Brain Predictors of Individual Differences in Placebo Responding

Placebo and Pain: From Bench to Bedside

Volumn , Issue , 2013, Pages 89-102

  Koban, Leonie ^a   Ruzic, Luka ^a   Wager, Tor D ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Brain imaging; Individual differences; Machine learning; Multivariate models; Pain; Personality; Placebo analgesia; Placebo responder; Situation

Indexed keywords

EID: 84902428450     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-397928-5.00010-6     Document Type: Chapter

References (95)

1. Price D.D., Finniss D.G., Benedetti F. A comprehensive review of the placebo effect: recent advances and current thought. Annu Rev Psychol 2008, 59:565-590.
2. Atlas L.Y., Bolger N., Lindquist M.A., Wager T.D. Brain mediators of predictive cue effects on perceived pain. J Neurosci 2010, 30(39):12964-12977.
3. Shapiro A.K., Struening E.L., Shapiro E. The reliability and validity of a placebo test. J Psychiatr Res 1979, 15(4):253-290.
4. Wager T.D., Atlas L.Y., Leotti L.A., Rilling J.K. Predicting individual differences in placebo analgesia: contributions of brain activity during anticipation and pain experience. J Neurosci 2011, 31(2):439-452.
5. Mischel W. Toward an integrative science of the person. Annu Rev Psychol 2004, 55:1-22.
6. Shapiro A.K., Shapiro E. The Powerful Placebo: from Ancient Priest to Modern Physician 1997, Johns Hopkins University Press, Baltimore.
7. Beecher H.K.S., Keats A., Mosteller F., Lasagna L. The effectiveness of oral analgesics (morphine, codeine, acetylsalicylic acid) and the problem of placebo 'reactors' and 'non-reactors'. J Pharmacol Exp Ther 1953, 109(4):393-400.
8. De Pascalis V., Chiaradia C., Carotenuto E. The contribution of suggestibility and expectation to placebo analgesia phenomenon in an experimental setting. Pain 2002, 96(3):393-402.
9. Morton D.L., El-Deredy W., Watson A., Jones A.K. Placebo analgesia as a case of a cognitive style driven by prior expectation. Brain Res 2010, 1359:137-141.
10. Geers A.L., Kosbab K., Helfer S.G., et al. Further evidence for individual differences in placebo responding: an interactionist perspective. J Psychosom Res 2007, 62(5):563-570.
11. Morton D.L., Watson A., El-Deredy W., Jones A.K. Reproducibility of placebo analgesia: Effect of dispositional optimism. Pain 2009, 146(1-2):194-198.
12. Watson A., El-Deredy W., Iannetti G.D., et al. Placebo conditioning and placebo analgesia modulate a common brain network during pain anticipation and perception. Pain 2009, 145(1-2):24-30.
13. Peciña M., Azhar H., Love T.M., et al. Personality Trait Predictors of Placebo Analgesia and Neurobiological Correlates. Neuropsychopharmacology 2013, 38(4):639-646. 10.1038/npp.2012.227.
14. Schweinhardt P., Kuchinad A., Pukall C.F., Bushnell M.C. Increased gray matter density in young women with chronic vulvar pain. Pain 2008, 140(3):411-419.
15. Lyby P.S., Aslaksen P.M., Flaten M.A. Is fear of pain related to placebo analgesia?. J Psychosom Res 2010, 68(4):369-377.
16. Ober K., Benson S., Vogelsang M., et al. Plasma noradrenaline and state anxiety levels predict placebo response in learned immunosuppression. Clin Pharmacol Ther 2012, 2:220-226.
17. Atlas L.Y., Whittington R.A., Lindquist M.A., et al. Dissociable influences of opiates and expectations on pain. J Neurosci 2012, 32(23):8053-8064. 10.1523/JNEUROSCI.0383-12.2012.
18. Kirsch I. Response expectancy as a determinant of experience and behavior. Am Psychologist 1985, 40:1189-1202.
19. Price D.D., Milling L., Kirsch I., et al. An analysis of factors that contribute to the magnitude of placebo analgesia in an experimental paradigm. Pain 1999, 83:147-156.
20. Vase L., Robinson M., Verne G., Price D. Increased placebo analgesia over time in irritable bowel syndrome (IBS) patients is associated with desire and expectation but not endogenous opioid mechanisms. Pain 2005, 115(3):338-347.
