Simvastatin treatment attenuates increased respiratory variability and apnea/hypopnea index in rats with chronic heart failure

Hypertension

Volumn 63, Issue 5, 2014, Pages 1041-1049

  Haack, Karla K V ^a   Marcus, Noah J ^a   Del Rio, Rodrigo ^a   Zucker, Irving H ^a   Schultz, Harold D ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Carotid body; Cheyne Stokes Respiration; Simvastatin; Systolic heart failure

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; KRUPPEL LIKE FACTOR 2; SIMVASTATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APNEA HYPOPNEA INDEX; ARTICLE; BREATHING PATTERN; CAROTID BODY; CAROTID BODY CHEMORECEPTOR; CHEMORECEPTOR REFLEX; CONTROLLED STUDY; CORONARY ARTERY LIGATION; HEART ARRHYTHMIA; HEART FAILURE; HEART FUNCTION; HEART RHYTHM; HYPOXIA; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RESPIRATORY TRACT PARAMETERS; RESPIRATORY VARIABILITY; SOLITARY TRACT NUCLEUS; SPRAGUE DAWLEY RAT;

CAROTID BODY; CHEYNE-STOKES RESPIRATION; SIMVASTATIN; SYSTOLIC HEART FAILURE;

ANIMALS; ARRHYTHMIAS, CARDIAC; CAROTID BODY; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; HEART FAILURE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ANGIOTENSIN, TYPE 1; RESPIRATION; SIMVASTATIN; SLEEP APNEA SYNDROMES;

EID: 84902275098     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.113.02535     Document Type: Article

References (57)

