Shared genetic factors influence risk for bipolar disorder and alcohol use disorders

European Psychiatry

Volumn 29, Issue 5, 2014, Pages 282-287

  Carmiol, N ^a   Peralta, J M ^a,b   Almasy, L ^b   Contreras, J ^a   Pacheco, A ^a   Escamilla, M A ^c   Knowles, E E M ^d,e   Raventos H ^a   Glahn, D C ^d,e  

^a UNIVERSIDAD DE COSTA RICA   (Costa Rica)

^b SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^c TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^d INSTITUTE OF LIVING   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alcohol use disorder; Bipolar disorder; Central Valley of Costa Rica; Family studies; Genetic correlation; Heritability

Indexed keywords

ADULT; ALCOHOL ABUSE; ALCOHOL USE DISORDER; ANXIETY; ANXIETY DISORDER; ARTICLE; BIPOLAR DISORDER; BIPOLAR I DISORDER; BIPOLAR II DISORDER; CONTROLLED STUDY; COSTA RICA; FEMALE; GENETIC CORRELATION; GENETIC RISK; HEREDITY; HERITABILITY; HUMAN; LIFESPAN; MAJOR CLINICAL STUDY; MALE; PEDIGREE; PHENOTYPE; PRIORITY JOURNAL; SCHIZOAFFECTIVE PSYCHOSIS; TOBACCO DEPENDENCE; ADOLESCENT; AGED; ALCOHOL-RELATED DISORDERS; COMORBIDITY; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALCOHOL-RELATED DISORDERS; BIPOLAR DISORDER; COMORBIDITY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; PEDIGREE; PHENOTYPE; YOUNG ADULT;

EID: 84902368365     PISSN: 09249338     EISSN: 17783585     Source Type: Journal    
DOI: 10.1016/j.eurpsy.2013.10.001     Document Type: Article

References (60)

