Curcumin suppresses vasculogenic mimicry capacity of hepatocellular carcinoma cells through STAT3 and PI3K/AKT inhibition

Anticancer Research

Volumn 34, Issue 4, 2014, Pages 1857-1864

  Chiablaem, Khajeelak ^a   Lirdprapamongkol, Kriengsak ^a   Keeratichamroen, Siriporn ^a   Surarit, Rudee ^a,b   Svasti, Jisnuson ^a  

^a Krung Thep Maha Nakhon   (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

Author keywords

Antimetastatic; Curcumin; Hepatocellular carcinoma; Natural products; Vasculogenic mimicry

Indexed keywords

CURCUMIN; GELATIN; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MATRIGEL; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STAT3 PROTEIN; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT;

ANGIOGENESIS; ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CELL MIGRATION; CELL MIGRATION ASSAY; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LIVER CELL CARCINOMA; ONCOLOGICAL PARAMETERS; SIGNAL TRANSDUCTION; VASCULOGENIC MIMICRY; ZYMOGRAPHY; ANTIMETASTATIC; BIOSYNTHESIS; CELL MOTION; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; LIVER TUMOR; METABOLISM; NATURAL PRODUCTS; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE;

ANTIMETASTATIC; CURCUMIN; HEPATOCELLULAR CARCINOMA; NATURAL PRODUCTS; VASCULOGENIC MIMICRY;

