Oridonin induces NPM mutant protein translocation and apoptosis in NPM1c+ acute myeloid leukemia cells in vitro

Acta Pharmacologica Sinica

Volumn 35, Issue 6, 2014, Pages 806-813

  Li, Fei Fei ^a   Yi, Sha ^a   Wen, Lu ^a   He, Jing ^a   Yang, Li Jing ^a   Zhao, Jie ^a   Zhang, Ben Ping ^a   Cui, Guo Hui ^a   Chen, Yan ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

acute myeloid leukemia; apoptosis; Crm1; NPM mutation; nucleoporin98; Oridonin; p14arf; p53; protein trafficking

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; CASPASE 3; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DITERPENOID; EXPORTIN 1; MESSENGER RNA; MUTANT PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NUCLEOPHOSMIN; NUCLEOPORIN 98; ORIDONIN; PROTEIN P53; ANTINEOPLASTIC AGENT; KAURANE DERIVATIVE; NUCLEAR PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; CELL GROWTH; CELL NUCLEUS; CELL VIABILITY; CELLULAR DISTRIBUTION; CHINESE MEDICINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; FLOW CYTOMETRY; GENE EXPRESSION; GENE MUTATION; GROWTH INHIBITION; IC 50; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; MTT ASSAY; MYELOID LEUKEMIA CELL LINE; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RABDOSIA; RABDOSIA RUBESCENS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; CHEMISTRY; DRUG EFFECTS; GENETICS; HUMAN; ISODON; LEUKEMIA, MYELOID, ACUTE; METABOLISM; MUTATION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; DITERPENES, KAURANE; HUMANS; ISODON; LEUKEMIA, MYELOID, ACUTE; MUTATION; NUCLEAR PROTEINS; PROTEIN TRANSPORT;

EID: 84902255660     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2014.25     Document Type: Article

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