CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration

Journal of Neurochemistry

Volumn 129, Issue 6, 2014, Pages 1013-1023

  Liman, Jan ^a,b   Deeg, Sebastian ^a,b   Voigt, Aaron ^c   Voßfeldt, Hannes ^c   Dohm, Christoph P ^a,b   Karch, André ^a   Weishaupt, Jochen ^d   Schulz, Jörg B ^c   Bähr, Mathias ^a,b   Kermer, Pawel ^a,b,e  

^a Department of Neurology ^*  (Germany)

^b Cluster of Excellence Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB)   (Germany)

^c RWTH AACHEN UNIVERSITY   (Germany)

^d UNIVERSITY OF ULM   (Germany)

^e Nordwest Krankenhaus Sanderbusch   (Germany)

Author keywords

Ataxin 3; caspase; CDK5; neurodegeneration; SCA3

Indexed keywords

ATAXIN 3; CASPASE; CYCLIN DEPENDENT KINASE 5;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DROSOPHILA; HUMAN; HUMAN CELL; LONGEVITY; MALE; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CLEAVAGE; SPINOCEREBELLAR DEGENERATION;

ATAXIN-3; CASPASE; CDK5; SCA3, NEURODEGENERATION;

ANIMALS; BLOTTING, WESTERN; CASPASES; CELL DEATH; CELL LINE, TUMOR; CELL NUCLEUS; CYCLIN-DEPENDENT KINASE 5; DENSITOMETRY; DROSOPHILA; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; HUNTINGTON DISEASE; IMMUNOHISTOCHEMISTRY; MACHADO-JOSEPH DISEASE; MUTAGENESIS, SITE-DIRECTED; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PLASMIDS; REPRESSOR PROTEINS; SURVIVAL ANALYSIS; TRANSFECTION;

EID: 84902381345     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12684     Document Type: Article

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