Role of nitric oxide on pathogenesis of 5-fluorouracil induced experimental oral mucositis in hamster

Cancer Chemotherapy and Pharmacology

Volumn 59, Issue 5, 2007, Pages 603-612

  Leitao R F C ^a   Ribeiro, R A ^a   Bellaguarda, E A L ^a   MacEdo, F D B ^a   Silva, L R ^a   Oria R B ^a   Vale, M L ^a   Cunha, F Q ^b   Brito, G A C ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

1,400 W; 5 fluorouracil; Aminoguanidine; N Nitro L Arginine Methyl Ester; Nitric oxide; Nitric oxide synthase; Oral mucositis

Indexed keywords

AMINOGUANIDINE; FLUOROURACIL; MYELOPEROXIDASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CHEEK POUCH; CONTROLLED STUDY; ENZYME ACTIVITY; HAMSTER; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; STOMATITIS; SURGICAL TECHNIQUE;

ANIMALS; ANTINEOPLASTIC AGENTS; CRICETINAE; ENZYME INHIBITORS; FLUOROURACIL; GUANIDINES; IMMUNOHISTOCHEMISTRY; MALE; MESOCRICETUS; MOUTH MUCOSA; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PEROXIDASE; STOMATITIS;

EID: 33847097914     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-006-0301-y     Document Type: Article

References (64)