ANGIOGENESIS INHIBITORS; ANTINEOPLASTIC AGENTS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; CURCUMIN; HUMANS; LIVER NEOPLASMS; MATRIX METALLOPROTEINASE 9; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 84902255940     PISSN: 02507005     EISSN: 17917530     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Maniotis AJ, Folberg R, Hess A, Seftor EA, Gardner LM, Pe'er J, Trent JM, Meltzer PS and Hendrix MJ: Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry. Am J Pathol 155: 739-752, 1999.
2. Sood AK, Seftor EA, Fletcher MS, Gardner LM, Heidger PM, Buller RE, Seftor RE and Hendrix MJ: Molecular determinants of ovarian cancer plasticity. Am J Pathol 158: 1279-1288, 2001.
3. Sun B, Zhang S, Zhao X, Zhang W and Hao X: Vasculogenic mimicry is associated with poor survival in patients with mesothelial sarcomas and alveolar rhabdomyosarcomas. Int J Oncol 25: 1609-1614, 2004.
4. Sun B, Zhang S, Zhang D, Du J, Guo H, Zhao X, Zhang W and Hao X: Vasculogenic mimicry is associated with high tumor grade, invasion and metastasis, and short survival in patients with hepatocellular carcinoma. Oncol Rep 16: 693-698, 2006.
5. Liu Z, Sun B, Qi L, Li H, Gao J and Leng X: Zinc finger E-box binding homeobox 1 promotes vasculogenic mimicry in colorectal cancer through induction of epithelial-to-mesenchymal transition. Cancer Sci 103: 813-820, 2012.
6. Wang W, Lin P, Han C, Cai W, Zhao X and Sun B: Vasculogenic mimicry contributes to lymph node metastasis of laryngeal squamous cell carcinoma. J Exp Clin Cancer Res 29: 60, 2010.
7. van der Schaft DW, Seftor RE, Seftor EA, Hess AR, Gruman LM, Kirschmann DA, Yokoyama Y, Griffioen AW and Hendrix MJ: Effects of angiogenesis inhibitors on vascular network formation by human endothelial and melanoma cells. J Natl Cancer Inst 96: 1473-1477, 2004.
8. Xu Y, Li Q, Li XY, Yang QY, Xu WW and Liu GL: Short-term anti-vascular endothelial growth factor treatment elicits vasculogenic mimicry formation of tumors to accelerate metastasis. J Exp Clin Cancer Res 31: 16, 2012.
9. Jechlinger M, Grunert S, Tamir IH, Janda E, Ludemann S, Waerner T, Seither P, Weith A, Beug H and Kraut N: Expression profiling of epithelial plasticity in tumor progression. Oncogene 22: 7155-7169, 2003.
10. Lirdprapamongkol K, Chiablaem K, Sila-Asna M, Surarit R, Bunyaratvej A and Svasti J: Exploring stemness gene expression and vasculogenic mimicry capacity in well- and poorly-differentiated hepatocellular carcinoma cell lines. Biochem Biophys Res Commun 422: 429-435, 2012.
11. Hess AR, Seftor EA, Seftor RE and Hendrix MJ: Phosphoinositide 3-kinase regulates membrane type 1-matrix metalloproteinase (MMP) and MMP-2 activity during melanoma cell vasculogenic mimicry. Cancer Res 63: 4757-4762, 2003.
12. Lissitzky JC, Parriaux D, Ristorcelli E, Verine A, Lombardo D and Verrando P: Cyclic AMP signaling as a mediator of vasculogenic mimicry in aggressive human melanoma cells in vitro. Cancer Res 69: 802-809, 2009.
13. Gest C, Mirshahi P, Li H, Pritchard LL, Joimel U, Blot E, Chidiac J, Poletto B, Vannier JP, Varin R, Mirshahi M, Cazin L, Pujade-Lauraine E, Soria J and Soria C: Ovarian cancer: STAT3, RHO A and IGF-IR as therapeutic targets. Cancer Lett 317: 207-217, 2012.
14. Aggarwal BB, Kumar A and Bharti AC: Anticancer potential of curcumin: Preclinical and clinical studies. Anticancer Res 23: 363-398, 2003.
15. Kunnumakkara AB, Anand P and Aggarwal BB: Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett 269: 199-225, 2008.
16. Yodkeeree S, Chaiwangyen W, Garbisa S and Limtrakul P: Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA. J Nutr Biochem 20: 87-95, 2009.
17. Senft C, Polacin M, Priester M, Seifert V, Kogel D and Weissenberger J: The nontoxic natural compound curcumin exerts anti-proliferative, anti-migratory, and anti-invasive properties against malignant gliomas. BMC Cancer 10: 491, 2010.
18. Chen LX, He YJ, Zhao SZ, Wu JG, Wang JT, Zhu LM, Lin TT, Sun BC and Li XR: Inhibition of tumor growth and vasculogenic mimicry by curcumin through down-regulation of the EPHA2/PI3K/MMP pathway in a murine choroidal melanoma model. Cancer Biol Ther 11: 229-235, 2011.
19. Lirdprapamongkol K, Kramb JP, Suthiphongchai T, Surarit R, Srisomsap C, Dannhardt G and Svasti J: Vanillin suppresses metastatic potential of human cancer cells through PI3K inhibition and decreases angiogenesis in vivo . J Agric Food Chem 57: 3055-3063, 2009.
20. Nakamura ES, Koizumi K, Yamaura T and Saiki I: Antitumor angiogenic effect of a matrix metalloproteinase inhibitor MMI270. Anticancer Res 23: 411-417, 2003.
21. Lirdprapamongkol K, Sakurai H, Abdelhamed S, Yokoyama S, Maruyama T, Athikomkulchai S, Viriyaroj A, Awale S, Yagita H, Ruchirawat S, Svasti J and Saiki I: A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells. Oncol Rep 30: 2357-2364, 2013.
22. Hillen F and Griffioen AW: Tumour vascularization: Sprouting angiogenesis and beyond. Cancer Metastasis Rev 26: 489-502, 2007.
23. Sun T, Zhao N, Zhao XL, Gu Q, Zhang SW, Che N, Wang XH, Du J, Liu YX and Sun BC: Expression and functional significance of Twist1 in hepatocellular carcinoma: Its role in vasculogenic mimicry. Hepatology 51: 545-556, 2010.
24. Masson V, de la Ballina LR, Munaut C, Wielockx B, Jost M, Maillard C, Blacher S, Bajou K, Itoh T, Itohara S, Werb Z, Libert C, Foidart JM and Noel A: Contribution of host MMP2 and MMP9 to promote tumor vascularization and invasion of malignant keratinocytes. FASEB J 19: 234-236, 2005.
25. Yoon SO, Shin S, Lee HJ, Chun HK and Chung AS: Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/AKT-dependent matrix metalloproteinase-9 expression. Mol Cancer Ther 5: 2666-2675, 2006.
26. Dechow TN, Pedranzini L, Leitch A, Leslie K, Gerald WL, Linkov I and Bromberg JF: Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by STAT3-C. Proc Natl Acad Sci USA 101: 10602-10607, 2004.
27. Gao SP and Bromberg JF: Touched and moved by STAT3. Sci STKE 2006: pe30, 2006.
28. Zhang S, Li M, Gu Y, Liu Z, Xu S, Cui Y and Sun B: Thalidomide influences growth and vasculogenic mimicry channel formation in melanoma. J Exp Clin Cancer Res 27: 60, 2008.
29. Cong R, Sun Q, Yang L, Gu H, Zeng Y and Wang B: Effect of genistein on vasculogenic mimicry formation by human uveal melanoma cells. J Exp Clin Cancer Res 28: 124, 2009.
30. Serwe A, Rudolph K, Anke T and Erkel G: Inhibition of TGF-β signaling, vasculogenic mimicry and proinflammatory gene expression by isoxanthohumol. Invest New Drugs 30: 898-915, 2012.