Expression of neonatal Nav1.5 in human brain astrocytoma and its effect on proliferation, invasion and apoptosis of astrocytoma cells

Oncology Reports

Volumn 31, Issue 6, 2014, Pages 2692-2700

  Xing, Deguang ^a   Wang, Jun ^a   Ou, Shaowu ^a   Wang, Yunjie ^a   Qiu, B O ^a   Ding, Daling ^a   Guo, Feng ^a   Gao, Qinghua ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Astrocytoma; NNav1.5; RNA interference; SiRNA; Voltage gated sodium channel

Indexed keywords

SMALL INTERFERING RNA; SODIUM CHANNEL NAV1.5; SCN5A PROTEIN, HUMAN;

ADULT; AGED; APOPTOSIS; ARTICLE; ASTROCYTOMA; ASTROCYTOMA CELL LINE; CELL INVASION; CELL MEMBRANE; CELL NUCLEUS; CELL PROLIFERATION; CONTROLLED STUDY; CYTOPLASM; DISEASE ASSOCIATION; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE MICROSCOPY; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; RNA INTERFERENCE; SCN5A GENE; BIOSYNTHESIS; BRAIN TUMOR; GENE EXPRESSION REGULATION; GENETICS; PATHOLOGY; TUMOR CELL LINE; TUMOR INVASION;

APOPTOSIS; ASTROCYTOMA; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; NEOPLASM INVASIVENESS; RNA, SMALL INTERFERING;

EID: 84902214271     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3143     Document Type: Article

References (45)