1. Ajuebor MN, Virag L, Flower RJ, Perretti M, Szabo C (1998) Role of inducible nitric oxide synthase in the regulation of neutrophil migration in zymosan-induced inflammation. Immunology 95(4):625-630
2. Allaker RP, Mendez LSS, Hardie JM, Benjamin N (2001) Antimicrobial effect of acidified nitrite on periodontal bacteria. Oral Microbiol Immunol 16:253-256
3. Beckman JS (1996) Oxidative damage and tyrosine nitration from peroxynitrite. Chem Res Toxicol 9(5):836-844 (review)
4. Beckman JS, Koppenol WH (1996) Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol 271:C1424-C1437
5. Brenner T, Brocke S, Szafer F, Sobel RA, Parkinson JF, Perez DH, Steinman L (1997) Inhibition of nitric oxide synthase for treatment of experimental autoimmune encephalomyelitis. J Immunol 158(6):2940-2946
6. Caballero GA, Ausman RK, Quebbeman EJ (1985) Long-term, ambulatory, continuous IV infusion of 5-FU for the treatment of advanced adenocarcinomas. Cancer Treat Rep 69(1):13-15
7. Chen JC, Chen HM, Shyr MH, Fan LL, Chi TY, Chi CP, Chen MF (2000) Selective inhibition of inducible nitric oxide in ischemia-reperfusion of rat small intestine. J Formos Med Assoc 99(3):213-218
8. Connor JR, Manning PT, Settle SL, Moore WM, Jerome GM, Webber RK, Tjoeng FS, Currie MG (1995) Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase. Eur J Pharmacol 273(1-2):15-24
9. Crow JP, Beckman JS (1996) The importance of superoxide in nitric oxide-dependent toxicity: evidence for peroxynitrite-mediated injury. Adv Exp Med Biol 387:147-161 (review)
10. Cuzzocrea S, Mazzon E, Calabro G, Dugo L, de Sarro A, Van De Loo FA, Caputi AP (2000) Inducible nitric oxide synthase-knockout mice exhibit resistance to pleurisy and lung injury caused by carrageenan. Am J Respir Crit Care Med 162(5):1859-1866
11. Cuzzocrea S, Zingarelli B, Hake P, Salzman AL, Szabo C (1998) Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation. Free Radic Biol Med 24(3):450-459
12. Da S Rocha JC, Peixoto ME, Jancar S, de Q Cunha F, de A Ribeiro R, da Rocha FA (2002) Dual effect of nitric oxide in articular inflammatory pain in zymosan-induced arthritis in rats. Br J Pharmacol 136(4):588-596
13. Dal Secco D, Paron JA, Oliveira SHP, Ferreira SH, Silva JS, Cunha FQ (2003) Neutrophil migration in inflammation: nitric oxide inhibits rolling, adhesion and induces apoptosis. Nitric Oxide 9:153-164
14. Dreizen S, McCredie K, Keating M, Bodey G (1982) Oral infections associated with chemotherapy in adults with acute leukemia. Postgrad Med 71(6):133-138, 143-146
15. Elting L, Cooksley C, Chambers M, Cantor S, Manzullo E, Rubenstein E (2003) The burdens of cancer therapy. Clinical and economic outcomes of chemotherapy-induced mucositis. Cancer 98(7):1531-1539
16. Epstein JB, Silverman S Jr, Paggiarino DA, Crockett S, Schubert MM, Senzer NM, Lockhart PB, Gallagher NJ, Petterson DE, Leveque FG (2001) Benzydamine HCl for prophylaxis of radiation-induced oral mucositis: results from a multicenter, randomized, double-blind, placebo-controlled clinical trial. Cancer 92(4):875-885
17. Estrada C, Gomez C, Martin C, Moncada S, Gonzalez C (1992) Nitric oxide mediates tumor necrosis factor-alpha cytotoxicity in endothelial cells. Biochem Biophys Res Commun 186(1):475-482
18. Franco-Penteado CF, De Souza I, Teixeira SA, Ribeiro Da Silva G, De Nucci G, Antunes E (2001) Involvement of nitric oxide on the peritoneal neutrophil influx induced by staphylococcal enterotoxin B in mouse. Toxicon 39(9):1383-1386
19. Franco-Penteado CF, De Souza I, Teixeira SA, Ribeiro Da Silva G, De Nucci G, Antunes E (2001) Role of nitric oxide on the increased vascular permeability and neutrophil accumulation induced by staphylococcal enterotoxin B into the mouse paw. Biochem Pharmacol 61(10):1305-1311
20. Garvey EP, Oplinger JA, Furfine ES, Kiffi RJ, Laszlo F, Whittle BJ, Knowles RG (1997) 1,400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem 272(8):4959-4963
