Isoproterenol up-regulates the expression of phosphorylated CrkL in the non-infarcted rat myocardium around the infarct lesions

Experimental and Clinical Cardiology

Volumn 20, Issue 5, 2014, Pages 3109-3132

  Zhu, Xue Feng ^a   Li, Gang ^a   Zhang, Can Jing ^b   Wang, Li Ping ^a   Zhu, Bing Bao ^a   Wang, Zhi Hua ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b Chongqing Xijiao Hospital   (China)

Author keywords

Adaptor protein; CrkL (v crk avian sarcoma virus ct 10 oncogene homolog like); Isoproterenol; Myocardial infarction; Myocardium

Indexed keywords

COLLAGEN; CRK LIKE PROTEIN; ISOPRENALINE; PHOSPHATE BUFFERED SALINE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL PARAMETERS; COLLAGEN VOLUME FRACTION; CONTROLLED STUDY; EXPERIMENTAL MYOCARDIAL INFARCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART MUSCLE; HEART WEIGHT; HISTOPATHOLOGY; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SHAM PROCEDURE; TISSUE HOMOGENATE; UPREGULATION; WESTERN BLOTTING;

EID: 84902258717     PISSN: 12056626     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Lal H, Verma SK, Foster DM, et al. Integrins and proximal signaling mechanisms in cardiovascular disease. Front Biosci 2009; 14:2307-34.
2. Nawata J, Ohno I, Isoyama S, et al. Differential expression of alpha 1, alpha 3 and alpha 5 integrin subunits in acute and chronic stages of myocardial infarction in rats. Cardiovasc Res 1999; 43:371-81.
3. Krishnamurthy P, Subramanian V, Singh M, Singh K. Deficiency of beta1 integrins results in increased myocardial dysfunction after myocardial infarction. Heart 2006; 92:1309-15.
4. Sun M, Opavsky MA, Stewart DJ, et al. Temporal response and localization of integrins beta1 and beta3 in the heart after myocardial infarction: regulation by cytokines. Circulation 2003; 107:1046-52.
5. Liu XL, Li G, Wang ZH, Zhao WJ, Wang LP. Increased expression of Dock180 protein in the noninfarcted myocardium in rats. J Chin Med Assoc 2013; 76:164-8.
6. Wang L, Li G, Wang Z, Liu X, Zhao W. Elevated expression of C3G protein in the peri-infarct myocardium of rats. Med Sci Monit Basic Res 2013; 19:1-5.
7. Garjani A, Andalib S, Biabani S, Soraya H, Doustar Y, Maleki-Dizaji N. Combined atorvastatin and coenzyme Q10 improve the left ventricular function in isoproterenol-induced heart failure in rat. Eur J Pharmacol 2011; 666:135-41.
8. Zhou J, Li G, Wang ZH, Wang LP, Dong PJ. Effects of low-dose hydroxychloroquine on expression of phosphorylated Akt and p53 proteins and cardiomyocyte apoptosis in peri-infarct myocardium in rats. Exp Clin Cardiol 2013; 18:e95-8.
9. Mu Y, Li G, Wang ZH, Zhang CJ. Up-Regulation of Phosphorylated ATM-ATR Substrate-Akt Expression by Phenylephrine in Peri-Infarct Myocardium in Rats. Acta Cardiol Sin 2011; 27:182-8.
10. Hakim ZS, DiMichele LA, Rojas M, Meredith D, Mack CP, Taylor JM. FAK regulates cardiomyocyte survival following ischemia/reperfusion. J Mol Cell Cardiol 2009; 46:241-8.
11. Ding L, Dong L, Chen X, et al. Increased expression of integrin-linked kinase attenuates left ventricular remodeling and improves cardiac function after myocardial infarction. Circulation 2009; 120:764-73.
12. Yan A, Li G, Zhang X, Zhu B, Linghu H. Pro-survival effect of Dock180 overexpression on rat-derived H9C2 cardiomyocytes. Med Sci Monit Basic Res 2013; 19:12-9.
13. Zhang X, Li G, Zhang L, et al. C3G overexpression promotes the survival of rat-derived H9C2 cardiomyocytes by p-ERK1/2. Cell Biol Int 2013; 37:1106-13.
14. Communal C, Singh M, Menon B, Xie Z, Colucci WS, Singh K. Beta1 integrins expression in adult rat ventricular myocytes and its role in the regulation of beta-adrenergic receptor-stimulated apoptosis. J Cell Biochem 2003; 89:381-8.
15. Balasubramanian S, Kuppuswamy D. RGD-containing peptides activate S6K1 through beta3 integrin in adult cardiac muscle cells. J Biol Chem 2003; 278:42214-24.
16. Lu H, Fedak PW, Dai X, et al. Integrin-linked kinase expression is elevated in human cardiac hypertrophy and induces hypertrophy in transgenic mice. Circulation 2006; 114:2271-9.
17. White DE, Coutu P, Shi YF, et al. Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure. Genes Dev 2006; 20:2355-60.
18. Del Re DP, Miyamoto S, Brown JH. Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection. J Biol Chem 2008; 283:35622-29.
19. Lal H, Guleria RS, Foster DM, et al. Integrins: novel therapeutic targets for cardiovascular diseases. Cardiovasc Hematol Agents Med Chem 2007; 5:109-32.
20. Feller SM. Crk family adaptors-signalling complex formation and biological roles. Oncogene 2001; 20:6348-71.
21. Birge RB, Kalodimos C, Inagaki F, Tanaka S. Crk and CrkL adaptor proteins: networks for physiological and pathological signaling. Cell Commun Signal 2009; 7:13.
22. Posern G, Zheng J, Knudsen BS, et al. Development of highly selective SH3 binding peptides for Crk and CRKL which disrupt Crk-complexes with DOCK180, SoS and C3G. Oncogene 1998; 16:1903-12.
23. Wang J, Che YL, Li G, et al. Crk and CrkL present with different expression and significance in epithelial ovarian carcinoma. Mol Carcinog 2011; 50:506-15.
24. Guris DL, Fantes J, Tara D, Druker BJ, Imamoto A. Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome. Nat Genet 2001; 27:293-8.
25. Lopes MM, Ribeiro GC, Tornatore TF, Clemente CF, Teixeira VP, Franchini KG. Increased expression and phosphorylation of focal adhesion kinase correlates with dysfunction in the volume-overloaded human heart. Clin Sci (Lond) 2007; 113:195-204.