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Volumn 166, Issue 1, 2014, Pages 3-11

How I determine if and when to recommend stopping tyrosine kinase inhibitor treatment for chronic myeloid leukaemia

Author keywords

BCR ABL1; Chronic myeloid leukaemia; Minimal residual disease; Treatment free remission; Tyrosine kinase inhibitors

Indexed keywords

IMATINIB; INTERFERON;

EID: 84902304839     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.12892     Document Type: Article
Times cited : (42)

References (54)
  • 5
    • 84860752177 scopus 로고    scopus 로고
    • BCR-ABL1 doubling times more reliably assess the dynamics of CML relapse compared with the BCR-ABL1 fold rise: implications for monitoring and management
    • Branford, S., Yeung, D.T., Prime, J.A., Choi, S.Y., Bang, J.H., Park, J.E., Kim, D.W., Ross, D.M. & Hughes, T.P. (2012) BCR-ABL1 doubling times more reliably assess the dynamics of CML relapse compared with the BCR-ABL1 fold rise: implications for monitoring and management. Blood, 119, 4264-4271.
    • (2012) Blood , vol.119 , pp. 4264-4271
    • Branford, S.1    Yeung, D.T.2    Prime, J.A.3    Choi, S.Y.4    Bang, J.H.5    Park, J.E.6    Kim, D.W.7    Ross, D.M.8    Hughes, T.P.9
  • 8
    • 77950496740 scopus 로고    scopus 로고
    • Sustained molecular response with interferon alfa maintenance after induction therapy with imatinib plus interferon alfa in patients with chronic myeloid leukemia
    • Burchert, A., Muller, M.C., Kostrewa, P., Erben, P., Bostel, T., Liebler, S., Hehlmann, R., Neubauer, A. & Hochhaus, A. (2010) Sustained molecular response with interferon alfa maintenance after induction therapy with imatinib plus interferon alfa in patients with chronic myeloid leukemia. Journal of Clinical Oncology, 28, 1429-1435.
    • (2010) Journal of Clinical Oncology , vol.28 , pp. 1429-1435
    • Burchert, A.1    Muller, M.C.2    Kostrewa, P.3    Erben, P.4    Bostel, T.5    Liebler, S.6    Hehlmann, R.7    Neubauer, A.8    Hochhaus, A.9
  • 9
    • 45749101780 scopus 로고    scopus 로고
    • Development and dynamics of robust T-cell responses to CML under imatinib treatment
    • Chen, C.I., Maecker, H.T. & Lee, P.P. (2008) Development and dynamics of robust T-cell responses to CML under imatinib treatment. Blood, 111, 5342-5349.
    • (2008) Blood , vol.111 , pp. 5342-5349
    • Chen, C.I.1    Maecker, H.T.2    Lee, P.P.3
  • 11
    • 33744486584 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction
    • Copland, M., Hamilton, A., Elrick, L.J., Baird, J.W., Allan, E.K., Jordanides, N., Barow, M., Mountford, J.C. & Holyoake, T.L. (2006) Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Blood, 107, 4532-4539.
    • (2006) Blood , vol.107 , pp. 4532-4539
    • Copland, M.1    Hamilton, A.2    Elrick, L.J.3    Baird, J.W.4    Allan, E.K.5    Jordanides, N.6    Barow, M.7    Mountford, J.C.8    Holyoake, T.L.9
  • 12
    • 84892568018 scopus 로고    scopus 로고
    • Inhibition of PI3K/mTOR overcomes nilotinib resistance in BCR-ABL1 positive leukemia cells through translational down-regulation of MDM2
    • Ding, J., Romani, J., Zaborski, M., Macleod, R.A., Nagel, S., Drexler, H.G. & Quentmeier, H. (2013) Inhibition of PI3K/mTOR overcomes nilotinib resistance in BCR-ABL1 positive leukemia cells through translational down-regulation of MDM2. PLoS ONE, 8, e83510.
    • (2013) PLoS ONE , vol.8
    • Ding, J.1    Romani, J.2    Zaborski, M.3    Macleod, R.A.4    Nagel, S.5    Drexler, H.G.6    Quentmeier, H.7