21. Gomes DA, Reis WL, Ventura LL, Giusti-Paiva A, Elias LL, Cunha FQ, Antunes Rodrigues J (2004) The role of carbon monoxide and nitric oxide in hyperosmolality-induced atrial natriuretic peptide release by hypothalamus in vitro. Brain Res 1016(1):33-39
22. Griffiths MJD, Messent M, MacAllister RJ, Evans TW (1993) Aminoguanidine selectively inhibits inducible nitric oxide synthase. Br J Pharmacol 110(3):963-968
23. Hall PD, Benko H, Hogan KR, Stuart RK (1995) The influence of serum tumor necrosis factor-alpha and interleukin-6 concentrations on nonhematologic toxicity and hematologic recovery in patients with acute myelogenous leukemia. Exp Hematol 23(12):1256-1260
24. Hickey MJ, Kubes P (1997) Role of nitric oxide in regulation of leucocyte-endothelial cell interactions. Exp Physiol 82(2):339-348 (review)
25. Hickey MJ, Sharkey KA, Sihota EG, Reinhardt PH, Macmicking JD, Nathan C, Kubes P (1997) Inducible nitric oxide synthase-deficient mice have enhanced leukocyte-endothelium interactions in endotoxemia. FASEB J 11(12):955-964
26. Hierholzer C, Harbrecht B, Menezes JM, Kane J, MacMicking J, Nathan CF, Peitzman AB, Billiar TR, Tweardy DJ (1998) Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock. J Exp Med 187(6):917-928
27. Hsu SM, Raine L (1981) Protein A, avidin, and biotin in immunohistochemistry. J Histochem Cytochem 29(11):1349-1353
28. Ischiropoulos H, Zhu L, Chen J, Tsai M, Martin JC, Smith CD, Beckman JS (1992) Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase. Arch Biochem Biophys 298(2):431-437
29. Kendall HK, Marshall RI, Bartold PM (2001) Nitric oxide and tissue destruction. Oral Dis 7:2-10
30. Kokal WA (1985) The impact of antitumor therapy on nutrition. Cancer 55(Suppl 1):273-278
31. Kong SK, Yim MB, Stadtman ER, Chock PB (1996) Peroxynitrite disables the tyrosine phosphorylation regulatory mechanism: lymphocyte-specific tyrosine kinase fails to phosphorylate nitrated cdc2(6-20)NH2 peptide. Proc Natl Acad Sci USA 93(8):3377-3382
32. Krenger W, Ferrara JL (1996) Dysregulation of cytokines during graft-versus-host disease. J Hematother 5(1):3-14 (review)
33. Krenger W, Ferrara JL (1996) Graft-versus-host disease and the Th1/Th2 paradigm. Immunol Res 15(1):50-73
34. Kröncke K, Fehsel K, Kolb-Bachofen V (1997) Nitric oxide: cytotoxicity versus cytoprotection - how, why, when, and where? Nitric Oxide: Biol Chem 1(2):107-120
35. Kubes P, Suzuki M, Granger DN (1991) Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 88(11):4651-4655
36. Lappin DF, Kjeldsen M, Sander L, Kinane DF (2000) Inducible nitric oxide synthase expression in periodontitis. J Periodontal Res 35(6):369-373
37. Laurent M, Lepoivre M, Tenu J (1996) Kinetic modelling of the nitric oxide gradient generated in vitro by adherent cells expressing inducible nitric oxide synthase. Biochem J 314:109-113
38. Lefer AM, Lefer DJ (1996) The role of nitric oxide and cell adhesion molecules on the microcirculation in ischaemia-reperfusion. Cardiovasc Res 32(4):743-751
39. Leitão RFC, Ribeiro RA, Chaves HV, Rocha FAC, Lima V, Brito GAC (2005) Nitric oxide synthase inhibition prevents alveolar bone resorption in experimental periodontitis in rats. J Periodontol 76(6):956-963
40. Leitão RFC, Rocha FAC, Chaves HV, Lima V, Cunha FQ, Ribeiro RA, Brito GAC (2004) Locally applied isosorbide decreases bone resorption in experimental periodontitis in rats. J Periodontol 75(9):1227-1232
41. Lima V, Brito GAC, Cunha FQ, Rebouças CG, Falcão BAA, Augusto RF, Souza MLP, Leitão BT, Ribeiro RA (2005) Effects of the tumor necrosis factor-alpha inhibitors pentoxifylline and thalidomide in short-term experimental oral mucositis in hamsters. Eur J Oral Sci 113(3):210-217
42. Liu X, Buffington JA, Tjalkens RB (2005) NF-kappaB-dependent production of nitric oxide by astrocytes mediates apoptosis in differentiated PC12 neurons following exposure to manganese and cytokines. Brain Res Mol Brain Res 141(1):39-47
43. Lockhart PB, Sonis ST (1979) Relationship of oral complications to peripheral blood leukocyte and platelet counts in patients receiving cancer chemotherapy. Oral Surg Oral Med Oral Pathol 48(1):21-28
