Highly active microbial phosphoantigen induces rapid yet sustained MEK/Erk- and PI-3K/Akt-mediated signal transduction in anti-tumor human γδ T-cells

PLoS ONE

Volumn 4, Issue 5, 2009, Pages

  Correia, Daniel V ^a,b   D'Orey, Francisco ^a,b   Cardoso, Bruno A ^a   Lança, Telma ^a,b   Grosso, Ana R ^a   DeBarros, Ana ^a,b   Martins, Leila R ^a   Barata, João T ^a   Silva Santos, Bruno ^a,b  

^a INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^b INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXY 3 METHYL BUTYL 2 ENYL PYROPHOSPHATE; ANTINEOPLASTIC AGENT; CYCLIN D2; FAS LIGAND; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; OKT 3; PHOSPHATIDYLINOSITOL 3 KINASE; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 4 HYDROXY 3 METHYLBUT 2 ENYL PYROPHOSPHATE; 4-HYDROXY-3-METHYLBUT-2-ENYL PYROPHOSPHATE; BACTERIAL ANTIGEN; CD3 ANTIGEN; LIGAND; LYMPHOCYTE ANTIGEN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN KINASE B; PYROPHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER IMMUNOTHERAPY; CELL ACTIVITY; CELL MEDIATED CYTOTOXICITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LEUKEMIA; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; ANIMAL; CYTOLOGY; CYTOTOXICITY; DRUG EFFECT; ENDOCYTOSIS; ENZYMOLOGY; IMMUNOLOGY; METABOLISM; MOLECULAR MIMICRY; MOUSE MUTANT; NEOPLASM; T LYMPHOCYTE; TUMOR CELL LINE;

BACTERIA (MICROORGANISMS); MUS; PROTOZOA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIGENS, BACTERIAL; ANTIGENS, CD3; CELL LINE, TUMOR; CYTOTOXICITY, IMMUNOLOGIC; DIPHOSPHATES; ENDOCYTOSIS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INTERLEUKIN-2; LIGANDS; LYMPHOCYTE ACTIVATION; MICE; MICE, SCID; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MOLECULAR MIMICRY; NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSCRIPTION, GENETIC;

EID: 66249119050     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005657     Document Type: Article

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