1. Agrawal A., Edenberg H.J., Foroud T., Bierut L.J., Dunne G., Hinrichs A.L., et al. Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. Behav Genet 2006, 36(5):640-650.
2. Almasy L., Blangero J. Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 1998, 62(5):1198-1211.
3. Almasy L., Dyer T.D., Blangero J. Bivariate quantitative trait linkage analysis: pleiotropy versus co-incident linkages. Genet Epidemiol 1997, 14(6):953-958.
4. Anticevic A., Brumbaugh M.S., Winkler A.M., Lombardo L.E., Barrett J., Corlett P.R., et al. Global prefrontal and fronto-amygdala dysconnectivity in bipolar I disorder with psychosis history. Biol Psychiatry 2013, 73(6):565-573.
5. Bearden C.E., Hoffman K.M., Cannon T.D. The neuropsychology and neuroanatomy of bipolar affective disorder: a critical review. Bipolar Disorders 2001, 3(3):106-150. [discussion 151-103].
6. Bierut L.J., Agrawal A., Bucholz K.K., Doheny K.F., Laurie C., Pugh E., et al. A genome-wide association study of alcohol dependence. Proc Natl Acad Sci U S A 2010, 107(11):5082-5087.
7. Castilla-Puentes R., Secin R., Grau A., Galeno R., De Mello M.F., Castilla-Puentes S., et al. A multicenter study of bipolar disorder among emergency department patients in Latin-American countries. Int J Psychiatry Med 2011, 42(1):49-67.
8. Chang Y.H., Chen S.L., Lee S.Y., Hsu Y.W., Wu J.Y., Chen S.H., et al. Neuropsychological functions in bipolar disorders I and II with and without comorbid alcohol dependence. Prog Neuropsychopharmacol Biol Psychiatry 2012, 37(2):211-216.
9. Chen C.H., Suckling J., Lennox B.R., Ooi C., Bullmore E.T. A quantitative meta-analysis of fMRI studies in bipolar disorder. Bipolar Disord 2011, 13(1):1-15.
10. Contreras J., Hare E., Pacheco A., Escamilla M., Raventos H. Is subclinical anxiety an endophenotype for bipolar I patients? A study from a Costa Rican sample. J Affect Disord 2010, 122(3):267-272.
11. Cuthbert B.N., Insel T.R. Toward new approaches to psychotic disorders: the NIMH Research Domain Criteria project. Schizophr Bull 2010, 36(6):1061-1062.
12. Delvecchio G., Sugranyes G., Frangou S. Evidence of diagnostic specificity in the neural correlates of facial affect processing in bipolar disorder and schizophrenia: a meta-analysis of functional imaging studies. Psychol Med 2013, 43(3):553-569.
13. Duggirala R., Williams J.T., Williams-Blangero S., Blangero J. A variance component approach to dichotomous trait linkage analysis using a throshold model. Genet Epidemiol 1997, 14:987-992.
14. Escamilla M.A., Batki S., Reus V.I., Spesny M., Molina J., Service S., et al. Comorbidity of bipolar disorder and substance abuse in Costa Rica: pedigree- and population-based studies. J Affect Disord 2002, 71(1-3):71-83.
15. Everitt B.J., Parkinson J.A., Olmstead M.C., Arroyo M., Robledo P., Robbins T.W. Associative processes in addiction and reward. The role of amygdala-ventral striatal subsystems. Ann N Y Acad Sci 1999, 877:412-438.
16. Falconer D.S., Mackay T.F.C. Quantitative Genetics 1996, Longman Group, Essex, UK.
17. Fowler T., Lifford K., Shelton K., Rice F., Thapar A., Neale M.C., et al. Exploring the relationship between genetic and environmental influences on initiation and progression of substance use. Addiction 2007, 102(3):413-422.
18. Freeman M.P., Freeman S.A., McElroy S.L. The comorbidity of bipolar and anxiety disorders: prevalence, psychobiology, and treatment issues. J Affect Disord 2002, 68(1):1-23.
19. Goldman D., Oroszi G., Ducci F. The genetics of addictions: uncovering the genes. Nat Rev Genet 2005, 6(7):521-532.
20. Grant B.F., Stinson F.S., Hasin D.S., Dawson D.A., Chou S.P., Ruan W.J., et al. Prevalence, correlates, and comorbidity of bipolar I disorder and axis I and II disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. J Clin Psychiatry 2005, 66(10):1205-1215.
21. Heffner J.L., Strawn J.R., DelBello M.P., Strakowski S.M., Anthenelli R.M. The co-occurrence of cigarette smoking and bipolar disorder: phenomenology and treatment considerations. Bipolar Disord 2011, 13(5-6):439-453.
22. Hyman S.E., Malenka R.C., Nestler E.J. Neural mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci 2006, 29:565-598.
23. Jaworski F., Dubertret C., Adès J., Gorwood P. Presence of co-morbid substance use disorder in bipolar patients worsens their social functioning to the level observed in patients with schizophrenia. Psychiatry Res 2011, 185(1-2):129-134.
24. Kaprio J., Koskenvuo M., Langinvainio H., Romanov K., Sarna S., Rose R.J. Genetic influences on use and abuse of alcohol: a study of 5638 adult Finnish twin brothers. Alcohol Clin Exp Res 1987, 11(4):349-356.
25. Kendler K.S. Twin studies of psychiatric illness. Current status and future directions. Arch Gen Psychiatry 1993, 50(11):905-915.
26. Kendler K.S., Walters E.E., Neale M.C., Kessler R.C., Heath A.C., Eaves L.J. The structure of the genetic and environmental risk factors for six major psychiatric disorders in women. Phobia, generalized anxiety disorder, panic disorder, bulimia, major depression, and alcoholism. Arch Gen Psychiatry 1995, 52(5):374-383.
27. Kendler K., Prescott C., Myers J., Neale M. The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women. Arch Gen Psychiatry 2003, 60(9):929-937.
28. Kessler R., Berglund P., Demler O., Jin R., Merikangas K., Walters E. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 2005, 62(6):593-602.
29. Koob G.F., Le Moal M. Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology 2001, 24(2):97-129.
30. Koob G., Volkow N. Neurocircuitry of addiction. Neuropsychopharmacology 2010, 35(1):217-238.
31. Lagerberg T.V., Andreassen O.A., Ringen P.A., Berg A.O., Larsson S., Agartz I., et al. Excessive substance use in bipolar disorder is associated with impaired functioning rather than clinical characteristics, a descriptive study. BMC Psychiatry 2010, 10:9.
32. Le-Niculescu H., McFarland M.J., Ogden C.A., Balaraman Y., Patel S., Tan J., et al. Phenomic, convergent functional genomic, and biomarker studies in a stress-reactive genetic animal model of bipolar disorder and co-morbid alcoholism. Am J Med Genet B Neuropsychiatr Genet 2008, 147B(2):134-166.