44. Lockhart PB, Sonis ST (1981) Alterations in the oral mucosa caused by chemotherapeutic agents. A histologic study. J Dermatol Surg Oncol 7(12):1019-1025
45. Lohinai Z, Benedek P, Feher E, Gyorfi A, Rosivall L, Fazekas A, Salzman AL, Szabo C (1998) Protective effects of mercaptoethylguanidine, a selective inhibitor of inducible nitric oxide synthase, in ligature-induced periodontitis in the rat. Br J Pharmacol 123(3):353-360. Erratum in: Br J Pharmacol 123(8):741
46. Lohinai Z, Stachlewitz R, Virag L, Szekely AD, Hasko G, Szabo C (2001) Evidence for reactive nitrogen species formation in the gingivomucosal tissue. J Dent Res 80(2):470-475
47. Lohinai ZM, Szabó C (1998) Role of nitric oxide physiology and pathophysiology of periodontal tissues. Med Sci Monit 4:1089-1095
48. Moncada S, Palmer RMJ, Hibbs JR, Higgs AE (1991) Nitric oxide: physiology pathophysiology and pharmacology. Pharmacol Rev 43:109
49. Muhl H, Dinarello CA (1997) Macrophage inflammatory protein-1 alpha production in lipopolysaccharide-stimulated human adherent blood mononuclear cells is inhibited by the nitric oxide synthase inhibitor N(G)-monomethyl-L- arginine. J Immunol 159(10):5063-5069
50. Nathan C (1997) Inducible nitric oxide synthase: what difference does it make? J Clin Invest 100(10):2417-2423
51. Peng HB, Spiecker M, Liao JK (1998) Inducible nitric oxide: an autoregulatory feedback inhibitor of vascular inflammation. J Immunol 161(4):1970-1976
52. Radi R, Beckman JS, Bush KM, Freeman BA (1991) Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide. J Biol Chem 266(7):4244-4250
53. Ralston SH, Todd D, Helfrich MH, Benjamin N, Grabowski P (1994) Human osteoblast-like cells produce nitric oxide and express inducible nitric oxide synthase. Endocrinology 135:330-336
54. Rubbo H, Radi L, Trugillo M, Telleri R, Kalyanaraman B, Barnes S, Kirk M, Freeman BA (1994) Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives. J Biol Chem 269(42):26066-26075
55. Sonis ST, Elting LS, Keefe D, Peterson DE, Schubert M, Hauer-Jensen M, Bekele BN, Rader-Durlacher J, Donnelly JP, Rubenstein EB (2004) Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 100(Suppl 9):1995-2025
56. Sonis ST, Peterson RL, Edwards LJ, Lucey CA, Wang L, Manson L, Login G, Ymamkawa M, Moses G, Bouchard P, Hayes LL, Bedrosian C, Dorner AJ (2000) Defining mechanisms of action of interleukin-11 on the progression of radiation-induced oral mucositis in hamsters. Oral Oncol 36(4):373-381
57. Sonis ST, Scherer J, Phelan S, Lucey CA, Barron JE, O'Donnell KE, Brennan RJ, Pan H, Busse P, Haley JD (2002) The gene expression sequence of radiated mucosa in an animal mucositis model. Cell Prolif 35(Suppl 1):93-102
58. Sonis ST, Sonis AL, Lieberman A (1978) Oral complications in patients receiving treatment for malignancies other than of the head and neck. J Am Dent Assoc 97(3):468-472
59. Souza MH, Troncon LE, Cunha FQ, Oliveira RB (2003) Decreased gastric tone and delayed gastric emptying precede neutrophil infiltration and mucosal lesion formation in indomethacin-induced gastric damage in rats. Braz J Med Biol Res 36(10):1383-1390
60. Souza-Filho MV, Lima MV, Pompeu MM, Ballejo G, Cunha FQ, Ribeiro RA (1997) Involvement of nitric oxide in the pathogenesis of cyclophosphamide- induced hemorrhagic cystitis. Am J Pathol 150(1):247-256
61. Stefanovic-Racic M, Stadler J, Evans CH (1993) Nitric oxide and arthritis. Arthritis Rheum 36(8):1036-1044
62. Szabo C (1996) The pathophysiological role of peroxynitrite in shock, inflammation, and ischemia-reperfusion injury. Shock 6(2):79-88
63. Szabo C, Ferrer-Sueta G, Zingarelli B, Southan GJ, Salzman AL, Radi L (1997) Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage. J Biol Chem 272(14):9030-9036
64. Veihelmann A, Landes J, Hofbauer A, Dorger M, Refior HJ, Messmer K, Krombach F (2001) Exacerbation of antigen-induced arthritis in inducible nitric oxide synthase-deficient mice. Arthritis Rheum 44(6):1420-1027