IκB kinase-dependent chronic activation of NF-κB is necessary for p21WAF1/Cip1 inhibition of differentiation-induced apoptosis of monocytes

Molecular and Cellular Biology

Volumn 21, Issue 6, 2001, Pages 1930-1941

  Pennington, Kevin N ^a   Taylor, Julie A ^a   Bren, Gary D ^a   Paya, Carlos V ^a,b  

^a MAYO GRADUATE SCHOOL   (United States)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOTRANSFERASE; PROTEIN P21; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CDKN1A PROTEIN, HUMAN; CHUK PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; ENZYME INHIBITOR; IKBKB PROTEIN, HUMAN; IKBKE PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; GENE MUTATION; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; LEUKOPOIESIS; MOLECULAR DYNAMICS; MONOCYTE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN TRANSPORT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; CYTOLOGY; DRUG EFFECT; ENZYME ACTIVATION; MACROPHAGE; METABOLISM; PHYSIOLOGY;

APOPTOSIS; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; I-KAPPA B KINASE; MACROPHAGES; MONOCYTES; NF-KAPPA B; PROTEIN-SERINE-THREONINE KINASES; TETRADECANOYLPHORBOL ACETATE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034743970     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.6.1930-1941.2001     Document Type: Article

References (62)

1. Asada, M., T. Yamada, H. Ichijo, D. Delia, K. Miyazono, K. Fukumuro, and S. Mizutani. 1999. Apoptosis inhibitory activity of cytoplasmic p21(Cip1/ WAF1) in monocytic differentiation. EMBO J. 18:1223-1234.
2. Asin, S., J. A. Taylor, S. Trushin, G. Bren, and C. V. Paya. 1999. Iκκ mediates NF-κB activation in human immunodeficiency virus-infected cells. J. Virol. 73:3893-3903.
3. Baeuerle, P. A., and D. Baltimore. 1996. NF-kappa B: ten years after. Cell 87:13-20.
4. Baeuerle, P. A., and T. Henkel. 1994. Function and activation of NF-kappa B in the immune system. Annu. Rev. Immunol. 12:141-79.
5. 1/S-phase transition. Mol. Cell. Biol. 17:6526-6536.
6. Beg, A. A., and D. Baltimore. 1996. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science 274:782-784.
7. Beg, A. A., W. C. Sha, R. T. Bronson, and D. Baltimore. 1995. Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice. Genes Dev. 9:2736-2746.
8. Casini, T., and P. G. Pelicci. 1999. A function of p21 during promyelocytic leukemia cell differentiation independent of CDK inhibition and cell cycle arrest. Oncogene 18:3235-3243.
9. Chellappan, S. P., A. Giordano, and P. B. Fisher. 1998. Role of cyclin-dependent kinases and their inhibitors in cellular differentiation and development. Curr. Top. Microbiol. Immunol. 227:57-103.
10. Chu, Z. L., T. A. McKinsey, L. Liu, J. J. Gentry, M. H. Malim, and D. W. Ballard. 1997. Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control. Proc. Natl. Acad. Sci. USA 94:10057-10062.
11. Cory, S. 1995. Regulation of lymphocyte survival by the bcl-2 gene family. Annu. Rev. Immunol. 13:513-543.
12. de Martin, R., J. A. Schmid, and R. Hofer-Warbinek. 1999. The NF-kappaB/ Rel family of transcription factors in oncogenic transformation and apoptosis. Mutat. Res. 437:231-243.
13. DiDonato, J. A., M. Hayakawa, D. M. Rothwarf, E. Zandi, and M. Karin. 1997. A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature 388:548-554.
14. Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475-89.
15. Donato, N. J., and M. Perez. 1998. Tumor necrosis factor-induced apoptosis stimulates p53 accumulation and p21WAF1 proteolysis in ME-180 cells. J. Biol. Chem. 273:5067-5072.
16. Ehinger, M., E. Nilsson, A. M. Persson, I. Olsson, and U. Gullberg. 1995. Involvement of the tumor suppressor gene p53 in tumor necrosis factor-induced differentiation of the leukemic cell line K562. Cell Growth Differ. 6:9-17.
17. el-Deiry, W. S., T. Tokino, V. E. Velculescu, D. B. Levy, R. Parsons, J. M. Trent, D. Lin, W. E. Mercer, K. W. Kinzler, and B. Vogelstein. 1993. WAF1, a potential mediator of p53 tumor suppression. Cell 75:817-825.