  • 16
    • 79955066374 scopus 로고    scopus 로고
    • Sensitive quantitation of minimal residual disease in chronic myeloid leukemia using nanofluidic digital polymerase chain reaction assay
    • Goh, H.G., Lin, M., Fukushima, T., Saglio, G., Kim, D., Choi, S.Y., Kim, S.H., Lee, J., Lee, Y.S., Oh, S.M. & Kim, D.W. (2011) Sensitive quantitation of minimal residual disease in chronic myeloid leukemia using nanofluidic digital polymerase chain reaction assay. Leukaemia & Lymphoma, 52, 896-904.
    • (2011) Leukaemia & Lymphoma , vol.52 , pp. 896-904
    • Goh, H.G.1    Lin, M.2    Fukushima, T.3    Saglio, G.4    Kim, D.5    Choi, S.Y.6    Kim, S.H.7    Lee, J.8    Lee, Y.S.9    Oh, S.M.10    Kim, D.W.11
  • 17
    • 30844457497 scopus 로고    scopus 로고
    • Why do chronic myelogenous leukemia stem cells survive allogeneic stem cell transplantation or imatinib: does it really matter?
    • Goldman, J. & Gordon, M. (2006) Why do chronic myelogenous leukemia stem cells survive allogeneic stem cell transplantation or imatinib: does it really matter? Leukaemia & Lymphoma, 47, 1-7.
    • (2006) Leukaemia & Lymphoma , vol.47 , pp. 1-7
    • Goldman, J.1    Gordon, M.2
  • 20
    • 77955624105 scopus 로고    scopus 로고
    • PR1-specific T cells are associated with unmaintained cytogenetic remission of chronic myelogenous leukemia after interferon withdrawal
    • Kanodia, S., Wieder, E., Lu, S., Talpaz, M., Alatrash, G., Clise-Dwyer, K. & Molldrem, J.J. (2010) PR1-specific T cells are associated with unmaintained cytogenetic remission of chronic myelogenous leukemia after interferon withdrawal. PLoS ONE, 5, e11770.
    • (2010) PLoS ONE , vol.5
    • Kanodia, S.1    Wieder, E.2    Lu, S.3    Talpaz, M.4    Alatrash, G.5    Clise-Dwyer, K.6    Molldrem, J.J.7
  • 22
    • 84855842631 scopus 로고    scopus 로고
    • Low BCR-ABL expression levels in hematopoietic precursor cells enable persistence of chronic myeloid leukemia under imatinib
    • Kumari, A., Brendel, C., Hochhaus, A., Neubauer, A. & Burchert, A. (2012) Low BCR-ABL expression levels in hematopoietic precursor cells enable persistence of chronic myeloid leukemia under imatinib. Blood, 119, 530-539.
    • (2012) Blood , vol.119 , pp. 530-539
    • Kumari, A.1    Brendel, C.2    Hochhaus, A.3    Neubauer, A.4    Burchert, A.5
  • 25
    • 84865776165 scopus 로고    scopus 로고
    • Second attempt to discontinue imatinib in CP-CML patients with a second sustained complete molecular response
    • Legros, L., Rousselot, P., Giraudier, S., Tulliez, M., Huguet, F., Nicolini, F.E. & Mahon, F.X. (2012) Second attempt to discontinue imatinib in CP-CML patients with a second sustained complete molecular response. Blood, 120, 1959-1960.
    • (2012) Blood , vol.120 , pp. 1959-1960
    • Legros, L.1    Rousselot, P.2    Giraudier, S.3    Tulliez, M.4    Huguet, F.5    Nicolini, F.E.6    Mahon, F.X.7
  • 27
    • 78049528573 scopus 로고    scopus 로고
    • Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial
    • Mahon, F.X., Rea, D., Guilhot, J., Guilhot, F., Huguet, F., Nicolini, F., Legros, L., Charbonnier, A., Guerci, A., Varet, B., Etienne, G., Reiffers, J. & Rousselot, P. (2010) Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial. Lancet Oncology, 11, 1029-1035.
    • (2010) Lancet Oncology , vol.11 , pp. 1029-1035
    • Mahon, F.X.1    Rea, D.2    Guilhot, J.3    Guilhot, F.4    Huguet, F.5    Nicolini, F.6    Legros, L.7    Charbonnier, A.8    Guerci, A.9    Varet, B.10    Etienne, G.11    Reiffers, J.12    Rousselot, P.13
