Ischaemia-induced mucus barrier loss and bacterial penetration are rapidly counteracted by increased goblet cell secretory activity in human and rat colon

Gut

Volumn 62, Issue 2, 2013, Pages 250-258

  Grootjans, Joep ^a,b   Hundscheid, Inca H R ^a   Lenaerts, Kaatje ^a   Boonen, Bas ^a   Renes, Ingrid B ^c   Verheyen, Fons K ^a   Dejong, Cornelis H ^a   Von Meyenfeldt, Maarten F ^a   Beets, Geerard L ^a   Buurman, Wim A ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Slotervaartziekenhuis ^*  (Netherlands)

^c SOPHIA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL TISSUE; ARTICLE; BACTERIAL PENETRATION; CELL ACTIVITY; CELLULAR SECRETION; CLINICAL ARTICLE; COLON ISCHEMIA; COLON MUCOSA; CONTROLLED STUDY; GOBLET CELL; HUMAN; HUMAN TISSUE; INFLAMMATION; INTESTINE CRYPT; MALE; MICROBIAL ACTIVITY; MUCUS BARRIER LOSS; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION;

ANIMALS; COLITIS, ISCHEMIC; COLON; CYTOKINES; FLUORESCENT ANTIBODY TECHNIQUE; GOBLET CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; INFLAMMATION; INTESTINAL MUCOSA; MALE; MUCIN-2; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

EID: 84872081287     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2011-301956     Document Type: Article

References (25)

1. Cerf-Bensussan N, Gaboriau-Routhiau V. The immune system and the gut microbiota: friends or foes? Nat Rev Immunol 2010;10:735-44.
2. Deplancke B, Gaskins HR. Microbial modulation of innate defense: goblet cells and the intestinal mucus layer. Am J Clin Nutr 2001;73:1131Se41S.
3. Johansson ME, Phillipson M, Petersson J, et al. The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc Natl Acad Sci U S A 2008;105:15064-9.
4. McGuckin MA, Linden SK, Sutton P, et al. Mucin dynamics and enteric pathogens. Nat Rev Microbiol 2011;9:265-78.
5. Davis CW, Dickey BF. Regulated airway goblet cell mucin secretion. Annu Rev Physiol 2008;70:487-512. (Pubitemid 351738189)
6. Van der Sluis M, De Koning BA, De Bruijn AC, et al. Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. Gastroenterology 2006;131:117-29. (Pubitemid 44015753)
7. Johansson ME, Gustafsson JK, Sjoberg KE, et al . Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model. PLoS One 2010;5:e12238.
8. Heazlewood CK, Cook MC, Eri R, et al. Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Med 2008;5:e54.
9. Anon. American gastroenterological association medical position statement: guidelines on intestinal ischaemia. Gastroenterology 2000;118:951-3.
10. Longstreth GF, Yao JF. Epidemiology, clinical features, high-risk factors, and outcome of acute large bowel ischaemia. Clin Gastroenterol Hepatol 2009;7:1075-80.e1-2; quiz 23.
11. Feuerstadt P, Brandt LJ. Colon ischaemia: recent insights and advances. Curr Gastroenterol Rep 2010;12:383-90.
12. Brandt LJ, Feuerstadt P, Blaszka MC, et al. Anatomic patterns, patient characteristics, and clinical outcomes in ischemic colitis: a study of 313 cases supported by histology. Am J Gastroenterol 2010;105:2245-52; quiz 53.
13. Colgan SP, Taylor CT. Hypoxia: an alarm signal during intestinal inflammation. Nat Rev Gastroenterol Hepatol 2010;7:281-7.
14. Karhausen J, Furuta GT, Tomaszewski JE, et al. Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J Clin Invest 2004;114:1098-106. (Pubitemid 39578699)
15. Derikx JP, Matthijsen RA, de Bruine AP, et al. A New model to study intestinal ischaemia-reperfusion damage in man. J Surg Res 2009;166:222-6.
16. Grootjans J, Lenaerts K, Derikx JP, et al. Human intestinal ischaemia-reperfusion-induced inflammation characterized: experiences from a new translational model. Am J Pathol 2010;176:2283-91.
17. Grootjans J, Hodin CM, de Haan JJ, et al. Level of activation of the unfolded protein response correlates with Paneth cell apoptosis in human small intestine exposed to ischaemia/reperfusion. Gastroenterology 2011;140 :529-39.e3.
18. Bergstrom KS, Kissoon-Singh V, Gibson DL, et al. Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa. PLoS Pathog 2010;6:e1000902.
19. Garcia MA, Yang N, Quinton PM. Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator-dependent bicarbonate secretion. J Clin Invest 2009;119:2613-22.
20. Verdugo P. Goblet cells secretion and mucogenesis. Annu Rev Physiol 1990;52:157-76. (Pubitemid 20103532)
21. Montoro MA, Brandt LJ, Santolaria S, et al. Clinical patterns and outcomes of ischaemic colitis: results of the working group for the study of ischaemic colitis in Spain (CIE study). Scand J Gastroenterol 2011;46:236-46.
22. Elder K, Lashner BA, Al Solaiman F. Clinical approach to colonic ischemia. Cleve Clin J Med 2009;76:401-9.
23. Green BT, Tendler DA. Ischemic colitis: a clinical review. South Med J 2005;98:217-22. (Pubitemid 40279759)
24. Fu J, Wei B, Wen T, et al. Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice. J Clin Invest 2011;121:1657-66.
25. Podolsky DK, Fournir DA. Alterations in mucosal content of colonic glycoconjugates in inflammatory bowel disease defined by monoclonal antibodies. Gastroenterology 1988;95:379-87.