1. Badr S. Central sleep apnea in patients with congestive heart failure. Heart Fail Rev. 2009; 14: 135-141.
2. Hanly PJ, Zuberi-Khokhar NS. Increased mortality associated with Cheyne-Stokes respiration in patients with congestive heart failure. Am J Respir Crit Care Med. 1996; 153: 272-276. (Pubitemid 26026861)
3. Lanfranchi PA, Braghiroli A, Bosimini E., Mazzuero G, Colombo R, Donner C.F., Giannuzzi P. Prognostic value of nocturnal Cheyne-Stokes respiration in chronic heart failure. Circulation. 1999; 99: 1435-1440. (Pubitemid 29140908)
4. Leung RS, Diep TM, Bowman M.E., Lorenzi-Filho G, Bradley TD Provocation of ventricular ectopy by Cheyne-Stokes respiration in patients with heart failure. Sleep. 2004; 27: 1337-1343. (Pubitemid 44138900)
5. van de Borne P, Oren R, Abouassaly C, Anderson E, Somers VK. Effect of Cheyne-Stokes respiration on muscle sympathetic nerve activity in severe congestive heart failure secondary to ischemic or idiopathic dilated car-diomyopathy. Am J Cardiol. 1998; 81: 432-436. (Pubitemid 28099533)
6. Esler M, Kaye D. Increased sympathetic nervous system activity and its therapeutic reduction in arterial hypertension, portal hypertension and heart failure. J Auton Nerv Syst. 1998; 72: 210-219. (Pubitemid 28522198)
7. Floras JS. Clinical aspects of sympathetic activation and parasympathetic withdrawal in heart failure. J Am Coll Cardiol. 1993; 22(4 Suppl A): 72A-84A. (Pubitemid 23285800)
8. Sun SY, Wang W, Zucker I.H., Schultz HD Enhanced activity of carotid body chemoreceptors in rabbits with heart failure: role of nitric oxide. J Appl Physiol (1985). 1999; 86: 1273-1282. (Pubitemid 29172162)
9. Sun SY, Wang W, Zucker I.H., Schultz HD Enhanced peripheral chemo-reflex function in conscious rabbits with pacing-induced heart failure. J Appl Physiol (1985). 1999; 86: 1264-1272. (Pubitemid 29172161)
10. Kline DD. Chronic intermittent hypoxia affects integration of sensory input by neurons in the nucleus tractus solitarii. Respir Physiol Neurobiol. 2010; 174: 29-36.
11. Ding Y, Li YL, Zimmerman M.C., Davisson RL, Schultz HD Role of CuZn superoxide dismutase on carotid body function in heart failure rabbits. Cardiovasc Res. 2009; 81: 678-685.
12. Li YL, Sun SY, Overholt J.L., Prabhakar NR, Rozanski GJ, Zucker IH, Schultz HD Attenuated outward potassium currents in carotid body glo-mus cells of heart failure rabbit: involvement of nitric oxide. J Physiol. 2004; 555(Pt 1): 219-229. (Pubitemid 38313072)
13. Li YL, Li YF, Liu D, Cornish K.G., Patel KP, Zucker IH, Channon KM, Schultz HD Gene transfer of neuronal nitric oxide synthase to carotid body reverses enhanced chemoreceptor function in heart failure rabbits. Circ Res. 2005; 97: 260-267. (Pubitemid 41105452)
14. Li YL, Gao L, Zucker I.H., Schultz HD NADPH oxidase-derived superoxide anion mediates angiotensin II-enhanced carotid body chemoreceptor sensitivity in heart failure rabbits. Cardiovasc Res. 2007; 75: 546-554. (Pubitemid 47080964)
15. Del Rio R., Moya EA, Iturriaga R. Contribution of inflammation on carotid body chemosensory potentiation induced by intermittent hypoxia. Adv Exp Med Biol. 2012; 758: 199-205.
16. Adam O, Laufs U. Antioxidative effects of statins. Arch Toxicol. 2008; 82: 885-892.
17. Laufs U, Gertz K, Dirnagl U., Böhm M, Nickenig G., Endres M. Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothe-lial nitric oxide synthase and protects from ischemic stroke in mice. Brain Res. 2002; 942: 23-30. (Pubitemid 34597065)
18. Deo SH, Fisher JP, Vianna L.C., Kim A., Chockalingam A, Zimmerman MC, Zucker I.H., Fadel PJ. Statin therapy lowers muscle sympathetic nerve activity and oxidative stress in patients with heart failure. Am J Physiol Heart Circ Physiol. 2012; 303:H377-H385.
19. Gao L, Wang W, Zucker IH Simvastatin inhibits central sympathetic out-flow in heart failure by a nitric-oxide synthase mechanism. J Pharmacol Exp Ther. 2008; 326: 278-285. (Pubitemid 351872118)
