The CD3 conformational change in the γδ T cell receptor is not triggered by antigens but can be enforced to enhance tumor killing

Cell Reports

Volumn 7, Issue 5, 2014, Pages 1704-1715

  Dopfer, Elaine P ^a,b   Hartl, Frederike A ^a,b   Oberg, Hans Heinrich ^c   Siegers, Gabrielle M ^a,b,d   Yousefi, O Sascha ^a,b   Kock, Sylvia ^e   Fiala, Gina J ^a,b   Garcillán, Beatriz ^f   Sandstrom, Andrew ^g   Alarcón, Balbino ^h   Regueiro, Jose R ^f   Kabelitz, Dieter ^c   Adams, Erin J ^g   Minguet, Susana ^a,b   Wesch, Daniela ^c   Fisch, Paul ^e   Schamel, Wolfgang W A ^a,b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^c UNIVERSITY OF KIEL   (Germany)

^d ROBARTS RESEARCH INSTITUTE   (Canada)

^e UNIVERSITY OF FREIBURG   (Germany)

^f UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^g THE UNIVERSITY OF CHICAGO   (United States)

^h UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CYTOKINE; GAMMA INTERFERON; HETERODIMER; MONOCLONAL ANTIBODY CD3; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; TUMOR NECROSIS FACTOR ALPHA; CALCIUM ION; CD3 ANTIBODY;

ANIMAL CELL; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOKINE RELEASE; GENE ACTIVATION; IMMUNOSTIMULATION; IMMUNOTHERAPY; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; TUMOR CELL DESTRUCTION; ANTIGEN BINDING; BINDING AFFINITY; BINDING SITE; CALCIUM TRANSPORT; DEGLYCOSYLATION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; UPREGULATION;

EID: 84902317661     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.04.049     Document Type: Article

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