Contribution of inflammation on carotid body chemosensory potentiation induced by intermittent hypoxia

Advances in Experimental Medicine and Biology

Volumn 758, Issue , 2012, Pages 199-205

  Del Rio, Rodrigo ^a   Moya, Esteban A ^a   Iturriaga, Rodrigo ^a  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

Carotid body; Chemosensory discharge; Cytokines; IL 1 ; Inflammation; Intermittent hypoxia; Obstructive sleep apnea; TNF

Indexed keywords

IBUPROFEN; INTERLEUKIN 1BETA; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BIOACCUMULATION; CAROTID BODY; CHEMOSENSORY POTENTIATION; CHRONIC DRUG ADMINISTRATION; CHRONIC INTERMITTENT HYPOXIA; CONFERENCE PAPER; CONTROLLED STUDY; IMMUNOREACTIVITY; INFLAMMATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENSORY SYSTEM ELECTROPHYSIOLOGY;

EID: 84870414152     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-94-007-4584-1_28     Document Type: Conference Paper

References (14)

1. Del Rio R, Moya EA, Iturriaga R (2010) Carotid body and cardiorespiratory alterations in intermittent hypoxia: The oxidative link. Eur Respir J 36:143-150
2. Del Rio R, Moya EA, Iturriaga R (2011) Differential expression of pro-in fl ammatory cytokines, endothelin-1 and nitric oxide synthases in the rat carotid body exposed to intermittent hypoxia. Brain Res 1395:74-85
3. Garvey JF, Taylor CT, McNicholas WT (2009) Cardiovascular disease in obstructive sleep apnoea syndrome: The role of intermittent hypoxia and in fl ammation. Eur Respir J 33:1195-1205
4. González C, Agapito MT, Rocher A, González-Martin MC, Vega-Agapito V, Gomez-Niño A, Rigual R, Castañeda J, Obeso A (2007) Chemoreception in the context of the general biology of ROS. Respir Physiol Neurobiol 157:30-44
5. Iturriaga R, Moya EA, Del Rio R (2009) Carotid body potentiation induced by intermittent hypoxia: Implications for cardiorespiratory changes induced by sleep apnoea. Clin Exp Pharmacol Physiol 36:1197-1204
6. Janssen-Heininger YM, Poynter ME, Baeuerle PA (2000) Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB. Free Radic Biol Med 28:1317-1327
7. Lam SY, Tipoe GL, Liong EC, Fung ML (2008) Chronic hypoxia upregulates the expression and function of proin fl ammatory cytokines in the rat carotid body. Histochem Cell Biol 130:549-559
8. Liu X, He L, Stensaas L, Dinger B, Fidone S (2009) Adaptation to chronic hypoxia involves immune cell invasion and increased expression of in fl ammatory cytokines in rat carotid body. Am J Physiol Lung Cell Mol Physiol L158-L166
9. Pawar A, Nanduri J, Yuan G, Khan SA, Wang N, Kumar GK, Prabhakar NR (2009) Reactive oxygen species-dependent endothelin signaling is required for augmented hypoxic sensory response of the neonatal carotid body by intermittent hypoxia. Am J Physiol Regul Integr Comp Physiol 296:R735-R742
10. Peng YJ, Overholt JL, Kline D, Kumar GK, Prabhakar NR (2003) Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: Implications for recurrent apneas. Proc Natl Acad Sci U S A 100:10073-10078
11. Rey S, Del Rio R, Alcayaga J, Iturriaga R (2004) Chronic intermittent hypoxia enhances cat chemosensory and ventilatory responses to hypoxia. J Physiol 560:577-586
12. Shu HF, Wang BR, Wang SR, Yao W, Huang HP, Zhou Z, Wang X, Fan J, Wang T, Ju G (2007) IL-1 b eta inhibits IK and increases [Ca 2+ ]i in the carotid body glomus cells and increases carotid sinus nerve fi rings in the rat. Eur J Neurosci 25:3638-3647
13. Somers VK, White DP, Amin R, Abraham WT, Costa F, Culebras A, Daniels S, Floras JS, Hunt CE, Olson LJ, Pickering TG, Russell R, Woo M, Young T (2008) Sleep apnea and cardiovascular disease. J Am Coll Cardiol 52:686-717
14. Wang X, Wang BR, Duan XL, Zhang P, Ding YQ, Jia Y, Jiao XY, Ju G (2002) Strong expression of interleukin-1 receptor type I in the rat carotid body. J Histochem Cytochem 50:1677-1684