Er-Miao-San, a traditional herbal formula containing Rhizoma Atractylodis and Cortex Phellodendri inhibits inflammatory mediators in LPS-stimulated RAW264.7 macrophages through inhibition of NF-κB pathway and MAPKs activation

Journal of Ethnopharmacology

Volumn 154, Issue 3, 2014, Pages 711-718

  Chen, Gang ^a   Li, Kai Kai ^b   Fung, Chak Hei ^b   Liu, Cheuk Lun ^b   Wong, Hing Lok ^b   Leung, Ping Chung ^b   Ko, Chun Hay ^b  

^a CHONGQING TECHNOLOGY AND BUSINESS UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Er Miao San; Inducible nitric oxide synthase; Nitric oxide; Nuclear factor B; P38; Traditional Chinese medicine

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; NUCLEAR FACTOR; PLANT EXTRACT; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; CYTOKINE; ER-MIAO-SAN; HERBACEOUS AGENT; MITOGEN ACTIVATED PROTEIN KINASE; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA BINDING; ENZYME INHIBITION; HERBAL MEDICINE; MACROPHAGE ACTIVATION; MEDIATOR; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RHIZOME; TRADITIONAL MEDICINE; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL CULTURE; CHEMISTRY; CHINESE MEDICINE; CORK TREE; DRUG EFFECTS; ISOLATION AND PURIFICATION; MACROPHAGE; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELLS, CULTURED; CYTOKINES; DRUGS, CHINESE HERBAL; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MEDICINE, CHINESE TRADITIONAL; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; PHELLODENDRON; RHIZOME;

EID: 84902456212     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2014.04.042     Document Type: Article

References (37)

