Glutamine supplementation, but not combined glutamine and arginine supplementation, improves gut barrier function during chemotherapy-induced intestinal mucositis in rats

Clinical Nutrition

Volumn 33, Issue 4, 2014, Pages 694-701

  Beutheu, Stéphanie ^a,b   Ouelaa, Wassila ^a,b   Guérin, Charlène ^a,b   Belmonte, Liliana ^a,b   Aziz, Moutaz ^c   Tennoune, Naouel ^a,b   BÔle Feysot, Christine ^a,b   Galas, Ludovic ^a,b   Déchelotte, Pierre ^a,b,c   Coëffier, Moïse ^a,b,c  

^a UNIVERSITÉ DE ROUEN   (France)

^b UNIVERSITY OF ROUEN   (France)

^c ROUEN UNIVERSITY HOSPITAL   (France)

Author keywords

Arginine; Chemotherapy; Glutamine; Gut barrier; Signaling pathways

Indexed keywords

ARGININE; CLAUDIN 1; GLUTAMINE; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; METHOTREXATE; MITOGEN ACTIVATED PROTEIN KINASE; OCCLUDIN; PROTEIN ZO1; TIGHT JUNCTION PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CANCER CHEMOTHERAPY; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENTERITIS; FOOD INTAKE; HISTOLOGY; IMMUNOHISTOCHEMISTRY; INTESTINE MUCOSA PERMEABILITY; INTESTINE VILLUS; JEJUNUM MUCOSA; MONOTHERAPY; MUCOSA INFLAMMATION; NONHUMAN; PERMEABILITY BARRIER; PROPHYLAXIS; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SURVIVAL RATE; ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; GASTROINTESTINAL TRACT; GENETICS; INTESTINE; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ARGININE; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; GASTROINTESTINAL TRACT; GLUTAMINE; IMMUNOHISTOCHEMISTRY; INTESTINES; MALE; METHOTREXATE; MUCOSITIS; NF-KAPPA B; OCCLUDIN; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 84902374335     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2013.09.003     Document Type: Article

References (32)

