Evaluation of doxorubicin-loaded pH-sensitive polymeric micelle release from tumor blood vessels and anticancer efficacy using a dorsal skin-fold window chamber model

Acta Pharmacologica Sinica

Volumn 35, Issue 6, 2014, Pages 839-845

  Jin, Zhe Hu ^a,b   Jin, Ming Ji ^a   Jiang, Chang Gao ^b   Yin, Xue Zhe ^b   Jin, Shuai Xing ^b   Quan, Xiu Quan ^b   Gao, Zhong Gao ^a,b  

^a PEKING UNION MEDICAL COLLEGE   (China)

^b YANBIAN UNIVERSITY   (China)

Author keywords

Anticancer drug; dorsal skin fold window chamber model; doxorubicin; drug release; nanoparticle; pH; pharmacokinetics; polymeric micelle

Indexed keywords

DOXORUBICIN; ANTINEOPLASTIC ANTIBIOTIC; DELAYED RELEASE FORMULATION; MICELLE; POLYMER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; BREAST CANCER CELL LINE; CANCER INHIBITION; DORSAL SKIN FOLD WINDOW CHAMBER; DRUG EFFICACY; DRUG HALF LIFE; DRUG RELEASE; DRUG SCREENING; FEMALE; FLOW CYTOMETRY; IN VITRO STUDY; IN VIVO STUDY; INTERSTITIUM; MICELLE; NONHUMAN; PH; POLYMERIZATION; RAT; SKINFOLD; TUMOR VASCULARIZATION; TUMOR XENOGRAFT; VASCULAR TUMOR; ANIMAL; BAGG ALBINO MOUSE; BREAST; BREAST NEOPLASMS; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG EFFECTS; HUMAN; NUDE MOUSE; PATHOLOGY; PROSTHESES AND ORTHOSES; SPRAGUE DAWLEY RAT; TUMOR CELL LINE; VASCULARIZATION;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BREAST; BREAST NEOPLASMS; CELL LINE, TUMOR; DELAYED-ACTION PREPARATIONS; DOXORUBICIN; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; MICE, INBRED BALB C; MICE, NUDE; MICELLES; POLYMERS; PROSTHESES AND IMPLANTS; RATS, SPRAGUE-DAWLEY;

EID: 84902298809     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2014.12     Document Type: Article

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