Increased expression of Dock180 protein in the noninfarcted myocardium in rats

Journal of the Chinese Medical Association

Volumn 76, Issue 3, 2013, Pages 164-168

  Liu, Xiao Lan ^a   Li, Gang ^a   Wang, Zhi Hua ^a   Zhao, Wen Ju ^a   Wang, Li Ping ^a  

^a THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Guanine nucleotide exchange factors; Myocardial infarction; Myocardium; Proteins; Rats

Indexed keywords

BETA1 INTEGRIN; COLLAGEN; DOCK180 PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DOPPLER ECHOCARDIOGRAPHY; ECHOCARDIOGRAPHY; HEART FUNCTION; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE; HEART MUSCLE CELL; HEART RATE; HISTOLOGY; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; TRANSTHORACIC ECHOCARDIOGRAPHY; WESTERN BLOTTING;

ANIMALS; MALE; MYOCARDIAL INFARCTION; MYOCARDIUM; RAC GTP-BINDING PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; VENTRICULAR FUNCTION, LEFT;

EID: 84875255534     PISSN: 17264901     EISSN: 17287731     Source Type: Journal    
DOI: 10.1016/j.jcma.2012.11.003     Document Type: Article

References (16)

1. Krishnamurthy P., Subramanian V., Singh M., Singh K. Deficiency of beta1 integrins results in increased myocardial dysfunction after myocardial infarction. Heart 2006, 92:1309-1315.
2. Hakim Z.S., DiMichele L.A., Rojas M., Meredith D., Mack C.P., Taylor J.M. FAK regulates cardiomyocyte survival following ischemia/reperfusion. J Mol Cell Cardiol 2009, 46:241-248.
3. Lal H., Verma S.K., Foster D.M., Golden H.B., Reneau J.C., Watson L.E., et al. Integrins and proximal signaling mechanisms in cardiovascular disease. Front Biosci 2009, 14:2307-2334.
4. Mu Y., Li G., Wang Z.H., Zhang C.J. Up-regulation of phosphorylated ATM/ATR substrate/Akt expression by phenylephrine in peri-infarct myocardium in rats. Acta Cardiol Sin 2011, 27:182-188.
5. Ding L., Dong L., Chen X., Zhang L., Xu X., Ferro A., et al. Increased expression of integrin-linked kinase attenuates left ventricular remodeling and improves cardiac function after myocardial infarction. Circulation 2009, 120:764-773.
6. Communal C., Singh M., Menon B., Xie Z., Colucci W.S., Singh K. Beta1 integrins expression in adult rat ventricular myocytes and its role in the regulation of beta-adrenergic receptor-stimulated apoptosis. J Cell Biochem 2003, 89:381-388.
7. Balasubramanian S., Kuppuswamy D. RGD-containing peptides activate S6K1 through beta3 integrin in adult cardiac muscle cells. J Biol Chem 2003, 278:42214-42224.
8. Lu H., Fedak P.W., Dai X., Du C., Zhou Y.Q., Henkelman M., et al. Integrin-linked kinase expression is elevated in human cardiac hypertrophy and induces hypertrophy in transgenic mice. Circulation 2006, 114:2271-2279.
9. White D.E., Coutu P., Shi Y.F., Tardif J.C., Nattel S., St Arnaud R., et al. Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure. Genes Dev 2006, 20:2355-2360.
10. Del Re D.P., Miyamoto S., Brown J.H. Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection. J Biol Chem 2008, 283:35622-35629.
11. Lal H., Guleria R.S., Foster D.M., Lu G., Watson L.E., Sanghi S., et al. Integrins: novel therapeutic targets for cardiovascular diseases. Cardiovasc Hematol Agents Med Chem 2007, 5:109-132.
12. Sanematsu F., Hirashima M., Laurin M., Takii R., Nishikimi A., Kitajima K., et al. DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4. Circ Res 2010, 107:1102-1105.
13. Côté J.F., Vuori K. GEF what? Dock180 and related proteins help Rac to polarize cells in new ways. Trends Cell Biol 2007, 17:383-393.
14. Wang H., Linghu H., Wang J., Che Y.L., Xiang T.X., Tang W.X., et al. The role of Crk/Dock180/Rac1 pathway in the malignant behavior of human ovarian cancer cell SKOV3. Tumour Biol 2010, 31:59-67.
15. Nawata J., Ohno I., Isoyama S., Suzuki J., Miura S., Ikeda J., et al. Differential expression of alpha 1, alpha 3 and alpha 5 integrin subunits in acute and chronic stages of myocardial infarction in rats. Cardiovasc Res 1999, 43:371-381.
16. Sun M., Opavsky M.A., Stewart D.J., Rabinovitch M., Dawood F., Wen W.H., et al. Temporal response and localization of integrins beta1 and beta3 in the heart after myocardial infarction: regulation by cytokines. Circulation 2003, 107:1046-1052.