1. Binello E and Germano IM: Targeting glioma stem cells: a novel framework for brain tumors. Cancer Sci 102: 1958-1966, 2011.
2. + channels: multiplicity of expression, plasticity, functional implications and pathophysiological aspects. Eur Biophys J 33: 180-193, 2004.
3. Monk M and Holding C: Human embryonic genes re-expressed in cancer cells. Oncogene 20: 8085-8091, 2001. (Pubitemid 34028332)
4. Kunzelmann K: Ion channels and cancer. J Membr Biol 205: 159-173, 2005.
5. McFerrin MB and Sontheimer H: A role for ion channels in glioma cell invasion. Neuron Glia Biol 2: 39-49, 2006.
6. + channels in cellular migration: regulation of central nervous system development and potentiation of invasive cancers. Neuroscientist 14: 571-583, 2008.
7. + channels in the brain. J Neurogenet 22: 57-75, 2008.
8. + channels in human neuroblastoma cells are encoded by new variants of Nav1.5/SCN5A. Eur J Neurosci 22: 793-801, 2005.
9. Wang J, Ou SW, Wang YJ, Kameyama M, Kameyama A and Zong ZH: Analysis of four novel variants of Nav1.5/SCN5A cloned from the brain. Neurosci Res 64: 339-347, 2009.
10. + channel activity. FEBS Lett 569: 191-194, 2004.
11. Fraser SP, Diss JK, Chioni AM, et al: Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis. Clin Cancer Res 11: 5381-5389, 2005. (Pubitemid 41060811)
12. Brackenbury WJ, Chioni AM, Diss JK and Djamgoz MB: The neonatal splice variant of Nav1.5 potentiates in vitro invasive behaviour of MDA-MB-231 human breast cancer cells. Breast Cancer Res Treat 101: 149-160, 2007. (Pubitemid 46115421)
13. Qiu B, Sun X, Zhang D, Wang Y, Tao J and Ou S: TRAIL and paclitaxel synergize to kill U87 cells and U87-derived stem-like cells in vitro. Int J Mol Sci 13: 9142-9156, 2012.
14. Yan X, Liang H, Deng T, et al: The identification of novel targets of miR-16 and characterization of their biological functions in cancer cells. Mol Cancer 12: 92, 2013.
15. Han G, Zhao W, Wang L, et al: Leptin enhances the invasive ability of glioma stem-like cells depending on leptin receptor expression. Brain Res 1543: 1-8, 2014.
16. + T cell-independent tumor regression induced by Fc-OX40L and therapeutic vaccination in a mouse model of glioma. J Immunol 192: 224-233, 2014.
17. Ning J, Wakimoto H and Rabkin SD: Immunovirotherapy for glioblastoma. Cell Cycle 13: 175-176, 2014.
18. van Gool S: Immunotherapy for high-grade glioma: how to go beyond Phase I/II clinical trials. Immunotherapy 5: 1043-1046, 2013.
19. Kawaguchi A, Asano H, Matsushima K, Wada T, Yoshida S and Ichida S: Enhancement of sodium current in NG108-15 cells during neural differentiation is mainly due to an increase in NaV1.7 expression. Neurochem Res 32: 1469-1475, 2007. (Pubitemid 47094408)
20. + channels contribute to regulatory volume increases in human glioma cells. Am J Physiol Cell Physiol 293: C1181-C1185, 2007.
21. Weiss RE and Sidell N: Sodium currents during differentiation in a human neuroblastoma cell line. J Gen Physiol 97: 521-539, 1991.
22. Olsen ML, Schade S, Lyons SA, Amaral MD and Sontheimer H: Expression of voltage-gated chloride channels in human glioma cells. J Neurosci 23: 5572-5582, 2003. (Pubitemid 36807833)
23. Ducret T, Vacher AM and Vacher P: Voltage-dependent ionic conductances in the human malignant astrocytoma cell line U87-MG. Mol Membr Biol 20: 329-343, 2003. (Pubitemid 37392089)
24. Vila-Carriles WH, Kovacs GG, Jovov B, et al: Surface expression of ASIC2 inhibits the amiloride-sensitive current and migration of glioma cells. J Biol Chem 281: 19220-19232, 2006. (Pubitemid 44035426)
25. Wang WX and Ji YH: Scorpion venom induces glioma cell apoptosis in vivo and inhibits glioma tumor growth in vitro. J Neurooncol 73: 1-7, 2005.
26. Onganer PU and Djamgoz MB: Small-cell lung cancer (human): potentiation of endocytic membrane activity by voltage-gated Na+ channel expression in vitro. J Membr Biol 204: 67-75, 2005. (Pubitemid 41285538)
27. + channel expression to cell behaviors involved in the metastatic cascade in rat prostate cancer: II. Secretory membrane activity. J Cell Physiol 195: 461-469, 2003.
28. Ren CT, Li DM, Ou SW, et al: Cloning and expression of the two new variants of Nav1.5/SCN5A in rat brain. Mol Cell Biochem 365: 139-148, 2012.
29. Catterall WA: From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron 26: 13-25, 2000.
30. Roger S, Besson P and Le Guennec JY: Involvement of a novel fast inward sodium current in the invasion capacity of a breast cancer cell line. Biochim Biophys Acta 1616: 107-111, 2003.
31. Roger S, Rollin J, Barascu A, et al: Voltage-gated sodium channels potentiate the invasive capacities of human non-small-cell lung cancer cell lines. Int J Biochem Cell Biol 39: 774-786, 2007. (Pubitemid 46366805)
32. + channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion. Cancer Res 70: 6957-6967, 2010.
33. Gao R, Shen Y, Cai J, Lei M and Wang Z: Expression of voltage-gated sodium channel α subunit in human ovarian cancer. Oncol Rep 23: 1293-1299, 2010.
34. Diaz D, Delgadillo DM, Hernández-Gallegos E, et al: Functional expression of voltage-gated sodium channels in primary cultures of human cervical cancer. J Cell Physiol 210: 469-478, 2007. (Pubitemid 44956892)
35. Diss JK, Stewart D, Pani F, et al: A potential novel marker for human prostate cancer: voltage-gated sodium channel expression in vivo. Prostate Cancer Prostatic Dis 8: 266-273, 2005. (Pubitemid 43118065)
36. Yang M, Kozminski DJ, Wold LA, et al: Therapeutic potential for phenytoin: targeting Nav1.5 sodium channels to reduce migration and invasion in metastatic breast cancer. Breast Cancer Res Treat 134: 603-615, 2012.
37. Onkal R, Mattis JH, Fraser SP, et al: Alternative splicing of Nav1.5: an electrophysiological comparison of 'neonatal' and 'adult' isoforms and critical involvement of a lysine residue. J Cell Physiol 216: 716-726, 2008.
38. Aman TK, Grieco-Calub TM, Chen C, et al: Regulation of persistent Na current by interactions between β subunits of voltage-gated Na channels. J Neurosci 29: 2027-2042, 2009.
39. Leterrier C, Brachet A, Fache MP and Dargent B: Voltage-gated sodium channel organization in neurons: protein interactions and trafficking pathways. Neurosci Lett 486: 92-100, 2010.
40. Corry B and Thomas M: Mechanism of ion permeation and selectivity in a voltage gated sodium channel. J Am Chem Soc 134: 1840-1846, 2012.
41. Chioni AM, Shao D, Grose R and Djamgoz MB: Protein kinase A and regulation of neonatal Nav1.5 expression in human breast cancer cells: activity-dependent positive feedback and cellular migration. Int J Biochem Cell Biol 42: 346-358, 2010.
42. Brackenbury WJ: Voltage-gated sodium channels and metastatic disease. Channels 6: 352-361, 2012.
43. Abdul M and Hoosein N: Voltage-gated potassium ion channels in colon cancer. Oncol Rep 9: 961-964, 2002.
44. + channels in human endothelial cells: modulation of vascular endothelial growth factor (VEGF) signaling. J Biol Chem 286: 16846-16860, 2011.
45. Fraser SP, Grimes JA and Djamgoz MB: Effects of voltage-gated ion channel modulators on rat prostatic cancer cell proliferation: comparison of strongly and weakly metastatic cell lines. Prostate 44: 61-76, 2000. (Pubitemid 30390067)