Effects of releasing recombinant human growth and differentiation factor-5 from poly(lactic-co-glycolic acid) microspheres for repair of the rat degenerated intervertebral disc

Journal of Biomaterials Applications

Volumn 29, Issue 1, 2014, Pages 72-80

  Yan, Jihong ^a   Yang, Shu ^a   Sun, Huaimei ^a   Guo, Duo ^a   Wu, Bo ^a   Ji, Fengqing ^a   Zhou, Deshan ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

annulus fibrosus; human growth and differentiation factor 5; intervertebral disc degeneration; nucleus pulposus; Poly(lactic co glycolic acid) microspheres

Indexed keywords

COLLAGEN; EMULSIFICATION; GENE EXPRESSION; MICROSPHERES; NEEDLES; NUCLEIC ACIDS; RATS; REPAIR;

ANNULUS FIBROSUS; HUMAN GROWTH AND DIFFERENTIATION FACTOR-5; INTER-VERTEBRAL DISC DEGENERATION; NUCLEUS PULPOSUS; POLY(LACTICCO-GLYCOLIC ACID) MICROSPHERE;

COPOLYMERS;

AGGRECAN; COLLAGEN TYPE 1; COLLAGEN TYPE 2; DRUG VEHICLE; EOSIN; GLYCOSAMINOGLYCAN; GLYCOSAMINOGLYCAN POLYSULFATE; GROWTH DIFFERENTIATION FACTOR 5; HEMATOXYLIN; MESSENGER RNA; MICROSPHERE; POLYGLACTIN; RECOMBINANT GROWTH FACTOR; RECOMBINANT HUMAN GROWTH AND DIFFERENTIATION FACTOR 5; SOLVENT; UNCLASSIFIED DRUG; BIOMATERIAL; COLLAGEN; GDF5 PROTEIN, HUMAN; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE REGENERATION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DNA CONTENT; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG EFFICACY; DRUG RELEASE; EMULSION; ENCAPSULATION; EVAPORATION; GENE EXPRESSION; HISTOLOGY; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; MALE; NONHUMAN; NUCLEUS PULPOSUS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; SUSTAINED DRUG RELEASE; ANIMAL; DELAYED RELEASE FORMULATION; DISEASE MODEL; GENETICS; HUMAN; MATERIALS TESTING; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT;

AGGRECANS; ANIMALS; BIOCOMPATIBLE MATERIALS; COLLAGEN; DELAYED-ACTION PREPARATIONS; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; GROWTH DIFFERENTIATION FACTOR 5; HUMANS; INTERVERTEBRAL DISC DEGENERATION; LACTIC ACID; MALE; MATERIALS TESTING; MICROSPHERES; POLYGLYCOLIC ACID; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; RNA, MESSENGER;

EID: 84902360659     PISSN: 08853282     EISSN: 15308022     Source Type: Journal    
DOI: 10.1177/0885328213515034     Document Type: Article

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