20. Sen-Banerjee S., Mir S, Lin Z., Hamik A, Atkins GB, Das H, Banerjee P., Kumar A, Jain MK. Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells. Circulation. 2005; 112: 720-726. (Pubitemid 41099052)
21. Gao L, Li Y, Schultz H.D., Wang WZ, Wang W, Finch M, Smith L.M., Zucker IH. Downregulated Kv4.3 expression in the RVLM as a potential mechanism for sympathoexcitation in rats with chronic heart failure. Am J Physiol Heart Circ Physiol. 2010; 298:H945-H955.
22. Pierno S, Didonna MP, Cippone V, de Luca A, Pisoni M, Frigeri A., Nicchia GP, Svelto M, Chiesa G, Sirtori C, Scanziani E, Rizzo C, De Vito D, Conte Camerino D. Effects of chronic treatment with statins and fenofibrate on rat skeletal muscle: a biochemical, histological and electro-physiological study. Br J Pharmacol. 2006; 149: 909-919. (Pubitemid 44851715)
23. Del Rio R., Moya EA, Iturriaga R. Carotid body and cardiorespiratory alterations in intermittent hypoxia: the oxidative link. Eur Respir J. 2010; 36: 143-150.
24. Aboukhalil A, Nielsen L, Saeed M., Mark RG, Clifford GD Reducing false alarm rates for critical arrhythmias using the arterial blood pressure waveform. J Biomed Inform. 2008; 41: 442-451.
25. Del Rio R., Marcus NJ, Schultz HD Carotid chemoreceptor ablation improves survival in heart failure: rescuing autonomic control of cardiore-spiratory function. J Am Coll Cardiol. 2013; 62: 2422-2430.
26. Kleiber AC, Zheng H, Schultz H.D., Peuler JD, Patel KP Exercise training normalizes enhanced glutamate-mediated sympathetic activation from the PVN in heart failure. Am J Physiol Regul Integr Comp Physiol. 2008; 294:R1863-R1872.
27. Haack KK, Engler CW, Papoutsi E, Pipinos I.I., Patel KP, Zucker IH Parallel changes in neuronal AT1R and GRK5 expression following exercise training in heart failure. Hypertension. 2012; 60: 354-361.
28. Del Rio R., Moya EA, Parga M.J., Madrid C., Iturriaga R. Carotid body inflammation and cardiorespiratory alterations in intermittent hypoxia. Eur Respir J. 2012; 39: 1492-1500.
29. Dawson-Saunders B., Trapp RG Basic and Clinical Biostatistics. Norwalk, CT: Appleton & Lange; 1994.
30. Bitter T, Gutleben KJ, Nolker G, Westerheide N., Prinz C, Dimitriadis Z, Horstkotte D., Vogt J, Oldenburg O. Treatment of Cheyne-Stokes respiration reduces arrhythmic events in chronic heart failure. J Cardiovasc Electrophysiol. 2013; 24: 1132-1140.
31. Podrid PJ, Fuchs T, Candinas R. Role of the sympathetic nervous system in the genesis of ventricular arrhythmia. Circulation. 1990; 82(2 Suppl):I103-I113.
32. Giannoni A, Emdin M, Poletti R., Bramanti F, Prontera C, Piepoli M., Passino C. Clinical significance of chemosensitivity in chronic heart failure: influence on neurohormonal derangement, Cheyne-Stokes respiration and arrhythmias. Clin Sci (Lond). 2008; 114: 489-497. (Pubitemid 351548757)
33. Li YL, Schultz HD Enhanced sensitivity of Kv channels to hypoxia in the rabbit carotid body in heart failure: role of angiotensin II. J Physiol. 2006; 575(Pt 1): 215-227. (Pubitemid 44178139)
34. Dekker RJ, van Thienen JV, Rohlena J, de Jager SC, Elderkamp YW, Seppen J, de Vries CJ, Biessen EA, van Berkel TJ, Pannekoek H, Horrevoets AJ. Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes. Am J Pathol. 2005; 167: 609-618. (Pubitemid 43026114)
35. Ding Y, Li YL, Schultz HD Role of blood flow in carotid body chemore-flex function in heart failure. J Physiol. 2011; 589(Pt 1): 245-258.
36. Lin Z, Kumar A, SenBanerjee S., Staniszewski K, Parmar K, Vaughan D.E., Gimbrone MA Jr, Balasubramanian V, García-Cardeña G, Jain MK. Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function. Circ Res. 2005; 96:e48-e57.
37. SenBanerjee S, Lin Z, Atkins G.B., Greif DM, Rao RM, Kumar A, Feinberg M.W., Chen Z., Simon DI, Luscinskas FW, Michel TM, Gimbrone MA Jr, García-Cardeña G, Jain MK. KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation. J Exp Med. 2004; 199: 1305-1315. (Pubitemid 38685723)
38. Lin Z, Hamik A, Jain R., Kumar A, Jain MK Kruppel-like factor 2 inhibits protease activated receptor-1 expression and thrombin-mediated endothe-lial activation. Arterioscler Thromb Vasc Biol. 2006; 26: 1185-1189. (Pubitemid 43732131)