21. Colloca L., Benedetti F. Placebo analgesia induced by social observational learning. Pain 2009, 144(1-2):28-34.
22. Wager TD, Fields H. Placebo analgesia. In: Textbook of Pain. In press.
23. Apkarian A.V., Bushnell M.C., Treede R.D., Zubieta J.K. Human brain mechanisms of pain perception and regulation in health and disease. Eur J Pain 2005, 9(4):463-484.
24. Bushnell M.C., Duncan G.H., Hofbauer R.K., et al. Pain perception: is there a role for primary somatosensory cortex?. Proc Natl Acad Sci USA 1999, 96(14):7705-7709.
25. Iannetti G.D., Mouraux A. From the neuromatrix to the pain matrix (and back). Expl Brain Res 2010, 205(1):1-12.
26. Rainville P., Duncan G.H., Price D.D., et al. Pain affect encoded in human anterior cingulate but not somatosensory cortex. Science 1997, 277(5328):968-971.
27. Martina Amanzio, Fabrizio Benedetti, Porro Carlo A., et al. Activation likelihood estimation meta-analysis of brain correlates of placebo analgesia in human experimental pain. Hum Brain Map 2011, 10.1002/hbm.21471.
28. Eippert F., Finsterbusch J., Bingel U., Buchel C. Direct evidence for spinal cord involvement in placebo analgesia. Science 2009, 326(5951):404.
29. Meissner K., Bingel U., Colloca L., et al. The placebo effect: advances from different methodological approaches. J Neurosci 2011, 31(45):16117-16124.
30. Petrovic P., Kalso E., Petersson K.M., Ingvar M. Placebo and opioid analgesia - imaging a shared neuronal network. Science 2002, 95(5560):1737-1740.
31. Price D.D., Craggs J., Verne G., et al. Placebo analgesia is accompanied by large reductions in pain-related brain activity in irritable bowel syndrome patients. Pain 2007, 127:63-72.
32. Wager T.D., Rilling J.K., Smith E.E., et al. Placebo-induced changes in FMRI in the anticipation and experience of pain. Science 2004, 303(5661):1162-1167.
33. Zubieta J., Bueller J., Jackson L., et al. Placebo effects mediated by endogenous opioid activity on mu-opioid receptors. J Neurosci 2005, 25(34):7754-7762.
34. Petrovic P., Kalso E., Petersson K.M., et al. A prefrontal non-opioid mechanism in placebo analgesia. Pain 2010, 150:59-65.
35. Scott D., Stohler C., Egnatuk C., et al. Individual differences in reward responding explain placebo-induced expectations and effects. Neuron 2007, 55(2):325-336.
36. Krummenacher P., Candia V., Folkers G., et al. Prefrontal cortex modulates placebo analgesia. Pain 2010, 148:368-374.
37. Lui F., Colloca L., Duzzi D., et al. Neural bases of conditioned placebo analgesia. Pain 2010, 151(3):816-824.
38. Tibshirani R. Regression shrinkage and selection via the lasso. J Roy Statist Soc Series B (Methodological) 1996, 58(1):267-288.
39. Geuter S., Eippert F., Hindi A., et al. Cortical and subcortical responses to high and low effective placebo treatments. Neuroimage 2013, 67:227-236.
40. Eippert F., Bingel U., Schoell E., et al. Activation of the opioidergic descending pain control system underlies placebo analgesia. Neuron 2009, 63:533-543.
41. Wager T., Scott D.J., Zubieta J.K. Placebo effects on human μ-opioid activity during pain. Proc Natl Acad Sci USA 2007, 104(26):11056-11061.
42. Hashmi J.A., Baria A.T., Baliki M.N., et al. Brain networks predicting placebo analgesia in a clinical trial for chronic back pain. Pain 2012, 153(12):2393-2402.
43. Kong J., Jensen K., Loiotile R., et al. Functional connectivity of the frontoparietal network predicts cognitive modulation of pain. Pain 2013, 10.1016/j.pain.2012.12.004.
44. Schweinhardt P., Seminowicz D.A., Jaeger E., et al. The anatomy of the mesolimbic reward system: a link between personality and the placebo analgesic response. J Neurosci 2009, 29(15):4882-4887.
45. Stein N., Sprenger C., Scholz J., et al. White matter integrity of the descending pain modulatory system is associated with interindividual differences in placebo analgesia. Pain 2012, 153(11):2210-2217.
46. Amanzio M., Benedetti F. Neuropharmacological dissection of placebo analgesia: expectation-activated opioid systems versus conditioning-activated specific subsystems. J Neurosci 1999, 19(1):484-494.
