Induction of cell-mediated immune responses in mice by DNA vaccines that express hepatitis C virus NS3 mutants lacking serine protease and NTPase/RNA helicase activities

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Ratnoglik, Suratno Lulut ^a,b   Jiang, Da Peng ^a   Aoki, Chie ^a,b   Sudarmono, Pratiwi ^b   Shoji, Ikuo ^a   Deng, Lin ^a   Hotta, Hak ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF INDONESIA   (Indonesia)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ARGININE; ASPARAGINE; GAMMA INTERFERON; GLUTAMINE; LYSINE; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 4A; NUCLEOSIDE TRIPHOSPHATASE; RNA HELICASE; SERINE; SERINE PROTEINASE; TRYPTOPHAN; DNA VACCINE; HEPATITIS VACCINE; NS3 PROTEIN, HEPATITIS C VIRUS; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATALYSIS; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNIZATION; INTERFERON PRODUCTION; MOUSE; NONHUMAN; POINT MUTATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; T LYMPHOCYTE ACTIVATION; VIRAL CLEARANCE; VIRUS MUTANT; WILD TYPE; ANIMAL; BIOSYNTHESIS; CELL LINE; DISEASE MODEL; GENE EXPRESSION; GENETICS; IMMUNOLOGY; MALE; METABOLISM; MUTATION; T LYMPHOCYTE SUBPOPULATION; VIRUS GENOME;

ANIMALS; CELL LINE; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION; GENOME, VIRAL; HEPATITIS C; HUMANS; IMMUNITY, CELLULAR; INTERFERON-GAMMA; MALE; MICE; MUTATION; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, CYTOTOXIC; VACCINES, DNA; VIRAL HEPATITIS VACCINES; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84902436687     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0098877     Document Type: Article

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