  • 30
    • 0033826799 scopus 로고    scopus 로고
    • Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia
    • Molldrem, J.J., Lee, P.P., Wang, C., Felio, K., Kantarjian, H.M., Champlin, R.E. & Davis, M.M. (2000) Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia. Nature Medicine, 6, 1018-1023.
    • (2000) Nature Medicine , vol.6 , pp. 1018-1023
    • Molldrem, J.J.1    Lee, P.P.2    Wang, C.3    Felio, K.4    Kantarjian, H.M.5    Champlin, R.E.6    Davis, M.M.7
  • 33
    • 70349562580 scopus 로고    scopus 로고
    • Programmed death 1 signaling on chronic myeloid leukemia-specific T cells results in T-cell exhaustion and disease progression
    • Mumprecht, S., Schurch, C., Schwaller, J., Solenthaler, M. & Ochsenbein, A.F. (2009) Programmed death 1 signaling on chronic myeloid leukemia-specific T cells results in T-cell exhaustion and disease progression. Blood, 114, 1528-1536.
    • (2009) Blood , vol.114 , pp. 1528-1536
    • Mumprecht, S.1    Schurch, C.2    Schwaller, J.3    Solenthaler, M.4    Ochsenbein, A.F.5
  • 34
    • 78751703163 scopus 로고    scopus 로고
    • Very late recurrences of leukemia: why does leukemia awake after many years of dormancy?
    • Norkin, M., Uberti, J.P. & Schiffer, C.A. (2011) Very late recurrences of leukemia: why does leukemia awake after many years of dormancy? Leukemia Research, 35, 139-144.
    • (2011) Leukemia Research , vol.35 , pp. 139-144
    • Norkin, M.1    Uberti, J.P.2    Schiffer, C.A.3
  • 35
    • 84859218819 scopus 로고    scopus 로고
    • Increased natural killer cells and decreased CD3(+)CD8(+)CD62L(+) T cells in CML patients who sustained complete molecular remission after discontinuation of imatinib
    • Ohyashiki, K., Katagiri, S., Tauchi, T., Ohyashiki, J.H., Maeda, Y., Matsumura, I. & Kyo, T. (2012) Increased natural killer cells and decreased CD3(+)CD8(+)CD62L(+) T cells in CML patients who sustained complete molecular remission after discontinuation of imatinib. British Journal of Haematology, 157, 254-256.
    • (2012) British Journal of Haematology , vol.157 , pp. 254-256
    • Ohyashiki, K.1    Katagiri, S.2    Tauchi, T.3    Ohyashiki, J.H.4    Maeda, Y.5    Matsumura, I.6    Kyo, T.7
  • 39
    • 84902303185 scopus 로고    scopus 로고
    • Low natural killer (NK) cell counts and functionality are associated with molecular relapse after imatinib discontinuation in patients (pts) with chronic phase (CP)-chronic myeloid leukemia (CML) with undetectable BCR-ABL transcripts for at least 2 years: preliminary results from immunostim, On Behalf Of STIM Investigators
    • Rea, D., Dulphy, N., Henry, G., Guilhot, J., Guilhot, F., Nicolini, F.E., Legros, L., Rousselot, P., Mahon, F.X. & Toubert, A. (2013) Low natural killer (NK) cell counts and functionality are associated with molecular relapse after imatinib discontinuation in patients (pts) with chronic phase (CP)-chronic myeloid leukemia (CML) with undetectable BCR-ABL transcripts for at least 2 years: preliminary results from immunostim, On Behalf Of STIM Investigators. Blood (ASH Annual Meeting Abstracts), 122, 856.
    • (2013) Blood (ASH Annual Meeting Abstracts) , vol.122 , pp. 856
    • Rea, D.1    Dulphy, N.2    Henry, G.3    Guilhot, J.4    Guilhot, F.5    Nicolini, F.E.6    Legros, L.7    Rousselot, P.8    Mahon, F.X.9    Toubert, A.10
  • 40
    • 33749524667 scopus 로고    scopus 로고
    • Dynamic modeling of imatinib-treated chronic myeloid leukemia: functional insights and clinical implications
