A novel herbal medicine, KIOM-C, induces autophagic and apoptotic cell death mediated by activation of JNK and reactive oxygen species in HT1080 human fibrosarcoma cells

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Kim, Aeyung ^a   Im, Minju ^a   Yim, Nam Hui ^a   Kim, Taesoo ^a   Ma, Jin Yeul ^a  

^a Korea Institute of Oriental Medicine (KIOM)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTINEOPLASTIC AGENT; BECLIN 1; CASPASE 3; CYCLIN D1; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HERBACEOUS AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KIOM C; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN C JUN; PROTEIN P21; PROTEIN P27; PROTEIN P53; PROTEIN P62; PROTEIN SERINE THREONINE KINASE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; ULK1 PROTEIN; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL LINE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; FEMALE; FIBROSARCOMA CELL LINE; G1 PHASE CELL CYCLE CHECKPOINT; HERBAL MEDICINE; HT1080 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MEDICINAL PLANT; MOUSE; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RADIX ANGELICAE GIGANTIS; RADIX GLYCYRRHIZAE; RADIX PAEONIAE ALBA; RADIX SCUTELLARIAE; SIGNAL TRANSDUCTION; TUMOR GROWTH; UPREGULATION; ANIMAL; CELL CYCLE G1 PHASE; CELL DEATH; DRUG EFFECTS; FIBROSARCOMA; GENE EXPRESSION REGULATION; LIVER CELL; METABOLISM; NUDE MOUSE; PROCEDURES; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL DEATH; CELL LINE, TUMOR; DOWN-REGULATION; FEMALE; FIBROSARCOMA; G1 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATOCYTES; HERBAL MEDICINE; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MICE, NUDE; PLANTS, MEDICINAL; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84902322567     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0098703     Document Type: Article

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