47. Bingel U., Lorenz J., Schoell E., et al. Mechanisms of placebo analgesia: rACC recruitment of a subcortical antinociceptive network. Pain 2006, 120(1-2):8-15.
48. Levine J.D., Gordon N.C., Fields H.L. The mechanism of placebo analgesia. Lancet 1978, 2(8091):654-657.
49. Scott D.J., Stohler C., Egnatuk C., et al. Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses. Arch Gen Psychiatr 2008, 65(2):220-231.
50. Aslaksen P.M., Bystad M., Vambheim S.M., Flaten M.A. Gender differences in placebo analgesia: event-related potentials and emotional modulation. Psychosom Med 2011, 73(2):193-199. doi:PSY.0b013e3182080d73.
51. Colloca L., Tinazzi M., Recchia S., et al. Learning potentiates neurophysiological and behavioral placebo analgesic responses. Pain 2008, 139(2):306-314.
52. Flaten M.A., Aslaksen P.M., Lyby P.S., Bjorkedal E. The relation of emotions to placebo responses. Phil Trans R Soc Ser B 2011, 366(1572):1818-1827.
53. Morton D.L., Brown C.A., Watson A., et al. Cognitive changes as a result of a single exposure to placebo. Neuropsychologia 2010, 48(7):1958-1964.
54. Wager T.D., Matre D., Casey K.L. Placebo effects in laser-evoked pain potentials. Brain Behav Immun 2006, 20(3):219-230.
55. Watson A., El-Deredy W., Vogt B.A., Jones A.K. Placebo analgesia is not due to compliance or habituation: EEG and behavioural evidence. Neurorep 2007, 18(8):771-775.
56. Koban L., Brass M., Lynn M.T., et al. Placebo analgesia affects brain correlates of error processing. PLoS One 2012, 7(11):e49784.
57. Ridderinkhof K.R., Ramautar J.R., Wijnen J.G. To P(E) or not to P(E): a P3-like ERP component reflecting the processing of response errors. Psychophysiology 2009, 46(3):531-538.
58. Ullsperger M., Harsay H.A., Wessel J.R., et al. Conscious perception of errors and its relation to the anterior insula. Brain Struct Funct 2010, 214(5-6):629-643.
59. O'Doherty J., Kringelbach M.L., Rolls E.T., et al. Abstract reward and punishment representations in the human orbitofrontal cortex. Nat Neurosci 2001, 4(1):95-102.
60. O'Doherty J.P., Dayan P., Friston K., et al. Temporal difference models and reward-related learning in the human brain. Neuron 2003, 38(2):329-337.
61. Roy M., Shohamy D., Wager T.D. Ventromedial prefrontal-subcortical systems and the generation of affective meaning. Trends Cogn Sci 2012, 16:147-156.
62. Schultz W. Neural coding of basic reward terms of animal learning theory, game theory, microeconomics and behavioural ecology. Curr Opin Neurobiol 2004, 14(2):139-147.
63. Carver C.S., White T.L. Behavioral inhibition, behavioral activation, and affective responses to impending reward and punishment: the BIS/BAS Scales. J Pers Soc Psychol 1994, 67(2):319-333.
64. Leknes S., Tracey I. A common neurobiology for pain and pleasure. Nat Rev Neurosci 2008, 9(4):314-320. 10.1038/nrn2333.
65. Miller E.K., Cohen J.D. An integrative theory of prefrontal cortex function. Annu Rev Neurosci 2001, 24:167-202.
66. Nee D.E., Wager T.D., Jonides J. Interference resolution: insights from a meta-analysis of neuroimaging tasks. Cogn Affect Behav Neurosci 2007, 7(1):1-17.
67. Geers A.L., Helfer S.G., Kosbab K., et al. Reconsidering the role of personality in placebo effects: dispositional optimism, situational expectations, and the placebo response. J Psychosom Res 2005, 58(2):121-127.
68. Makel M.C., Plucker J.A., Hegarty B. Replications in psychology research: how often do they really occur?. Perspect Psychol Sci 2012, 7(6):537-542.
69. Pashler H., Harris C.R. Is the replicability crisis overblown? Three arguments examined. Perspect Psychol Sci 2012, 7(6):531-536.
70. Mischel W. Personality and Assessment 1968, Wiley, New York.
71. Kriegeskorte N., Lindquist M.A., Nichols T.E., et al. Everything you never wanted to know about circular analysis, but were afraid to ask. J Cereb Blood Flow Metab 2010, 30(9):1551-1557. 10.1038/jcbfm.2010.86.