18. Fahlman, C., F. W. Jacobsen, O. P. Veiby, I. K. McNiece, H. K. Blomhoff, and S. E. Jacobsen. 1994. Tumor necrosis factor-alpha (TNF-α) potently enhances in vitro macrophage production from primitive murine hematopoietic progenitor cells in combination with stem cell factor and interleukin-7: novel stimulatory role of p55 TNF receptors. Blood 84:1528-1533.
19. Foo, S. Y., and G. P. Nolan. 1999. NF-kappaB to the rescue: RELs, apoptosis and cellular transformation. Trends Genet. 15:229-235.
20. Freemerman, A. J., J. A. Vrana, R. M. Tombes, H. Jiang, S. P. Chellappan, P. B. Fisher, and S. Grant. 1997. Effects of antisense p21 (WAF1/CIP1/ MDA6) expression on the induction of differentiation and drug-mediated apoptosis in human myeloid leukemia cells (HL-60). Leukemia 11:504-513.
21. 1+ Mol. Cell. Biol. 8:1614-1624.
22. Friedman, A. D., B. L. Krieder, D. Venturelli, and G. Rovera. 1991. Transcriptional regulation of two myeloid-specific genes, myeloperoxidase and lactoferrin, during differentiation of the murine cell line 32D C13. Blood 78:2426-2432.
23. Ghoda, L., X. Lin, and W. C. Greene. 1997. The 90-kDa ribosomal S6 kinase (pp90rsk) phosphorylates the N-terminal regulatory domain of IkappaBalpha and stimulates its degradation in vitro. J. Biol. Chem. 272:21281-21288.
24. Griffin, G. E., K. Leung, T. M. Folks, S. Kunkel, and G. J. Nabel. 1989. Activation of HIV gene expression during monocyte differentiation by induction of NF-kappa B. Nature 339:70-73.
25. Griffin, G. E., K. Leung, T. M. Folks, S. Kunkel, and G. J. Nabel. 1991. Induction of NF-kappa B during monocyte differentiation is associated with activation of HIV-gene expression. Res. Virol. 142:233-238.
26. Henkel, G. W., S. R. McKercher, P. J. Leenen, and R. A. Maki. 1999. Commitment to the monocytic lineage occurs in the absence of the transcription factor PU.1. Blood 93:2849-2858.
27. Iotsova, V., J. Caamano, J. Loy, Y. Yang, A. Lewin, and R. Bravo. 1997. Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2. Nat. Med. 3:1285-1289.
28. Ishida, Y., Y. Furukawa, J. A. Decaprio, M. Saito, and J. D. Griffin. 1992. Treatment of myeloid leukemic cells with the phosphatase inhibitor okadaic acid induces cell cycle arrest at either G1/S or G2/M depending on dose. J. Cell Physiol. 150:484-492.
29. Javelaud, D., J. Wietzerbin, O. Delattre, and F. Besancon. 2000. Induction of p21Waf1/Cip1 by TNFalpha requires NF-kappaB activity and antagonizes apoptosis in Ewing tumor cells. Oncogene 19:61-68.
30. Jiang, Y., and A. G. Porter. 1998. Prevention of tumor necrosis factor (TNF)-mediated induction of p21WAF1/CIP1 sensitizes MCF-7 carcinoma cells to TNF-induced apoptosis. Biochem. Biophys. Res. Commun. 245:691-697.
31. Karin, M. 1999. The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation. J. Biol. Chem. 274:27339-27342.
32. Kelly, L. M., U. Englmeier, I. Lafon, M. H. Sieweke, and T. Graf. 2000. MafB is an inducer of monocytic differentiation. EMBO J. 19:1987-1997.
33. Kowenz-Leutz, E., P. Herr, K. Niss, and A. Leutz. 1997. The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation. Cell 91:185-195.
34. Lernbecher, T., U. Muller, and T. Wirth. 1993. Distinct NF-kappa B/Rel transcription factors are responsible for tissue-specific and inducible gene activation. Nature 365:767-770.
35. Liou, H. C., W. C. Sha, M. L. Scott, and D. Baltimore. 1994. Sequential induction of NF-κB/Rel family proteins during B-cell terminal differentiation. Mol. Cell. Biol. 14:5349-5359.
36. Luque, I., and C. Gelinas. 1997. Rel/NF-kappa B and I kappa B factors in oncogenesis. Semin. Cancer Biol. 8:103-111.
37. Macleod, K. F., N. Sherry, G. Hannon, D. Beach, T. Tokino, K. Kinzler, B. Vogelstein, and T. Jacks. 1995. p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev. 9:935-944.
38. Mak, N. K., K. N. Leung, M. C. Fung, and A. J. Hapel. 1994. Augmentation of tumor necrosis factor-alpha-induced monocytic differentiation of a myelomonocytic leukemia (WEHI-3B JCS) by pertussis toxin. Immunobiology 190:1-12.
