regulation mechanisms. Prog Neurobiol 60:1-12.
9. Benbernou N, Esnault S, Shin HC, Fekkar H, Guenounou M (1997) Differential regulation of IFN-gamma, IL-10 and inducible nitric oxide synthase in human T cells by cyclic AMP-dependent signal transduction pathway. Immunology 91:361-368.
10. Eigler A, Siegmund B, Emmerich U, Baumann KH, Hartmann G, Endres S (1998) Anti-inflammatory activities of cAMP-elevating agents: Enhancement of IL-10 synthesis and concurrent suppression of TNF production. J Leukoc Biol 63:101-107.
11. Mendez J, Kadia TM, Somayazula RK, El-Badawi KI, Cowen DS (1999) Differential coupling of serotonin 5-HT1A and 5-HT1B receptors to activation of ERK2 and inhibition of adenylyl cyclase in transfected CHO cells. J Neurochem 73:162-168.
12. Chennaoui M, Grimaldi B, Fillion MP, Bonnin A, Drogou C, Fillion G, Guezennec CY (2000) Effects of physical training on functional activity of 5-HT1B receptors in rat central nervous system: role of 5-HT-moduline. Naunyn Schmiedebergs Arch Pharmacol 361:600-604.
13. Grimaldi B, Bonnin A, Fillion MP, Prudhomme N, Fillion G (1999) 5-Hydroxytryptamine-moduline: A novel endogenous peptide involved in the control of anxiety. Neuroscience 93:1223-1225.
14. Maes M (1999) Psychological stress, cytokines and the inflammatory response system. Curr Opin Psychiatry 12:695-700.
15. Katsikis PD, Cohen SB, Londei M, Feldmann M (1995) Are CD4+ Th1 cells pro-inflammatory or anti-inflammatory? The ratio of IL-10 to IFN-gamma or IL-2 determines their function. Int Immunol 7:1287-1294.