72. Lieberman M.D., Berkman E.T., Wager T.D. Correlations in social neuroscience aren't voodoo: commentary on Vul et al. (2009). Perspect Psychol Sci 2009, 4(3):299-307.
73. Vul E., Harris C., Winkielman P., Pashler H. Puzzlingly high correlations in fMRI studies of emotion, personality, and social cognition 1. Perspect Psychol Sci 2009, 4(3):274-290.
74. Yarkoni T. Big correlations in little studies: inflated fMRI correlations reflect low statistical power-commentary on Vul et al. (2009). Perspect Psychol Sci 2009, 4(3):294-298.
75. Hastie T., Tibshirani R., Friedman J., Franklin J. The elements of statistical learning: data mining, inference and prediction. Mathemat Intelligen 2005, 27(2):83-85.
76. Yarkoni T., Poldrack R.A., Van Essen D.C., Wager T.D. Cognitive neuroscience 2.0: building a cumulative science of human brain function. Trends Cogn Sci 2010, 14(11):489-496. 10.1016/j.tics.2010.08.004.
77. Liberman R. An experimental study of the placebo response under three different situations of pain. J Psychiatr Res 1964, 33:233-246.
78. Whalley B., Hyland M., Kirsch I. Consistency of the placebo effect. J Psychosom Res 2008, 64(5):537-541.
79. Benedetti F. Placebo Effects: Understanding the Mechanisms in Health and Disease 2009, Oxford University Press, Oxford.
80. Colloca L., Petrovic P., Wager T.D., et al. How the number of learning trials affects placebo and nocebo responses. Pain 2010, 151(2):430-439.
81. Schaefer S., Wager T.D. Separable correlates of experience and belief in placebo analgesia October 13-17, 2012, Paper presented at the Neuroscience, New Orleans.
82. Kaptchuk T., Friedlander E., Kelley J., Sanchez M. Placebos without deception: a randomized controlled trial in irritable bowel syndrome. PLoS One 2010, 5(12):e15591.
83. Epstein S., O'Brien E.J. The person-situation debate in historical and current perspective. Psychol Bull 1985, 98(3):513-537.
84. Kenrick D.T., Funder D.C. Profiting from controversy: lessons from the person-situation debate. Am Psychologist 1988, 43(1):23-34.
85. Gelfand D.M., Gelfand S., Rardin M.W. Some personality factors associated with placebo responsivity. Psychol Rep 1965, 17(2):555-562.
86. Benedetti F. Mechanisms of placebo and placebo-related effects across diseases and treatments. Annu Rev Pharmacol Toxicol 2007, 10.1146/annurev.pharmtox.48.113006.094711.
87. Benedetti F., Mayberg H.S., Wager T.D., et al. Neurobiological mechanisms of the placebo effect. J Neurosci 2005, 25(45):10390-10402.
88. Elsenbruch S., Kotsis V., Benson S., et al. Neural mechanisms mediating the effects of expectation in visceral placebo analgesia: an fMRI study in healthy placebo responders and nonresponders. Pain 2012, 153(2):382-390.
89. Kong J., Gollub R.L., Rosman I.S., et al. Brain activity associated with expectancy-enhanced placebo analgesia as measured by functional magnetic resonance imaging. J Neurosci 2006, 26(2):381-388.
90. Kong J., Kaptchuk T.J., Polich G., et al. Expectancy and treatment interactions: a dissociation between acupuncture analgesia and expectancy evoked placebo analgesia. NeuroImage 2009, 45(3):940-949.
91. Kotsis V., Benson S., Bingel U., et al. Perceived treatment group affects behavioral and neural responses to visceral pain in a deceptive placebo study. Neurogastroenterol. Motil 2012, 24(10). 935-e462.
92. Lieberman M.D., Jarcho J.M., Berman S., et al. The neural correlates of placebo effects: a disruption account. NeuroImage 2004, 22(1):447-455.
93. Lyby P.S., Aslaksen P.M., Flaten M.A. Variability in placebo analgesia and the role of fear of pain - an ERP study. Pain 2011, 152(10):2405-2412.
94. Wiech K., Lin C., Brodersen K.H., Bingel U., et al. Anterior insula integrates information about salience into perceptual decisions about pain. J Neurosci 2010, 30(48):16324-16331.
95. Zubieta J., Yau W., Scott D.J., Stohler C.S. Belief or need? Accounting for individual variations in the neurochemistry of the placebo effect. Brain Behav Immun 2006, 20(1):15-26.