    • Roeder, I., Horn, M., Glauche, I., Hochhaus, A., Mueller, M.C. & Loeffler, M. (2006) Dynamic modeling of imatinib-treated chronic myeloid leukemia: functional insights and clinical implications. Nature Medicine, 12, 1181-1184.
    • (2006) Nature Medicine , vol.12 , pp. 1181-1184
    • Roeder, I.1    Horn, M.2    Glauche, I.3    Hochhaus, A.4    Mueller, M.C.5    Loeffler, M.6
  • 42
    • 80355125811 scopus 로고    scopus 로고
    • Durable complete molecular remission of chronic myeloid leukemia following dasatinib cessation, despite adverse disease features
    • Ross, D.M., Bartley, P.A., Goyne, J., Morley, A.A., Seymour, J.F. & Grigg, A.P. (2011) Durable complete molecular remission of chronic myeloid leukemia following dasatinib cessation, despite adverse disease features. Haematologica, 96, 1720-1722.
    • (2011) Haematologica , vol.96 , pp. 1720-1722
    • Ross, D.M.1    Bartley, P.A.2    Goyne, J.3    Morley, A.A.4    Seymour, J.F.5    Grigg, A.P.6
  • 46
    • 0035383797 scopus 로고    scopus 로고
    • Expression of nuclear transcription factor interferon consensus sequence binding protein in chronic myeloid leukemia correlates with pretreatment risk features and cytogenetic response to interferon-alpha
    • Schmidt, M., Hochhaus, A., Nitsche, A., Hehlmann, R. & Neubauer, A. (2001) Expression of nuclear transcription factor interferon consensus sequence binding protein in chronic myeloid leukemia correlates with pretreatment risk features and cytogenetic response to interferon-alpha. Blood, 97, 3648-3650.
    • (2001) Blood , vol.97 , pp. 3648-3650
    • Schmidt, M.1    Hochhaus, A.2    Nitsche, A.3    Hehlmann, R.4    Neubauer, A.5
  • 51
    • 47649123285 scopus 로고    scopus 로고
    • Sustained complete molecular response after imatinib discontinuation in a patient with chronic myeloid leukemia not previously exposed to interferon alpha
    • Verma, D., Kantarjian, H., Jain, N. & Cortes, J. (2008) Sustained complete molecular response after imatinib discontinuation in a patient with chronic myeloid leukemia not previously exposed to interferon alpha. Leukaemia & Lymphoma, 49, 1399-1402.
    • (2008) Leukaemia & Lymphoma , vol.49 , pp. 1399-1402
    • Verma, D.1    Kantarjian, H.2    Jain, N.3    Cortes, J.4
  • 52
    • 84887392984 scopus 로고    scopus 로고
    • JAK of all trades: JAK2-STAT5 as novel therapeutic targets in BCR-ABL1+ chronic myeloid leukemia
    • Warsch, W., Walz, C. & Sexl, V. (2013) JAK of all trades: JAK2-STAT5 as novel therapeutic targets in BCR-ABL1+ chronic myeloid leukemia. Blood, 122, 2167-2175.
    • (2013) Blood , vol.122 , pp. 2167-2175
    • Warsch, W.1    Walz, C.2    Sexl, V.3
  • 53
    • 84862794931 scopus 로고    scopus 로고
    • Imatinib mesylate discontinuation in patients with chronic myeloid leukemia who have received front-line imatinib mesylate therapy and achieved complete molecular response
    • Yhim, H.Y., Lee, N.R., Song, E.K., Yim, C.Y., Jeon, S.Y., Shin, S., Kim, J.A., Kim, H.S., Cho, E.H. & Kwak, J.Y. (2012) Imatinib mesylate discontinuation in patients with chronic myeloid leukemia who have received front-line imatinib mesylate therapy and achieved complete molecular response. Leukemia Research, 36, 689-693.
    • (2012) Leukemia Research , vol.36 , pp. 689-693
    • Yhim, H.Y.1    Lee, N.R.2    Song, E.K.3    Yim, C.Y.4    Jeon, S.Y.5    Shin, S.6    Kim, J.A.7    Kim, H.S.8    Cho, E.H.9    Kwak, J.Y.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.