33. Levander E., Frye M.A., McElroy S., Suppes T., Grunze H., Nolen W.A., et al. Alcoholism and anxiety in bipolar illness: differential lifetime anxiety comorbidity in bipolar I women with and without alcoholism. J Affect Disord 2007, 101(1-3):211-217.
34. Lichtenstein P., Yip B., Björk C., Pawitan Y., Cannon T., Sullivan P., et al. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet 2009, 373(9659):234-239.
35. Lydall G.J., Bass N.J., McQuillin A., Lawrence J., Anjorin A., Kandaswamy R., et al. Confirmation of prior evidence of genetic susceptibility to alcoholism in a genome-wide association study of comorbid alcoholism and bipolar disorder. Psychiatr Genet 2011, 21(6):294-306.
36. Mathews C.A., Reus V.I., Bejarano J., Escamilla M.A., Fournier E., Herrera L.D., et al. Genetic studies of neuropsychiatric disorders in Costa Rica: a model for the use of isolated populations. Psychiatr Genet 2004, 14(1):13-23.
37. Maxwell M.E. Manual for the FIGS 1992, National Institute of Mental Health, Bethesda, MD.
38. Merikangas K.R., Akiskal H.S., Angst J., Greenberg P.E., Hirschfeld R.M., Petukhova M., et al. Lifetime and 12-month prevalence of bipolar spectrum disorder in the national comorbidity survey replication. Arch Gen Psychiatry 2007, 64(5):543-552.
39. Murray C.J.L., Lopez A.D. The global burden of disease: a comprehensive assessment of mortality, injuries and risk factors in 1990 and projected to 2020 1996, Harvard School of Public Health and the World Health Organisation, Boston.
40. Nery F., Hatch J., Glahn D., Nicoletti M., Monkul E., Najt P., et al. Temperament and character traits in patients with bipolar disorder and associations with comorbid alcoholism or anxiety disorders. J Psychiatr Res 2008, 42(7):569-577.
41. Nestler E.J., Carlezon W.A. The mesolimbic dopamine reward circuit in depression. Biol Psychiatry 2006, 59(12):1151-1159.
42. Neves F.S., Malloy-Diniz L., Romano-Silva M.A., Campos S.B., Miranda D.M., De Marco L., et al. The role of BDNF genetic polymorphisms in bipolar disorder with psychiatric comorbidities. J Affect Disord 2011, 131(1-3):307-311.
43. Niculescu A.B., Segal D.S., Kuczenski R., Barrett T., Hauger R.L., Kelsoe J.R. Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach. Physiol Genomics 2000, 4(1):83-91.
44. Nurnberger J.I., Blehar M.C., Kaufmann C.A., York-Cooler C., Simpson S.G., Harkavy-Friedman J., et al. Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch Gen Psychiatry 1994, 51(11):849-859.
45. Olvera R.L., Bearden C.E., Velligan D.I., Almasy L., Carless M.A., Curran J.E., et al. Common genetic influences on depression, alcohol, and substance use disorders in Mexican-American families. Am J Med Genet B Neuropsychiatr Genet 2011.
46. Petry N.M., Stinson F.S., Grant B.F. Comorbidity of DSM-IV pathological gambling and other psychiatric disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. J Clin Psychiatry 2005, 66(5):564-574.
47. Prescott C., Aggen S., Kendler K. Sex-specific genetic influences on the comorbidity of alcoholism and major depression in a population-based sample of US twins. Arch Gen Psychiatry 2000, 57(8):803-811.
48. Prisciandaro J.J., Brown D.G., Brady K.T., Tolliver B.K. Comorbid anxiety disorders and baseline medication regimens predict clinical outcomes in individuals with co-occurring bipolar disorder and alcohol dependence: results of a randomized controlled trial. Psychiatry Res 2011, 188(3):361-365.
49. Purcell S., Wray N., Stone J., Visscher P., O'Donovan M., Sullivan P., et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009, 460(7256):748-752.
50. Segura-Wang M., Raventós H., Escamilla M., Barrantes R. Assessment of genetic ancestry and population substructure in Costa Rica by analysis of individuals with a familial history of mental disorder. Ann Hum Genet 2010, 74(6):516-524.
51. Simon N.M., Otto M.W., Wisniewski S.R., Fossey M., Sagduyu K., Frank E., et al. Anxiety disorder comorbidity in bipolar disorder patients: data from the first 500 participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). Am J Psychiatry 2004, 161(12):2222-2229.
52. Smoller J., Finn C. Family, twin, and adoption studies of bipolar disorder. Am J Med Genet C Semin Med Genet 2003, 123C(1):48-58.
53. Strakowski S.M., Keck P.E., McElroy S.L., West S.A., Sax K.W., Hawkins J.M., et al. Twelve-month outcome after a first hospitalization for affective psychosis. Arch Gen Psychiatry 1998, 55(1):49-55.
54. Strakowski S.M., Adler C.M., Holland S.K., Mills N., DelBello M.P. A preliminary FMRI study of sustained attention in euthymic, unmedicated bipolar disorder. Neuropsychopharmacology 2004, 29(9):1734-1740.
55. True W.R., Xian H., Scherrer J.F., Madden P.A., Bucholz K.K., Heath A.C., et al. Common genetic vulnerability for nicotine and alcohol dependence in men. Arch Gen Psychiatry 1999, 56(7):655-661.
56. Waxmonsky J.A., Thomas M.R., Miklowitz D.J., Allen M.H., Wisniewski S.R., Zhang H., et al. Prevalence and correlates of tobacco use in bipolar disorder: data from the first 2000 participants in the Systematic Treatment Enhancement Program. Gen Hosp Psychiatry 2005, 27(5):321-328.
57. Williams J.T., Blangero J. Power of variance component linkage analysis to detect quantitative trait loci. Ann Hum Genet 1999, 63:545-563.
58. Winokur G., Coryell W., Endicott J., Keller M., Akiskal H., Solomon D. Familial alcoholism in manic-depressive (bipolar) disease. Am J Med Genet 1996, 67(2):197-201.
59. Young S.E., Rhee S.H., Stallings M.C., Corley R.P., Hewitt J.K. Genetic and environmental vulnerabilities underlying adolescent substance use and problem use: general or specific?. Behav Genet 2006, 36(4):603-615.
60. Zhang T., Gao W., Cao W., Zhan S., Lv J., Pang Z., et al. The genetic correlation between cigarette smoking and alcohol drinking among Chinese adult male twins: an ordinal bivariate genetic analysis. Twin Res Hum Genet 2012, 15(4):483-490.