1. Keefe D.M., Cummins A.G., Dale B.M., Kotasek D., Robb T.A., Sage R.E. Effect of high-dose chemotherapy on intestinal permeability in humans. Clin Sci (Lond) 1997, 92:385-389.
2. Pico J.L., Avila-Garavito A., Naccache P. Mucositis: its occurrence, consequences, and treatment in the oncology setting. Oncologist 1998, 3:446-451.
3. Leblond J., Le Pessot F., Hubert-Buron A., Duclos C., Vuichoud J., Faure M., et al. Chemotherapy-induced mucositis is associated with changes in proteolytic pathways. Exp Biol Med (Maywood) 2008, 233:219-228.
4. Beutheu Youmba S., Belmonte L., Galas L., Boukhettala N., Bole-Feysot C., Dechelotte P., et al. Methotrexate modulates tight junctions through NF-kappaB, MEK, and JNK pathways. JPediatr Gastroenterol Nutr 2012, 54:463-470.
5. Hamada K., Shitara Y., Sekine S., Horie T. Zonula Occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats. Cancer Chemother Pharmacol 2010, 66:1031-1036.
6. Gulgun M., Karaoglu A., Kesik V., Kurt B., Erdem O., Tok D., et al. Effect of proanthocyanidin, arginine and glutamine supplementation on methotrexate-induced gastrointestinal toxicity in rats. Methods Find Exp Clin Pharmacol 2010, 32:657-661.
7. Boukhettala N., Ibrahim A., Aziz M., Vuichoud J., Saudan K.Y., Blum S., et al. Adiet containing whey protein, free glutamine, and transforming growth factor-beta ameliorates nutritional outcome and intestinal mucositis during repeated chemotherapeutic challenges in rats. JNutr 2010, 140:799-805.
8. Xue H., Sawyer M.B., Field C.J., Dieleman L.A., Murray D., Baracos V.E. Bolus oral glutamine protects rats against CPT-11-induced diarrhea and differentially activates cytoprotective mechanisms in host intestine but not tumor. JNutr 2008, 138:740-746.
9. De-Souza D.A., Greene L.J. Intestinal permeability and systemic infections in critically ill patients: effect of glutamine. Crit Care Med 2005, 33:1125-1135.
10. Li N., Lewis P., Samuelson D., Liboni K., Neu J. Glutamine regulates Caco-2 cell tight junction proteins. Am J Physiol Gastrointest Liver Physiol 2004, 287:G726-G733.
11. Corl B.A., Odle J., Niu X., Moeser A.J., Gatlin L.A., Phillips O.T., et al. Arginine activates intestinal p70(S6k) and protein synthesis in piglet rotavirus enteritis. JNutr 2008, 138:24-29.
12. Gennari R., Alexander J.W., Eaves-Pyles T. Effect of different combinations of dietary additives on bacterial translocation and survival in gut-derived sepsis. JParenter Enteral Nutr 1995, 19:319-325.
13. Lechowski S., Feilhauer K., Staib L., Coeffier M., Bischoff S.C., Lorentz A. Combined arginine and glutamine decrease release of de novo synthesized leukotrienes and expression of proinflammatory cytokines in activated human intestinal mast cells. Eur J Nutr 2013, 52:505-512.
14. Lecleire S., Hassan A., Marion-Letellier R., Antonietti M., Savoye G., Bole-Feysot C., et al. Combined glutamine and arginine decrease proinflammatory cytokine production by biopsies from Crohn's patients in association with changes in nuclear factor-kappaB and p38 mitogen-activated protein kinase pathways. JNutr 2008, 138:2481-2486.
15. Kul M., Vurucu S., Demirkaya E., Tunc T., Aydinoz S., Meral C., et al. Enteral glutamine and/or arginine supplementation have favorable effects on oxidative stress parameters in Neonatal rat intestine. JPediatr Gastroenterol Nutr 2009, 49:85-89.
16. Beutheu S., Ghouzali I., Galas L., Dechelotte P., Coeffier M. Glutamine and arginine improve permeability and tight junction protein expression in methotrexate-treated Caco-2 cells. Clin Nutr 2013, [in press].
17. Boukhettala N., Leblond J., Claeyssens S., Faure M., Le Pessot F., Bole-Feysot C., et al. Methotrexate induces intestinal mucositis and alters gut protein metabolism independently of reduced food intake. Am J Physiol Endocrinol Metab 2009, 296:E182-E190.
18. Ameho C.K., Adjei A.A., Harrison E.K., Takeshita K., Morioka T., Arakaki Y., et al. Prophylactic effect of dietary glutamine supplementation on interleukin 8 and tumour necrosis factor alpha production in trinitrobenzene sulphonic acid induced colitis. Gut 1997, 41:487-493.
19. Moinard C., Belabed L., Gupta S., Besson V., Marchand-Verrecchia C., Chaumeil J.C., et al. Arginine-enriched diet limits plasma and muscle glutamine depletion in head-injured rats. Nutrition 2006, 22:1039-1044.
20. Boukhettala N., Ibrahim A., Claeyssens S., Faure M., Le Pessot F., Vuichoud J., et al. Adiet containing whey protein, glutamine, and TGFbeta modulates gut protein metabolism during chemotherapy-induced mucositis in rats. Dig Dis Sci 2010, 55:2172-2181.
21. Choi K., Lee S.S., Oh S.J., Lim S.Y., Jeon W.K., Oh T.Y., et al. The effect of oral glutamine on 5-fluorouracil/leucovorin-induced mucositis/stomatitis assessed by intestinal permeability test. Clin Nutr 2007, 26:57-62.
22. Daniele B., Perrone F., Gallo C., Pignata S., De Martino S., De Vivo R., et al. Oral glutamine in the prevention of fluorouracil induced intestinal toxicity: a double blind, placebo controlled, randomised trial. Gut 2001, 48:28-33.
23. Boukhettala N., Claeyssens S., Bensifi M., Maurer B., Abed J., Lavoinne A., et al. Effects of essential amino acids or glutamine deprivation on intestinal permeability and protein synthesis in HCT-8 cells: involvement of GCN2 and mTOR pathways. Amino Acids 2012, 42:375-383.
24. Beutheu Youmba S., Belmonte L., Galas L., et al. Methotrexate modulates tight junctions through NF-kB, MEK and JNK pathways. J Pediatr Gastroenterol Nutr 2012, 54:463-470.
25. Vermeulen M.A., de Jong J., Vaessen M.J., van Leeuwen P.A., Houdijk A.P. Glutamate reduces experimental intestinal hyperpermeability and facilitates glutamine support of gut integrity. World J Gastroenterol 2011, 17:1569-1573.
26. Seth A., Basuroy S., Sheth P., Rao R.K. L-Glutamine ameliorates acetaldehyde-induced increase in paracellular permeability in Caco-2 cell monolayer. Am J Physiol Gastrointest Liver Physiol 2004, 287:G510-G517.
27. Li N., Neu J. Glutamine deprivation alters intestinal tight junctions via a PI3-K/Akt mediated pathway in Caco-2 cells. JNutr 2009, 139:710-714.
28. Hubert-Buron A., Leblond J., Jacquot A., Ducrotte P., Dechelotte P., Coeffier M. Glutamine pretreatment reduces IL-8 production in human intestinal epithelial cells by limiting IkappaBalpha ubiquitination. JNutr 2006, 136:1461-1465.
29. Liboni K.C., Li N., Scumpia P.O., Neu J. Glutamine modulates LPS-induced IL-8 production through IkappaB/NF-kappaB in human fetal and adult intestinal epithelium. JNutr 2005, 135:245-251.
30. Unno N., Wang H., Menconi M.J., Tytgat S.H., Larkin V., Smith M., et al. Inhibition of inducible nitric oxide synthase ameliorates endotoxin-induced gut mucosal barrier dysfunction in rats. Gastroenterology 1997, 113:1246-1257.
31. Katsube T., Tsuji H., Onoda M. Nitric oxide attenuates hydrogen peroxide-induced barrier disruption and protein tyrosine phosphorylation in monolayers of intestinal epithelial cell. Biochim Biophys Acta 2007, 1773:794-803.
32. Leitao R.F., Ribeiro R.A., Bellaguarda E.A., Macedo F.D., Silva L.R., Oria R.B., et al. Role of nitric oxide on pathogenesis of 5-fluorouracil induced experimental oral mucositis in hamster. Cancer Chemother Pharmacol 2007, 59:603-612.