39. McElhinny, J. A., S. A. Trushin, G. D. Bren, N. Chester, and C. V. Paya. 1996. Casein kinase II phosphorylates IκB α at S-283, S-289, S-293, and T-291 and is required for its degradation. Mol. Cell. Biol. 16:899-906.
40. Miyamoto, S., B. J. Seufzer, and S. D. Shumway. 1998. Novel IκB α proteolytic pathway in WEHI231 immature B cells. Mol. Cell. Biol. 18:19-29.
41. Mosialos, G. 1997. The role of Rel/NF-kappa B proteins in viral oncogenesis and the regulation of viral transcription. Semin. Cancer Biol. 8:121-129.
42. Nakajima, K., Y. Yamanaka, K. Nakae, H. Kojima, M. Ichiba, N. Kiuchi, T. Kitaoka, T. Fukada, M. Hibi, and T. Hirano. 1996. A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells. EMBO J. 15:3651-3658.
43. Nerlov, C., and T. Graf. 1998. PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors. Genes Dev. 12:2403-2412.
44. Nguyen, H. Q., B. Hoffman-Liebermann, and D. A. Liebermann. 1993. The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage. Cell 72:197-209.
45. Oberg, F., J. Botling, and K. Nilsson. 1993. Macrophages and the cytokine network. Transplant Proc. 25:2044-2047.
46. Perlman, H., L. J. Pagliari, C. Georganas, T. Mano, K. Walsh, and R. M. Pope. 1999. FLICE-inhibitory protein expression during macrophage differentiation confers resistance to fas-mediated apoptosis. J. Exp. Med. 190: 1679-1688.
47. Scott, E. W., R. C. Fisher, M. C. Olson, E. W. Kehrli, M. C. Simon, and H. Singh. 1997. PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors. Immunity 6:437-447.
48. Scott, E. W., M. C. Simon, J. Anastasi, and H. Singh. 1994. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 265:1573-1577.
49. Seitz, C. S., H. Deng, K. Hinata, Q. Lin, and P. A. Khavari. 2000. Nuclear factor kappaB subunits induce epithelial cell growth arrest. Cancer Res. 60:4085-4092.
50. Sherr, C. J., and J. M. Roberts. 1995. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9:1149-1163.
51. Stein, G. H., and V. Dulic. 1998. Molecular mechanisms for the senescent cell cycle arrest. J. Investig. Dermatol. Symp. Proc. 3:14-18.
52. Taylor, J. A., G. D. Bren, K. N. Pennington, S. A. Trushin, S. Asin, and C. V. Paya. 1999. Serine 32 and serine 36 of IkappaBalpha are directly phosphorylated by protein kinase CKII in vitro. J. Mol. Biol. 290:839-850.
53. Van Antwerp, D. J., S. J. Martin, T. Kafri, D. R. Green, and I. M. Verma. 1996. Suppression of TNF-alpha-induced apoptosis by NF-kappaB. Science 274:787-789.
54. Van Antwerp, D. J., S. J. Martin, I. M. Verma, and D. R. Green. 1998. Inhibition of TNF-induced apoptosis by NF-kappa B. Trends Cell Biol. 8:107-111.
55. Van Antwerp, D. J., and I. M. Verma. 1996. Signal-induced degradation of IκBα: association with NF-κB and the PEST sequence in IκBα are not required. Mol. Cell. Biol. 16:6037-45.
56. Verma, I. M., J. K. Stevenson, E. M. Schwarz, D. Van Antwerp, and S. Miyamoto. 1995. Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 9:2723-35.
57. Vrana, J. A., A. M. Saunders, S. P. Chellappan, and S. Grant. 1998. Divergent effects of bryostatin I and phorbol myristate acetate on cell cycle arrest and maturation in human myelomonocytic leukemia cells (U937). Differentiation 63:33-42.
58. Wang, C. Y., J. C. Cusack, Jr., R. Liu, and A. S. Baldwin, Jr. 1999. Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB. Nat. Med. 5:412-417.
59. Wang, C. Y., M. W. Mayo, and A. S. Baldwin, Jr. 1996. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB. Science 274:784-7.
60. Wang, Z., Z. Z. Su, P. B. Fisher, S. Wang, G. VanTuyle, and S. Grant. 1998. Evidence of a functional role for the cyclin-dependent kinase inhibitor p21(WAF1/CIP1/MDA6) in the reciprocal regulation of PKC activator-induced apoptosis and differentiation in human myelomonocytic leukemia cells. Exp. Cell Res. 244:105-116.
61. Zandi, E., Y. Chen, and M. Karin. 1998. Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate. Science 281:1360-1363.
62. Zuniga-Pflucker, J. C., J. Di, and M. J. Lenardo. 1995. Requirement for TNF-alpha and IL-1 alpha in fetal thymocyte commitment and differentiation. Science 268:1906-1909.