39. Mitra AK, Gao L, Zucker IH Angiotensin II-induced upregulation of AT(1) receptor expression: sequential activation of NF-kappaB and Elk-1 in neurons. Am J Physiol Cell Physiol. 2010; 299:C561-C569.
40. Cardinale JP, Sriramula S, Mariappan N., Agarwal D, Francis J. Angiotensin II-induced hypertension is modulated by nuclear factor-κBin the paraventricular nucleus. Hypertension. 2012; 59: 113-121.
41. Kawanami D, Mahabeleshwar GH, Lin Z, Atkins G.B., Hamik A., Haldar SM, Maemura K, Lamanna JC, Jain MK Kruppel-like factor 2 inhibits hypoxia-inducible factor 1alpha expression and function in the endothe-lium. J Biol Chem. 2009; 284: 20522-20530.
42. Li YL, Ding Y, Agnew C., Schultz HD Exercise training improves peripheral chemoreflex function in heart failure rabbits. J Appl Physiol (1985). 2008; 105: 782-790.
43. Gao L, Wang W, Li Y.L., Schultz HD, Liu D, Cornish KG, Zucker IH Simvastatin therapy normalizes sympathetic neural control in experimental heart failure: roles of angiotensin II type 1 receptors and NAD(P)H oxidase. Circulation. 2005; 112: 1763-1770. (Pubitemid 41368152)
44. Marino F, Maresca AM, Cosentino M, Castiglioni L., Rasini E, Mongiardi C, Maio R.C., Legnaro M., Schembri L, Dentali F, Grandi AM, Guasti L. Angiotensin II type 1 and type 2 receptor expression in circulating mono-cytes of diabetic and hypercholesterolemic patients over 3-month rosuv-astatin treatment. Cardiovasc Diabetol. 2012; 11: 153.
45. Liao JK. Clinical implications for statin pleiotropy. Curr Opin Lipidol. 2005; 16: 624-629. (Pubitemid 43012159)
46. Apiyasawat S, Sritara P, Ngarmukos T., Sriratanasathavorn C, Kasemsuwan P. Association of statin therapy with ventricular arrhythmias among patients with acute coronary syndrome. Heart Asia. 2013; 5: 39-41.
47. Ryan CM, Usui K, Floras J.S., Bradley TD Effect of continuous positive airway pressure on ventricular ectopy in heart failure patients with obstructive sleep apnoea. Thorax. 2005; 60: 781-785. (Pubitemid 41297899)
48. Javaheri S. Effects of continuous positive airway pressure on sleep apnea and ventricular irritability in patients with heart failure. Circulation. 2000; 101: 392-397. (Pubitemid 30067395)
49. Yamada S, Sakakibara, M, Matsushima S., Saito A, Homma T, Fukushima A., Masaki Y, Watanabe M, Mitsuyama H, Yokoshiki H, Tsutsui H. Successful termination of recurrent ventricular arrhythmias by adaptive servo-ventilation in a patient with heart failure. J Cardiol Cases. 2011; 1:e57-e61.
50. Andreas S, Hagenah G, Moller C., Werner GS, Kreuzer H. Cheyne-Stokes respiration and prognosis in congestive heart failure. Am J Cardiol. 1996; 78: 1260-1264. (Pubitemid 126657205)
51. Ramasubbu K, Estep J, White D.L., Deswal A., Mann DL Experimental and clinical basis for the use of statins in patients with ischemic and non-ischemic cardiomyopathy. J Am Coll Cardiol. 2008; 51: 415-426.
52. Pliquett RU, Cornish KG, Peuler J.D., Zucker IH Simvastatin normalizes autonomic neural control in experimental heart failure. Circulation. 2003; 107: 2493-2498. (Pubitemid 36605234)
53. Pliquett RU, Cornish KG, Zucker IH Statin therapy restores sympa-thovagal balance in experimental heart failure. J Appl Physiol (1985). 2003; 95: 700-704. (Pubitemid 36944294)
54. Reagan-Shaw S., Nihal M, Ahmad N. Dose translation from animal to human studies revisited. FASEB J. 2008; 22: 659-661. (Pubitemid 351348146)
55. Maritz FJ, Conradie MM, Hulley P.A., Gopal R., Hough S. Effect of statins on bone mineral density and bone histomorphometry in rodents. Arterioscler Thromb Vasc Biol. 2001; 21: 1636-1641. (Pubitemid 34215584)
56. Simsek Ozek N., Bal IB, Sara Y, Onur R., Severcan F. Structural and functional characterization of simvastatin-induced myotoxicity in different skeletal muscles. Biochim Biophys Acta. 2014; 1840: 406-415.
57. Kostapanos MS, Liberopoulos EN, Goudevenos J.A., Mikhailidis DP, Elisaf MS Do statins have an antiarrhythmic activity? Cardiovasc Res. 2007; 75: 10-20. (Pubitemid 46873508)