1. A.A. Beg, S.M. Ruben, R.I. Scheinman, S. Haskill, C.A. Rosen, and A.S. Baldwin Jr. I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention Genes and Development 6 1992 1899 1913
2. B. Beutler, and A. Cerami The biology of cachectin/TNF - a primary mediator of the host response Annual Review of Immunology 7 1989 625 655
3. D.S. Bredt Endogenous nitric oxide synthesis: biological functions and pathophysiology Free Radical Research 31 1999 577 596
4. Y.X. Bao, C.K. Wong, E.K. Li, L.S. Tam, P.C. Leung, Y.B. Yin, and C.W. Lam Immunomodulatory effects of lingzhi and San-Miao-San supplementation on patients with rheumatoid arthritis Immunopharmacology Immunotoxicology 28 2006 197 200
5. L. Connelly, A.T. Jacobs, M. Palacios-Callender, S. Moncada, and A.J. Hobbs Macrophage endothelial nitric-oxide synthase autoregulates cellular activation and pro-inflammatory protein expression Journal of Biological Chemistry 278 2003 26480 26487
6. P. Conti, and M. DiGioacchino MCP-1 and RANTES are mediators of acute and chronic inflammation Allergy and Asthma Proceedings 22 2001 133 137
7. Y. Dai, P.P. But, Y.P. Chan, H. Matsuda, and M. Kubo Antipruritic and antiinflammatory effects of aqueous extract from Si-Wu-Tang Biological and Pharmaceutical Bulletin 25 2002 1175 1178
8. M.A. Gonzalez-Gay, J. Llorca, E. Sanchez, M.A. Lopez-Nevot, M. Amoli, C. Garcia-Porrua, W.E. Ollier, and J. Martin Inducible but not endothelial nitric oxide synthase polymorphism is associated with susceptibility to rheumatoid arthritis in northwest Spain Rheumatology 43 2004 1182 1185
9. K. Jarvinen, K. Vuolteenaho, R. Nieminen, T. Moilanen, R.G. Knowles, and E. Moilanen Selective iNOS inhibitor 1400 W enhances anti-catabolic IL-10 and reduces destructive MMP-10 in OA cartilage. Survey of the effects of 1400 W on inflammatory mediators produced by OA cartilage as detected by protein antibody array Clinical and Experimental Rheumatology 26 2008 275 282
10. X. Jiang, N. Takahashi, N. Matsui, T. Tetsuka, and T. Okamoto The NF-kappa B activation in lymphotoxin beta receptor signaling depends on the phosphorylation of p65 at serine 536 Journal of Biological Chemistry 278 2003 919 926
11. P.K. Lai, J.Y. Chan, L. Cheng, C.P. Lau, S.Q. Han, P.C. Leung, K.P. Fung, and C.B. Lau Isolation of anti-inflammatory fractions and compounds from the root of Astragalus membranaceus Phytotherapy Research 27 2013 581 587
12. F.F. Lam, I.W. Ko, E.S. Ng, L.S. Tam, P.C. Leung, and E.K. Li Analgesic and anti-arthritic effects of Lingzhi and San Miao San supplementation in a rat model of arthritis induced by Freund's complete adjuvant Journal of Ethnopharmacology 120 2008 44 50
13. K.M. Lau, K.K. Lai, C.L. Liu, J.C. Tam, M.H. To, H.F. Kwok, C.P. Lau, C.H. Ko, P.C. Leung, K.P. Fung, S.K. Poon, and C.B. Lau Synergistic interaction between Astragali Radix and Rehmanniae Radix in a Chinese herbal formula to promote diabetic wound healing Journal of Ethnopharmacology 141 2012 250 256
14. F.S. Lee, R.T. Peters, L.C. Dang, and T. Maniatis MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta Proceedings of the National Academy of Sciences USA 95 1998 9319 9324
15. E.K. Li, L.S. Tam, C.K. Wong, W.C. Li, C.W. Lam, S. Wachtel-Galor, I.F. Benzie, Y.X. Bao, P.C. Leung, and B. Tomlinson Safety and efficacy of Ganoderma lucidum (lingzhi) and San Miao San supplementation in patients with rheumatoid arthritis: a double-blind, randomized, placebo-controlled pilot trial Arthritis and Rheumatism 57 2007 1143 1150
16. J. Lu, J.S. Wang, and L.Y. Kong Anti-inflammatory effects of Huang-Lian-Jie-Du decoction, its two fractions and four typical compounds Journal of Ethnopharmacology 134 2011 911 918
17. P. Lu, L. Li, G. Liu, T. Baba, Y. Ishida, M. Nosaka, T. Kondo, X. Zhang, and N. Mukaida Critical role of TNF-alpha-induced macrophage VEGF and iNOS production in the experimental corneal neovascularization Investigative Ophthalmology and Visual Science 53 2012 3516 3526
18. Y.F. Mao, Y.Q. Li, L. Zong, X.M. You, F.Q. Lin, and L. Jiang Methanol extract of Phellodendri cortex alleviates lipopolysaccharide-induced acute airway inflammation in mice Immunopharmacology and Immunotoxicology 32 2010 110 115
19. R.G. Molloy, J.A. Mannick, and M.L. Rodrick Cytokines, sepsis and immunomodulation British Journal of Surgery 80 1993 289 297
20. G. Nagy, J.M. Clark, E.I. Buzas, C.L. Gorman, and A.P. Cope Nitric oxide, chronic inflammation and autoimmunity Immunology Letters 111 2007 1 5
21. 2+- and redox-dependent production of nitric oxide Journal of Immunology 171 2003 5188 5197
22. J.C. Oates, M.C. Levesque, M.R. Hobbs, E.G. Smith, I.D. Molano, G.P. Page, B.S. Hill, J.B. Weinberg, G.S. Cooper, and G.S. Gilkeson Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in African-Americans Journal of Rheumatology 30 2003 60 67
23. J.C. Oates, S.R. Shaftman, S.E. Self, and G.S. Gilkeson Association of serum nitrate and nitrite levels with longitudinal assessments of disease activity and damage in systemic lupus erythematosus and lupus nephritis Arthritis and Rheumatism 58 2008 263 272
24. O. Onur, A.S. Akinci, F. Akbiyik, and I. Unsal Elevated levels of nitrate in rheumatoid arthritis Rheumatology International 20 2001 154 158
25. K.N. Pennington, J.A. Taylor, G.D. Bren, and C.V. Paya IkappaB kinase-dependent chronic activation of NF-kappaB is necessary for p21(WAF1/Cip1) inhibition of differentiation-induced apoptosis of monocytes Molecular and Cellular Biology 21 2001 1930 1941
26. Y.K. Park, Y.S. Chung, Y.S. Kim, O.Y. Kwon, and T.H. Joh Inhibition of gene expression and production of iNOS and TNF-alpha in LPS-stimulated microglia by methanol extract of Phellodendri cortex International Immunopharmacology 7 2007 955 962
27. Y. Sakaguchi, H. Shirahase, A. Ichikawa, M. Kanda, Y. Nozaki, and Y. Uehara Effects of selective iNOS inhibition on type II collagen-induced arthritis in mice Life Sciences 75 2004 2257 2267
28. C.Y. Sasaki, T.J. Barberi, P. Ghosh, and D.L. Longo Phosphorylation of RelA/p65 on serine 536 defines an I{kappa}B{alpha}-independent NF-{kappa}B pathway Journal of Biological Chemistry 280 2005 34538 34547
29. A.G. Tennyson, and S.J. Lippard Generation, translocation, and action of nitric oxide in living systems Chemistry and Biology 18 2011 1211 1220
30. B. Tian, D.E. Nowak, M. Jamaluddin, S. Wang, and A.R. Brasier Identification of direct genomic targets downstream of the nuclear factor-kappaB transcription factor mediating tumor necrosis factor signaling Journal of Biological Chemistry 280 2005 17435 17448
31. R.J. van't Hof, and S.H. Ralston Nitric oxide and bone Immunology 103 2001 255 261
32. A.J. van Zonneveld, H.C. de Boer, E.P. van der Veer, and T.J. Rabelink Inflammation, vascular injury and repair in rheumatoid arthritis Annals of the Rheumatic Diseases 69 Suppl. 1 2010 i57 i60
33. W.K. Wang, T.L. Hsu, Y. Chiang, and Y.Y. Wang Pulse spectrum study on the effect of Sie-Zie-Tang and Radix aconite American Journal of Chinese Medicine 25 1997 357 366
34. Q.W. Xie, H.J. Cho, J. Calaycay, R.A. Mumford, K.M. Swiderek, T.D. Lee, A. Ding, T. Troso, and C. Nathan Cloning and characterization of inducible nitric oxide synthase from mouse macrophages Science 256 1992 225 228
35. Q. Xu, K. Yuan, J. Lu, R. Wang, and F. Wu A new strategy for regulating the immunological liver injury - effectiveness of DTH-inhibiting agents on DTH-induced liver injury to picryl chloride Pharmacological Research 36 1997 401 409
36. C.M. Yao, and X.W. Yang Bioactivity-guided isolation of polyacetylenes with inhibitory activity against NO production in LPS-activated RAW264.7 macrophages from the rhizomes of Atractylodes macrocephala Journal of Ethnopharmacology 151 2014 791 799
37. F. Yang, E. Tang, K. Guan, and C.Y. Wang IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide Journal of Immunology 170 2003 5630 5635